Protective Effects of PEP-1-GSTA2 Protein in Hippocampal Neuronal Cell Damage Induced by Oxidative Stress

Glutathione S-transferase alpha 2 (GSTA2), a member of the glutathione S-transferase family, plays the role of cellular detoxification against oxidative stress. Although oxidative stress is related to ischemic injury, the role of GSTA2 against ischemia has not been elucidated. Thus, we studied wheth...
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Autor*in:	Yeon Joo Choi [verfasserIn] Min Jea Shin [verfasserIn] Gi Soo Youn [verfasserIn] Jung Hwan Park [verfasserIn] Hyeon Ji Yeo [verfasserIn] Eun Ji Yeo [verfasserIn] Hyun Jung Kwon [verfasserIn] Lee Re Lee [verfasserIn] Na Yeon Kim [verfasserIn] Su Yeon Kwon [verfasserIn] Hyo Young Jung [verfasserIn] Yong-Jun Cho [verfasserIn] Dae Won Kim [verfasserIn] Jinseu Park [verfasserIn] Kyu Hyung Han [verfasserIn] Keun Wook Lee [verfasserIn] Jong Kook Park [verfasserIn] Chan Hee Lee [verfasserIn] Won Sik Eum [verfasserIn] Soo Young Choi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	ischemia PEP-1-GSTA2 oxidative stress neuroprotection protein therapy

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 24(2023), 3, p 2767
Übergeordnetes Werk:	volume:24 ; year:2023 ; number:3, p 2767

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijms24032767

Katalog-ID:	DOAJ080633331

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allfields_unstemmed	10.3390/ijms24032767 doi (DE-627)DOAJ080633331 (DE-599)DOAJfc0aedb1cfb2463180e92c7570e3b6cb DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Yeon Joo Choi verfasserin aut Protective Effects of PEP-1-GSTA2 Protein in Hippocampal Neuronal Cell Damage Induced by Oxidative Stress 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Glutathione S-transferase alpha 2 (GSTA2), a member of the glutathione S-transferase family, plays the role of cellular detoxification against oxidative stress. Although oxidative stress is related to ischemic injury, the role of GSTA2 against ischemia has not been elucidated. Thus, we studied whether GSTA2 prevents ischemic injury by using the PEP-1-GSTA2 protein which has a cell-permeable protein transduction domain. We revealed that cell-permeable PEP-1-GSTA2 transduced into HT-22 cells and markedly protected cell death via the inhibition of reactive oxygen species (ROS) production and DNA damage induced by oxidative stress. Additionally, transduced PEP-1-GSTA2 promoted mitogen-activated protein kinase (MAPK), and nuclear factor-kappaB (NF-κB) activation. Furthermore, PEP-1-GSTA2 regulated Bcl-2, Bax, cleaved Caspase-3 and -9 expression protein levels. An in vivo ischemic animal model, PEP-1-GSTA2, markedly prevented the loss of hippocampal neurons and reduced the activation of microglia and astrocytes. These findings indicate that PEP-1-GSTA2 suppresses hippocampal cell death by regulating the MAPK and apoptotic signaling pathways. Therefore, we suggest that PEP-1-GSTA2 will help to develop the therapies for oxidative-stress-induced ischemic injury. ischemia PEP-1-GSTA2 oxidative stress neuroprotection protein therapy Biology (General) Chemistry Min Jea Shin verfasserin aut Gi Soo Youn verfasserin aut Jung Hwan Park verfasserin aut Hyeon Ji Yeo verfasserin aut Eun Ji Yeo verfasserin aut Hyun Jung Kwon verfasserin aut Lee Re Lee verfasserin aut Na Yeon Kim verfasserin aut Su Yeon Kwon verfasserin aut Hyo Young Jung verfasserin aut Yong-Jun Cho verfasserin aut Dae Won Kim verfasserin aut Jinseu Park verfasserin aut Kyu Hyung Han verfasserin aut Keun Wook Lee verfasserin aut Jong Kook Park verfasserin aut Chan Hee Lee verfasserin aut Won Sik Eum verfasserin aut Soo Young Choi verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 3, p 2767 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:3, p 2767 https://doi.org/10.3390/ijms24032767 kostenfrei https://doaj.org/article/fc0aedb1cfb2463180e92c7570e3b6cb kostenfrei https://www.mdpi.com/1422-0067/24/3/2767 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 3, p 2767
