Characteristics and Correlations of the Oral and Gut Fungal Microbiome with Hypertension

ABSTRACT The mycobiome is an essential constituent of the human microbiome and is associated with various diseases. However, the role of oral and gut fungi in hypertension (HTN) remains largely unexplored. In this study, saliva, subgingival plaques, and feces were collected from 36 participants with HTN and 24 healthy controls for metagenomic sequencing. The obtained sequences were analyzed using the Kraken2 taxonomic annotation pipeline to assess fungal composition and diversity. Correlations between oral and gut fungi and clinic parameters, between fungi within the same sample types, and between different sample types were identified by Spearman’s correlation analysis. Overall, the subgingival fungal microbiome had substantially higher alpha diversity than the salivary and fecal fungal microbiomes. The fungal microbiomes of the three sample types displayed distinct beta diversity from each other. Oral fungi but not gut fungi in HTN had beta diversity significantly different from that of controls. Among the fungi shared in the oral cavity and gut, Exophiala was the genus with the most notable changes. Exophiala spinifera was the most abundant salivary species in HTN. Some fungal species directly correlated with blood pressure, including gut Exophiala xenobiotica and Exophiala mesophila. The markedly impaired ecological cocorrelation networks of oral and gut fungi in HTN suggested compromised association among fungal species. Most fungi were shared in the oral cavity and gut, and their correlations suggested the potential interplays between oral and gut fungi. In conclusion, the oral cavity and intestine have unique fungal ecological environments. The fungal enrichment and ecology in HTN, the correlations between oral and gut fungi, and the associations between oral and gut fungi and clinical parameters suggest an important role that the fungal microbiome may play in HTN. IMPORTANCE Our study fills the gap in human studies investigating the oral and gut fungal microbiota in association with blood pressure. It characterizes the diversity and composition of the oral and gut fungal microbiome in human subjects, elucidates the dysbiosis of fungal ecology in a hypertensive population, and establishes oral-gut fungal correlations and fungus-clinical parameter correlations. Targeting fungi in the oral cavity and/or gut may provide novel strategies for the prevention and treatment of hypertension. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Bo-Yan Chen [verfasserIn] Wen-Zhen Lin [verfasserIn] Yu-Lin Li [verfasserIn] Chao Bi [verfasserIn] Lin-Juan Du [verfasserIn] Yuan Liu [verfasserIn] Lu-Jun Zhou [verfasserIn] Ting Liu [verfasserIn] Shuo Xu [verfasserIn] Chao-Ji Shi [verfasserIn] Hong Zhu [verfasserIn] Yong-Li Wang [verfasserIn] Jian-Yong Sun [verfasserIn] Yan Liu [verfasserIn] Wu-Chang Zhang [verfasserIn] Zhiyuan Zhang [verfasserIn] Hui-li Zhang [verfasserIn] Ya-Qin Zhu [verfasserIn] Sheng-Zhong Duan [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	gut fungal microbiome hypertension oral fungal microbiome oral-gut fungal correlations

Übergeordnetes Werk:	In: Microbiology Spectrum - American Society for Microbiology, 2022, 11(2023), 1
Übergeordnetes Werk:	volume:11 ; year:2023 ; number:1

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1128/spectrum.01956-22

Katalog-ID:	DOAJ080471951

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allfields	10.1128/spectrum.01956-22 doi (DE-627)DOAJ080471951 (DE-599)DOAJ537dd5e490e04690aad0233584470ae0 DE-627 ger DE-627 rakwb eng QR1-502 Bo-Yan Chen verfasserin aut Characteristics and Correlations of the Oral and Gut Fungal Microbiome with Hypertension 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT The mycobiome is an essential constituent of the human microbiome and is associated with various diseases. However, the role of oral and gut fungi in hypertension (HTN) remains largely unexplored. In this study, saliva, subgingival plaques, and feces were collected from 36 participants with HTN and 24 healthy controls for metagenomic sequencing. The