Is Metabolic Syndrome Useful for Identifying Youths with Obesity at Risk for NAFLD?

The definition of metabolic syndrome (MetS) in childhood is controversial. Recently, a modified version of the International Diabetes Federation (IDF) definition was proposed using reference data from an international population for high waist circumference (WC) and blood pressure (BP), while the fi...
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Autor*in:	Procolo Di Bonito [verfasserIn] Anna Di Sessa [verfasserIn] Maria Rosaria Licenziati [verfasserIn] Domenico Corica [verfasserIn] Malgorzata Wasniewska [verfasserIn] Giuseppina Rosaria Umano [verfasserIn] Anita Morandi [verfasserIn] Claudio Maffeis [verfasserIn] Maria Felicia Faienza [verfasserIn] Enza Mozzillo [verfasserIn] Valeria Calcaterra [verfasserIn] Francesca Franco [verfasserIn] Giulio Maltoni [verfasserIn] Giuliana Valerio [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	metabolic syndrome non-alcoholic fatty liver disease pediatric obesity insulin-resistance abdominal obesity

Übergeordnetes Werk:	In: Children - MDPI AG, 2014, 10(2023), 2, p 233
Übergeordnetes Werk:	volume:10 ; year:2023 ; number:2, p 233

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/children10020233

Katalog-ID:	DOAJ080982999

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allfields	10.3390/children10020233 doi (DE-627)DOAJ080982999 (DE-599)DOAJd91dad36a44a451e85681493a8ac75ff DE-627 ger DE-627 rakwb eng RJ1-570 Procolo Di Bonito verfasserin aut Is Metabolic Syndrome Useful for Identifying Youths with Obesity at Risk for NAFLD? 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The definition of metabolic syndrome (MetS) in childhood is controversial. Recently, a modified version of the International Diabetes Federation (IDF) definition was proposed using reference data from an international population for high waist circumference (WC) and blood pressure (BP), while the fixed cutoffs for lipids and glucose were not changed. We analyzed MetS prevalence using this modified definition (MetS-IDF<sub<m</sub<) and its association with non-alcoholic fatty liver disease (NAFLD) in 1057 youths (age 6–17 years) with overweight/obesity (OW/OB). A comparison with another modified definition of MetS according to the Adult Treatment Panel III (MetS-ATPIII<sub<m</sub<) was performed. The prevalence of MetS-IDF<sub<m</sub< was 27.8% and 28.9% by MetS-ATPIII<sub<m</sub<. The Odds (95% Confidence Intervals) of NAFLD was 2.70 (1.30–5.60) (<i<p</i< = 0.008) for high WC, 1.68 (1.25–2.26)(<i<p</i< = 0.001) for MetS, 1.54 (1.12–2.11)(<i<p</i< = 0.007) for low HDL-Cholesterol, 1.49 (1.04–2.13)(<i<p</i< = 0.032) for high triglycerides and 1.37 (1.03–1.82)(<i<p</i< = 0.033) for high BP. No substantial difference was found in the prevalence of MetS-IDF<sub<m</sub< and frequency of NAFLD compared to Mets-ATPIII<sub<m</sub< definition. Our data demonstrate that one third of youths with OW/OB have MetS, whichever was the criterion. Neither definition was superior to some of their components in identifying youths with OW/OB at risk for NAFLD. metabolic syndrome non-alcoholic fatty liver disease pediatric obesity insulin-resistance abdominal obesity Pediatrics Anna Di Sessa verfasserin aut Maria Rosaria Licenziati verfasserin aut Domenico Corica verfasserin aut Malgorzata Wasniewska verfasserin aut Giuseppina Rosaria Umano verfasserin aut Anita Morandi verfasserin aut Claudio Maffeis verfasserin aut Maria Felicia Faienza verfasserin aut Enza Mozzillo verfasserin aut Valeria Calcaterra verfasserin aut Francesca Franco verfasserin aut Giulio Maltoni verfasserin aut Giuliana Valerio verfasserin aut In Children MDPI AG, 2014 10(2023), 2, p 233 (DE-627)768093007 (DE-600)2732685-8 22279067 nnns volume:10 year:2023 number:2, p 233 https://doi.org/10.3390/children10020233 kostenfrei https://doaj.org/article/d91dad36a44a451e85681493a8ac75ff kostenfrei https://www.mdpi.com/2227-9067/10/2/233 kostenfrei https://doaj.org/toc/2227-9067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2023 2, p 233
