Estradiol decreases the excitability of RA projection neurons in adult male zebra finches

Zebra finches are essential animal models for studying learned vocal signals. The robust nucleus of the arcopallium (RA) plays an important role in regulating singing behavior. Our previous study showed that castration inhibited the electrophysiological activity of RA projection neurons (PNs) in mal...
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Autor*in:	Yutao Zhang [verfasserIn] Yalun Sun [verfasserIn] Yanran Wu [verfasserIn] Wei Sun [verfasserIn] Kun Zhang [verfasserIn] Wei Meng [verfasserIn] Songhua Wang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	estradiol excitability robust nucleus of the arcopallium zebra finches projection neuron

Übergeordnetes Werk:	In: Frontiers in Cellular Neuroscience - Frontiers Media S.A., 2008, 17(2023)
Übergeordnetes Werk:	volume:17 ; year:2023

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fncel.2023.1046984

Katalog-ID:	DOAJ080467679

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520			\|a Zebra finches are essential animal models for studying learned vocal signals. The robust nucleus of the arcopallium (RA) plays an important role in regulating singing behavior. Our previous study showed that castration inhibited the electrophysiological activity of RA projection neurons (PNs) in male zebra finches, demonstrating that testosterone modulates the excitability of RA PNs. Testosterone can be converted into estradiol (E2) in the brain through aromatase; however, the physiological functions of E2 in RA are still unknown. This study aimed to investigate the electrophysiological activities of E2 on the RA PNs of male zebra finches through patch-clamp recording. E2 rapidly decreased the rate of evoked and spontaneous action potentials (APs) of RA PNs, hyperpolarized the resting membrane potential, and decreased the membrane input resistance. Moreover, the G-protein–coupled membrane-bound estrogen receptor (GPER) agonist G1 decreased both the evoked and spontaneous APs of RA PNs. Furthermore, the GPER antagonist G15 had no effect on the evoked and spontaneous APs of RA PNs; E2 and G15 together also had no effect on the evoked and spontaneous APs of RA PNs. These findings suggested that E2 rapidly decreased the excitability of RA PNs and its binding to GPER suppressed the excitability of RA PNs. These pieces of evidence helped us fully understand the principle of E2 signal mediation via its receptors to modulate the excitability of RA PNs in songbirds.
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allfields	10.3389/fncel.2023.1046984 doi (DE-627)DOAJ080467679 (DE-599)DOAJaeb5e102a8274f3984eaca131977a2d4 DE-627 ger DE-627 rakwb eng RC321-571 Yutao Zhang verfasserin aut Estradiol decreases the excitability of RA projection neurons in adult male zebra finches 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Zebra finches are essential animal models for studying learned vocal signals. The robust nucleus of the arcopallium (RA) plays an important role in regulating singing behavior. Our previous study showed that castration inhibited the electrophysiological activity of RA projection neurons (PNs) in male zebra finches, demonstrating that testosterone modulates the excitability of RA PNs. Testosterone can be converted into estradiol (E2) in the brain through aromatase; however, the physiological functions of E2 in RA are still unknown. This study aimed to investigate the electrophysiological activities of E2 on the RA PNs of male zebra finches through patch-clamp recording. E2 rapidly decreased the rate of evoked and spontaneous action potentials (APs) of RA PNs, hyperpolarized the resting membrane potential, and decreased the membrane input resistance. Moreover, the G-protein–coupled membrane-bound estrogen receptor (GPER) agonist G1 decreased both the evoked and spontaneous APs of RA PNs. Furthermore, the GPER antagonist G15 had no effect on the evoked and spontaneous APs of RA PNs; E2 and G15 together also had no effect on the evoked and spontaneous APs of RA PNs. These findings suggested that E2 rapidly decreased the excitability of RA PNs and its binding to GPER suppressed the excitability of RA PNs. These pieces of evidence helped us fully understand the principle of E2 signal mediation via its receptors to modulate the excitability of RA PNs in songbirds. estradiol excitability robust nucleus of the arcopallium zebra finches projection neuron Neurosciences. Biological psychiatry. Neuropsychiatry Yalun Sun verfasserin aut Yanran Wu verfasserin aut Wei Sun verfasserin aut Kun Zhang verfasserin aut Wei Meng verfasserin aut Songhua Wang verfasserin aut In Frontiers in Cellular Neuroscience Frontiers Media S.A., 2008 17(2023) (DE-627)579826414 (DE-600)2452963-1 16625102 nnns volume:17 year:2023 https://doi.org/10.3389/fncel.2023.1046984 kostenfrei https://doaj.org/article/aeb5e102a8274f3984eaca131977a2d4 kostenfrei https://www.frontiersin.org/articles/10.3389/fncel.2023.1046984/full kostenfrei https://doaj.org/toc/1662-5102 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2023
