Apical-basal polarity precisely determines intestinal stem cell number by regulating Prospero threshold

Summary: Apical-basal polarity and cell-fate determinants are crucial for the cell fate and control of stem cell numbers. However, their interplay leading to a precise stem cell number remains unclear. Drosophila pupal intestinal stem cells (pISCs) asymmetrically divide, generating one apical ISC pr...
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Autor*in:	Song Wu [verfasserIn] Yang Yang [verfasserIn] Ruizhi Tang [verfasserIn] Song Zhang [verfasserIn] Peizhong Qin [verfasserIn] Rong Lin [verfasserIn] Neus Rafel [verfasserIn] Elena M. Lucchetta [verfasserIn] Benjamin Ohlstein [verfasserIn] Zheng Guo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	CP: Stem cell research CP: Cell biology

Übergeordnetes Werk:	In: Cell Reports - Elsevier, 2015, 42(2023), 2, Seite 112093-
Übergeordnetes Werk:	volume:42 ; year:2023 ; number:2 ; pages:112093-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.celrep.2023.112093

Katalog-ID:	DOAJ080567436

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520			\|a Summary: Apical-basal polarity and cell-fate determinants are crucial for the cell fate and control of stem cell numbers. However, their interplay leading to a precise stem cell number remains unclear. Drosophila pupal intestinal stem cells (pISCs) asymmetrically divide, generating one apical ISC progenitor and one basal Prospero (Pros)+ enteroendocrine mother cell (EMC), followed by symmetric divisions of each daughter before adulthood, providing an ideal system to investigate the outcomes of polarity loss. Using lineage tracing and ex vivo live imaging, we identify an interlocked polarity regulation network precisely determining ISC number: Bazooka inhibits Pros accumulation by activating Notch signaling to maintain stem cell fate in pISC apical daughters. A threshold of Pros promotes differentiation to EMCs and avoids ISC-like cell fate, and over-threshold of Pros inhibits miranda expression to ensure symmetric divisions in pISC basal daughters. Our work suggests that a polarity-dependent threshold of a differentiation factor precisely controls stem cell number.
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publishDate	2023
allfields	10.1016/j.celrep.2023.112093 doi (DE-627)DOAJ080567436 (DE-599)DOAJ0409143243ff454f9ea99b69f269d349 DE-627 ger DE-627 rakwb eng QH301-705.5 Song Wu verfasserin aut Apical-basal polarity precisely determines intestinal stem cell number by regulating Prospero threshold 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Apical-basal polarity and cell-fate determinants are crucial for the cell fate and control of stem cell numbers. However, their interplay leading to a precise stem cell number remains unclear. Drosophila pupal intestinal stem cells (pISCs) asymmetrically divide, generating one apical ISC progenitor and one basal Prospero (Pros)+ enteroendocrine mother cell (EMC), followed by symmetric divisions of each daughter before adulthood, providing an ideal system to investigate the outcomes of polarity loss. Using lineage tracing and ex vivo live imaging, we identify an interlocked polarity regulation network precisely determining ISC number: Bazooka inhibits Pros accumulation by activating Notch signaling to maintain stem cell fate in pISC apical daughters. A threshold of Pros promotes differentiation to EMCs and avoids ISC-like cell fate, and over-threshold of Pros inhibits miranda expression to ensure symmetric divisions in pISC basal daughters. Our work suggests that a polarity-dependent threshold of a differentiation factor precisely controls stem cell number. CP: Stem cell research CP: Cell biology Biology (General) Yang Yang verfasserin aut Ruizhi Tang verfasserin aut Song Zhang verfasserin aut Peizhong Qin verfasserin aut Rong Lin verfasserin aut Neus Rafel verfasserin aut Elena M. Lucchetta verfasserin aut Benjamin Ohlstein verfasserin aut Zheng Guo verfasserin aut In Cell Reports Elsevier, 2015 42(2023), 2, Seite 112093- (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:42 year:2023 number:2 pages:112093- https://doi.org/10.1016/j.celrep.2023.112093 kostenfrei https://doaj.org/article/0409143243ff454f9ea99b69f269d349 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124723001043 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 42 2023 2 112093-