obtained sequences were analyzed using the Kraken2 taxonomic annotation pipeline to assess fungal composition and diversity. Correlations between oral and gut fungi and clinic parameters, between fungi within the same sample types, and between different sample types were identified by Spearman’s correlation analysis. Overall, the subgingival fungal microbiome had substantially higher alpha diversity than the salivary and fecal fungal microbiomes. The fungal microbiomes of the three sample types displayed distinct beta diversity from each other. Oral fungi but not gut fungi in HTN had beta diversity significantly different from that of controls. Among the fungi shared in the oral cavity and gut, Exophiala was the genus with the most notable changes. Exophiala spinifera was the most abundant salivary species in HTN. Some fungal species directly correlated with blood pressure, including gut Exophiala xenobiotica and Exophiala mesophila. The markedly impaired ecological cocorrelation networks of oral and gut fungi in HTN suggested compromised association among fungal species. Most fungi were shared in the oral cavity and gut, and their correlations suggested the potential interplays between oral and gut fungi. In conclusion, the oral cavity and intestine have unique fungal ecological environments. The fungal enrichment and ecology in HTN, the correlations between oral and gut fungi, and the associations between oral and gut fungi and clinical parameters suggest an important role that the fungal microbiome may play in HTN. IMPORTANCE Our study fills the gap in human studies investigating the oral and gut fungal microbiota in association with blood pressure. It characterizes the diversity and composition of the oral and gut fungal microbiome in human subjects, elucidates the dysbiosis of fungal ecology in a hypertensive population, and establishes oral-gut fungal correlations and fungus-clinical parameter correlations. Targeting fungi in the oral cavity and/or gut may provide novel strategies for the prevention and treatment of hypertension. gut fungal microbiome hypertension oral fungal microbiome oral-gut fungal correlations Microbiology Wen-Zhen Lin verfasserin aut Yu-Lin Li verfasserin aut Chao Bi verfasserin aut Lin-Juan Du verfasserin aut Yuan Liu verfasserin aut Lu-Jun Zhou verfasserin aut Ting Liu verfasserin aut Shuo Xu verfasserin aut Chao-Ji Shi verfasserin aut Hong Zhu verfasserin aut Yong-Li Wang verfasserin aut Jian-Yong Sun verfasserin aut Yan Liu verfasserin aut Wu-Chang Zhang verfasserin aut Zhiyuan Zhang verfasserin aut Hui-li Zhang verfasserin aut Ya-Qin Zhu verfasserin aut Sheng-Zhong Duan verfasserin aut In Microbiology Spectrum American Society for Microbiology, 2022 11(2023), 1 (DE-627)816693293 (DE-600)2807133-5 21650497 nnns volume:11 year:2023 number:1 https://doi.org/10.1128/spectrum.01956-22 kostenfrei https://doaj.org/article/537dd5e490e04690aad0233584470ae0 kostenfrei https://journals.asm.org/doi/10.1128/spectrum.01956-22 kostenfrei https://doaj.org/toc/2165-0497 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2023 1
spelling	10.1128/spectrum.01956-22 doi (DE-627)DOAJ080471951 (DE-599)DOAJ537dd5e490e04690aad0233584470ae0 DE-627 ger DE-627 rakwb eng QR1-502 Bo-Yan Chen verfasserin aut Characteristics and Correlations of the Oral and Gut Fungal Microbiome with Hypertension 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT The mycobiome is an essential constituent of the human microbiome and is associated with various diseases. However, the role of oral and gut fungi in hypertension (HTN) remains largely unexplored. In this study, saliva, subgingival plaques, and feces were collected from 36 participants with HTN and 24 healthy controls for metagenomic sequencing. The obtained sequences were analyzed using the Kraken2 taxonomic annotation pipeline to assess fungal composition and diversity. Correlations between oral and gut fungi and clinic parameters, between fungi within the same sample types, and between different sample types were identified by Spearman’s correlation analysis. Overall, the subgingival fungal microbiome had substantially higher alpha