Alkaloids and Styryl lactones from <i<Goniothalamus ridleyi</i< King and Their <i<α</i<-Glucosidase Inhibitory Activity

Gonioridleylactam (<b<1</b<), a new compound, is a unique dimeric aristolactam isolated from the EtOAc extract of the twigs of <i<Goniothalamus ridleyi</i< King. The structure of gonioridleylactam (<b<1</b<) consists of two different aristolactams linked together...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Isaraporn Polbuppha [verfasserIn] Passakorn Teerapongpisan [verfasserIn] Piyaporn Phukhatmuen [verfasserIn] Virayu Suthiphasilp [verfasserIn] Tharakorn Maneerat [verfasserIn] Rawiwan Charoensup [verfasserIn] Raymond J. Andersen [verfasserIn] Surat Laphookhieo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	dimeric aristolactam styryl lactone

Übergeordnetes Werk:	In: Molecules - MDPI AG, 2003, 28(2023), 3, p 1158
Übergeordnetes Werk:	volume:28 ; year:2023 ; number:3, p 1158

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/molecules28031158

Katalog-ID:	DOAJ080614892

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520			\|a Gonioridleylactam (<b<1</b<), a new compound, is a unique dimeric aristolactam isolated from the EtOAc extract of the twigs of <i<Goniothalamus ridleyi</i< King. The structure of gonioridleylactam (<b<1</b<) consists of two different aristolactams linked together with two methylenedioxy bridges at C–3/C–3′ and C–4/C–4′, generating a ten-membered ring of [1,3,6,8]tetraoxecine. A new natural product, gonioridleyindole (3-hydroxymethyl-1-methyl-1<i<H</i<-benz[<i<f</i<]indole-4,9-dione, <b<2</b<), together with eight known compounds (<b<3–10</b<) were also isolated from this plant. Their structures were extensively characterized by spectroscopic methods and comparisons were made with the literature. Compounds <b<1–4</b<, <b<7</b<, and <b<9</b< were evaluated for their <i<α</i<-glucosidase inhibitory activity. Of these, 3,5-demethoxypiperolide (<b<7</b<) displayed the highest <i<α</i<-glucosidase inhibitory activity, with an IC<sub<50</sub< value of 1.25 µM.
650		4	\|a <i<Goniothalamus ridleyi</i<
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allfields	10.3390/molecules28031158 doi (DE-627)DOAJ080614892 (DE-599)DOAJe749b71c36ad418c8b2a5a3d1c78e739 DE-627 ger DE-627 rakwb eng QD241-441 Isaraporn Polbuppha verfasserin aut Alkaloids and Styryl lactones from <i<Goniothalamus ridleyi</i< King and Their <i<α</i<-Glucosidase Inhibitory Activity 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gonioridleylactam (<b<1</b<), a new compound, is a unique dimeric aristolactam isolated from the EtOAc extract of the twigs of <i<Goniothalamus ridleyi</i< King. The structure of gonioridleylactam (<b<1</b<) consists of two different aristolactams linked together with two methylenedioxy bridges at C–3/C–3′ and C–4/C–4′, generating a ten-membered ring of [1,3,6,8]tetraoxecine. A new natural product, gonioridleyindole (3-hydroxymethyl-1-methyl-1<i<H</i<-benz[<i<f</i<]indole-4,9-dione, <b<2</b<), together with eight known compounds (<b<3–10</b<) were also isolated from this plant. Their structures were extensively characterized by spectroscopic methods and comparisons were made with the literature. Compounds <b<1–4</b<, <b<7</b<, and <b<9</b< were evaluated for their <i<α</i<-glucosidase inhibitory activity. Of these, 3,5-demethoxypiperolide (<b<7</b<) displayed the highest <i<α</i<-glucosidase inhibitory activity, with an IC<sub<50</sub< value of 1.25 µM. <i<Goniothalamus ridleyi</i< dimeric aristolactam styryl lactone <i<α</i<-glucosidase inhibitory activity Organic chemistry Passakorn Teerapongpisan verfasserin aut Piyaporn Phukhatmuen verfasserin aut Virayu Suthiphasilp verfasserin aut Tharakorn Maneerat verfasserin aut Rawiwan Charoensup verfasserin aut Raymond J. Andersen verfasserin aut Surat Laphookhieo verfasserin aut In Molecules MDPI AG, 2003 28(2023), 3, p 1158 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:28 year:2023 number:3, p 1158 https://doi.org/10.3390/molecules28031158 kostenfrei https://doaj.org/article/e749b71c36ad418c8b2a5a3d1c78e739 kostenfrei https://www.mdpi.com/1420-3049/28/3/1158 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2023 3, p 1158
