A cooperative nano-CRISPR scaffold potentiates immunotherapy via activation of tumour-intrinsic pyroptosis

Delivery of immune therapy drugs to tumours might be hampered by their limited bioavailability and the difficulty of targeting complex exogenous compounds. Here authors trigger immunologic cell death, via activating tumour-cell-intrinsic pathways via CRISPR-based nanotechnology to enable efficient a...
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Autor*in:	Ning Wang [verfasserIn] Chao Liu [verfasserIn] Yingjie Li [verfasserIn] Dongxue Huang [verfasserIn] Xinyue Wu [verfasserIn] Xiaorong Kou [verfasserIn] Xiye Wang [verfasserIn] Qinjie Wu [verfasserIn] Changyang Gong [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 14(2023), 1, Seite 14
Übergeordnetes Werk:	volume:14 ; year:2023 ; number:1 ; pages:14

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41467-023-36550-9

Katalog-ID:	DOAJ080536999

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author	Ning Wang
spellingShingle	Ning Wang misc Science misc Q A cooperative nano-CRISPR scaffold potentiates immunotherapy via activation of tumour-intrinsic pyroptosis
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topic_title	A cooperative nano-CRISPR scaffold potentiates immunotherapy via activation of tumour-intrinsic pyroptosis
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title	A cooperative nano-CRISPR scaffold potentiates immunotherapy via activation of tumour-intrinsic pyroptosis
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title_full	A cooperative nano-CRISPR scaffold potentiates immunotherapy via activation of tumour-intrinsic pyroptosis
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author_browse	Ning Wang Chao Liu Yingjie Li Dongxue Huang Xinyue Wu Xiaorong Kou Xiye Wang Qinjie Wu Changyang Gong
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title_sort	cooperative nano-crispr scaffold potentiates immunotherapy via activation of tumour-intrinsic pyroptosis
title_auth	A cooperative nano-CRISPR scaffold potentiates immunotherapy via activation of tumour-intrinsic pyroptosis
abstract	Delivery of immune therapy drugs to tumours might be hampered by their limited bioavailability and the difficulty of targeting complex exogenous compounds. Here authors trigger immunologic cell death, via activating tumour-cell-intrinsic pathways via CRISPR-based nanotechnology to enable efficient anti-tumour immune response in mouse models of melanoma.
abstractGer	Delivery of immune therapy drugs to tumours might be hampered by their limited bioavailability and the difficulty of targeting complex exogenous compounds. Here authors trigger immunologic cell death, via activating tumour-cell-intrinsic pathways via CRISPR-based nanotechnology to enable efficient anti-tumour immune response in mouse models of melanoma.
abstract_unstemmed	Delivery of immune therapy drugs to tumours might be hampered by their limited bioavailability and the difficulty of targeting complex exogenous compounds. Here authors trigger immunologic cell death, via activating tumour-cell-intrinsic pathways via CRISPR-based nanotechnology to enable efficient anti-tumour immune response in mouse models of melanoma.
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title_short	A cooperative nano-CRISPR scaffold potentiates immunotherapy via activation of tumour-intrinsic pyroptosis
url	https://doi.org/10.1038/s41467-023-36550-9 https://doaj.org/article/018777d89ad74859a575751e3cacdcdf https://doaj.org/toc/2041-1723
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