Integrated single-cell multiomics reveals novel immune candidate markers for post-traumatic coagulopathy

IntroductionPost-traumatic coagulopathy (PTC) is a critical pathology in traumatic brain injury (TBI), however, its potential mechanism is not clear. To explore this in peripheral samples, we integrated single cell RNA-sequencing and T cell repertoire (TCR)-sequencing across a cohort of patients wit...
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Autor*in:	Ping Zheng [verfasserIn] Ning Zhang [verfasserIn] Dabin Ren [verfasserIn] Cong Yu [verfasserIn] Bin Zhao [verfasserIn] Qingke Bai [verfasserIn] Yisong Zhang [verfasserIn] Wanju Sun [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	single-cell multi-omics RNA-seq TCR-seq post-traumatic coagulopathy

Übergeordnetes Werk:	In: Frontiers in Immunology - Frontiers Media S.A., 2011, 13(2023)
Übergeordnetes Werk:	volume:13 ; year:2023

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fimmu.2022.1095657

Katalog-ID:	DOAJ080853552

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520			\|a IntroductionPost-traumatic coagulopathy (PTC) is a critical pathology in traumatic brain injury (TBI), however, its potential mechanism is not clear. To explore this in peripheral samples, we integrated single cell RNA-sequencing and T cell repertoire (TCR)-sequencing across a cohort of patients with TBI.MethodsClinical samples from patients with more brain severity demonstrated overexpression of T cell receptor–encoding genes and less TCR diversity.ResultsBy mapping TCR clonality, we found patients with PTC have less TCR clones, and the TCR clones are mainly distributed in cytotoxic effector CD8+T cell. In addition, the counts of CD8+ T cell and natural killer (NK) cells are associated with the coagulation parameter by WGCNA, and the granzyme and lectin-like receptor profiles are also decreased in the peripheral blood from TBI patients, suggesting that reduced peripheral CD8+ clonality and cytotoxic profiles may be involved in PTC after TBI.ConclusionOur work systematically revealed the critical immune status in PTC patients at the single-cell level.
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allfields	10.3389/fimmu.2022.1095657 doi (DE-627)DOAJ080853552 (DE-599)DOAJc0b4792aef594c84be2dfa697705a297 DE-627 ger DE-627 rakwb eng RC581-607 Ping Zheng verfasserin aut Integrated single-cell multiomics reveals novel immune candidate markers for post-traumatic coagulopathy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionPost-traumatic coagulopathy (PTC) is a critical pathology in traumatic brain injury (TBI), however, its potential mechanism is not clear. To explore this in peripheral samples, we integrated single cell RNA-sequencing and T cell repertoire (TCR)-sequencing across a cohort of patients with TBI.MethodsClinical samples from patients with more brain severity demonstrated overexpression of T cell receptor–encoding genes and less TCR diversity.ResultsBy mapping TCR clonality, we found patients with PTC have less TCR clones, and the TCR clones are mainly distributed in cytotoxic effector CD8+T cell. In addition, the counts of CD8+ T cell and natural killer (NK) cells are associated with the coagulation parameter by WGCNA, and the granzyme and lectin-like receptor profiles are also decreased in the peripheral blood from TBI patients, suggesting that reduced peripheral CD8+ clonality and cytotoxic profiles may be involved in PTC after TBI.ConclusionOur work systematically revealed the critical immune status in PTC patients at the single-cell level. single-cell multi-omics RNA-seq TCR-seq post-traumatic coagulopathy Immunologic diseases. Allergy Ping Zheng verfasserin aut Ning Zhang verfasserin aut Dabin Ren verfasserin aut Cong Yu verfasserin aut Bin Zhao verfasserin aut Qingke Bai verfasserin aut Yisong Zhang verfasserin aut Wanju Sun verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2023) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2023 https://doi.org/10.3389/fimmu.2022.1095657 kostenfrei https://doaj.org/article/c0b4792aef594c84be2dfa697705a297 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.1095657/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023