spelling	10.3390/molecules28031158 doi (DE-627)DOAJ080614892 (DE-599)DOAJe749b71c36ad418c8b2a5a3d1c78e739 DE-627 ger DE-627 rakwb eng QD241-441 Isaraporn Polbuppha verfasserin aut Alkaloids and Styryl lactones from <i<Goniothalamus ridleyi</i< King and Their <i<α</i<-Glucosidase Inhibitory Activity 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gonioridleylactam (<b<1</b<), a new compound, is a unique dimeric aristolactam isolated from the EtOAc extract of the twigs of <i<Goniothalamus ridleyi</i< King. The structure of gonioridleylactam (<b<1</b<) consists of two different aristolactams linked together with two methylenedioxy bridges at C–3/C–3′ and C–4/C–4′, generating a ten-membered ring of [1,3,6,8]tetraoxecine. A new natural product, gonioridleyindole (3-hydroxymethyl-1-methyl-1<i<H</i<-benz[<i<f</i<]indole-4,9-dione, <b<2</b<), together with eight known compounds (<b<3–10</b<) were also isolated from this plant. Their structures were extensively characterized by spectroscopic methods and comparisons were made with the literature. Compounds <b<1–4</b<, <b<7</b<, and <b<9</b< were evaluated for their <i<α</i<-glucosidase inhibitory activity. Of these, 3,5-demethoxypiperolide (<b<7</b<) displayed the highest <i<α</i<-glucosidase inhibitory activity, with an IC<sub<50</sub< value of 1.25 µM. <i<Goniothalamus ridleyi</i< dimeric aristolactam styryl lactone <i<α</i<-glucosidase inhibitory activity Organic chemistry Passakorn Teerapongpisan verfasserin aut Piyaporn Phukhatmuen verfasserin aut Virayu Suthiphasilp verfasserin aut Tharakorn Maneerat verfasserin aut Rawiwan Charoensup verfasserin aut Raymond J. Andersen verfasserin aut Surat Laphookhieo verfasserin aut In Molecules MDPI AG, 2003 28(2023), 3, p 1158 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:28 year:2023 number:3, p 1158 https://doi.org/10.3390/molecules28031158 kostenfrei https://doaj.org/article/e749b71c36ad418c8b2a5a3d1c78e739 kostenfrei https://www.mdpi.com/1420-3049/28/3/1158 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2023 3, p 1158
allfields_unstemmed	10.3390/molecules28031158 doi (DE-627)DOAJ080614892 (DE-599)DOAJe749b71c36ad418c8b2a5a3d1c78e739 DE-627 ger DE-627 rakwb eng QD241-441 Isaraporn Polbuppha verfasserin aut Alkaloids and Styryl lactones from <i<Goniothalamus ridleyi</i< King and Their <i<α</i<-Glucosidase Inhibitory Activity 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gonioridleylactam (<b<1</b<), a new compound, is a unique dimeric aristolactam isolated from the EtOAc extract of the twigs of <i<Goniothalamus ridleyi</i< King. The structure of gonioridleylactam (<b<1</b<) consists of two different aristolactams linked together with two methylenedioxy bridges at C–3/C–3′ and C–4/C–4′, generating a ten-membered ring of [1,3,6,8]tetraoxecine. A new natural product, gonioridleyindole (3-hydroxymethyl-1-methyl-1<i<H</i<-benz[<i<f</i<]indole-4,9-dione, <b<2</b<), together with eight known compounds (<b<3–10</b<) were also isolated from this plant. Their structures were extensively characterized by spectroscopic methods and comparisons were made with the literature. Compounds <b<1–4</b<, <b<7</b<, and <b<9</b< were evaluated for their <i<α</i<-glucosidase inhibitory activity. Of these, 3,5-demethoxypiperolide (<b<7</b<) displayed the highest <i<α</i<-glucosidase inhibitory activity, with an IC<sub<50</sub< value of 1.25 µM. <i<Goniothalamus ridleyi</i< dimeric aristolactam styryl lactone <i<α</i<-glucosidase inhibitory activity Organic chemistry Passakorn Teerapongpisan verfasserin aut Piyaporn Phukhatmuen verfasserin aut Virayu Suthiphasilp verfasserin aut Tharakorn Maneerat verfasserin aut Rawiwan Charoensup verfasserin aut Raymond J. Andersen verfasserin aut Surat Laphookhieo verfasserin aut In Molecules MDPI AG, 2003 28(2023), 3, p 1158 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:28 year:2023 number:3, p 1158 https://doi.org/10.3390/molecules28031158 kostenfrei https://doaj.org/article/e749b71c36ad418c8b2a5a3d1c78e739 kostenfrei https://www.mdpi.com/1420-3049/28/3/1158 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2023 3, p 1158
