Perampanel in Brain Tumor-Related Epilepsy: A Systematic Review

Brain tumor-related epilepsy (BTRE) is a common comorbidity in patients with brain neoplasms and it may be either the first symptom or develop after the tumor diagnosis. Increasing evidence suggests that brain tumors and BTRE share common pathophysiological mechanisms. Glutamatergic mechanisms can p...
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Autor*in:	Payam Tabaee Damavandi [verfasserIn] Francesco Pasini [verfasserIn] Gaia Fanella [verfasserIn] Giulia Sofia Cereda [verfasserIn] Gabriele Mainini [verfasserIn] Jacopo C. DiFrancesco [verfasserIn] Eugen Trinka [verfasserIn] Simona Lattanzi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	perampanel AMPA receptors brain tumor epilepsy glutamate glioma

Übergeordnetes Werk:	In: Brain Sciences - MDPI AG, 2012, 13(2023), 2, p 326
Übergeordnetes Werk:	volume:13 ; year:2023 ; number:2, p 326

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/brainsci13020326

Katalog-ID:	DOAJ080996159

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520			\|a Brain tumor-related epilepsy (BTRE) is a common comorbidity in patients with brain neoplasms and it may be either the first symptom or develop after the tumor diagnosis. Increasing evidence suggests that brain tumors and BTRE share common pathophysiological mechanisms. Glutamatergic mechanisms can play a central role in promoting both primary brain tumor growth and epileptogenesis. Perampanel (PER), which acts as a selective antagonist of glutamate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, may play a role both in the reduction in tumor growth and the control of epileptiform activity. This systematic review aimed to summarize the pre-clinical and clinical evidence about the antitumor properties, antiseizure effects and tolerability of PER in BTRE. Eight pre-clinical and eight clinical studies were identified. The currently available evidence suggests that PER can be an effective and generally well-tolerated therapeutic option in patients with BTRE. In vitro studies demonstrated promising antitumor activity of PER, while no role in slowing tumor progression has been demonstrated in rat models; clinical data on the potential antitumor activity of PER are scarce. Additional studies are needed to explore further the effects of PER on tumor progression and fully characterize its potentialities in patients with BTRE.
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allfieldsSound	10.3390/brainsci13020326 doi (DE-627)DOAJ080996159 (DE-599)DOAJ66dc999e18114cf6a26b69372b0c83b1 DE-627 ger DE-627 rakwb eng RC321-571 Payam Tabaee Damavandi verfasserin aut Perampanel in Brain Tumor-Related Epilepsy: A Systematic Review 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Brain tumor-related epilepsy (BTRE) is a common comorbidity in patients with brain neoplasms and it may be either the first symptom or develop after the tumor diagnosis. Increasing evidence suggests that brain tumors and BTRE share common pathophysiological mechanisms. Glutamatergic mechanisms can play a central role in promoting both primary brain tumor growth and epileptogenesis. Perampanel (PER), which acts as a selective antagonist of glutamate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, may play a role both in the reduction in tumor growth and the control of epileptiform activity. This systematic review aimed to summarize the pre-clinical and clinical evidence about the antitumor properties, antiseizure effects and tolerability of PER in BTRE. Eight pre-clinical and eight clinical studies were identified. The currently available evidence suggests that PER can be an effective and generally well-tolerated therapeutic option in patients with BTRE. In vitro studies demonstrated promising antitumor activity of PER, while no role in slowing tumor progression has been demonstrated in rat models; clinical data on the potential antitumor activity of PER are scarce. Additional studies are needed to explore further the effects of PER on tumor progression and fully characterize its potentialities in patients with BTRE. perampanel AMPA receptors brain tumor epilepsy glutamate glioma Neurosciences. Biological psychiatry. Neuropsychiatry Francesco Pasini verfasserin aut Gaia Fanella verfasserin aut Giulia Sofia Cereda verfasserin aut Gabriele Mainini verfasserin aut Jacopo C. DiFrancesco verfasserin aut Eugen Trinka verfasserin aut Simona Lattanzi verfasserin aut In Brain Sciences MDPI AG, 2012 13(2023), 2, p 326 (DE-627)687718139 (DE-600)2651993-8 20763425 nnns volume:13 year:2023 number:2, p 326 https://doi.org/10.3390/brainsci13020326 kostenfrei https://doaj.org/article/66dc999e18114cf6a26b69372b0c83b1 kostenfrei https://www.mdpi.com/2076-3425/13/2/326 kostenfrei https://doaj.org/toc/2076-3425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 2, p 326
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callnumber-first	R - Medicine
author	Payam Tabaee Damavandi
spellingShingle	Payam Tabaee Damavandi misc RC321-571 misc perampanel misc AMPA receptors misc brain tumor misc epilepsy misc glutamate misc glioma misc Neurosciences. Biological psychiatry. Neuropsychiatry Perampanel in Brain Tumor-Related Epilepsy: A Systematic Review