diversity than the salivary and fecal fungal microbiomes. The fungal microbiomes of the three sample types displayed distinct beta diversity from each other. Oral fungi but not gut fungi in HTN had beta diversity significantly different from that of controls. Among the fungi shared in the oral cavity and gut, Exophiala was the genus with the most notable changes. Exophiala spinifera was the most abundant salivary species in HTN. Some fungal species directly correlated with blood pressure, including gut Exophiala xenobiotica and Exophiala mesophila. The markedly impaired ecological cocorrelation networks of oral and gut fungi in HTN suggested compromised association among fungal species. Most fungi were shared in the oral cavity and gut, and their correlations suggested the potential interplays between oral and gut fungi. In conclusion, the oral cavity and intestine have unique fungal ecological environments. The fungal enrichment and ecology in HTN, the correlations between oral and gut fungi, and the associations between oral and gut fungi and clinical parameters suggest an important role that the fungal microbiome may play in HTN. IMPORTANCE Our study fills the gap in human studies investigating the oral and gut fungal microbiota in association with blood pressure. It characterizes the diversity and composition of the oral and gut fungal microbiome in human subjects, elucidates the dysbiosis of fungal ecology in a hypertensive population, and establishes oral-gut fungal correlations and fungus-clinical parameter correlations. Targeting fungi in the oral cavity and/or gut may provide novel strategies for the prevention and treatment of hypertension. gut fungal microbiome hypertension oral fungal microbiome oral-gut fungal correlations Microbiology Wen-Zhen Lin verfasserin aut Yu-Lin Li verfasserin aut Chao Bi verfasserin aut Lin-Juan Du verfasserin aut Yuan Liu verfasserin aut Lu-Jun Zhou verfasserin aut Ting Liu verfasserin aut Shuo Xu verfasserin aut Chao-Ji Shi verfasserin aut Hong Zhu verfasserin aut Yong-Li Wang verfasserin aut Jian-Yong Sun verfasserin aut Yan Liu verfasserin aut Wu-Chang Zhang verfasserin aut Zhiyuan Zhang verfasserin aut Hui-li Zhang verfasserin aut Ya-Qin Zhu verfasserin aut Sheng-Zhong Duan verfasserin aut In Microbiology Spectrum American Society for Microbiology, 2022 11(2023), 1 (DE-627)816693293 (DE-600)2807133-5 21650497 nnns volume:11 year:2023 number:1 https://doi.org/10.1128/spectrum.01956-22 kostenfrei https://doaj.org/article/537dd5e490e04690aad0233584470ae0 kostenfrei https://journals.asm.org/doi/10.1128/spectrum.01956-22 kostenfrei https://doaj.org/toc/2165-0497 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2023 1
allfields_unstemmed	10.1128/spectrum.01956-22 doi (DE-627)DOAJ080471951 (DE-599)DOAJ537dd5e490e04690aad0233584470ae0 DE-627 ger DE-627 rakwb eng QR1-502 Bo-Yan Chen verfasserin aut Characteristics and Correlations of the Oral and Gut Fungal Microbiome with Hypertension 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT The mycobiome is an essential constituent of the human microbiome and is associated with various diseases. However, the role of oral and gut fungi in hypertension (HTN) remains largely unexplored. In this study, saliva, subgingival plaques, and feces were collected from 36 participants with HTN and 24 healthy controls for metagenomic sequencing. The obtained sequences were analyzed using the Kraken2 taxonomic annotation pipeline to assess fungal composition and diversity. Correlations between oral and gut fungi and clinic parameters, between fungi within the same sample types, and between different sample types were identified by Spearman’s correlation analysis. Overall, the subgingival fungal microbiome had substantially higher alpha diversity than the salivary and fecal fungal microbiomes. The fungal microbiomes of the three sample types displayed distinct beta diversity from each other. Oral fungi but not gut fungi in HTN had beta diversity significantly different from that of controls. Among the fungi shared in the oral cavity and gut, Exophiala was the genus with the most notable changes. Exophiala spinifera