allfieldsGer	10.3390/molecules28031158 doi (DE-627)DOAJ080614892 (DE-599)DOAJe749b71c36ad418c8b2a5a3d1c78e739 DE-627 ger DE-627 rakwb eng QD241-441 Isaraporn Polbuppha verfasserin aut Alkaloids and Styryl lactones from <i<Goniothalamus ridleyi</i< King and Their <i<α</i<-Glucosidase Inhibitory Activity 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gonioridleylactam (<b<1</b<), a new compound, is a unique dimeric aristolactam isolated from the EtOAc extract of the twigs of <i<Goniothalamus ridleyi</i< King. The structure of gonioridleylactam (<b<1</b<) consists of two different aristolactams linked together with two methylenedioxy bridges at C–3/C–3′ and C–4/C–4′, generating a ten-membered ring of [1,3,6,8]tetraoxecine. A new natural product, gonioridleyindole (3-hydroxymethyl-1-methyl-1<i<H</i<-benz[<i<f</i<]indole-4,9-dione, <b<2</b<), together with eight known compounds (<b<3–10</b<) were also isolated from this plant. Their structures were extensively characterized by spectroscopic methods and comparisons were made with the literature. Compounds <b<1–4</b<, <b<7</b<, and <b<9</b< were evaluated for their <i<α</i<-glucosidase inhibitory activity. Of these, 3,5-demethoxypiperolide (<b<7</b<) displayed the highest <i<α</i<-glucosidase inhibitory activity, with an IC<sub<50</sub< value of 1.25 µM. <i<Goniothalamus ridleyi</i< dimeric aristolactam styryl lactone <i<α</i<-glucosidase inhibitory activity Organic chemistry Passakorn Teerapongpisan verfasserin aut Piyaporn Phukhatmuen verfasserin aut Virayu Suthiphasilp verfasserin aut Tharakorn Maneerat verfasserin aut Rawiwan Charoensup verfasserin aut Raymond J. Andersen verfasserin aut Surat Laphookhieo verfasserin aut In Molecules MDPI AG, 2003 28(2023), 3, p 1158 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:28 year:2023 number:3, p 1158 https://doi.org/10.3390/molecules28031158 kostenfrei https://doaj.org/article/e749b71c36ad418c8b2a5a3d1c78e739 kostenfrei https://www.mdpi.com/1420-3049/28/3/1158 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2023 3, p 1158
allfieldsSound	10.3390/molecules28031158 doi (DE-627)DOAJ080614892 (DE-599)DOAJe749b71c36ad418c8b2a5a3d1c78e739 DE-627 ger DE-627 rakwb eng QD241-441 Isaraporn Polbuppha verfasserin aut Alkaloids and Styryl lactones from <i<Goniothalamus ridleyi</i< King and Their <i<α</i<-Glucosidase Inhibitory Activity 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gonioridleylactam (<b<1</b<), a new compound, is a unique dimeric aristolactam isolated from the EtOAc extract of the twigs of <i<Goniothalamus ridleyi</i< King. The structure of gonioridleylactam (<b<1</b<) consists of two different aristolactams linked together with two methylenedioxy bridges at C–3/C–3′ and C–4/C–4′, generating a ten-membered ring of [1,3,6,8]tetraoxecine. A new natural product, gonioridleyindole (3-hydroxymethyl-1-methyl-1<i<H</i<-benz[<i<f</i<]indole-4,9-dione, <b<2</b<), together with eight known compounds (<b<3–10</b<) were also isolated from this plant. Their structures were extensively characterized by spectroscopic methods and comparisons were made with the literature. Compounds <b<1–4</b<, <b<7</b<, and <b<9</b< were evaluated for their <i<α</i<-glucosidase inhibitory activity. Of these, 3,5-demethoxypiperolide (<b<7</b<) displayed the highest <i<α</i<-glucosidase inhibitory activity, with an IC<sub<50</sub< value of 1.25 µM. <i<Goniothalamus ridleyi</i< dimeric aristolactam styryl lactone <i<α</i<-glucosidase inhibitory activity Organic chemistry Passakorn Teerapongpisan verfasserin aut Piyaporn Phukhatmuen verfasserin aut Virayu Suthiphasilp verfasserin aut Tharakorn Maneerat verfasserin aut Rawiwan Charoensup verfasserin aut Raymond J. Andersen verfasserin aut Surat Laphookhieo verfasserin aut In Molecules MDPI AG, 2003 28(2023), 3, p 1158 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:28 year:2023 number:3, p 1158 https://doi.org/10.3390/molecules28031158 kostenfrei https://doaj.org/article/e749b71c36ad418c8b2a5a3d1c78e739 kostenfrei https://www.mdpi.com/1420-3049/28/3/1158 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2023 3, p 1158