spelling	10.3389/fimmu.2022.1095657 doi (DE-627)DOAJ080853552 (DE-599)DOAJc0b4792aef594c84be2dfa697705a297 DE-627 ger DE-627 rakwb eng RC581-607 Ping Zheng verfasserin aut Integrated single-cell multiomics reveals novel immune candidate markers for post-traumatic coagulopathy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionPost-traumatic coagulopathy (PTC) is a critical pathology in traumatic brain injury (TBI), however, its potential mechanism is not clear. To explore this in peripheral samples, we integrated single cell RNA-sequencing and T cell repertoire (TCR)-sequencing across a cohort of patients with TBI.MethodsClinical samples from patients with more brain severity demonstrated overexpression of T cell receptor–encoding genes and less TCR diversity.ResultsBy mapping TCR clonality, we found patients with PTC have less TCR clones, and the TCR clones are mainly distributed in cytotoxic effector CD8+T cell. In addition, the counts of CD8+ T cell and natural killer (NK) cells are associated with the coagulation parameter by WGCNA, and the granzyme and lectin-like receptor profiles are also decreased in the peripheral blood from TBI patients, suggesting that reduced peripheral CD8+ clonality and cytotoxic profiles may be involved in PTC after TBI.ConclusionOur work systematically revealed the critical immune status in PTC patients at the single-cell level. single-cell multi-omics RNA-seq TCR-seq post-traumatic coagulopathy Immunologic diseases. Allergy Ping Zheng verfasserin aut Ning Zhang verfasserin aut Dabin Ren verfasserin aut Cong Yu verfasserin aut Bin Zhao verfasserin aut Qingke Bai verfasserin aut Yisong Zhang verfasserin aut Wanju Sun verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2023) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2023 https://doi.org/10.3389/fimmu.2022.1095657 kostenfrei https://doaj.org/article/c0b4792aef594c84be2dfa697705a297 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.1095657/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023
allfields_unstemmed	10.3389/fimmu.2022.1095657 doi (DE-627)DOAJ080853552 (DE-599)DOAJc0b4792aef594c84be2dfa697705a297 DE-627 ger DE-627 rakwb eng RC581-607 Ping Zheng verfasserin aut Integrated single-cell multiomics reveals novel immune candidate markers for post-traumatic coagulopathy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionPost-traumatic coagulopathy (PTC) is a critical pathology in traumatic brain injury (TBI), however, its potential mechanism is not clear. To explore this in peripheral samples, we integrated single cell RNA-sequencing and T cell repertoire (TCR)-sequencing across a cohort of patients with TBI.MethodsClinical samples from patients with more brain severity demonstrated overexpression of T cell receptor–encoding genes and less TCR diversity.ResultsBy mapping TCR clonality, we found patients with PTC have less TCR clones, and the TCR clones are mainly distributed in cytotoxic effector CD8+T cell. In addition, the counts of CD8+ T cell and natural killer (NK) cells are associated with the coagulation parameter by WGCNA, and the granzyme and lectin-like receptor profiles are also decreased in the peripheral blood from TBI patients, suggesting that reduced peripheral CD8+ clonality and cytotoxic profiles may be involved in PTC after TBI.ConclusionOur work systematically revealed the critical immune status in PTC patients at the single-cell level. single-cell multi-omics RNA-seq TCR-seq post-traumatic coagulopathy Immunologic diseases. Allergy Ping Zheng verfasserin aut Ning Zhang verfasserin aut Dabin Ren verfasserin aut Cong Yu verfasserin aut Bin Zhao verfasserin aut Qingke Bai verfasserin aut Yisong Zhang verfasserin aut Wanju Sun verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2023) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2023 https://doi.org/10.3389/fimmu.2022.1095657 kostenfrei https://doaj.org/article/c0b4792aef594c84be2dfa697705a297 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.1095657/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023
allfieldsGer	10.3389/fimmu.2022.1095657 doi (DE-627)DOAJ080853552 (DE-599)DOAJc0b4792aef594c84be2dfa697705a297 DE-627 ger DE-627 rakwb eng RC581-607 Ping Zheng verfasserin aut Integrated single-cell multiomics reveals novel immune candidate markers for post-traumatic coagulopathy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionPost-traumatic coagulopathy (PTC) is a critical pathology in traumatic brain injury (TBI), however, its potential mechanism is not clear. To explore this in peripheral samples, we integrated single cell RNA-sequencing and T cell repertoire (TCR)-sequencing across a cohort of patients with TBI.MethodsClinical samples from patients with more brain severity demonstrated overexpression of T cell receptor–encoding genes and less TCR diversity.ResultsBy mapping TCR clonality, we found patients with PTC have less TCR clones, and the TCR clones are mainly distributed in cytotoxic effector CD8+T cell. In addition, the counts of CD8+ T cell and natural killer (NK) cells are associated with the coagulation parameter by WGCNA, and the granzyme and lectin-like receptor profiles are also decreased in the peripheral blood from TBI patients, suggesting that reduced peripheral CD8+ clonality and cytotoxic profiles may be involved in PTC after TBI.ConclusionOur work systematically revealed the critical immune status in PTC patients at the single-cell level. single-cell multi-omics RNA-seq TCR-seq post-traumatic coagulopathy Immunologic diseases. Allergy Ping Zheng verfasserin aut Ning Zhang verfasserin aut Dabin Ren verfasserin aut Cong Yu verfasserin aut Bin Zhao verfasserin aut Qingke Bai verfasserin aut Yisong Zhang verfasserin aut Wanju Sun verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2023) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2023 https://doi.org/10.3389/fimmu.2022.1095657 kostenfrei https://doaj.org/article/c0b4792aef594c84be2dfa697705a297 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.1095657/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023