spelling	10.1016/j.celrep.2023.112093 doi (DE-627)DOAJ080567436 (DE-599)DOAJ0409143243ff454f9ea99b69f269d349 DE-627 ger DE-627 rakwb eng QH301-705.5 Song Wu verfasserin aut Apical-basal polarity precisely determines intestinal stem cell number by regulating Prospero threshold 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Apical-basal polarity and cell-fate determinants are crucial for the cell fate and control of stem cell numbers. However, their interplay leading to a precise stem cell number remains unclear. Drosophila pupal intestinal stem cells (pISCs) asymmetrically divide, generating one apical ISC progenitor and one basal Prospero (Pros)+ enteroendocrine mother cell (EMC), followed by symmetric divisions of each daughter before adulthood, providing an ideal system to investigate the outcomes of polarity loss. Using lineage tracing and ex vivo live imaging, we identify an interlocked polarity regulation network precisely determining ISC number: Bazooka inhibits Pros accumulation by activating Notch signaling to maintain stem cell fate in pISC apical daughters. A threshold of Pros promotes differentiation to EMCs and avoids ISC-like cell fate, and over-threshold of Pros inhibits miranda expression to ensure symmetric divisions in pISC basal daughters. Our work suggests that a polarity-dependent threshold of a differentiation factor precisely controls stem cell number. CP: Stem cell research CP: Cell biology Biology (General) Yang Yang verfasserin aut Ruizhi Tang verfasserin aut Song Zhang verfasserin aut Peizhong Qin verfasserin aut Rong Lin verfasserin aut Neus Rafel verfasserin aut Elena M. Lucchetta verfasserin aut Benjamin Ohlstein verfasserin aut Zheng Guo verfasserin aut In Cell Reports Elsevier, 2015 42(2023), 2, Seite 112093- (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:42 year:2023 number:2 pages:112093- https://doi.org/10.1016/j.celrep.2023.112093 kostenfrei https://doaj.org/article/0409143243ff454f9ea99b69f269d349 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124723001043 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 42 2023 2 112093-
allfields_unstemmed	10.1016/j.celrep.2023.112093 doi (DE-627)DOAJ080567436 (DE-599)DOAJ0409143243ff454f9ea99b69f269d349 DE-627 ger DE-627 rakwb eng QH301-705.5 Song Wu verfasserin aut Apical-basal polarity precisely determines intestinal stem cell number by regulating Prospero threshold 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Apical-basal polarity and cell-fate determinants are crucial for the cell fate and control of stem cell numbers. However, their interplay leading to a precise stem cell number remains unclear. Drosophila pupal intestinal stem cells (pISCs) asymmetrically divide, generating one apical ISC progenitor and one basal Prospero (Pros)+ enteroendocrine mother cell (EMC), followed by symmetric divisions of each daughter before adulthood, providing an ideal system to investigate the outcomes of polarity loss. Using lineage tracing and ex vivo live imaging, we identify an interlocked polarity regulation network precisely determining ISC number: Bazooka inhibits Pros accumulation by activating Notch signaling to maintain stem cell fate in pISC apical daughters. A threshold of Pros promotes differentiation to EMCs and avoids ISC-like cell fate, and over-threshold of Pros inhibits miranda expression to ensure symmetric divisions in pISC basal daughters. Our work suggests that a polarity-dependent threshold of a differentiation factor precisely controls stem cell number. CP: Stem cell research CP: Cell biology Biology (General) Yang Yang verfasserin aut Ruizhi Tang verfasserin aut Song Zhang verfasserin aut Peizhong Qin verfasserin aut Rong Lin verfasserin aut Neus Rafel verfasserin aut Elena M. Lucchetta verfasserin aut Benjamin Ohlstein verfasserin aut Zheng Guo verfasserin aut In Cell Reports Elsevier, 2015 42(2023), 2, Seite 112093- (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:42 year:2023 number:2 pages:112093- https://doi.org/10.1016/j.celrep.2023.112093 kostenfrei https://doaj.org/article/0409143243ff454f9ea99b69f269d349 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124723001043 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 42 2023 2 112093-
allfieldsGer	10.1016/j.celrep.2023.112093 doi (DE-627)DOAJ080567436 (DE-599)DOAJ0409143243ff454f9ea99b69f269d349 DE-627 ger DE-627 rakwb eng QH301-705.5 Song Wu verfasserin aut Apical-basal polarity precisely determines intestinal stem cell number by regulating Prospero threshold 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Apical-basal polarity and cell-fate determinants are crucial for the cell fate and control of stem cell numbers. However, their interplay leading to a precise stem cell number remains unclear. Drosophila pupal intestinal stem cells (pISCs) asymmetrically divide, generating one apical ISC progenitor and one basal Prospero (Pros)+ enteroendocrine mother cell (EMC), followed by symmetric divisions of each daughter before adulthood, providing an ideal system to investigate the outcomes of polarity loss. Using lineage tracing and ex vivo live imaging, we identify