language	English
source	In Molecules 28(2023), 3, p 1158 volume:28 year:2023 number:3, p 1158
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callnumber-first	Q - Science
author	Isaraporn Polbuppha
spellingShingle	Isaraporn Polbuppha misc QD241-441 misc <i<Goniothalamus ridleyi</i< misc dimeric aristolactam misc styryl lactone misc <i<α</i<-glucosidase inhibitory activity misc Organic chemistry Alkaloids and Styryl lactones from <i<Goniothalamus ridleyi</i< King and Their <i<α</i<-Glucosidase Inhibitory Activity
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issn	14203049
topic_title	QD241-441 Alkaloids and Styryl lactones from <i<Goniothalamus ridleyi</i< King and Their <i<α</i<-Glucosidase Inhibitory Activity <i<Goniothalamus ridleyi</i< dimeric aristolactam styryl lactone <i<α</i<-glucosidase inhibitory activity
topic	misc QD241-441 misc <i<Goniothalamus ridleyi</i< misc dimeric aristolactam misc styryl lactone misc <i<α</i<-glucosidase inhibitory activity misc Organic chemistry
topic_unstemmed	misc QD241-441 misc <i<Goniothalamus ridleyi</i< misc dimeric aristolactam misc styryl lactone misc <i<α</i<-glucosidase inhibitory activity misc Organic chemistry
topic_browse	misc QD241-441 misc <i<Goniothalamus ridleyi</i< misc dimeric aristolactam misc styryl lactone misc <i<α</i<-glucosidase inhibitory activity misc Organic chemistry
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hierarchy_parent_title	Molecules
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title	Alkaloids and Styryl lactones from <i<Goniothalamus ridleyi</i< King and Their <i<α</i<-Glucosidase Inhibitory Activity
ctrlnum	(DE-627)DOAJ080614892 (DE-599)DOAJe749b71c36ad418c8b2a5a3d1c78e739
title_full	Alkaloids and Styryl lactones from <i<Goniothalamus ridleyi</i< King and Their <i<α</i<-Glucosidase Inhibitory Activity
author_sort	Isaraporn Polbuppha
journal	Molecules
journalStr	Molecules
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lang_code	eng
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publishDateSort	2023
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author_browse	Isaraporn Polbuppha Passakorn Teerapongpisan Piyaporn Phukhatmuen Virayu Suthiphasilp Tharakorn Maneerat Rawiwan Charoensup Raymond J. Andersen Surat Laphookhieo
container_volume	28
class	QD241-441
format_se	Elektronische Aufsätze
author-letter	Isaraporn Polbuppha
doi_str_mv	10.3390/molecules28031158
author2-role	verfasserin
title_sort	alkaloids and styryl lactones from <i<goniothalamus ridleyi</i< king and their <i<α</i<-glucosidase inhibitory activity
callnumber	QD241-441
title_auth	Alkaloids and Styryl lactones from <i<Goniothalamus ridleyi</i< King and Their <i<α</i<-Glucosidase Inhibitory Activity
abstract	Gonioridleylactam (<b<1</b<), a new compound, is a unique dimeric aristolactam isolated from the EtOAc extract of the twigs of <i<Goniothalamus ridleyi</i< King. The structure of gonioridleylactam (<b<1</b<) consists of two different aristolactams linked together with two methylenedioxy bridges at C–3/C–3′ and C–4/C–4′, generating a ten-membered ring of [1,3,6,8]tetraoxecine. A new natural product, gonioridleyindole (3-hydroxymethyl-1-methyl-1<i<H</i<-benz[<i<f</i<]indole-4,9-dione, <b<2</b<), together with eight known compounds (<b<3–10</b<) were also isolated from this plant. Their structures were extensively characterized by spectroscopic methods and comparisons were made with the literature. Compounds <b<1–4</b<, <b<7</b<, and <b<9</b< were evaluated for their <i<α</i<-glucosidase inhibitory activity. Of these, 3,5-demethoxypiperolide (<b<7</b<) displayed the highest <i<α</i<-glucosidase inhibitory activity, with an IC<sub<50</sub< value of 1.25 µM.