allfieldsSound	10.3389/fimmu.2022.1095657 doi (DE-627)DOAJ080853552 (DE-599)DOAJc0b4792aef594c84be2dfa697705a297 DE-627 ger DE-627 rakwb eng RC581-607 Ping Zheng verfasserin aut Integrated single-cell multiomics reveals novel immune candidate markers for post-traumatic coagulopathy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionPost-traumatic coagulopathy (PTC) is a critical pathology in traumatic brain injury (TBI), however, its potential mechanism is not clear. To explore this in peripheral samples, we integrated single cell RNA-sequencing and T cell repertoire (TCR)-sequencing across a cohort of patients with TBI.MethodsClinical samples from patients with more brain severity demonstrated overexpression of T cell receptor–encoding genes and less TCR diversity.ResultsBy mapping TCR clonality, we found patients with PTC have less TCR clones, and the TCR clones are mainly distributed in cytotoxic effector CD8+T cell. In addition, the counts of CD8+ T cell and natural killer (NK) cells are associated with the coagulation parameter by WGCNA, and the granzyme and lectin-like receptor profiles are also decreased in the peripheral blood from TBI patients, suggesting that reduced peripheral CD8+ clonality and cytotoxic profiles may be involved in PTC after TBI.ConclusionOur work systematically revealed the critical immune status in PTC patients at the single-cell level. single-cell multi-omics RNA-seq TCR-seq post-traumatic coagulopathy Immunologic diseases. Allergy Ping Zheng verfasserin aut Ning Zhang verfasserin aut Dabin Ren verfasserin aut Cong Yu verfasserin aut Bin Zhao verfasserin aut Qingke Bai verfasserin aut Yisong Zhang verfasserin aut Wanju Sun verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2023) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2023 https://doi.org/10.3389/fimmu.2022.1095657 kostenfrei https://doaj.org/article/c0b4792aef594c84be2dfa697705a297 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.1095657/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023
language	English
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authorswithroles_txt_mv	Ping Zheng @@aut@@ Ning Zhang @@aut@@ Dabin Ren @@aut@@ Cong Yu @@aut@@ Bin Zhao @@aut@@ Qingke Bai @@aut@@ Yisong Zhang @@aut@@ Wanju Sun @@aut@@
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To explore this in peripheral samples, we integrated single cell RNA-sequencing and T cell repertoire (TCR)-sequencing across a cohort of patients with TBI.MethodsClinical samples from patients with more brain severity demonstrated overexpression of T cell receptor–encoding genes and less TCR diversity.ResultsBy mapping TCR clonality, we found patients with PTC have less TCR clones, and the TCR clones are mainly distributed in cytotoxic effector CD8+T cell. In addition, the counts of CD8+ T cell and natural killer (NK) cells are associated with the coagulation parameter by WGCNA, and the granzyme and lectin-like receptor profiles are also decreased in the peripheral blood from TBI patients, suggesting that reduced peripheral CD8+ clonality and cytotoxic profiles may be involved in PTC after TBI.ConclusionOur work systematically revealed the critical immune status in PTC patients at the single-cell level.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">single-cell</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">multi-omics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">RNA-seq</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">TCR-seq</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">post-traumatic coagulopathy</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Immunologic diseases. 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callnumber-first	R - Medicine
author	Ping Zheng
spellingShingle	Ping Zheng misc RC581-607 misc single-cell misc multi-omics misc RNA-seq misc TCR-seq misc post-traumatic coagulopathy misc Immunologic diseases. Allergy Integrated single-cell multiomics reveals novel immune candidate markers for post-traumatic coagulopathy
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topic_title	RC581-607 Integrated single-cell multiomics reveals novel immune candidate markers for post-traumatic coagulopathy single-cell multi-omics RNA-seq TCR-seq post-traumatic coagulopathy
topic	misc RC581-607 misc single-cell misc multi-omics misc RNA-seq misc TCR-seq misc post-traumatic coagulopathy misc Immunologic diseases. Allergy
topic_unstemmed	misc RC581-607 misc single-cell misc multi-omics misc RNA-seq misc TCR-seq misc post-traumatic coagulopathy misc Immunologic diseases. Allergy
