Measuring Nasal Patency and the Sense of Smell in CRSwNP Patients Treated with Dupilumab

Chronic rhinosinusitis with nasal polyps (CRSwNP) in the most severe forms is associated with a poor quality of life. Dupilumab has been suggested as an add-on treatment option for severe CRSwNP. Severe CRSwNP patients treated with dupilumab in different rhinological units were followed up at 1, 3,...
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Autor*in:	Giancarlo Ottaviano [verfasserIn] Eugenio De Corso [verfasserIn] Elena Cantone [verfasserIn] Andrea Ciofalo [verfasserIn] Tommaso Saccardo [verfasserIn] Riccardo Bernardi [verfasserIn] Edoardo Mairani [verfasserIn] Claudio Montuori [verfasserIn] Giuseppe Roccuzzo [verfasserIn] Livia Soldati [verfasserIn] Benedetto Randon [verfasserIn] Sonny Zampollo [verfasserIn] Alessandra Di Chicco [verfasserIn] Francesca Visconti [verfasserIn] Bruno Scarpa [verfasserIn] Piero Nicolai [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	dupilumab PNIF SNOT-22 VAS NPS Sniffin’ Sticks

Übergeordnetes Werk:	In: Journal of Personalized Medicine - MDPI AG, 2012, 13(2023), 2, p 234
Übergeordnetes Werk:	volume:13 ; year:2023 ; number:2, p 234

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jpm13020234

Katalog-ID:	DOAJ080238106

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allfields	10.3390/jpm13020234 doi (DE-627)DOAJ080238106 (DE-599)DOAJe097f24ff97d416fa945fedddf5ae0e8 DE-627 ger DE-627 rakwb eng Giancarlo Ottaviano verfasserin aut Measuring Nasal Patency and the Sense of Smell in CRSwNP Patients Treated with Dupilumab 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Chronic rhinosinusitis with nasal polyps (CRSwNP) in the most severe forms is associated with a poor quality of life. Dupilumab has been suggested as an add-on treatment option for severe CRSwNP. Severe CRSwNP patients treated with dupilumab in different rhinological units were followed up at 1, 3, 6 and 12 months from the first administration and were considered for this study. At baseline (T0) and at each follow-up, patients underwent nasal endoscopy and completed the sinonasal outcome test (SNOT)-22, a visual analogue scale (VAS) for smell/nasal obstruction, peak nasal inspiratory flow (PNIF) and the Sniffin’ Sticks identification test (SSIT). The aim of the present study was to evaluate the effects of dupilumab in patients with severe uncontrolled CRSwNP on recovering nasal obstruction and smell impairment. Moreover, the method between PNIF and SSIT with the highest correlation with patients’ response to dupilumab was evaluated. One hundred forty-seven patients were included. All parameters improved during treatment (<i<p</i< < 0.001). At T0, no correlations were found between PNIF and nasal symptoms. Nevertheless, during the following evaluations significant correlations between PNIF changes and both nasal symptoms and NPS were observed (<i<p</i< < 0.05). At T0, SSIT did not correlate with SNOT-22. Similarly to PNIF, during the follow-up SSIT changes significantly correlated with nasal symptom and NPS (<i<p</i< < 0.05). Comparing PNIF and SSIT correlations with SNOT-22 and NPS, PNIF showed a higher correlation with both. Dupilumab improves nasal obstruction and the sense of smell. PNIF and SSIT are effective tools in monitoring patients’ response to dupilumab. dupilumab PNIF SNOT-22 VAS NPS Sniffin’ Sticks Medicine R Eugenio De Corso verfasserin aut Elena Cantone verfasserin aut Andrea Ciofalo verfasserin aut Tommaso Saccardo verfasserin aut Riccardo Bernardi verfasserin aut Edoardo Mairani verfasserin aut Claudio Montuori verfasserin aut Giuseppe Roccuzzo verfasserin aut Livia Soldati verfasserin aut Benedetto Randon verfasserin aut Sonny Zampollo verfasserin aut Alessandra Di Chicco verfasserin aut Francesca Visconti verfasserin aut Bruno Scarpa verfasserin aut Piero Nicolai verfasserin aut In Journal of Personalized Medicine MDPI AG, 2012 13(2023), 2, p 234 (DE-627)71862713X (DE-600)2662248-8 20754426 nnns volume:13 year:2023 number:2, p 234 https://doi.org/10.3390/jpm13020234 kostenfrei https://doaj.org/article/e097f24ff97d416fa945fedddf5ae0e8 kostenfrei https://www.mdpi.com/2075-4426/13/2/234 kostenfrei https://doaj.org/toc/2075-4426 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 2, p 234