spelling	10.3390/children10020233 doi (DE-627)DOAJ080982999 (DE-599)DOAJd91dad36a44a451e85681493a8ac75ff DE-627 ger DE-627 rakwb eng RJ1-570 Procolo Di Bonito verfasserin aut Is Metabolic Syndrome Useful for Identifying Youths with Obesity at Risk for NAFLD? 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The definition of metabolic syndrome (MetS) in childhood is controversial. Recently, a modified version of the International Diabetes Federation (IDF) definition was proposed using reference data from an international population for high waist circumference (WC) and blood pressure (BP), while the fixed cutoffs for lipids and glucose were not changed. We analyzed MetS prevalence using this modified definition (MetS-IDF<sub<m</sub<) and its association with non-alcoholic fatty liver disease (NAFLD) in 1057 youths (age 6–17 years) with overweight/obesity (OW/OB). A comparison with another modified definition of MetS according to the Adult Treatment Panel III (MetS-ATPIII<sub<m</sub<) was performed. The prevalence of MetS-IDF<sub<m</sub< was 27.8% and 28.9% by MetS-ATPIII<sub<m</sub<. The Odds (95% Confidence Intervals) of NAFLD was 2.70 (1.30–5.60) (<i<p</i< = 0.008) for high WC, 1.68 (1.25–2.26)(<i<p</i< = 0.001) for MetS, 1.54 (1.12–2.11)(<i<p</i< = 0.007) for low HDL-Cholesterol, 1.49 (1.04–2.13)(<i<p</i< = 0.032) for high triglycerides and 1.37 (1.03–1.82)(<i<p</i< = 0.033) for high BP. No substantial difference was found in the prevalence of MetS-IDF<sub<m</sub< and frequency of NAFLD compared to Mets-ATPIII<sub<m</sub< definition. Our data demonstrate that one third of youths with OW/OB have MetS, whichever was the criterion. Neither definition was superior to some of their components in identifying youths with OW/OB at risk for NAFLD. metabolic syndrome non-alcoholic fatty liver disease pediatric obesity insulin-resistance abdominal obesity Pediatrics Anna Di Sessa verfasserin aut Maria Rosaria Licenziati verfasserin aut Domenico Corica verfasserin aut Malgorzata Wasniewska verfasserin aut Giuseppina Rosaria Umano verfasserin aut Anita Morandi verfasserin aut Claudio Maffeis verfasserin aut Maria Felicia Faienza verfasserin aut Enza Mozzillo verfasserin aut Valeria Calcaterra verfasserin aut Francesca Franco verfasserin aut Giulio Maltoni verfasserin aut Giuliana Valerio verfasserin aut In Children MDPI AG, 2014 10(2023), 2, p 233 (DE-627)768093007 (DE-600)2732685-8 22279067 nnns volume:10 year:2023 number:2, p 233 https://doi.org/10.3390/children10020233 kostenfrei https://doaj.org/article/d91dad36a44a451e85681493a8ac75ff kostenfrei https://www.mdpi.com/2227-9067/10/2/233 kostenfrei https://doaj.org/toc/2227-9067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2023 2, p 233
allfields_unstemmed	10.3390/children10020233 doi (DE-627)DOAJ080982999 (DE-599)DOAJd91dad36a44a451e85681493a8ac75ff DE-627 ger DE-627 rakwb eng RJ1-570 Procolo Di Bonito verfasserin aut Is Metabolic Syndrome Useful for Identifying Youths with Obesity at Risk for NAFLD? 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The definition of metabolic syndrome (MetS) in childhood is controversial. Recently, a modified version of the International Diabetes Federation (IDF) definition was proposed using reference data from an international population for high waist circumference (WC) and blood pressure (BP), while the fixed cutoffs for lipids and glucose were not changed. We analyzed MetS prevalence using this modified definition (MetS-IDF<sub<m</sub<) and its association with non-alcoholic fatty liver disease (NAFLD) in 1057 youths (age 6–17 years) with overweight/obesity (OW/OB). A comparison