topic_browse	misc RC581-607 misc single-cell misc multi-omics misc RNA-seq misc TCR-seq misc post-traumatic coagulopathy misc Immunologic diseases. Allergy
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title	Integrated single-cell multiomics reveals novel immune candidate markers for post-traumatic coagulopathy
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title_full	Integrated single-cell multiomics reveals novel immune candidate markers for post-traumatic coagulopathy
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author_browse	Ping Zheng Ning Zhang Dabin Ren Cong Yu Bin Zhao Qingke Bai Yisong Zhang Wanju Sun
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title_sort	integrated single-cell multiomics reveals novel immune candidate markers for post-traumatic coagulopathy
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title_auth	Integrated single-cell multiomics reveals novel immune candidate markers for post-traumatic coagulopathy
abstract	IntroductionPost-traumatic coagulopathy (PTC) is a critical pathology in traumatic brain injury (TBI), however, its potential mechanism is not clear. To explore this in peripheral samples, we integrated single cell RNA-sequencing and T cell repertoire (TCR)-sequencing across a cohort of patients with TBI.MethodsClinical samples from patients with more brain severity demonstrated overexpression of T cell receptor–encoding genes and less TCR diversity.ResultsBy mapping TCR clonality, we found patients with PTC have less TCR clones, and the TCR clones are mainly distributed in cytotoxic effector CD8+T cell. In addition, the counts of CD8+ T cell and natural killer (NK) cells are associated with the coagulation parameter by WGCNA, and the granzyme and lectin-like receptor profiles are also decreased in the peripheral blood from TBI patients, suggesting that reduced peripheral CD8+ clonality and cytotoxic profiles may be involved in PTC after TBI.ConclusionOur work systematically revealed the critical immune status in PTC patients at the single-cell level.
abstractGer	IntroductionPost-traumatic coagulopathy (PTC) is a critical pathology in traumatic brain injury (TBI), however, its potential mechanism is not clear. To explore this in peripheral samples, we integrated single cell RNA-sequencing and T cell repertoire (TCR)-sequencing across a cohort of patients with TBI.MethodsClinical samples from patients with more brain severity demonstrated overexpression of T cell receptor–encoding genes and less TCR diversity.ResultsBy mapping TCR clonality, we found patients with PTC have less TCR clones, and the TCR clones are mainly distributed in cytotoxic effector CD8+T cell. In addition, the counts of CD8+ T cell and natural killer (NK) cells are associated with the coagulation parameter by WGCNA, and the granzyme and lectin-like receptor profiles are also decreased in the peripheral blood from TBI patients, suggesting that reduced peripheral CD8+ clonality and cytotoxic profiles may be involved in PTC after TBI.ConclusionOur work systematically revealed the critical immune status in PTC patients at the single-cell level.
abstract_unstemmed	IntroductionPost-traumatic coagulopathy (PTC) is a critical pathology in traumatic brain injury (TBI), however, its potential mechanism is not clear. To explore this in peripheral samples, we integrated single cell RNA-sequencing and T cell repertoire (TCR)-sequencing across a cohort of patients with TBI.MethodsClinical samples from patients with more brain severity demonstrated overexpression of T cell receptor–encoding genes and less TCR diversity.ResultsBy mapping TCR clonality, we found patients with PTC have less TCR clones, and the TCR clones are mainly distributed in cytotoxic effector CD8+T cell. In addition, the counts of CD8+ T cell and natural killer (NK) cells are associated with the coagulation parameter by WGCNA, and the granzyme and lectin-like receptor profiles are also decreased in the peripheral blood from TBI patients, suggesting that reduced peripheral CD8+ clonality and cytotoxic profiles may be involved in PTC after TBI.ConclusionOur work systematically revealed the critical immune status in PTC patients at the single-cell level.
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title_short	Integrated single-cell multiomics reveals novel immune candidate markers for post-traumatic coagulopathy
url	https://doi.org/10.3389/fimmu.2022.1095657 https://doaj.org/article/c0b4792aef594c84be2dfa697705a297 https://www.frontiersin.org/articles/10.3389/fimmu.2022.1095657/full https://doaj.org/toc/1664-3224
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author2	Ping Zheng Ning Zhang Dabin Ren Cong Yu Bin Zhao Qingke Bai Yisong Zhang Wanju Sun
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up_date	2024-07-03T16:53:37.992Z
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