was the most abundant salivary species in HTN. Some fungal species directly correlated with blood pressure, including gut Exophiala xenobiotica and Exophiala mesophila. The markedly impaired ecological cocorrelation networks of oral and gut fungi in HTN suggested compromised association among fungal species. Most fungi were shared in the oral cavity and gut, and their correlations suggested the potential interplays between oral and gut fungi. In conclusion, the oral cavity and intestine have unique fungal ecological environments. The fungal enrichment and ecology in HTN, the correlations between oral and gut fungi, and the associations between oral and gut fungi and clinical parameters suggest an important role that the fungal microbiome may play in HTN. IMPORTANCE Our study fills the gap in human studies investigating the oral and gut fungal microbiota in association with blood pressure. It characterizes the diversity and composition of the oral and gut fungal microbiome in human subjects, elucidates the dysbiosis of fungal ecology in a hypertensive population, and establishes oral-gut fungal correlations and fungus-clinical parameter correlations. Targeting fungi in the oral cavity and/or gut may provide novel strategies for the prevention and treatment of hypertension. gut fungal microbiome hypertension oral fungal microbiome oral-gut fungal correlations Microbiology Wen-Zhen Lin verfasserin aut Yu-Lin Li verfasserin aut Chao Bi verfasserin aut Lin-Juan Du verfasserin aut Yuan Liu verfasserin aut Lu-Jun Zhou verfasserin aut Ting Liu verfasserin aut Shuo Xu verfasserin aut Chao-Ji Shi verfasserin aut Hong Zhu verfasserin aut Yong-Li Wang verfasserin aut Jian-Yong Sun verfasserin aut Yan Liu verfasserin aut Wu-Chang Zhang verfasserin aut Zhiyuan Zhang verfasserin aut Hui-li Zhang verfasserin aut Ya-Qin Zhu verfasserin aut Sheng-Zhong Duan verfasserin aut In Microbiology Spectrum American Society for Microbiology, 2022 11(2023), 1 (DE-627)816693293 (DE-600)2807133-5 21650497 nnns volume:11 year:2023 number:1 https://doi.org/10.1128/spectrum.01956-22 kostenfrei https://doaj.org/article/537dd5e490e04690aad0233584470ae0 kostenfrei https://journals.asm.org/doi/10.1128/spectrum.01956-22 kostenfrei https://doaj.org/toc/2165-0497 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2023 1
allfieldsGer	10.1128/spectrum.01956-22 doi (DE-627)DOAJ080471951 (DE-599)DOAJ537dd5e490e04690aad0233584470ae0 DE-627 ger DE-627 rakwb eng QR1-502 Bo-Yan Chen verfasserin aut Characteristics and Correlations of the Oral and Gut Fungal Microbiome with Hypertension 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT The mycobiome is an essential constituent of the human microbiome and is associated with various diseases. However, the role of oral and gut fungi in hypertension (HTN) remains largely unexplored. In this study, saliva, subgingival plaques, and feces were collected from 36 participants with HTN and 24 healthy controls for metagenomic sequencing. The obtained sequences were analyzed using the Kraken2 taxonomic annotation pipeline to assess fungal composition and diversity. Correlations between oral and gut fungi and clinic parameters, between fungi within the same sample types, and between different sample types were identified by Spearman’s correlation analysis. Overall, the subgingival fungal microbiome had substantially higher alpha diversity than the salivary and fecal fungal microbiomes. The fungal microbiomes of the three sample types displayed distinct beta diversity from each other. Oral fungi but not gut fungi in HTN had beta diversity significantly different from that of controls. Among the fungi shared in the oral cavity and gut, Exophiala was the genus with the most notable changes. Exophiala spinifera was the most abundant salivary species in HTN. Some fungal species directly correlated with blood pressure, including gut Exophiala xenobiotica and Exophiala mesophila. The markedly impaired ecological cocorrelation networks of oral and gut fungi in HTN suggested compromised association among fungal species. Most fungi were shared in the oral cavity and gut, and their correlations suggested