an interlocked polarity regulation network precisely determining ISC number: Bazooka inhibits Pros accumulation by activating Notch signaling to maintain stem cell fate in pISC apical daughters. A threshold of Pros promotes differentiation to EMCs and avoids ISC-like cell fate, and over-threshold of Pros inhibits miranda expression to ensure symmetric divisions in pISC basal daughters. Our work suggests that a polarity-dependent threshold of a differentiation factor precisely controls stem cell number. CP: Stem cell research CP: Cell biology Biology (General) Yang Yang verfasserin aut Ruizhi Tang verfasserin aut Song Zhang verfasserin aut Peizhong Qin verfasserin aut Rong Lin verfasserin aut Neus Rafel verfasserin aut Elena M. Lucchetta verfasserin aut Benjamin Ohlstein verfasserin aut Zheng Guo verfasserin aut In Cell Reports Elsevier, 2015 42(2023), 2, Seite 112093- (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:42 year:2023 number:2 pages:112093- https://doi.org/10.1016/j.celrep.2023.112093 kostenfrei https://doaj.org/article/0409143243ff454f9ea99b69f269d349 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124723001043 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 42 2023 2 112093-
allfieldsSound	10.1016/j.celrep.2023.112093 doi (DE-627)DOAJ080567436 (DE-599)DOAJ0409143243ff454f9ea99b69f269d349 DE-627 ger DE-627 rakwb eng QH301-705.5 Song Wu verfasserin aut Apical-basal polarity precisely determines intestinal stem cell number by regulating Prospero threshold 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Apical-basal polarity and cell-fate determinants are crucial for the cell fate and control of stem cell numbers. However, their interplay leading to a precise stem cell number remains unclear. Drosophila pupal intestinal stem cells (pISCs) asymmetrically divide, generating one apical ISC progenitor and one basal Prospero (Pros)+ enteroendocrine mother cell (EMC), followed by symmetric divisions of each daughter before adulthood, providing an ideal system to investigate the outcomes of polarity loss. Using lineage tracing and ex vivo live imaging, we identify an interlocked polarity regulation network precisely determining ISC number: Bazooka inhibits Pros accumulation by activating Notch signaling to maintain stem cell fate in pISC apical daughters. A threshold of Pros promotes differentiation to EMCs and avoids ISC-like cell fate, and over-threshold of Pros inhibits miranda expression to ensure symmetric divisions in pISC basal daughters. Our work suggests that a polarity-dependent threshold of a differentiation factor precisely controls stem cell number. CP: Stem cell research CP: Cell biology Biology (General) Yang Yang verfasserin aut Ruizhi Tang verfasserin aut Song Zhang verfasserin aut Peizhong Qin verfasserin aut Rong Lin verfasserin aut Neus Rafel verfasserin aut Elena M. Lucchetta verfasserin aut Benjamin Ohlstein verfasserin aut Zheng Guo verfasserin aut In Cell Reports Elsevier, 2015 42(2023), 2, Seite 112093- (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:42 year:2023 number:2 pages:112093- https://doi.org/10.1016/j.celrep.2023.112093 kostenfrei https://doaj.org/article/0409143243ff454f9ea99b69f269d349 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124723001043 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 42 2023 2 112093-
language	English
source	In Cell Reports 42(2023), 2, Seite 112093- volume:42 year:2023 number:2 pages:112093-
sourceStr	In Cell Reports 42(2023), 2, Seite 112093- volume:42 year:2023 number:2 pages:112093-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	CP: Stem cell research CP: Cell biology Biology (General)
isfreeaccess_bool	true
container_title	Cell Reports
authorswithroles_txt_mv	Song Wu @@aut@@ Yang Yang @@aut@@ Ruizhi Tang @@aut@@ Song Zhang @@aut@@ Peizhong Qin @@aut@@ Rong Lin @@aut@@ Neus Rafel @@aut@@ Elena M. Lucchetta @@aut@@ Benjamin Ohlstein @@aut@@ Zheng Guo @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	684964562
id	DOAJ080567436
language_de	englisch
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callnumber-first	Q - Science
author	Song Wu
spellingShingle	Song Wu misc QH301-705.5 misc CP: Stem cell research misc CP: Cell biology misc Biology (General) Apical-basal polarity precisely determines intestinal stem cell number by regulating Prospero threshold
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topic_title	QH301-705.5 Apical-basal polarity precisely determines intestinal stem cell number by regulating Prospero threshold CP: Stem cell research CP: Cell biology
topic	misc QH301-705.5 misc CP: Stem cell research misc CP: Cell biology misc Biology (General)
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title	Apical-basal polarity precisely determines intestinal stem cell number by regulating Prospero threshold