with another modified definition of MetS according to the Adult Treatment Panel III (MetS-ATPIII<sub<m</sub<) was performed. The prevalence of MetS-IDF<sub<m</sub< was 27.8% and 28.9% by MetS-ATPIII<sub<m</sub<. The Odds (95% Confidence Intervals) of NAFLD was 2.70 (1.30–5.60) (<i<p</i< = 0.008) for high WC, 1.68 (1.25–2.26)(<i<p</i< = 0.001) for MetS, 1.54 (1.12–2.11)(<i<p</i< = 0.007) for low HDL-Cholesterol, 1.49 (1.04–2.13)(<i<p</i< = 0.032) for high triglycerides and 1.37 (1.03–1.82)(<i<p</i< = 0.033) for high BP. No substantial difference was found in the prevalence of MetS-IDF<sub<m</sub< and frequency of NAFLD compared to Mets-ATPIII<sub<m</sub< definition. Our data demonstrate that one third of youths with OW/OB have MetS, whichever was the criterion. Neither definition was superior to some of their components in identifying youths with OW/OB at risk for NAFLD. metabolic syndrome non-alcoholic fatty liver disease pediatric obesity insulin-resistance abdominal obesity Pediatrics Anna Di Sessa verfasserin aut Maria Rosaria Licenziati verfasserin aut Domenico Corica verfasserin aut Malgorzata Wasniewska verfasserin aut Giuseppina Rosaria Umano verfasserin aut Anita Morandi verfasserin aut Claudio Maffeis verfasserin aut Maria Felicia Faienza verfasserin aut Enza Mozzillo verfasserin aut Valeria Calcaterra verfasserin aut Francesca Franco verfasserin aut Giulio Maltoni verfasserin aut Giuliana Valerio verfasserin aut In Children MDPI AG, 2014 10(2023), 2, p 233 (DE-627)768093007 (DE-600)2732685-8 22279067 nnns volume:10 year:2023 number:2, p 233 https://doi.org/10.3390/children10020233 kostenfrei https://doaj.org/article/d91dad36a44a451e85681493a8ac75ff kostenfrei https://www.mdpi.com/2227-9067/10/2/233 kostenfrei https://doaj.org/toc/2227-9067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2023 2, p 233
allfieldsGer	10.3390/children10020233 doi (DE-627)DOAJ080982999 (DE-599)DOAJd91dad36a44a451e85681493a8ac75ff DE-627 ger DE-627 rakwb eng RJ1-570 Procolo Di Bonito verfasserin aut Is Metabolic Syndrome Useful for Identifying Youths with Obesity at Risk for NAFLD? 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The definition of metabolic syndrome (MetS) in childhood is controversial. Recently, a modified version of the International Diabetes Federation (IDF) definition was proposed using reference data from an international population for high waist circumference (WC) and blood pressure (BP), while the fixed cutoffs for lipids and glucose were not changed. We analyzed MetS prevalence using this modified definition (MetS-IDF<sub<m</sub<) and its association with non-alcoholic fatty liver disease (NAFLD) in 1057 youths (age 6–17 years) with overweight/obesity (OW/OB). A comparison with another modified definition of MetS according to the Adult Treatment Panel III (MetS-ATPIII<sub<m</sub<) was performed. The prevalence of MetS-IDF<sub<m</sub< was 27.8% and 28.9% by MetS-ATPIII<sub<m</sub<. The Odds (95% Confidence Intervals) of NAFLD was 2.70 (1.30–5.60) (<i<p</i< = 0.008) for high WC, 1.68 (1.25–2.26)(<i<p</i< = 0.001) for MetS, 1.54 (1.12–2.11)(<i<p</i< = 0.007) for low HDL-Cholesterol, 1.49 (1.04–2.13)(<i<p</i< = 0.032) for high triglycerides and 1.37 (1.03–1.82)(<i<p</i< = 0.033) for high BP. No substantial difference was found in the prevalence of MetS-IDF<sub<m</sub< and frequency of NAFLD compared to Mets-ATPIII<sub<m</sub< definition. Our data demonstrate that one third of youths with OW/OB have MetS, whichever was the criterion. Neither definition was superior to some of their components in identifying youths with OW/OB at risk for NAFLD. metabolic syndrome non-alcoholic fatty liver disease pediatric obesity insulin-resistance abdominal obesity Pediatrics Anna Di Sessa verfasserin aut Maria Rosaria Licenziati verfasserin aut Domenico Corica verfasserin aut Malgorzata