the potential interplays between oral and gut fungi. In conclusion, the oral cavity and intestine have unique fungal ecological environments. The fungal enrichment and ecology in HTN, the correlations between oral and gut fungi, and the associations between oral and gut fungi and clinical parameters suggest an important role that the fungal microbiome may play in HTN. IMPORTANCE Our study fills the gap in human studies investigating the oral and gut fungal microbiota in association with blood pressure. It characterizes the diversity and composition of the oral and gut fungal microbiome in human subjects, elucidates the dysbiosis of fungal ecology in a hypertensive population, and establishes oral-gut fungal correlations and fungus-clinical parameter correlations. Targeting fungi in the oral cavity and/or gut may provide novel strategies for the prevention and treatment of hypertension. gut fungal microbiome hypertension oral fungal microbiome oral-gut fungal correlations Microbiology Wen-Zhen Lin verfasserin aut Yu-Lin Li verfasserin aut Chao Bi verfasserin aut Lin-Juan Du verfasserin aut Yuan Liu verfasserin aut Lu-Jun Zhou verfasserin aut Ting Liu verfasserin aut Shuo Xu verfasserin aut Chao-Ji Shi verfasserin aut Hong Zhu verfasserin aut Yong-Li Wang verfasserin aut Jian-Yong Sun verfasserin aut Yan Liu verfasserin aut Wu-Chang Zhang verfasserin aut Zhiyuan Zhang verfasserin aut Hui-li Zhang verfasserin aut Ya-Qin Zhu verfasserin aut Sheng-Zhong Duan verfasserin aut In Microbiology Spectrum American Society for Microbiology, 2022 11(2023), 1 (DE-627)816693293 (DE-600)2807133-5 21650497 nnns volume:11 year:2023 number:1 https://doi.org/10.1128/spectrum.01956-22 kostenfrei https://doaj.org/article/537dd5e490e04690aad0233584470ae0 kostenfrei https://journals.asm.org/doi/10.1128/spectrum.01956-22 kostenfrei https://doaj.org/toc/2165-0497 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2023 1
allfieldsSound	10.1128/spectrum.01956-22 doi (DE-627)DOAJ080471951 (DE-599)DOAJ537dd5e490e04690aad0233584470ae0 DE-627 ger DE-627 rakwb eng QR1-502 Bo-Yan Chen verfasserin aut Characteristics and Correlations of the Oral and Gut Fungal Microbiome with Hypertension 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT The mycobiome is an essential constituent of the human microbiome and is associated with various diseases. However, the role of oral and gut fungi in hypertension (HTN) remains largely unexplored. In this study, saliva, subgingival plaques, and feces were collected from 36 participants with HTN and 24 healthy controls for metagenomic sequencing. The obtained sequences were analyzed using the Kraken2 taxonomic annotation pipeline to assess fungal composition and diversity. Correlations between oral and gut fungi and clinic parameters, between fungi within the same sample types, and between different sample types were identified by Spearman’s correlation analysis. Overall, the subgingival fungal microbiome had substantially higher alpha diversity than the salivary and fecal fungal microbiomes. The fungal microbiomes of the three sample types displayed distinct beta diversity from each other. Oral fungi but not gut fungi in HTN had beta diversity significantly different from that of controls. Among the fungi shared in the oral cavity and gut, Exophiala was the genus with the most notable changes. Exophiala spinifera was the most abundant salivary species in HTN. Some fungal species directly correlated with blood pressure, including gut Exophiala xenobiotica and Exophiala mesophila. The markedly impaired ecological cocorrelation networks of oral and gut fungi in HTN suggested compromised association among fungal species. Most fungi were shared in the oral cavity and gut, and their correlations suggested the potential interplays between oral and gut fungi. In conclusion, the oral cavity and intestine have unique fungal ecological environments. The fungal enrichment and ecology in HTN, the correlations between oral and gut fungi, and the associations between oral and gut fungi and clinical parameters suggest an important role that the fungal microbiome may play in HTN. IMPORTANCE Our study