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title_full	Apical-basal polarity precisely determines intestinal stem cell number by regulating Prospero threshold
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author_browse	Song Wu Yang Yang Ruizhi Tang Song Zhang Peizhong Qin Rong Lin Neus Rafel Elena M. Lucchetta Benjamin Ohlstein Zheng Guo
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doi_str_mv	10.1016/j.celrep.2023.112093
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title_sort	apical-basal polarity precisely determines intestinal stem cell number by regulating prospero threshold
callnumber	QH301-705.5
title_auth	Apical-basal polarity precisely determines intestinal stem cell number by regulating Prospero threshold
abstract	Summary: Apical-basal polarity and cell-fate determinants are crucial for the cell fate and control of stem cell numbers. However, their interplay leading to a precise stem cell number remains unclear. Drosophila pupal intestinal stem cells (pISCs) asymmetrically divide, generating one apical ISC progenitor and one basal Prospero (Pros)+ enteroendocrine mother cell (EMC), followed by symmetric divisions of each daughter before adulthood, providing an ideal system to investigate the outcomes of polarity loss. Using lineage tracing and ex vivo live imaging, we identify an interlocked polarity regulation network precisely determining ISC number: Bazooka inhibits Pros accumulation by activating Notch signaling to maintain stem cell fate in pISC apical daughters. A threshold of Pros promotes differentiation to EMCs and avoids ISC-like cell fate, and over-threshold of Pros inhibits miranda expression to ensure symmetric divisions in pISC basal daughters. Our work suggests that a polarity-dependent threshold of a differentiation factor precisely controls stem cell number.
abstractGer	Summary: Apical-basal polarity and cell-fate determinants are crucial for the cell fate and control of stem cell numbers. However, their interplay leading to a precise stem cell number remains unclear. Drosophila pupal intestinal stem cells (pISCs) asymmetrically divide, generating one apical ISC progenitor and one basal Prospero (Pros)+ enteroendocrine mother cell (EMC), followed by symmetric divisions of each daughter before adulthood, providing an ideal system to investigate the outcomes of polarity loss. Using lineage tracing and ex vivo live imaging, we identify an interlocked polarity regulation network precisely determining ISC number: Bazooka inhibits Pros accumulation by activating Notch signaling to maintain stem cell fate in pISC apical daughters. A threshold of Pros promotes differentiation to EMCs and avoids ISC-like cell fate, and over-threshold of Pros inhibits miranda expression to ensure symmetric divisions in pISC basal daughters. Our work suggests that a polarity-dependent threshold of a differentiation factor precisely controls stem cell number.
abstract_unstemmed	Summary: Apical-basal polarity and cell-fate determinants are crucial for the cell fate and control of stem cell numbers. However, their interplay leading to a precise stem cell number remains unclear. Drosophila pupal intestinal stem cells (pISCs) asymmetrically divide, generating one apical ISC progenitor and one basal Prospero (Pros)+ enteroendocrine mother cell (EMC), followed by symmetric divisions of each daughter before adulthood, providing an ideal system to investigate the outcomes of polarity loss. Using lineage tracing and ex vivo live imaging, we identify an interlocked polarity regulation network precisely determining ISC number: Bazooka inhibits Pros accumulation by activating Notch signaling to maintain stem cell fate in pISC apical daughters. A threshold of Pros promotes differentiation to EMCs and avoids ISC-like cell fate, and over-threshold of Pros inhibits miranda expression to ensure symmetric divisions in pISC basal daughters. Our work suggests that a polarity-dependent threshold of a differentiation factor precisely controls stem cell number.
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title_short	Apical-basal polarity precisely determines intestinal stem cell number by regulating Prospero threshold
url	https://doi.org/10.1016/j.celrep.2023.112093 https://doaj.org/article/0409143243ff454f9ea99b69f269d349 http://www.sciencedirect.com/science/article/pii/S2211124723001043 https://doaj.org/toc/2211-1247
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up_date	2024-07-03T15:20:33.246Z
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Apical-basal polarity precisely determines intestinal stem cell number by regulating Prospero threshold

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