allfieldsGer	10.3390/ijms24032767 doi (DE-627)DOAJ080633331 (DE-599)DOAJfc0aedb1cfb2463180e92c7570e3b6cb DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Yeon Joo Choi verfasserin aut Protective Effects of PEP-1-GSTA2 Protein in Hippocampal Neuronal Cell Damage Induced by Oxidative Stress 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Glutathione S-transferase alpha 2 (GSTA2), a member of the glutathione S-transferase family, plays the role of cellular detoxification against oxidative stress. Although oxidative stress is related to ischemic injury, the role of GSTA2 against ischemia has not been elucidated. Thus, we studied whether GSTA2 prevents ischemic injury by using the PEP-1-GSTA2 protein which has a cell-permeable protein transduction domain. We revealed that cell-permeable PEP-1-GSTA2 transduced into HT-22 cells and markedly protected cell death via the inhibition of reactive oxygen species (ROS) production and DNA damage induced by oxidative stress. Additionally, transduced PEP-1-GSTA2 promoted mitogen-activated protein kinase (MAPK), and nuclear factor-kappaB (NF-κB) activation. Furthermore, PEP-1-GSTA2 regulated Bcl-2, Bax, cleaved Caspase-3 and -9 expression protein levels. An in vivo ischemic animal model, PEP-1-GSTA2, markedly prevented the loss of hippocampal neurons and reduced the activation of microglia and astrocytes. These findings indicate that PEP-1-GSTA2 suppresses hippocampal cell death by regulating the MAPK and apoptotic signaling pathways. Therefore, we suggest that PEP-1-GSTA2 will help to develop the therapies for oxidative-stress-induced ischemic injury. ischemia PEP-1-GSTA2 oxidative stress neuroprotection protein therapy Biology (General) Chemistry Min Jea Shin verfasserin aut Gi Soo Youn verfasserin aut Jung Hwan Park verfasserin aut Hyeon Ji Yeo verfasserin aut Eun Ji Yeo verfasserin aut Hyun Jung Kwon verfasserin aut Lee Re Lee verfasserin aut Na Yeon Kim verfasserin aut Su Yeon Kwon verfasserin aut Hyo Young Jung verfasserin aut Yong-Jun Cho verfasserin aut Dae Won Kim verfasserin aut Jinseu Park verfasserin aut Kyu Hyung Han verfasserin aut Keun Wook Lee verfasserin aut Jong Kook Park verfasserin aut Chan Hee Lee verfasserin aut Won Sik Eum verfasserin aut Soo Young Choi verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 3, p 2767 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:3, p 2767 https://doi.org/10.3390/ijms24032767 kostenfrei https://doaj.org/article/fc0aedb1cfb2463180e92c7570e3b6cb kostenfrei https://www.mdpi.com/1422-0067/24/3/2767 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 3, p 2767
allfieldsSound	10.3390/ijms24032767 doi (DE-627)DOAJ080633331 (DE-599)DOAJfc0aedb1cfb2463180e92c7570e3b6cb DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Yeon Joo Choi verfasserin aut Protective Effects of PEP-1-GSTA2 Protein in Hippocampal Neuronal Cell Damage Induced by Oxidative Stress 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Glutathione S-transferase alpha 2 (GSTA2), a member of the glutathione S-transferase family, plays the role of cellular detoxification against oxidative stress. Although oxidative stress is related to ischemic injury, the role of GSTA2 against ischemia has not been elucidated. Thus, we studied whether GSTA2 prevents ischemic injury by using the PEP-1-GSTA2 protein which has a cell-permeable protein transduction domain. We revealed that cell-permeable PEP-1-GSTA2 transduced into HT-22 cells and markedly protected cell death via the inhibition of reactive oxygen species (ROS) production and DNA damage induced by oxidative stress. Additionally, transduced PEP-1-GSTA2 promoted mitogen-activated protein kinase (MAPK), and nuclear factor-kappaB (NF-κB) activation. Furthermore, PEP-1-GSTA2 regulated Bcl-2, Bax, cleaved Caspase-3 and -9 expression protein levels. An in vivo ischemic animal model, PEP-1-GSTA2, markedly prevented the loss of hippocampal neurons and reduced the activation of microglia and astrocytes. These findings indicate that PEP-1-GSTA2 suppresses hippocampal cell death by regulating the MAPK and apoptotic signaling pathways. Therefore, we suggest that PEP-1-GSTA2 will help to develop the therapies for oxidative-stress-induced ischemic injury. ischemia PEP-1-GSTA2 oxidative stress neuroprotection protein therapy Biology (General) Chemistry Min Jea Shin verfasserin aut Gi Soo Youn verfasserin aut Jung Hwan Park verfasserin aut Hyeon Ji Yeo verfasserin aut Eun Ji Yeo verfasserin aut Hyun Jung Kwon verfasserin aut Lee Re Lee verfasserin aut Na Yeon Kim verfasserin aut Su Yeon Kwon verfasserin aut Hyo Young Jung verfasserin aut Yong-Jun Cho verfasserin aut Dae Won Kim verfasserin aut Jinseu Park verfasserin aut Kyu Hyung Han verfasserin aut Keun Wook Lee verfasserin aut Jong Kook Park verfasserin aut Chan Hee Lee verfasserin aut Won Sik Eum verfasserin aut Soo Young Choi verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 3, p 2767 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:3, p 2767 https://doi.org/10.3390/ijms24032767 kostenfrei https://doaj.org/article/fc0aedb1cfb2463180e92c7570e3b6cb kostenfrei https://www.mdpi.com/1422-0067/24/3/2767 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 3, p 2767