spelling	10.3390/jpm13020234 doi (DE-627)DOAJ080238106 (DE-599)DOAJe097f24ff97d416fa945fedddf5ae0e8 DE-627 ger DE-627 rakwb eng Giancarlo Ottaviano verfasserin aut Measuring Nasal Patency and the Sense of Smell in CRSwNP Patients Treated with Dupilumab 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Chronic rhinosinusitis with nasal polyps (CRSwNP) in the most severe forms is associated with a poor quality of life. Dupilumab has been suggested as an add-on treatment option for severe CRSwNP. Severe CRSwNP patients treated with dupilumab in different rhinological units were followed up at 1, 3, 6 and 12 months from the first administration and were considered for this study. At baseline (T0) and at each follow-up, patients underwent nasal endoscopy and completed the sinonasal outcome test (SNOT)-22, a visual analogue scale (VAS) for smell/nasal obstruction, peak nasal inspiratory flow (PNIF) and the Sniffin’ Sticks identification test (SSIT). The aim of the present study was to evaluate the effects of dupilumab in patients with severe uncontrolled CRSwNP on recovering nasal obstruction and smell impairment. Moreover, the method between PNIF and SSIT with the highest correlation with patients’ response to dupilumab was evaluated. One hundred forty-seven patients were included. All parameters improved during treatment (<i<p</i< < 0.001). At T0, no correlations were found between PNIF and nasal symptoms. Nevertheless, during the following evaluations significant correlations between PNIF changes and both nasal symptoms and NPS were observed (<i<p</i< < 0.05). At T0, SSIT did not correlate with SNOT-22. Similarly to PNIF, during the follow-up SSIT changes significantly correlated with nasal symptom and NPS (<i<p</i< < 0.05). Comparing PNIF and SSIT correlations with SNOT-22 and NPS, PNIF showed a higher correlation with both. Dupilumab improves nasal obstruction and the sense of smell. PNIF and SSIT are effective tools in monitoring patients’ response to dupilumab. dupilumab PNIF SNOT-22 VAS NPS Sniffin’ Sticks Medicine R Eugenio De Corso verfasserin aut Elena Cantone verfasserin aut Andrea Ciofalo verfasserin aut Tommaso Saccardo verfasserin aut Riccardo Bernardi verfasserin aut Edoardo Mairani verfasserin aut Claudio Montuori verfasserin aut Giuseppe Roccuzzo verfasserin aut Livia Soldati verfasserin aut Benedetto Randon verfasserin aut Sonny Zampollo verfasserin aut Alessandra Di Chicco verfasserin aut Francesca Visconti verfasserin aut Bruno Scarpa verfasserin aut Piero Nicolai verfasserin aut In Journal of Personalized Medicine MDPI AG, 2012 13(2023), 2, p 234 (DE-627)71862713X (DE-600)2662248-8 20754426 nnns volume:13 year:2023 number:2, p 234 https://doi.org/10.3390/jpm13020234 kostenfrei https://doaj.org/article/e097f24ff97d416fa945fedddf5ae0e8 kostenfrei https://www.mdpi.com/2075-4426/13/2/234 kostenfrei https://doaj.org/toc/2075-4426 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 2, p 234
allfields_unstemmed	10.3390/jpm13020234 doi (DE-627)DOAJ080238106 (DE-599)DOAJe097f24ff97d416fa945fedddf5ae0e8 DE-627 ger DE-627 rakwb eng Giancarlo Ottaviano verfasserin aut Measuring Nasal Patency and the Sense of Smell in CRSwNP Patients Treated with Dupilumab 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Chronic rhinosinusitis with nasal polyps (CRSwNP) in the most severe forms is associated with a poor quality of life. Dupilumab has been suggested as an add-on treatment option for severe CRSwNP. Severe CRSwNP patients treated with dupilumab in different rhinological units were followed up at 1, 3, 6 and 12 months from the first administration and were considered for this study. At baseline (T0) and at each follow-up, patients underwent nasal endoscopy and completed the sinonasal outcome test (SNOT)-22, a visual analogue scale (VAS) for smell/nasal obstruction, peak nasal inspiratory flow (PNIF) and the Sniffin’ Sticks identification test (SSIT). The aim of the present study was to evaluate the effects of dupilumab in patients with severe uncontrolled CRSwNP on recovering nasal obstruction and smell impairment. Moreover, the method between PNIF and SSIT with the highest correlation with patients’ response to dupilumab was evaluated. One hundred forty-seven patients were included. All parameters improved during treatment (<i<p</i< < 0.001). At T0, no correlations were found between PNIF and nasal symptoms. Nevertheless, during the following evaluations significant correlations between PNIF changes and both nasal symptoms and NPS were observed (<i<p</i< < 0.05). At T0, SSIT did not correlate with SNOT-22. Similarly to PNIF, during the follow-up SSIT changes significantly correlated with nasal symptom and NPS (<i<p</i< < 0.05). Comparing PNIF and SSIT correlations with SNOT-22 and NPS, PNIF showed a higher correlation with both. Dupilumab improves nasal obstruction and the sense of smell. PNIF and SSIT are effective tools in monitoring patients’ response to dupilumab. dupilumab PNIF SNOT-22 VAS NPS Sniffin’ Sticks Medicine R Eugenio De Corso verfasserin aut Elena Cantone verfasserin aut Andrea Ciofalo verfasserin aut Tommaso Saccardo verfasserin aut Riccardo Bernardi verfasserin aut Edoardo Mairani verfasserin aut Claudio Montuori verfasserin aut Giuseppe Roccuzzo verfasserin aut Livia Soldati verfasserin aut Benedetto Randon verfasserin aut Sonny Zampollo verfasserin aut Alessandra Di Chicco verfasserin aut Francesca Visconti verfasserin aut Bruno Scarpa verfasserin aut Piero Nicolai verfasserin aut In Journal of Personalized Medicine MDPI AG, 2012 13(2023), 2, p 234 (DE-627)71862713X (DE-600)2662248-8 20754426 nnns volume:13 year:2023 number:2, p 234 https://doi.org/10.3390/jpm13020234 kostenfrei https://doaj.org/article/e097f24ff97d416fa945fedddf5ae0e8 kostenfrei https://www.mdpi.com/2075-4426/13/2/234 kostenfrei https://doaj.org/toc/2075-4426 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 2, p 234
allfieldsGer	10.3390/jpm13020234 doi (DE-627)DOAJ080238106 (DE-599)DOAJe097f24ff97d416fa945fedddf5ae0e8 DE-627 ger DE-627 rakwb eng Giancarlo Ottaviano verfasserin aut Measuring Nasal Patency and the Sense of Smell in CRSwNP Patients Treated with Dupilumab 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Chronic rhinosinusitis with nasal polyps (CRSwNP) in the most severe forms is associated with a poor quality of life. Dupilumab has been suggested as an add-on treatment option for severe CRSwNP. Severe CRSwNP patients treated with dupilumab in different rhinological units were followed up at 1, 3, 6 and 12 months from the first administration and were considered for this study. At baseline (T0) and at each follow-up, patients underwent nasal endoscopy and completed the sinonasal outcome test (SNOT)-22, a visual analogue scale (VAS) for smell/nasal obstruction, peak nasal inspiratory flow (PNIF) and the Sniffin’ Sticks identification test (SSIT). The aim of the present study was to evaluate the effects of dupilumab in patients with severe uncontrolled CRSwNP on recovering nasal obstruction and smell impairment. Moreover, the method between PNIF and SSIT with the highest correlation with patients’ response to dupilumab was evaluated. One hundred forty-seven patients were included. All parameters improved during treatment (<i<p</i< < 0.001). At T0, no correlations were found between PNIF and nasal symptoms. Nevertheless, during the following evaluations significant correlations between PNIF changes and both nasal symptoms and NPS were observed (<i<p</i< < 0.05). At T0, SSIT did not correlate with SNOT-22. Similarly to PNIF, during the follow-up SSIT changes significantly correlated with nasal symptom and NPS (<i<p</i< < 0.05). Comparing PNIF and SSIT correlations with SNOT-22 and NPS, PNIF showed a higher correlation with both. Dupilumab improves nasal obstruction and the sense of smell. PNIF and