Wasniewska verfasserin aut Giuseppina Rosaria Umano verfasserin aut Anita Morandi verfasserin aut Claudio Maffeis verfasserin aut Maria Felicia Faienza verfasserin aut Enza Mozzillo verfasserin aut Valeria Calcaterra verfasserin aut Francesca Franco verfasserin aut Giulio Maltoni verfasserin aut Giuliana Valerio verfasserin aut In Children MDPI AG, 2014 10(2023), 2, p 233 (DE-627)768093007 (DE-600)2732685-8 22279067 nnns volume:10 year:2023 number:2, p 233 https://doi.org/10.3390/children10020233 kostenfrei https://doaj.org/article/d91dad36a44a451e85681493a8ac75ff kostenfrei https://www.mdpi.com/2227-9067/10/2/233 kostenfrei https://doaj.org/toc/2227-9067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2023 2, p 233
allfieldsSound	10.3390/children10020233 doi (DE-627)DOAJ080982999 (DE-599)DOAJd91dad36a44a451e85681493a8ac75ff DE-627 ger DE-627 rakwb eng RJ1-570 Procolo Di Bonito verfasserin aut Is Metabolic Syndrome Useful for Identifying Youths with Obesity at Risk for NAFLD? 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The definition of metabolic syndrome (MetS) in childhood is controversial. Recently, a modified version of the International Diabetes Federation (IDF) definition was proposed using reference data from an international population for high waist circumference (WC) and blood pressure (BP), while the fixed cutoffs for lipids and glucose were not changed. We analyzed MetS prevalence using this modified definition (MetS-IDF<sub<m</sub<) and its association with non-alcoholic fatty liver disease (NAFLD) in 1057 youths (age 6–17 years) with overweight/obesity (OW/OB). A comparison with another modified definition of MetS according to the Adult Treatment Panel III (MetS-ATPIII<sub<m</sub<) was performed. The prevalence of MetS-IDF<sub<m</sub< was 27.8% and 28.9% by MetS-ATPIII<sub<m</sub<. The Odds (95% Confidence Intervals) of NAFLD was 2.70 (1.30–5.60) (<i<p</i< = 0.008) for high WC, 1.68 (1.25–2.26)(<i<p</i< = 0.001) for MetS, 1.54 (1.12–2.11)(<i<p</i< = 0.007) for low HDL-Cholesterol, 1.49 (1.04–2.13)(<i<p</i< = 0.032) for high triglycerides and 1.37 (1.03–1.82)(<i<p</i< = 0.033) for high BP. No substantial difference was found in the prevalence of MetS-IDF<sub<m</sub< and frequency of NAFLD compared to Mets-ATPIII<sub<m</sub< definition. Our data demonstrate that one third of youths with OW/OB have MetS, whichever was the criterion. Neither definition was superior to some of their components in identifying youths with OW/OB at risk for NAFLD. metabolic syndrome non-alcoholic fatty liver disease pediatric obesity insulin-resistance abdominal obesity Pediatrics Anna Di Sessa verfasserin aut Maria Rosaria Licenziati verfasserin aut Domenico Corica verfasserin aut Malgorzata Wasniewska verfasserin aut Giuseppina Rosaria Umano verfasserin aut Anita Morandi verfasserin aut Claudio Maffeis verfasserin aut Maria Felicia Faienza verfasserin aut Enza Mozzillo verfasserin aut Valeria Calcaterra verfasserin aut Francesca Franco verfasserin aut Giulio Maltoni verfasserin aut Giuliana Valerio verfasserin aut In Children MDPI AG, 2014 10(2023), 2, p 233 (DE-627)768093007 (DE-600)2732685-8 22279067 nnns volume:10 year:2023 number:2, p 233 https://doi.org/10.3390/children10020233 kostenfrei https://doaj.org/article/d91dad36a44a451e85681493a8ac75ff kostenfrei https://www.mdpi.com/2227-9067/10/2/233 kostenfrei https://doaj.org/toc/2227-9067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2023 2, p 233
language	English
source	In Children 10(2023), 2, p 233 volume:10 year:2023 number:2, p 233
sourceStr	In Children 10(2023), 2, p 233 volume:10 year:2023 number:2, p 233
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	metabolic syndrome non-alcoholic fatty liver disease pediatric obesity insulin-resistance abdominal obesity Pediatrics
isfreeaccess_bool	true
container_title	Children