abstractGer	Gonioridleylactam (<b<1</b<), a new compound, is a unique dimeric aristolactam isolated from the EtOAc extract of the twigs of <i<Goniothalamus ridleyi</i< King. The structure of gonioridleylactam (<b<1</b<) consists of two different aristolactams linked together with two methylenedioxy bridges at C–3/C–3′ and C–4/C–4′, generating a ten-membered ring of [1,3,6,8]tetraoxecine. A new natural product, gonioridleyindole (3-hydroxymethyl-1-methyl-1<i<H</i<-benz[<i<f</i<]indole-4,9-dione, <b<2</b<), together with eight known compounds (<b<3–10</b<) were also isolated from this plant. Their structures were extensively characterized by spectroscopic methods and comparisons were made with the literature. Compounds <b<1–4</b<, <b<7</b<, and <b<9</b< were evaluated for their <i<α</i<-glucosidase inhibitory activity. Of these, 3,5-demethoxypiperolide (<b<7</b<) displayed the highest <i<α</i<-glucosidase inhibitory activity, with an IC<sub<50</sub< value of 1.25 µM.
abstract_unstemmed	Gonioridleylactam (<b<1</b<), a new compound, is a unique dimeric aristolactam isolated from the EtOAc extract of the twigs of <i<Goniothalamus ridleyi</i< King. The structure of gonioridleylactam (<b<1</b<) consists of two different aristolactams linked together with two methylenedioxy bridges at C–3/C–3′ and C–4/C–4′, generating a ten-membered ring of [1,3,6,8]tetraoxecine. A new natural product, gonioridleyindole (3-hydroxymethyl-1-methyl-1<i<H</i<-benz[<i<f</i<]indole-4,9-dione, <b<2</b<), together with eight known compounds (<b<3–10</b<) were also isolated from this plant. Their structures were extensively characterized by spectroscopic methods and comparisons were made with the literature. Compounds <b<1–4</b<, <b<7</b<, and <b<9</b< were evaluated for their <i<α</i<-glucosidase inhibitory activity. Of these, 3,5-demethoxypiperolide (<b<7</b<) displayed the highest <i<α</i<-glucosidase inhibitory activity, with an IC<sub<50</sub< value of 1.25 µM.
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container_issue	3, p 1158
title_short	Alkaloids and Styryl lactones from <i<Goniothalamus ridleyi</i< King and Their <i<α</i<-Glucosidase Inhibitory Activity
url	https://doi.org/10.3390/molecules28031158 https://doaj.org/article/e749b71c36ad418c8b2a5a3d1c78e739 https://www.mdpi.com/1420-3049/28/3/1158 https://doaj.org/toc/1420-3049
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author2	Passakorn Teerapongpisan Piyaporn Phukhatmuen Virayu Suthiphasilp Tharakorn Maneerat Rawiwan Charoensup Raymond J. Andersen Surat Laphookhieo
author2Str	Passakorn Teerapongpisan Piyaporn Phukhatmuen Virayu Suthiphasilp Tharakorn Maneerat Rawiwan Charoensup Raymond J. Andersen Surat Laphookhieo
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doi_str	10.3390/molecules28031158
callnumber-a	QD241-441
up_date	2024-07-03T15:36:57.317Z
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