BCG-induced trained immunity: history, mechanisms and potential applications

Abstract The Bacillus Calmette-Guérin (BCG) vaccine was discovered a century ago and has since been clinically applicable. BCG can not only be used for the prevention of tuberculosis, but also has a non-specific protective effect on the human body called trained immunity that is mediated by innate i...
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Autor*in:	Jingjing Chen [verfasserIn] Li Gao [verfasserIn] Xinya Wu [verfasserIn] Yuxin Fan [verfasserIn] Meixiao Liu [verfasserIn] Li Peng [verfasserIn] Jieqin Song [verfasserIn] Bingxue Li [verfasserIn] Aihua Liu [verfasserIn] Fukai Bao [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	BCG Trained immunity Epigenetic reprogramming Metabolic reprogramming Viral infection Cancer

Übergeordnetes Werk:	In: Journal of Translational Medicine - BMC, 2003, 21(2023), 1, Seite 9
Übergeordnetes Werk:	volume:21 ; year:2023 ; number:1 ; pages:9

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12967-023-03944-8

Katalog-ID:	DOAJ080533450

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allfields	10.1186/s12967-023-03944-8 doi (DE-627)DOAJ080533450 (DE-599)DOAJc40146c488ed477d91afa889197fe87b DE-627 ger DE-627 rakwb eng Jingjing Chen verfasserin aut BCG-induced trained immunity: history, mechanisms and potential applications 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The Bacillus Calmette-Guérin (BCG) vaccine was discovered a century ago and has since been clinically applicable. BCG can not only be used for the prevention of tuberculosis, but also has a non-specific protective effect on the human body called trained immunity that is mediated by innate immune cells such as monocytes, macrophages, and natural killer cells. Mechanisms of trained immunity include epigenetic reprogramming, metabolic reprogramming, and long-term protection mediated by hematopoietic stem cells. Trained immunity has so far shown beneficial effects on cancer, viral-infections, autoimmune diseases, and a variety of other diseases, especially bladder cancer, respiratory viruses, and type 1 diabetes. The modulation of the immune response by BCG has led to the development of a variety of recombinant vaccines. Although the specific mechanism of BCG prevention on diseases has not been fully clarified, the potential role of BCG deserves further exploration, which is of great significance for prevention and treatment of diseases. BCG Trained immunity Epigenetic reprogramming Metabolic reprogramming Viral infection Cancer Medicine R Li Gao verfasserin aut Xinya Wu verfasserin aut Yuxin Fan verfasserin aut Meixiao Liu verfasserin aut Li Peng verfasserin aut Jieqin Song verfasserin aut Bingxue Li verfasserin aut Aihua Liu verfasserin aut Fukai Bao verfasserin aut In Journal of Translational Medicine BMC, 2003 21(2023), 1, Seite 9 (DE-627)369084136 (DE-600)2118570-0 14795876 nnns volume:21 year:2023 number:1 pages:9 https://doi.org/10.1186/s12967-023-03944-8 kostenfrei https://doaj.org/article/c40146c488ed477d91afa889197fe87b kostenfrei https://doi.org/10.1186/s12967-023-03944-8 kostenfrei https://doaj.org/toc/1479-5876 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2023 1 9
spelling	10.1186/s12967-023-03944-8 doi (DE-627)DOAJ080533450 (DE-599)DOAJc40146c488ed477d91afa889197fe87b DE-627 ger DE-627 rakwb eng Jingjing Chen verfasserin aut BCG-induced trained immunity: history, mechanisms and potential applications 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The Bacillus Calmette-Guérin (BCG) vaccine was discovered a century ago and has since been clinically applicable. BCG can not only be used for the prevention of tuberculosis, but also has a non-specific protective effect on the human body called trained immunity that is mediated by innate immune cells such as monocytes, macrophages, and natural killer cells. Mechanisms of trained immunity include epigenetic reprogramming, metabolic reprogramming, and long-term protection mediated by hematopoietic stem cells. Trained immunity has so far shown beneficial effects on cancer, viral-infections, autoimmune diseases, and a variety of other