authorswithroles_txt_mv	Procolo Di Bonito @@aut@@ Anna Di Sessa @@aut@@ Maria Rosaria Licenziati @@aut@@ Domenico Corica @@aut@@ Malgorzata Wasniewska @@aut@@ Giuseppina Rosaria Umano @@aut@@ Anita Morandi @@aut@@ Claudio Maffeis @@aut@@ Maria Felicia Faienza @@aut@@ Enza Mozzillo @@aut@@ Valeria Calcaterra @@aut@@ Francesca Franco @@aut@@ Giulio Maltoni @@aut@@ Giuliana Valerio @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	768093007
id	DOAJ080982999
language_de	englisch
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callnumber-first	R - Medicine
author	Procolo Di Bonito
spellingShingle	Procolo Di Bonito misc RJ1-570 misc metabolic syndrome misc non-alcoholic fatty liver disease misc pediatric obesity misc insulin-resistance misc abdominal obesity misc Pediatrics Is Metabolic Syndrome Useful for Identifying Youths with Obesity at Risk for NAFLD?
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topic_title	RJ1-570 Is Metabolic Syndrome Useful for Identifying Youths with Obesity at Risk for NAFLD? metabolic syndrome non-alcoholic fatty liver disease pediatric obesity insulin-resistance abdominal obesity
topic	misc RJ1-570 misc metabolic syndrome misc non-alcoholic fatty liver disease misc pediatric obesity misc insulin-resistance misc abdominal obesity misc Pediatrics
topic_unstemmed	misc RJ1-570 misc metabolic syndrome misc non-alcoholic fatty liver disease misc pediatric obesity misc insulin-resistance misc abdominal obesity misc Pediatrics
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title	Is Metabolic Syndrome Useful for Identifying Youths with Obesity at Risk for NAFLD?
ctrlnum	(DE-627)DOAJ080982999 (DE-599)DOAJd91dad36a44a451e85681493a8ac75ff
title_full	Is Metabolic Syndrome Useful for Identifying Youths with Obesity at Risk for NAFLD?
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author_browse	Procolo Di Bonito Anna Di Sessa Maria Rosaria Licenziati Domenico Corica Malgorzata Wasniewska Giuseppina Rosaria Umano Anita Morandi Claudio Maffeis Maria Felicia Faienza Enza Mozzillo Valeria Calcaterra Francesca Franco Giulio Maltoni Giuliana Valerio
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title_sort	is metabolic syndrome useful for identifying youths with obesity at risk for nafld?
callnumber	RJ1-570
title_auth	Is Metabolic Syndrome Useful for Identifying Youths with Obesity at Risk for NAFLD?
abstract	The definition of metabolic syndrome (MetS) in childhood is controversial. Recently, a modified version of the International Diabetes Federation (IDF) definition was proposed using reference data from an international population for high waist circumference (WC) and blood pressure (BP), while the fixed cutoffs for lipids and glucose were not changed. We analyzed MetS prevalence using this modified definition (MetS-IDF<sub<m</sub<) and its association with non-alcoholic fatty liver disease (NAFLD) in 1057 youths (age 6–17 years) with overweight/obesity (OW/OB). A comparison with another modified definition of MetS according to the Adult Treatment Panel III (MetS-ATPIII<sub<m</sub<) was performed. The prevalence of MetS-IDF<sub<m</sub< was 27.8% and 28.9% by MetS-ATPIII<sub<m</sub<. The Odds (95% Confidence Intervals) of NAFLD was 2.70 (1.30–5.60) (<i<p</i< = 0.008) for high WC, 1.68 (1.25–2.26)(<i<p</i< = 0.001) for MetS, 1.54 (1.12–2.11)(<i<p</i< = 0.007) for low HDL-Cholesterol, 1.49 (1.04–2.13)(<i<p</i< = 0.032) for high triglycerides and 1.37 (1.03–1.82)(<i<p</i< = 0.033) for high BP. No substantial difference was found in the prevalence of MetS-IDF<sub<m</sub< and frequency of NAFLD compared to Mets-ATPIII<sub<m</sub< definition. Our data demonstrate that one third of youths with OW/OB have MetS, whichever was the criterion. Neither definition was superior to some of their components in identifying youths with OW/OB at risk for NAFLD.