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allfieldsGer	10.3389/fncel.2023.1046984 doi (DE-627)DOAJ080467679 (DE-599)DOAJaeb5e102a8274f3984eaca131977a2d4 DE-627 ger DE-627 rakwb eng RC321-571 Yutao Zhang verfasserin aut Estradiol decreases the excitability of RA projection neurons in adult male zebra finches 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Zebra finches are essential animal models for studying learned vocal signals. The robust nucleus of the arcopallium (RA) plays an important role in regulating singing behavior. Our previous study showed that castration inhibited the electrophysiological activity of RA projection neurons (PNs) in male zebra finches, demonstrating that testosterone modulates the excitability of RA PNs. Testosterone can be converted into estradiol (E2) in the brain through aromatase; however, the physiological functions of E2 in RA are still unknown. This study aimed to investigate the electrophysiological activities of E2 on the RA PNs of male zebra finches through patch-clamp recording. E2 rapidly decreased the rate of evoked and spontaneous action potentials (APs) of RA PNs, hyperpolarized the resting membrane potential, and decreased the membrane input resistance. Moreover, the G-protein–coupled membrane-bound estrogen receptor (GPER) agonist G1 decreased both the evoked and spontaneous APs of RA PNs. Furthermore, the GPER antagonist G15 had no effect on the evoked and spontaneous APs of RA PNs; E2 and G15 together also had no effect on the evoked and spontaneous APs of RA PNs. These findings suggested that E2 rapidly decreased the excitability of RA PNs and its binding to GPER suppressed the excitability of RA PNs. These pieces of evidence helped us fully understand the principle of E2 signal mediation via its receptors to modulate the excitability of RA PNs in songbirds. estradiol excitability robust nucleus of the arcopallium zebra finches projection neuron Neurosciences. Biological psychiatry. Neuropsychiatry Yalun Sun verfasserin aut Yanran Wu verfasserin aut Wei Sun verfasserin aut Kun Zhang verfasserin aut Wei Meng verfasserin aut Songhua Wang verfasserin aut In Frontiers in Cellular Neuroscience Frontiers Media S.A., 2008 17(2023) (DE-627)579826414 (DE-600)2452963-1 16625102 nnns volume:17 year:2023 https://doi.org/10.3389/fncel.2023.1046984 kostenfrei https://doaj.org/article/aeb5e102a8274f3984eaca131977a2d4 kostenfrei https://www.frontiersin.org/articles/10.3389/fncel.2023.1046984/full kostenfrei https://doaj.org/toc/1662-5102 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2023
allfieldsSound	10.3389/fncel.2023.1046984 doi (DE-627)DOAJ080467679 (DE-599)DOAJaeb5e102a8274f3984eaca131977a2d4 DE-627 ger DE-627 rakwb eng RC321-571 Yutao Zhang verfasserin aut Estradiol decreases the excitability of RA projection neurons in adult male zebra finches 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Zebra finches are essential animal models for studying learned vocal signals. The robust nucleus of the arcopallium (RA) plays an important role in regulating singing behavior. Our previous study showed that castration inhibited the electrophysiological activity of RA projection neurons (PNs) in male zebra finches, demonstrating that testosterone modulates the excitability of RA PNs. Testosterone can be converted into estradiol (E2) in the brain through aromatase; however, the physiological functions of E2 in RA are still unknown. This study aimed to investigate the electrophysiological activities of E2 on the RA PNs of male zebra finches through patch-clamp recording. E2 rapidly decreased the rate of evoked and spontaneous action potentials (APs) of RA PNs, hyperpolarized the resting membrane potential, and decreased the membrane input resistance. Moreover, the G-protein–coupled membrane-bound estrogen receptor (GPER) agonist G1 decreased both the evoked and spontaneous APs of RA PNs. Furthermore, the GPER antagonist G15 had no effect on the evoked and spontaneous APs of RA PNs; E2 and G15 together also had no effect on the evoked and spontaneous APs of RA PNs. These findings suggested that