SSIT are effective tools in monitoring patients’ response to dupilumab. dupilumab PNIF SNOT-22 VAS NPS Sniffin’ Sticks Medicine R Eugenio De Corso verfasserin aut Elena Cantone verfasserin aut Andrea Ciofalo verfasserin aut Tommaso Saccardo verfasserin aut Riccardo Bernardi verfasserin aut Edoardo Mairani verfasserin aut Claudio Montuori verfasserin aut Giuseppe Roccuzzo verfasserin aut Livia Soldati verfasserin aut Benedetto Randon verfasserin aut Sonny Zampollo verfasserin aut Alessandra Di Chicco verfasserin aut Francesca Visconti verfasserin aut Bruno Scarpa verfasserin aut Piero Nicolai verfasserin aut In Journal of Personalized Medicine MDPI AG, 2012 13(2023), 2, p 234 (DE-627)71862713X (DE-600)2662248-8 20754426 nnns volume:13 year:2023 number:2, p 234 https://doi.org/10.3390/jpm13020234 kostenfrei https://doaj.org/article/e097f24ff97d416fa945fedddf5ae0e8 kostenfrei https://www.mdpi.com/2075-4426/13/2/234 kostenfrei https://doaj.org/toc/2075-4426 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 2, p 234
allfieldsSound	10.3390/jpm13020234 doi (DE-627)DOAJ080238106 (DE-599)DOAJe097f24ff97d416fa945fedddf5ae0e8 DE-627 ger DE-627 rakwb eng Giancarlo Ottaviano verfasserin aut Measuring Nasal Patency and the Sense of Smell in CRSwNP Patients Treated with Dupilumab 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Chronic rhinosinusitis with nasal polyps (CRSwNP) in the most severe forms is associated with a poor quality of life. Dupilumab has been suggested as an add-on treatment option for severe CRSwNP. Severe CRSwNP patients treated with dupilumab in different rhinological units were followed up at 1, 3, 6 and 12 months from the first administration and were considered for this study. At baseline (T0) and at each follow-up, patients underwent nasal endoscopy and completed the sinonasal outcome test (SNOT)-22, a visual analogue scale (VAS) for smell/nasal obstruction, peak nasal inspiratory flow (PNIF) and the Sniffin’ Sticks identification test (SSIT). The aim of the present study was to evaluate the effects of dupilumab in patients with severe uncontrolled CRSwNP on recovering nasal obstruction and smell impairment. Moreover, the method between PNIF and SSIT with the highest correlation with patients’ response to dupilumab was evaluated. One hundred forty-seven patients were included. All parameters improved during treatment (<i<p</i< < 0.001). At T0, no correlations were found between PNIF and nasal symptoms. Nevertheless, during the following evaluations significant correlations between PNIF changes and both nasal symptoms and NPS were observed (<i<p</i< < 0.05). At T0, SSIT did not correlate with SNOT-22. Similarly to PNIF, during the follow-up SSIT changes significantly correlated with nasal symptom and NPS (<i<p</i< < 0.05). Comparing PNIF and SSIT correlations with SNOT-22 and NPS, PNIF showed a higher correlation with both. Dupilumab improves nasal obstruction and the sense of smell. PNIF and SSIT are effective tools in monitoring patients’ response to dupilumab. dupilumab PNIF SNOT-22 VAS NPS Sniffin’ Sticks Medicine R Eugenio De Corso verfasserin aut Elena Cantone verfasserin aut Andrea Ciofalo verfasserin aut Tommaso Saccardo verfasserin aut Riccardo Bernardi verfasserin aut Edoardo Mairani verfasserin aut Claudio Montuori verfasserin aut Giuseppe Roccuzzo verfasserin aut Livia Soldati verfasserin aut Benedetto Randon verfasserin aut Sonny Zampollo verfasserin aut Alessandra Di Chicco verfasserin aut Francesca Visconti verfasserin aut Bruno Scarpa verfasserin aut Piero Nicolai verfasserin aut In Journal of Personalized Medicine MDPI AG, 2012 13(2023), 2, p 234 (DE-627)71862713X (DE-600)2662248-8 20754426 nnns volume:13 year:2023 number:2, p 234 https://doi.org/10.3390/jpm13020234 kostenfrei https://doaj.org/article/e097f24ff97d416fa945fedddf5ae0e8 kostenfrei https://www.mdpi.com/2075-4426/13/2/234 kostenfrei https://doaj.org/toc/2075-4426 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 2, p 234
language	English