fills the gap in human studies investigating the oral and gut fungal microbiota in association with blood pressure. It characterizes the diversity and composition of the oral and gut fungal microbiome in human subjects, elucidates the dysbiosis of fungal ecology in a hypertensive population, and establishes oral-gut fungal correlations and fungus-clinical parameter correlations. Targeting fungi in the oral cavity and/or gut may provide novel strategies for the prevention and treatment of hypertension. gut fungal microbiome hypertension oral fungal microbiome oral-gut fungal correlations Microbiology Wen-Zhen Lin verfasserin aut Yu-Lin Li verfasserin aut Chao Bi verfasserin aut Lin-Juan Du verfasserin aut Yuan Liu verfasserin aut Lu-Jun Zhou verfasserin aut Ting Liu verfasserin aut Shuo Xu verfasserin aut Chao-Ji Shi verfasserin aut Hong Zhu verfasserin aut Yong-Li Wang verfasserin aut Jian-Yong Sun verfasserin aut Yan Liu verfasserin aut Wu-Chang Zhang verfasserin aut Zhiyuan Zhang verfasserin aut Hui-li Zhang verfasserin aut Ya-Qin Zhu verfasserin aut Sheng-Zhong Duan verfasserin aut In Microbiology Spectrum American Society for Microbiology, 2022 11(2023), 1 (DE-627)816693293 (DE-600)2807133-5 21650497 nnns volume:11 year:2023 number:1 https://doi.org/10.1128/spectrum.01956-22 kostenfrei https://doaj.org/article/537dd5e490e04690aad0233584470ae0 kostenfrei https://journals.asm.org/doi/10.1128/spectrum.01956-22 kostenfrei https://doaj.org/toc/2165-0497 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2023 1
language	English
source	In Microbiology Spectrum 11(2023), 1 volume:11 year:2023 number:1
sourceStr	In Microbiology Spectrum 11(2023), 1 volume:11 year:2023 number:1
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	gut fungal microbiome hypertension oral fungal microbiome oral-gut fungal correlations Microbiology
isfreeaccess_bool	true
container_title	Microbiology Spectrum
authorswithroles_txt_mv	Bo-Yan Chen @@aut@@ Wen-Zhen Lin @@aut@@ Yu-Lin Li @@aut@@ Chao Bi @@aut@@ Lin-Juan Du @@aut@@ Yuan Liu @@aut@@ Lu-Jun Zhou @@aut@@ Ting Liu @@aut@@ Shuo Xu @@aut@@ Chao-Ji Shi @@aut@@ Hong Zhu @@aut@@ Yong-Li Wang @@aut@@ Jian-Yong Sun @@aut@@ Yan Liu @@aut@@ Wu-Chang Zhang @@aut@@ Zhiyuan Zhang @@aut@@ Hui-li Zhang @@aut@@ Ya-Qin Zhu @@aut@@ Sheng-Zhong Duan @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	816693293
id	DOAJ080471951
language_de	englisch
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However, the role of oral and gut fungi in hypertension (HTN) remains largely unexplored. In this study, saliva, subgingival plaques, and feces were collected from 36 participants with HTN and 24 healthy controls for metagenomic sequencing. The obtained sequences were analyzed using the Kraken2 taxonomic annotation pipeline to assess fungal composition and diversity. Correlations between oral and gut fungi and clinic parameters, between fungi within the same sample types, and between different sample types were identified by Spearman’s correlation analysis. Overall, the subgingival fungal microbiome had substantially higher alpha diversity than the salivary and fecal fungal microbiomes. The fungal microbiomes of the three sample types displayed distinct beta diversity from each other. Oral fungi but not gut fungi in HTN had beta diversity significantly different from that of controls. Among the fungi shared in the oral cavity and gut, Exophiala was the genus with the most notable changes. Exophiala spinifera was the most abundant salivary species in HTN. Some fungal species directly correlated with blood pressure, including gut Exophiala xenobiotica and Exophiala mesophila. The markedly impaired ecological cocorrelation networks of oral and gut fungi in HTN suggested compromised association among fungal species. Most fungi were shared in the oral cavity and gut, and their correlations suggested the potential interplays between oral and gut fungi. In conclusion, the oral cavity and intestine have unique fungal ecological environments. The fungal enrichment and ecology in HTN, the correlations between oral and gut fungi, and the associations between oral and gut fungi and clinical parameters suggest an important role that the fungal microbiome may play in HTN. 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callnumber-first	Q - Science