E2 rapidly decreased the excitability of RA PNs and its binding to GPER suppressed the excitability of RA PNs. These pieces of evidence helped us fully understand the principle of E2 signal mediation via its receptors to modulate the excitability of RA PNs in songbirds. estradiol excitability robust nucleus of the arcopallium zebra finches projection neuron Neurosciences. Biological psychiatry. Neuropsychiatry Yalun Sun verfasserin aut Yanran Wu verfasserin aut Wei Sun verfasserin aut Kun Zhang verfasserin aut Wei Meng verfasserin aut Songhua Wang verfasserin aut In Frontiers in Cellular Neuroscience Frontiers Media S.A., 2008 17(2023) (DE-627)579826414 (DE-600)2452963-1 16625102 nnns volume:17 year:2023 https://doi.org/10.3389/fncel.2023.1046984 kostenfrei https://doaj.org/article/aeb5e102a8274f3984eaca131977a2d4 kostenfrei https://www.frontiersin.org/articles/10.3389/fncel.2023.1046984/full kostenfrei https://doaj.org/toc/1662-5102 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2023
language	English
source	In Frontiers in Cellular Neuroscience 17(2023) volume:17 year:2023
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topic_facet	estradiol excitability robust nucleus of the arcopallium zebra finches projection neuron Neurosciences. Biological psychiatry. Neuropsychiatry
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container_title	Frontiers in Cellular Neuroscience
authorswithroles_txt_mv	Yutao Zhang @@aut@@ Yalun Sun @@aut@@ Yanran Wu @@aut@@ Wei Sun @@aut@@ Kun Zhang @@aut@@ Wei Meng @@aut@@ Songhua Wang @@aut@@
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callnumber-first	R - Medicine
author	Yutao Zhang
spellingShingle	Yutao Zhang misc RC321-571 misc estradiol misc excitability misc robust nucleus of the arcopallium misc zebra finches misc projection neuron misc Neurosciences. Biological psychiatry. Neuropsychiatry Estradiol decreases the excitability of RA projection neurons in adult male zebra finches
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topic_title	RC321-571 Estradiol decreases the excitability of RA projection neurons in adult male zebra finches estradiol excitability robust nucleus of the arcopallium zebra finches projection neuron
topic	misc RC321-571 misc estradiol misc excitability misc robust nucleus of the arcopallium misc zebra finches misc projection neuron misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc estradiol misc excitability misc robust nucleus of the arcopallium misc zebra finches misc projection neuron misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Estradiol decreases the excitability of RA projection neurons in adult male zebra finches
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title_full	Estradiol decreases the excitability of RA projection neurons in adult male zebra finches
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title_sort	estradiol decreases the excitability of ra projection neurons in adult male zebra finches
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title_auth	Estradiol decreases the excitability of RA projection neurons in adult male zebra finches
abstract	Zebra finches are essential animal models for studying learned vocal signals. The robust nucleus of the arcopallium (RA) plays an important role in regulating singing behavior. Our previous study showed that castration inhibited the electrophysiological activity of RA projection neurons (PNs) in male zebra finches, demonstrating that testosterone modulates the excitability of RA PNs. Testosterone can be converted into estradiol (E2) in the brain through aromatase; however, the physiological functions of E2 in RA are still unknown. This study aimed to investigate the electrophysiological activities of E2 on the RA PNs of male zebra finches through patch-clamp recording. E2 rapidly decreased the rate of evoked and spontaneous action potentials (APs) of RA PNs, hyperpolarized the resting membrane potential, and decreased the membrane input resistance. Moreover, the G-protein–coupled membrane-bound estrogen receptor (GPER) agonist G1 decreased both the evoked and spontaneous APs of RA PNs. Furthermore, the GPER antagonist G15 had no effect on the evoked and spontaneous APs of RA PNs; E2 and G15 together also had no effect on the evoked and spontaneous APs of RA PNs. These findings suggested that E2 rapidly decreased the excitability of RA PNs and its binding to GPER suppressed the excitability of RA PNs. These pieces of evidence helped us fully understand the principle of E2 signal mediation via its receptors to modulate the excitability of RA PNs in songbirds.