diseases, especially bladder cancer, respiratory viruses, and type 1 diabetes. The modulation of the immune response by BCG has led to the development of a variety of recombinant vaccines. Although the specific mechanism of BCG prevention on diseases has not been fully clarified, the potential role of BCG deserves further exploration, which is of great significance for prevention and treatment of diseases. BCG Trained immunity Epigenetic reprogramming Metabolic reprogramming Viral infection Cancer Medicine R Li Gao verfasserin aut Xinya Wu verfasserin aut Yuxin Fan verfasserin aut Meixiao Liu verfasserin aut Li Peng verfasserin aut Jieqin Song verfasserin aut Bingxue Li verfasserin aut Aihua Liu verfasserin aut Fukai Bao verfasserin aut In Journal of Translational Medicine BMC, 2003 21(2023), 1, Seite 9 (DE-627)369084136 (DE-600)2118570-0 14795876 nnns volume:21 year:2023 number:1 pages:9 https://doi.org/10.1186/s12967-023-03944-8 kostenfrei https://doaj.org/article/c40146c488ed477d91afa889197fe87b kostenfrei https://doi.org/10.1186/s12967-023-03944-8 kostenfrei https://doaj.org/toc/1479-5876 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2023 1 9
allfields_unstemmed	10.1186/s12967-023-03944-8 doi (DE-627)DOAJ080533450 (DE-599)DOAJc40146c488ed477d91afa889197fe87b DE-627 ger DE-627 rakwb eng Jingjing Chen verfasserin aut BCG-induced trained immunity: history, mechanisms and potential applications 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The Bacillus Calmette-Guérin (BCG) vaccine was discovered a century ago and has since been clinically applicable. BCG can not only be used for the prevention of tuberculosis, but also has a non-specific protective effect on the human body called trained immunity that is mediated by innate immune cells such as monocytes, macrophages, and natural killer cells. Mechanisms of trained immunity include epigenetic reprogramming, metabolic reprogramming, and long-term protection mediated by hematopoietic stem cells. Trained immunity has so far shown beneficial effects on cancer, viral-infections, autoimmune diseases, and a variety of other diseases, especially bladder cancer, respiratory viruses, and type 1 diabetes. The modulation of the immune response by BCG has led to the development of a variety of recombinant vaccines. Although the specific mechanism of BCG prevention on diseases has not been fully clarified, the potential role of BCG deserves further exploration, which is of great significance for prevention and treatment of diseases. BCG Trained immunity Epigenetic reprogramming Metabolic reprogramming Viral infection Cancer Medicine R Li Gao verfasserin aut Xinya Wu verfasserin aut Yuxin Fan verfasserin aut Meixiao Liu verfasserin aut Li Peng verfasserin aut Jieqin Song verfasserin aut Bingxue Li verfasserin aut Aihua Liu verfasserin aut Fukai Bao verfasserin aut In Journal of Translational Medicine BMC, 2003 21(2023), 1, Seite 9 (DE-627)369084136 (DE-600)2118570-0 14795876 nnns volume:21 year:2023 number:1 pages:9 https://doi.org/10.1186/s12967-023-03944-8 kostenfrei https://doaj.org/article/c40146c488ed477d91afa889197fe87b kostenfrei https://doi.org/10.1186/s12967-023-03944-8 kostenfrei https://doaj.org/toc/1479-5876 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2023 1 9
allfieldsGer	10.1186/s12967-023-03944-8 doi (DE-627)DOAJ080533450 (DE-599)DOAJc40146c488ed477d91afa889197fe87b DE-627 ger DE-627 rakwb eng Jingjing Chen verfasserin aut BCG-induced trained immunity: history, mechanisms and potential applications 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The Bacillus Calmette-Guérin (BCG) vaccine was discovered a century ago and has since been clinically applicable. BCG can not only be used for the prevention of tuberculosis, but also has a non-specific protective effect on the human body called trained immunity that is mediated by innate immune cells such as monocytes, macrophages, and natural killer cells. Mechanisms of trained immunity include epigenetic reprogramming, metabolic reprogramming, and long-term protection mediated by hematopoietic stem cells. Trained immunity has so far shown beneficial effects on cancer, viral-infections, autoimmune