author	Bo-Yan Chen
spellingShingle	Bo-Yan Chen misc QR1-502 misc gut fungal microbiome misc hypertension misc oral fungal microbiome misc oral-gut fungal correlations misc Microbiology Characteristics and Correlations of the Oral and Gut Fungal Microbiome with Hypertension
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topic_title	QR1-502 Characteristics and Correlations of the Oral and Gut Fungal Microbiome with Hypertension gut fungal microbiome hypertension oral fungal microbiome oral-gut fungal correlations
topic	misc QR1-502 misc gut fungal microbiome misc hypertension misc oral fungal microbiome misc oral-gut fungal correlations misc Microbiology
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title	Characteristics and Correlations of the Oral and Gut Fungal Microbiome with Hypertension
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title_full	Characteristics and Correlations of the Oral and Gut Fungal Microbiome with Hypertension
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author_browse	Bo-Yan Chen Wen-Zhen Lin Yu-Lin Li Chao Bi Lin-Juan Du Yuan Liu Lu-Jun Zhou Ting Liu Shuo Xu Chao-Ji Shi Hong Zhu Yong-Li Wang Jian-Yong Sun Yan Liu Wu-Chang Zhang Zhiyuan Zhang Hui-li Zhang Ya-Qin Zhu Sheng-Zhong Duan
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title_sort	characteristics and correlations of the oral and gut fungal microbiome with hypertension
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title_auth	Characteristics and Correlations of the Oral and Gut Fungal Microbiome with Hypertension
abstract	ABSTRACT The mycobiome is an essential constituent of the human microbiome and is associated with various diseases. However, the role of oral and gut fungi in hypertension (HTN) remains largely unexplored. In this study, saliva, subgingival plaques, and feces were collected from 36 participants with HTN and 24 healthy controls for metagenomic sequencing. The obtained sequences were analyzed using the Kraken2 taxonomic annotation pipeline to assess fungal composition and diversity. Correlations between oral and gut fungi and clinic parameters, between fungi within the same sample types, and between different sample types were identified by Spearman’s correlation analysis. Overall, the subgingival fungal microbiome had substantially higher alpha diversity than the salivary and fecal fungal microbiomes. The fungal microbiomes of the three sample types displayed distinct beta diversity from each other. Oral fungi but not gut fungi in HTN had beta diversity significantly different from that of controls. Among the fungi shared in the oral cavity and gut, Exophiala was the genus with the most notable changes. Exophiala spinifera was the most abundant salivary species in HTN. Some fungal species directly correlated with blood pressure, including gut Exophiala xenobiotica and Exophiala mesophila. The markedly impaired ecological cocorrelation networks of oral and gut fungi in HTN suggested compromised association among fungal species. Most fungi were shared in the oral cavity and gut, and their correlations suggested the potential interplays between oral and gut fungi. In conclusion, the oral cavity and intestine have unique fungal ecological environments. The fungal enrichment and ecology in HTN, the correlations between oral and gut fungi, and the associations between oral and gut fungi and clinical parameters suggest an important role that the fungal microbiome may play in HTN. IMPORTANCE Our study fills the gap in human studies investigating the oral and gut fungal microbiota in association with blood pressure. It characterizes the diversity and composition of the oral and gut fungal microbiome in human subjects, elucidates the dysbiosis of fungal ecology in a hypertensive population, and establishes oral-gut fungal correlations and fungus-clinical parameter correlations. Targeting fungi in the oral cavity and/or gut may provide novel strategies for the prevention and treatment of hypertension.