abstractGer	Zebra finches are essential animal models for studying learned vocal signals. The robust nucleus of the arcopallium (RA) plays an important role in regulating singing behavior. Our previous study showed that castration inhibited the electrophysiological activity of RA projection neurons (PNs) in male zebra finches, demonstrating that testosterone modulates the excitability of RA PNs. Testosterone can be converted into estradiol (E2) in the brain through aromatase; however, the physiological functions of E2 in RA are still unknown. This study aimed to investigate the electrophysiological activities of E2 on the RA PNs of male zebra finches through patch-clamp recording. E2 rapidly decreased the rate of evoked and spontaneous action potentials (APs) of RA PNs, hyperpolarized the resting membrane potential, and decreased the membrane input resistance. Moreover, the G-protein–coupled membrane-bound estrogen receptor (GPER) agonist G1 decreased both the evoked and spontaneous APs of RA PNs. Furthermore, the GPER antagonist G15 had no effect on the evoked and spontaneous APs of RA PNs; E2 and G15 together also had no effect on the evoked and spontaneous APs of RA PNs. These findings suggested that E2 rapidly decreased the excitability of RA PNs and its binding to GPER suppressed the excitability of RA PNs. These pieces of evidence helped us fully understand the principle of E2 signal mediation via its receptors to modulate the excitability of RA PNs in songbirds.
abstract_unstemmed	Zebra finches are essential animal models for studying learned vocal signals. The robust nucleus of the arcopallium (RA) plays an important role in regulating singing behavior. Our previous study showed that castration inhibited the electrophysiological activity of RA projection neurons (PNs) in male zebra finches, demonstrating that testosterone modulates the excitability of RA PNs. Testosterone can be converted into estradiol (E2) in the brain through aromatase; however, the physiological functions of E2 in RA are still unknown. This study aimed to investigate the electrophysiological activities of E2 on the RA PNs of male zebra finches through patch-clamp recording. E2 rapidly decreased the rate of evoked and spontaneous action potentials (APs) of RA PNs, hyperpolarized the resting membrane potential, and decreased the membrane input resistance. Moreover, the G-protein–coupled membrane-bound estrogen receptor (GPER) agonist G1 decreased both the evoked and spontaneous APs of RA PNs. Furthermore, the GPER antagonist G15 had no effect on the evoked and spontaneous APs of RA PNs; E2 and G15 together also had no effect on the evoked and spontaneous APs of RA PNs. These findings suggested that E2 rapidly decreased the excitability of RA PNs and its binding to GPER suppressed the excitability of RA PNs. These pieces of evidence helped us fully understand the principle of E2 signal mediation via its receptors to modulate the excitability of RA PNs in songbirds.
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title_short	Estradiol decreases the excitability of RA projection neurons in adult male zebra finches
url	https://doi.org/10.3389/fncel.2023.1046984 https://doaj.org/article/aeb5e102a8274f3984eaca131977a2d4 https://www.frontiersin.org/articles/10.3389/fncel.2023.1046984/full https://doaj.org/toc/1662-5102
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author2	Yalun Sun Yanran Wu Wei Sun Kun Zhang Wei Meng Songhua Wang
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up_date	2024-07-03T14:47:16.207Z
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Estradiol decreases the excitability of RA projection neurons in adult male zebra finches

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