Assessment of Retinal Pigment Epithelium Alterations and Chorioretinal Vascular Network Analyses in Patients under Treatment with BRAF/MEK Inhibitor for Different Malignancies: A Pilot Study

In the last two decades, an increasing number of so-called molecular-targeted therapies have become available for the treatment of patients with advanced malignancies. These drugs have included inhibitors of proteins in the MAPK pathway, such as BRAF and MEK inhibitors, which are characterized by a...
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Autor*in:	Giuseppe Fasolino [verfasserIn] Gil Awada [verfasserIn] Laura Moschetta [verfasserIn] Jorgos Socrates Koulalis [verfasserIn] Bart Neyns [verfasserIn] Bert Verhelst [verfasserIn] Peter Van Elderen [verfasserIn] Pieter Nelis [verfasserIn] Paul Cardon de Lichtbuer [verfasserIn] Wilfried Cools [verfasserIn] Marcellinus Ten Tusscher [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	BRAF/MEK inhibitor adverse effect central serous chorioretinopathy MEK-inhibitor-associated retinopathy

Übergeordnetes Werk:	In: Journal of Clinical Medicine - MDPI AG, 2013, 12(2023), 3, p 1214
Übergeordnetes Werk:	volume:12 ; year:2023 ; number:3, p 1214