source	In Journal of Personalized Medicine 13(2023), 2, p 234 volume:13 year:2023 number:2, p 234
sourceStr	In Journal of Personalized Medicine 13(2023), 2, p 234 volume:13 year:2023 number:2, p 234
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	dupilumab PNIF SNOT-22 VAS NPS Sniffin’ Sticks Medicine R
isfreeaccess_bool	true
container_title	Journal of Personalized Medicine
authorswithroles_txt_mv	Giancarlo Ottaviano @@aut@@ Eugenio De Corso @@aut@@ Elena Cantone @@aut@@ Andrea Ciofalo @@aut@@ Tommaso Saccardo @@aut@@ Riccardo Bernardi @@aut@@ Edoardo Mairani @@aut@@ Claudio Montuori @@aut@@ Giuseppe Roccuzzo @@aut@@ Livia Soldati @@aut@@ Benedetto Randon @@aut@@ Sonny Zampollo @@aut@@ Alessandra Di Chicco @@aut@@ Francesca Visconti @@aut@@ Bruno Scarpa @@aut@@ Piero Nicolai @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	71862713X
id	DOAJ080238106
language_de	englisch
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author	Giancarlo Ottaviano
spellingShingle	Giancarlo Ottaviano misc dupilumab misc PNIF misc SNOT-22 misc VAS misc NPS misc Sniffin’ Sticks misc Medicine misc R Measuring Nasal Patency and the Sense of Smell in CRSwNP Patients Treated with Dupilumab
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topic_title	Measuring Nasal Patency and the Sense of Smell in CRSwNP Patients Treated with Dupilumab dupilumab PNIF SNOT-22 VAS NPS Sniffin’ Sticks
topic	misc dupilumab misc PNIF misc SNOT-22 misc VAS misc NPS misc Sniffin’ Sticks misc Medicine misc R
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title	Measuring Nasal Patency and the Sense of Smell in CRSwNP Patients Treated with Dupilumab
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title_full	Measuring Nasal Patency and the Sense of Smell in CRSwNP Patients Treated with Dupilumab
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author_browse	Giancarlo Ottaviano Eugenio De Corso Elena Cantone Andrea Ciofalo Tommaso Saccardo Riccardo Bernardi Edoardo Mairani Claudio Montuori Giuseppe Roccuzzo Livia Soldati Benedetto Randon Sonny Zampollo Alessandra Di Chicco Francesca Visconti Bruno Scarpa Piero Nicolai
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title_sort	measuring nasal patency and the sense of smell in crswnp patients treated with dupilumab
title_auth	Measuring Nasal Patency and the Sense of Smell in CRSwNP Patients Treated with Dupilumab
abstract	Chronic rhinosinusitis with nasal polyps (CRSwNP) in the most severe forms is associated with a poor quality of life. Dupilumab has been suggested as an add-on treatment option for severe CRSwNP. Severe CRSwNP patients treated with dupilumab in different rhinological units were followed up at 1, 3, 6 and 12 months from the first administration and were considered for this study. At baseline (T0) and at each follow-up, patients underwent nasal endoscopy and completed the sinonasal outcome test (SNOT)-22, a visual analogue scale (VAS) for smell/nasal obstruction, peak nasal inspiratory flow (PNIF) and the Sniffin’ Sticks identification test (SSIT). The aim of the present study was to evaluate the effects of dupilumab in patients with severe uncontrolled CRSwNP on recovering nasal obstruction and smell impairment. Moreover, the method between PNIF and SSIT with the highest correlation with patients’ response to dupilumab was evaluated. One hundred forty-seven patients were included. All parameters improved during treatment (<i<p</i< < 0.001). At T0, no correlations were found between PNIF and nasal symptoms. Nevertheless, during the following evaluations significant correlations between PNIF changes and both nasal symptoms and NPS were observed (<i<p</i< < 0.05). At T0, SSIT did not correlate with SNOT-22. Similarly to PNIF, during the follow-up SSIT changes significantly correlated with nasal symptom and NPS (<i<p</i< < 0.05). Comparing PNIF and SSIT correlations with SNOT-22 and NPS, PNIF showed a higher correlation with both. Dupilumab improves nasal obstruction and the sense of smell. PNIF and SSIT are effective tools in monitoring patients’ response to dupilumab.