diseases, and a variety of other diseases, especially bladder cancer, respiratory viruses, and type 1 diabetes. The modulation of the immune response by BCG has led to the development of a variety of recombinant vaccines. Although the specific mechanism of BCG prevention on diseases has not been fully clarified, the potential role of BCG deserves further exploration, which is of great significance for prevention and treatment of diseases. BCG Trained immunity Epigenetic reprogramming Metabolic reprogramming Viral infection Cancer Medicine R Li Gao verfasserin aut Xinya Wu verfasserin aut Yuxin Fan verfasserin aut Meixiao Liu verfasserin aut Li Peng verfasserin aut Jieqin Song verfasserin aut Bingxue Li verfasserin aut Aihua Liu verfasserin aut Fukai Bao verfasserin aut In Journal of Translational Medicine BMC, 2003 21(2023), 1, Seite 9 (DE-627)369084136 (DE-600)2118570-0 14795876 nnns volume:21 year:2023 number:1 pages:9 https://doi.org/10.1186/s12967-023-03944-8 kostenfrei https://doaj.org/article/c40146c488ed477d91afa889197fe87b kostenfrei https://doi.org/10.1186/s12967-023-03944-8 kostenfrei https://doaj.org/toc/1479-5876 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2023 1 9
allfieldsSound	10.1186/s12967-023-03944-8 doi (DE-627)DOAJ080533450 (DE-599)DOAJc40146c488ed477d91afa889197fe87b DE-627 ger DE-627 rakwb eng Jingjing Chen verfasserin aut BCG-induced trained immunity: history, mechanisms and potential applications 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The Bacillus Calmette-Guérin (BCG) vaccine was discovered a century ago and has since been clinically applicable. BCG can not only be used for the prevention of tuberculosis, but also has a non-specific protective effect on the human body called trained immunity that is mediated by innate immune cells such as monocytes, macrophages, and natural killer cells. Mechanisms of trained immunity include epigenetic reprogramming, metabolic reprogramming, and long-term protection mediated by hematopoietic stem cells. Trained immunity has so far shown beneficial effects on cancer, viral-infections, autoimmune diseases, and a variety of other diseases, especially bladder cancer, respiratory viruses, and type 1 diabetes. The modulation of the immune response by BCG has led to the development of a variety of recombinant vaccines. Although the specific mechanism of BCG prevention on diseases has not been fully clarified, the potential role of BCG deserves further exploration, which is of great significance for prevention and treatment of diseases. BCG Trained immunity Epigenetic reprogramming Metabolic reprogramming Viral infection Cancer Medicine R Li Gao verfasserin aut Xinya Wu verfasserin aut Yuxin Fan verfasserin aut Meixiao Liu verfasserin aut Li Peng verfasserin aut Jieqin Song verfasserin aut Bingxue Li verfasserin aut Aihua Liu verfasserin aut Fukai Bao verfasserin aut In Journal of Translational Medicine BMC, 2003 21(2023), 1, Seite 9 (DE-627)369084136 (DE-600)2118570-0 14795876 nnns volume:21 year:2023 number:1 pages:9 https://doi.org/10.1186/s12967-023-03944-8 kostenfrei https://doaj.org/article/c40146c488ed477d91afa889197fe87b kostenfrei https://doi.org/10.1186/s12967-023-03944-8 kostenfrei https://doaj.org/toc/1479-5876 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2023 1 9
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authorswithroles_txt_mv	Jingjing Chen @@aut@@ Li Gao @@aut@@ Xinya Wu @@aut@@ Yuxin Fan @@aut@@ Meixiao Liu @@aut@@ Li Peng @@aut@@ Jieqin Song @@aut@@ Bingxue Li @@aut@@ Aihua Liu @@aut@@ Fukai Bao @@aut@@
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author	Jingjing Chen
spellingShingle	Jingjing Chen misc BCG misc Trained immunity misc Epigenetic reprogramming misc Metabolic reprogramming misc Viral infection misc Cancer misc Medicine misc R BCG-induced trained immunity: history, mechanisms and potential applications
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topic_title	BCG-induced trained immunity: history, mechanisms and potential applications BCG Trained immunity Epigenetic reprogramming Metabolic reprogramming Viral infection Cancer