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jcm12031214

Katalog-ID:	DOAJ080625614

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spelling	10.3390/jcm12031214 doi (DE-627)DOAJ080625614 (DE-599)DOAJ1fb9b9d5cb1445c7a876de31f6154068 DE-627 ger DE-627 rakwb eng Giuseppe Fasolino verfasserin aut Assessment of Retinal Pigment Epithelium Alterations and Chorioretinal Vascular Network Analyses in Patients under Treatment with BRAF/MEK Inhibitor for Different Malignancies: A Pilot Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In the last two decades, an increasing number of so-called molecular-targeted therapies have become available for the treatment of patients with advanced malignancies. These drugs have included inhibitors of proteins in the MAPK pathway, such as BRAF and MEK inhibitors, which are characterized by a distinct toxicity profile. The eye is particularly susceptible to adverse effects due to MEK inhibitors, and the term MEKAR (MEK-inhibitor-associated retinopathy) indicates the presence of subretinal fluid, mimicking central serous chorioretinopathy (CSC). The pathogenesis of the retinal alterations related to MAPK pathway inhibitors is still unclear, and questions are still open. The present study aims to assess the presence of retinal pigment epithelium alterations as predictive parameters for retinal toxicity, analyzing, at the same time, the chorioretinal vascular network in patients undergoing BRAF/MEK inhibitor treatment for different malignancies. BRAF/MEK inhibitor adverse effect central serous chorioretinopathy MEK-inhibitor-associated retinopathy Medicine R Gil Awada verfasserin aut Laura Moschetta verfasserin aut Jorgos Socrates Koulalis verfasserin aut Bart Neyns verfasserin aut Bert Verhelst verfasserin aut Peter Van Elderen verfasserin aut Pieter Nelis verfasserin aut Paul Cardon de Lichtbuer verfasserin aut Wilfried Cools verfasserin aut Marcellinus Ten Tusscher verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 12(2023), 3, p 1214 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:12 year:2023 number:3, p 1214 https://doi.org/10.3390/jcm12031214 kostenfrei https://doaj.org/article/1fb9b9d5cb1445c7a876de31f6154068 kostenfrei https://www.mdpi.com/2077-0383/12/3/1214 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 3, p 1214
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allfieldsSound	10.3390/jcm12031214 doi (DE-627)DOAJ080625614 (DE-599)DOAJ1fb9b9d5cb1445c7a876de31f6154068 DE-627 ger DE-627 rakwb eng Giuseppe Fasolino verfasserin aut Assessment of Retinal Pigment Epithelium Alterations and Chorioretinal Vascular Network Analyses in Patients under Treatment with BRAF/MEK Inhibitor for Different Malignancies: A Pilot Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In the last two decades, an increasing number of so-called molecular-targeted therapies have become available for the treatment of patients with advanced malignancies. These drugs have included inhibitors of proteins in the MAPK pathway, such as BRAF and MEK inhibitors, which are characterized by a distinct toxicity profile. The eye is particularly susceptible to adverse effects due to MEK inhibitors, and the term MEKAR (MEK-inhibitor-associated retinopathy) indicates the presence of subretinal fluid, mimicking central serous chorioretinopathy (CSC). The pathogenesis of the retinal alterations related to MAPK pathway inhibitors is still unclear, and questions are still open. The present study aims to assess the presence of retinal pigment epithelium alterations as predictive parameters for retinal toxicity, analyzing, at the same time, the chorioretinal vascular network in patients undergoing BRAF/MEK inhibitor treatment for different malignancies. BRAF/MEK inhibitor adverse effect central serous chorioretinopathy MEK-inhibitor-associated retinopathy Medicine R Gil Awada verfasserin aut Laura Moschetta verfasserin aut Jorgos Socrates Koulalis verfasserin aut Bart Neyns verfasserin aut Bert Verhelst verfasserin aut Peter Van Elderen verfasserin aut Pieter Nelis verfasserin aut Paul Cardon de Lichtbuer verfasserin aut Wilfried Cools verfasserin aut Marcellinus Ten Tusscher verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 12(2023), 3, p 1214 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:12 year:2023 number:3, p 1214 https://doi.org/10.3390/jcm12031214 kostenfrei https://doaj.org/article/1fb9b9d5cb1445c7a876de31f6154068 kostenfrei https://www.mdpi.com/2077-0383/12/3/1214 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 3, p 1214
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author	Giuseppe Fasolino
spellingShingle	Giuseppe Fasolino misc BRAF/MEK inhibitor adverse effect misc central serous chorioretinopathy misc MEK-inhibitor-associated retinopathy misc Medicine misc R Assessment of Retinal Pigment Epithelium Alterations and Chorioretinal Vascular Network Analyses in Patients under Treatment with BRAF/MEK Inhibitor for Different Malignancies: A Pilot Study
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topic_title	Assessment of Retinal Pigment Epithelium Alterations and Chorioretinal Vascular Network Analyses in Patients under Treatment with BRAF/MEK Inhibitor for Different Malignancies: A Pilot Study BRAF/MEK inhibitor adverse effect central serous chorioretinopathy MEK-inhibitor-associated retinopathy
topic	misc BRAF/MEK inhibitor adverse effect misc central serous chorioretinopathy misc MEK-inhibitor-associated retinopathy misc Medicine misc R
topic_unstemmed	misc BRAF/MEK inhibitor adverse effect misc central serous chorioretinopathy misc MEK-inhibitor-associated retinopathy misc Medicine misc R
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title	Assessment of Retinal Pigment Epithelium Alterations and Chorioretinal Vascular Network Analyses in Patients under Treatment with BRAF/MEK Inhibitor for Different Malignancies: A Pilot Study
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title_full	Assessment of Retinal Pigment Epithelium Alterations and Chorioretinal Vascular Network Analyses in Patients under Treatment with BRAF/MEK Inhibitor for Different Malignancies: A Pilot Study
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author_browse	Giuseppe Fasolino Gil Awada Laura Moschetta Jorgos Socrates Koulalis Bart Neyns Bert Verhelst Peter Van Elderen Pieter Nelis Paul Cardon de Lichtbuer Wilfried Cools Marcellinus Ten Tusscher
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title_sort	assessment of retinal pigment epithelium alterations and chorioretinal vascular network analyses in patients under treatment with braf/mek inhibitor for different malignancies: a pilot study
title_auth	Assessment of Retinal Pigment Epithelium Alterations and Chorioretinal Vascular Network Analyses in Patients under Treatment with BRAF/MEK Inhibitor for Different Malignancies: A Pilot Study
abstract	In the last two decades, an increasing number of so-called molecular-targeted therapies have become available for the treatment of patients with advanced malignancies. These drugs have included inhibitors of proteins in the MAPK pathway, such as BRAF and MEK inhibitors, which are characterized by a distinct toxicity profile. The eye is particularly susceptible to adverse effects due to MEK inhibitors, and the term MEKAR (MEK-inhibitor-associated retinopathy) indicates the presence of subretinal fluid, mimicking central serous chorioretinopathy (CSC). The pathogenesis of the retinal alterations related to MAPK pathway inhibitors is still unclear, and questions are still open. The present study aims to assess the presence of retinal pigment epithelium alterations as predictive parameters for retinal toxicity, analyzing, at the same time, the chorioretinal vascular network in patients undergoing BRAF/MEK inhibitor treatment for different malignancies.
abstractGer	In the last two decades, an increasing number of so-called molecular-targeted therapies have become available for the treatment of patients with advanced malignancies. These drugs have included inhibitors of proteins in the MAPK pathway, such as BRAF and MEK inhibitors, which are characterized by a distinct toxicity profile. The eye is particularly susceptible to adverse effects due to MEK inhibitors, and the term MEKAR (MEK-inhibitor-associated retinopathy) indicates the presence of subretinal fluid, mimicking central serous chorioretinopathy (CSC). The pathogenesis of the retinal alterations related to MAPK pathway inhibitors is still unclear, and questions are still open. The present study aims to assess the presence of retinal pigment epithelium alterations as predictive parameters for retinal toxicity, analyzing, at the same time, the chorioretinal vascular network in patients undergoing BRAF/MEK inhibitor treatment for different malignancies.
abstract_unstemmed	In the last two decades, an increasing number of so-called molecular-targeted therapies have become available for the treatment of patients with advanced malignancies. These drugs have included inhibitors of proteins in the MAPK pathway, such as BRAF and MEK inhibitors, which are characterized by a distinct toxicity profile. The eye is particularly susceptible to adverse effects due to MEK inhibitors, and the term MEKAR (MEK-inhibitor-associated retinopathy) indicates the presence of subretinal fluid, mimicking central serous chorioretinopathy (CSC). The pathogenesis of the retinal alterations related to MAPK pathway inhibitors is still unclear, and questions are still open. The present study aims to assess the presence of retinal pigment epithelium alterations as predictive parameters for retinal toxicity, analyzing, at the same time, the chorioretinal vascular network in patients undergoing BRAF/MEK inhibitor treatment for different malignancies.
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title_short	Assessment of Retinal Pigment Epithelium Alterations and Chorioretinal Vascular Network Analyses in Patients under Treatment with BRAF/MEK Inhibitor for Different Malignancies: A Pilot Study
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up_date	2024-07-03T15:40:40.482Z
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