language	English
source	In International Journal of Molecular Sciences 24(2023), 3, p 2767 volume:24 year:2023 number:3, p 2767
sourceStr	In International Journal of Molecular Sciences 24(2023), 3, p 2767 volume:24 year:2023 number:3, p 2767
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	ischemia PEP-1-GSTA2 oxidative stress neuroprotection protein therapy Biology (General) Chemistry
isfreeaccess_bool	true
container_title	International Journal of Molecular Sciences
authorswithroles_txt_mv	Yeon Joo Choi @@aut@@ Min Jea Shin @@aut@@ Gi Soo Youn @@aut@@ Jung Hwan Park @@aut@@ Hyeon Ji Yeo @@aut@@ Eun Ji Yeo @@aut@@ Hyun Jung Kwon @@aut@@ Lee Re Lee @@aut@@ Na Yeon Kim @@aut@@ Su Yeon Kwon @@aut@@ Hyo Young Jung @@aut@@ Yong-Jun Cho @@aut@@ Dae Won Kim @@aut@@ Jinseu Park @@aut@@ Kyu Hyung Han @@aut@@ Keun Wook Lee @@aut@@ Jong Kook Park @@aut@@ Chan Hee Lee @@aut@@ Won Sik Eum @@aut@@ Soo Young Choi @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	316340715
id	DOAJ080633331
language_de	englisch
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callnumber-first	Q - Science
author	Yeon Joo Choi
spellingShingle	Yeon Joo Choi misc QH301-705.5 misc QD1-999 misc ischemia misc PEP-1-GSTA2 misc oxidative stress misc neuroprotection misc protein therapy misc Biology (General) misc Chemistry Protective Effects of PEP-1-GSTA2 Protein in Hippocampal Neuronal Cell Damage Induced by Oxidative Stress
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topic_title	QH301-705.5 QD1-999 Protective Effects of PEP-1-GSTA2 Protein in Hippocampal Neuronal Cell Damage Induced by Oxidative Stress ischemia PEP-1-GSTA2 oxidative stress neuroprotection protein therapy
topic	misc QH301-705.5 misc QD1-999 misc ischemia misc PEP-1-GSTA2 misc oxidative stress misc neuroprotection misc protein therapy misc Biology (General) misc Chemistry
topic_unstemmed	misc QH301-705.5 misc QD1-999 misc ischemia misc PEP-1-GSTA2 misc oxidative stress misc neuroprotection misc protein therapy misc Biology (General) misc Chemistry
topic_browse	misc QH301-705.5 misc QD1-999 misc ischemia misc PEP-1-GSTA2 misc oxidative stress misc neuroprotection misc protein therapy misc Biology (General) misc Chemistry
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title	Protective Effects of PEP-1-GSTA2 Protein in Hippocampal Neuronal Cell Damage Induced by Oxidative Stress
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title_full	Protective Effects of PEP-1-GSTA2 Protein in Hippocampal Neuronal Cell Damage Induced by Oxidative Stress
author_sort	Yeon Joo Choi
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author_browse	Yeon Joo Choi Min Jea Shin Gi Soo Youn Jung Hwan Park Hyeon Ji Yeo Eun Ji Yeo Hyun Jung Kwon Lee Re Lee Na Yeon Kim Su Yeon Kwon Hyo Young Jung Yong-Jun Cho Dae Won Kim Jinseu Park Kyu Hyung Han Keun Wook Lee Jong Kook Park Chan Hee Lee Won Sik Eum Soo Young Choi
container_volume	24
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author-letter	Yeon Joo Choi
doi_str_mv	10.3390/ijms24032767
author2-role	verfasserin
title_sort	protective effects of pep-1-gsta2 protein in hippocampal neuronal cell damage induced by oxidative stress
callnumber	QH301-705.5
title_auth	Protective Effects of PEP-1-GSTA2 Protein in Hippocampal Neuronal Cell Damage Induced by Oxidative Stress
abstract	Glutathione S-transferase alpha 2 (GSTA2), a member of the glutathione S-transferase family, plays the role of cellular detoxification against oxidative stress. Although oxidative stress is related to ischemic injury, the role of GSTA2 against ischemia has not been elucidated. Thus, we studied whether GSTA2 prevents ischemic injury by using the PEP-1-GSTA2 protein which has a cell-permeable protein transduction domain. We revealed that cell-permeable PEP-1-GSTA2 transduced into HT-22 cells and markedly protected cell death via the inhibition of reactive oxygen species (ROS) production and DNA damage induced by oxidative stress. Additionally, transduced PEP-1-GSTA2 promoted mitogen-activated protein kinase (MAPK), and nuclear factor-kappaB (NF-κB) activation. Furthermore, PEP-1-GSTA2 regulated Bcl-2, Bax, cleaved Caspase-3 and -9 expression protein levels. An in vivo ischemic animal model, PEP-1-GSTA2, markedly prevented the loss of hippocampal neurons and reduced the activation of microglia and astrocytes. These findings indicate that PEP-1-GSTA2 suppresses hippocampal cell death by regulating the MAPK and apoptotic signaling pathways. Therefore, we suggest that PEP-1-GSTA2 will help to develop the therapies for oxidative-stress-induced ischemic injury.