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topic_title	RC321-571 Perampanel in Brain Tumor-Related Epilepsy: A Systematic Review perampanel AMPA receptors brain tumor epilepsy glutamate glioma
topic	misc RC321-571 misc perampanel misc AMPA receptors misc brain tumor misc epilepsy misc glutamate misc glioma misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Perampanel in Brain Tumor-Related Epilepsy: A Systematic Review
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title_sort	perampanel in brain tumor-related epilepsy: a systematic review
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title_auth	Perampanel in Brain Tumor-Related Epilepsy: A Systematic Review
abstract	Brain tumor-related epilepsy (BTRE) is a common comorbidity in patients with brain neoplasms and it may be either the first symptom or develop after the tumor diagnosis. Increasing evidence suggests that brain tumors and BTRE share common pathophysiological mechanisms. Glutamatergic mechanisms can play a central role in promoting both primary brain tumor growth and epileptogenesis. Perampanel (PER), which acts as a selective antagonist of glutamate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, may play a role both in the reduction in tumor growth and the control of epileptiform activity. This systematic review aimed to summarize the pre-clinical and clinical evidence about the antitumor properties, antiseizure effects and tolerability of PER in BTRE. Eight pre-clinical and eight clinical studies were identified. The currently available evidence suggests that PER can be an effective and generally well-tolerated therapeutic option in patients with BTRE. In vitro studies demonstrated promising antitumor activity of PER, while no role in slowing tumor progression has been demonstrated in rat models; clinical data on the potential antitumor activity of PER are scarce. Additional studies are needed to explore further the effects of PER on tumor progression and fully characterize its potentialities in patients with BTRE.
abstractGer	Brain tumor-related epilepsy (BTRE) is a common comorbidity in patients with brain neoplasms and it may be either the first symptom or develop after the tumor diagnosis. Increasing evidence suggests that brain tumors and BTRE share common pathophysiological mechanisms. Glutamatergic mechanisms can play a central role in promoting both primary brain tumor growth and epileptogenesis. Perampanel (PER), which acts as a selective antagonist of glutamate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, may play a role both in the reduction in tumor growth and the control of epileptiform activity. This systematic review aimed to summarize the pre-clinical and clinical evidence about the antitumor properties, antiseizure effects and tolerability of PER in BTRE. Eight pre-clinical and eight clinical studies were identified. The currently available evidence suggests that PER can be an effective and generally well-tolerated therapeutic option in patients with BTRE. In vitro studies demonstrated promising antitumor activity of PER, while no role in slowing tumor progression has been demonstrated in rat models; clinical data on the potential antitumor activity of PER are scarce. Additional studies are needed to explore further the effects of PER on tumor progression and fully characterize its potentialities in patients with BTRE.
abstract_unstemmed	Brain tumor-related epilepsy (BTRE) is a common comorbidity in patients with brain neoplasms and it may be either the first symptom or develop after the tumor diagnosis. Increasing evidence suggests that brain tumors and BTRE share common pathophysiological mechanisms. Glutamatergic mechanisms can play a central role in promoting both primary brain tumor growth and epileptogenesis. Perampanel (PER), which acts as a selective antagonist of glutamate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, may play a role both in the reduction in tumor growth and the control of epileptiform activity. This systematic review aimed to summarize the pre-clinical and clinical evidence about the antitumor properties, antiseizure effects and tolerability of PER in BTRE. Eight pre-clinical and eight clinical studies were identified. The currently available evidence suggests that PER can be an effective and generally well-tolerated therapeutic option in patients with BTRE. In vitro studies demonstrated promising antitumor activity of PER, while no role in slowing tumor progression has been demonstrated in rat models; clinical data on the potential antitumor activity of PER are scarce. Additional studies are needed to explore further the effects of PER on tumor progression and fully characterize its potentialities in patients with BTRE.
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title_short	Perampanel in Brain Tumor-Related Epilepsy: A Systematic Review
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Perampanel in Brain Tumor-Related Epilepsy: A Systematic Review

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