topic	misc BCG misc Trained immunity misc Epigenetic reprogramming misc Metabolic reprogramming misc Viral infection misc Cancer misc Medicine misc R
topic_unstemmed	misc BCG misc Trained immunity misc Epigenetic reprogramming misc Metabolic reprogramming misc Viral infection misc Cancer misc Medicine misc R
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title	BCG-induced trained immunity: history, mechanisms and potential applications
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title_sort	bcg-induced trained immunity: history, mechanisms and potential applications
title_auth	BCG-induced trained immunity: history, mechanisms and potential applications
abstract	Abstract The Bacillus Calmette-Guérin (BCG) vaccine was discovered a century ago and has since been clinically applicable. BCG can not only be used for the prevention of tuberculosis, but also has a non-specific protective effect on the human body called trained immunity that is mediated by innate immune cells such as monocytes, macrophages, and natural killer cells. Mechanisms of trained immunity include epigenetic reprogramming, metabolic reprogramming, and long-term protection mediated by hematopoietic stem cells. Trained immunity has so far shown beneficial effects on cancer, viral-infections, autoimmune diseases, and a variety of other diseases, especially bladder cancer, respiratory viruses, and type 1 diabetes. The modulation of the immune response by BCG has led to the development of a variety of recombinant vaccines. Although the specific mechanism of BCG prevention on diseases has not been fully clarified, the potential role of BCG deserves further exploration, which is of great significance for prevention and treatment of diseases.
abstractGer	Abstract The Bacillus Calmette-Guérin (BCG) vaccine was discovered a century ago and has since been clinically applicable. BCG can not only be used for the prevention of tuberculosis, but also has a non-specific protective effect on the human body called trained immunity that is mediated by innate immune cells such as monocytes, macrophages, and natural killer cells. Mechanisms of trained immunity include epigenetic reprogramming, metabolic reprogramming, and long-term protection mediated by hematopoietic stem cells. Trained immunity has so far shown beneficial effects on cancer, viral-infections, autoimmune diseases, and a variety of other diseases, especially bladder cancer, respiratory viruses, and type 1 diabetes. The modulation of the immune response by BCG has led to the development of a variety of recombinant vaccines. Although the specific mechanism of BCG prevention on diseases has not been fully clarified, the potential role of BCG deserves further exploration, which is of great significance for prevention and treatment of diseases.
abstract_unstemmed	Abstract The Bacillus Calmette-Guérin (BCG) vaccine was discovered a century ago and has since been clinically applicable. BCG can not only be used for the prevention of tuberculosis, but also has a non-specific protective effect on the human body called trained immunity that is mediated by innate immune cells such as monocytes, macrophages, and natural killer cells. Mechanisms of trained immunity include epigenetic reprogramming, metabolic reprogramming, and long-term protection mediated by hematopoietic stem cells. Trained immunity has so far shown beneficial effects on cancer, viral-infections, autoimmune diseases, and a variety of other diseases, especially bladder cancer, respiratory viruses, and type 1 diabetes. The modulation of the immune response by BCG has led to the development of a variety of recombinant vaccines. Although the specific mechanism of BCG prevention on diseases has not been fully clarified, the potential role of BCG deserves further exploration, which is of great significance for prevention and treatment of diseases.
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title_short	BCG-induced trained immunity: history, mechanisms and potential applications
url	https://doi.org/10.1186/s12967-023-03944-8 https://doaj.org/article/c40146c488ed477d91afa889197fe87b https://doaj.org/toc/1479-5876
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