abstractGer	Glutathione S-transferase alpha 2 (GSTA2), a member of the glutathione S-transferase family, plays the role of cellular detoxification against oxidative stress. Although oxidative stress is related to ischemic injury, the role of GSTA2 against ischemia has not been elucidated. Thus, we studied whether GSTA2 prevents ischemic injury by using the PEP-1-GSTA2 protein which has a cell-permeable protein transduction domain. We revealed that cell-permeable PEP-1-GSTA2 transduced into HT-22 cells and markedly protected cell death via the inhibition of reactive oxygen species (ROS) production and DNA damage induced by oxidative stress. Additionally, transduced PEP-1-GSTA2 promoted mitogen-activated protein kinase (MAPK), and nuclear factor-kappaB (NF-κB) activation. Furthermore, PEP-1-GSTA2 regulated Bcl-2, Bax, cleaved Caspase-3 and -9 expression protein levels. An in vivo ischemic animal model, PEP-1-GSTA2, markedly prevented the loss of hippocampal neurons and reduced the activation of microglia and astrocytes. These findings indicate that PEP-1-GSTA2 suppresses hippocampal cell death by regulating the MAPK and apoptotic signaling pathways. Therefore, we suggest that PEP-1-GSTA2 will help to develop the therapies for oxidative-stress-induced ischemic injury.
abstract_unstemmed	Glutathione S-transferase alpha 2 (GSTA2), a member of the glutathione S-transferase family, plays the role of cellular detoxification against oxidative stress. Although oxidative stress is related to ischemic injury, the role of GSTA2 against ischemia has not been elucidated. Thus, we studied whether GSTA2 prevents ischemic injury by using the PEP-1-GSTA2 protein which has a cell-permeable protein transduction domain. We revealed that cell-permeable PEP-1-GSTA2 transduced into HT-22 cells and markedly protected cell death via the inhibition of reactive oxygen species (ROS) production and DNA damage induced by oxidative stress. Additionally, transduced PEP-1-GSTA2 promoted mitogen-activated protein kinase (MAPK), and nuclear factor-kappaB (NF-κB) activation. Furthermore, PEP-1-GSTA2 regulated Bcl-2, Bax, cleaved Caspase-3 and -9 expression protein levels. An in vivo ischemic animal model, PEP-1-GSTA2, markedly prevented the loss of hippocampal neurons and reduced the activation of microglia and astrocytes. These findings indicate that PEP-1-GSTA2 suppresses hippocampal cell death by regulating the MAPK and apoptotic signaling pathways. Therefore, we suggest that PEP-1-GSTA2 will help to develop the therapies for oxidative-stress-induced ischemic injury.
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container_issue	3, p 2767
title_short	Protective Effects of PEP-1-GSTA2 Protein in Hippocampal Neuronal Cell Damage Induced by Oxidative Stress
url	https://doi.org/10.3390/ijms24032767 https://doaj.org/article/fc0aedb1cfb2463180e92c7570e3b6cb https://www.mdpi.com/1422-0067/24/3/2767 https://doaj.org/toc/1661-6596 https://doaj.org/toc/1422-0067
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author2	Min Jea Shin Gi Soo Youn Jung Hwan Park Hyeon Ji Yeo Eun Ji Yeo Hyun Jung Kwon Lee Re Lee Na Yeon Kim Su Yeon Kwon Hyo Young Jung Yong-Jun Cho Dae Won Kim Jinseu Park Kyu Hyung Han Keun Wook Lee Jong Kook Park Chan Hee Lee Won Sik Eum Soo Young Choi
author2Str	Min Jea Shin Gi Soo Youn Jung Hwan Park Hyeon Ji Yeo Eun Ji Yeo Hyun Jung Kwon Lee Re Lee Na Yeon Kim Su Yeon Kwon Hyo Young Jung Yong-Jun Cho Dae Won Kim Jinseu Park Kyu Hyung Han Keun Wook Lee Jong Kook Park Chan Hee Lee Won Sik Eum Soo Young Choi
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up_date	2024-07-03T15:43:38.200Z
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