abstractGer	Chronic rhinosinusitis with nasal polyps (CRSwNP) in the most severe forms is associated with a poor quality of life. Dupilumab has been suggested as an add-on treatment option for severe CRSwNP. Severe CRSwNP patients treated with dupilumab in different rhinological units were followed up at 1, 3, 6 and 12 months from the first administration and were considered for this study. At baseline (T0) and at each follow-up, patients underwent nasal endoscopy and completed the sinonasal outcome test (SNOT)-22, a visual analogue scale (VAS) for smell/nasal obstruction, peak nasal inspiratory flow (PNIF) and the Sniffin’ Sticks identification test (SSIT). The aim of the present study was to evaluate the effects of dupilumab in patients with severe uncontrolled CRSwNP on recovering nasal obstruction and smell impairment. Moreover, the method between PNIF and SSIT with the highest correlation with patients’ response to dupilumab was evaluated. One hundred forty-seven patients were included. All parameters improved during treatment (<i<p</i< < 0.001). At T0, no correlations were found between PNIF and nasal symptoms. Nevertheless, during the following evaluations significant correlations between PNIF changes and both nasal symptoms and NPS were observed (<i<p</i< < 0.05). At T0, SSIT did not correlate with SNOT-22. Similarly to PNIF, during the follow-up SSIT changes significantly correlated with nasal symptom and NPS (<i<p</i< < 0.05). Comparing PNIF and SSIT correlations with SNOT-22 and NPS, PNIF showed a higher correlation with both. Dupilumab improves nasal obstruction and the sense of smell. PNIF and SSIT are effective tools in monitoring patients’ response to dupilumab.
abstract_unstemmed	Chronic rhinosinusitis with nasal polyps (CRSwNP) in the most severe forms is associated with a poor quality of life. Dupilumab has been suggested as an add-on treatment option for severe CRSwNP. Severe CRSwNP patients treated with dupilumab in different rhinological units were followed up at 1, 3, 6 and 12 months from the first administration and were considered for this study. At baseline (T0) and at each follow-up, patients underwent nasal endoscopy and completed the sinonasal outcome test (SNOT)-22, a visual analogue scale (VAS) for smell/nasal obstruction, peak nasal inspiratory flow (PNIF) and the Sniffin’ Sticks identification test (SSIT). The aim of the present study was to evaluate the effects of dupilumab in patients with severe uncontrolled CRSwNP on recovering nasal obstruction and smell impairment. Moreover, the method between PNIF and SSIT with the highest correlation with patients’ response to dupilumab was evaluated. One hundred forty-seven patients were included. All parameters improved during treatment (<i<p</i< < 0.001). At T0, no correlations were found between PNIF and nasal symptoms. Nevertheless, during the following evaluations significant correlations between PNIF changes and both nasal symptoms and NPS were observed (<i<p</i< < 0.05). At T0, SSIT did not correlate with SNOT-22. Similarly to PNIF, during the follow-up SSIT changes significantly correlated with nasal symptom and NPS (<i<p</i< < 0.05). Comparing PNIF and SSIT correlations with SNOT-22 and NPS, PNIF showed a higher correlation with both. Dupilumab improves nasal obstruction and the sense of smell. PNIF and SSIT are effective tools in monitoring patients’ response to dupilumab.
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title_short	Measuring Nasal Patency and the Sense of Smell in CRSwNP Patients Treated with Dupilumab
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