abstractGer	ABSTRACT The mycobiome is an essential constituent of the human microbiome and is associated with various diseases. However, the role of oral and gut fungi in hypertension (HTN) remains largely unexplored. In this study, saliva, subgingival plaques, and feces were collected from 36 participants with HTN and 24 healthy controls for metagenomic sequencing. The obtained sequences were analyzed using the Kraken2 taxonomic annotation pipeline to assess fungal composition and diversity. Correlations between oral and gut fungi and clinic parameters, between fungi within the same sample types, and between different sample types were identified by Spearman’s correlation analysis. Overall, the subgingival fungal microbiome had substantially higher alpha diversity than the salivary and fecal fungal microbiomes. The fungal microbiomes of the three sample types displayed distinct beta diversity from each other. Oral fungi but not gut fungi in HTN had beta diversity significantly different from that of controls. Among the fungi shared in the oral cavity and gut, Exophiala was the genus with the most notable changes. Exophiala spinifera was the most abundant salivary species in HTN. Some fungal species directly correlated with blood pressure, including gut Exophiala xenobiotica and Exophiala mesophila. The markedly impaired ecological cocorrelation networks of oral and gut fungi in HTN suggested compromised association among fungal species. Most fungi were shared in the oral cavity and gut, and their correlations suggested the potential interplays between oral and gut fungi. In conclusion, the oral cavity and intestine have unique fungal ecological environments. The fungal enrichment and ecology in HTN, the correlations between oral and gut fungi, and the associations between oral and gut fungi and clinical parameters suggest an important role that the fungal microbiome may play in HTN. IMPORTANCE Our study fills the gap in human studies investigating the oral and gut fungal microbiota in association with blood pressure. It characterizes the diversity and composition of the oral and gut fungal microbiome in human subjects, elucidates the dysbiosis of fungal ecology in a hypertensive population, and establishes oral-gut fungal correlations and fungus-clinical parameter correlations. Targeting fungi in the oral cavity and/or gut may provide novel strategies for the prevention and treatment of hypertension.
abstract_unstemmed	ABSTRACT The mycobiome is an essential constituent of the human microbiome and is associated with various diseases. However, the role of oral and gut fungi in hypertension (HTN) remains largely unexplored. In this study, saliva, subgingival plaques, and feces were collected from 36 participants with HTN and 24 healthy controls for metagenomic sequencing. The obtained sequences were analyzed using the Kraken2 taxonomic annotation pipeline to assess fungal composition and diversity. Correlations between oral and gut fungi and clinic parameters, between fungi within the same sample types, and between different sample types were identified by Spearman’s correlation analysis. Overall, the subgingival fungal microbiome had substantially higher alpha diversity than the salivary and fecal fungal microbiomes. The fungal microbiomes of the three sample types displayed distinct beta diversity from each other. Oral fungi but not gut fungi in HTN had beta diversity significantly different from that of controls. Among the fungi shared in the oral cavity and gut, Exophiala was the genus with the most notable changes. Exophiala spinifera was the most abundant salivary species in HTN. Some fungal species directly correlated with blood pressure, including gut Exophiala xenobiotica and Exophiala mesophila. The markedly impaired ecological cocorrelation networks of oral and gut fungi in HTN suggested compromised association among fungal species. Most fungi were shared in the oral cavity and gut, and their correlations suggested the potential interplays between oral and gut fungi. In conclusion, the oral cavity and intestine have unique fungal ecological environments. The fungal enrichment and ecology in HTN, the correlations between oral and gut fungi, and the associations between oral and gut fungi and clinical parameters suggest an important role that the fungal microbiome may play in HTN. IMPORTANCE Our study fills the gap in human studies investigating the oral and gut fungal microbiota in association with blood pressure. It characterizes the diversity and composition of the oral and gut fungal microbiome in human subjects, elucidates the dysbiosis of fungal ecology in a hypertensive population, and establishes oral-gut fungal correlations and fungus-clinical parameter correlations. Targeting fungi in the oral cavity and/or gut may provide novel strategies for the prevention and treatment of hypertension.
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title_short	Characteristics and Correlations of the Oral and Gut Fungal Microbiome with Hypertension
url	https://doi.org/10.1128/spectrum.01956-22 https://doaj.org/article/537dd5e490e04690aad0233584470ae0 https://journals.asm.org/doi/10.1128/spectrum.01956-22 https://doaj.org/toc/2165-0497
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