abstractGer	The definition of metabolic syndrome (MetS) in childhood is controversial. Recently, a modified version of the International Diabetes Federation (IDF) definition was proposed using reference data from an international population for high waist circumference (WC) and blood pressure (BP), while the fixed cutoffs for lipids and glucose were not changed. We analyzed MetS prevalence using this modified definition (MetS-IDF<sub<m</sub<) and its association with non-alcoholic fatty liver disease (NAFLD) in 1057 youths (age 6–17 years) with overweight/obesity (OW/OB). A comparison with another modified definition of MetS according to the Adult Treatment Panel III (MetS-ATPIII<sub<m</sub<) was performed. The prevalence of MetS-IDF<sub<m</sub< was 27.8% and 28.9% by MetS-ATPIII<sub<m</sub<. The Odds (95% Confidence Intervals) of NAFLD was 2.70 (1.30–5.60) (<i<p</i< = 0.008) for high WC, 1.68 (1.25–2.26)(<i<p</i< = 0.001) for MetS, 1.54 (1.12–2.11)(<i<p</i< = 0.007) for low HDL-Cholesterol, 1.49 (1.04–2.13)(<i<p</i< = 0.032) for high triglycerides and 1.37 (1.03–1.82)(<i<p</i< = 0.033) for high BP. No substantial difference was found in the prevalence of MetS-IDF<sub<m</sub< and frequency of NAFLD compared to Mets-ATPIII<sub<m</sub< definition. Our data demonstrate that one third of youths with OW/OB have MetS, whichever was the criterion. Neither definition was superior to some of their components in identifying youths with OW/OB at risk for NAFLD.
abstract_unstemmed	The definition of metabolic syndrome (MetS) in childhood is controversial. Recently, a modified version of the International Diabetes Federation (IDF) definition was proposed using reference data from an international population for high waist circumference (WC) and blood pressure (BP), while the fixed cutoffs for lipids and glucose were not changed. We analyzed MetS prevalence using this modified definition (MetS-IDF<sub<m</sub<) and its association with non-alcoholic fatty liver disease (NAFLD) in 1057 youths (age 6–17 years) with overweight/obesity (OW/OB). A comparison with another modified definition of MetS according to the Adult Treatment Panel III (MetS-ATPIII<sub<m</sub<) was performed. The prevalence of MetS-IDF<sub<m</sub< was 27.8% and 28.9% by MetS-ATPIII<sub<m</sub<. The Odds (95% Confidence Intervals) of NAFLD was 2.70 (1.30–5.60) (<i<p</i< = 0.008) for high WC, 1.68 (1.25–2.26)(<i<p</i< = 0.001) for MetS, 1.54 (1.12–2.11)(<i<p</i< = 0.007) for low HDL-Cholesterol, 1.49 (1.04–2.13)(<i<p</i< = 0.032) for high triglycerides and 1.37 (1.03–1.82)(<i<p</i< = 0.033) for high BP. No substantial difference was found in the prevalence of MetS-IDF<sub<m</sub< and frequency of NAFLD compared to Mets-ATPIII<sub<m</sub< definition. Our data demonstrate that one third of youths with OW/OB have MetS, whichever was the criterion. Neither definition was superior to some of their components in identifying youths with OW/OB at risk for NAFLD.
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title_short	Is Metabolic Syndrome Useful for Identifying Youths with Obesity at Risk for NAFLD?
url	https://doi.org/10.3390/children10020233 https://doaj.org/article/d91dad36a44a451e85681493a8ac75ff https://www.mdpi.com/2227-9067/10/2/233 https://doaj.org/toc/2227-9067
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