Antiperiodontitis Effects of <i<Siegesbeckia glabrescens</i< In Vitro

<i<Siegesbeckia glabrescens</i< is generally grown in fields or roadsides in Korea and used for the treatment of inflammatory diseases. The effects of <i<S. glabrescens</i< on periodontitis are unknown. In this study, we determined the effects of an <i<S. glabrescens<...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Arce Defeo Bellere [verfasserIn] Duna Yu [verfasserIn] Sarang Oh [verfasserIn] Myeongju Kim [verfasserIn] Jeyong Jung [verfasserIn] Minzhe Fang [verfasserIn] Shengdao Zheng [verfasserIn] Tae-Hoo Yi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	periodontitis antioxidants biofilms

Übergeordnetes Werk:	In: Antioxidants - MDPI AG, 2013, 12(2023), 2, p 471
Übergeordnetes Werk:	volume:12 ; year:2023 ; number:2, p 471

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/antiox12020471

Katalog-ID:	DOAJ08102424X

Internformat


LEADER	01000caa a22002652 4500
001	DOAJ08102424X
003	DE-627
005	20240413064611.0
007	cr uuu---uuuuu
008	230310s2023 xx \|\|\|\|\|o 00\| \|\|eng c
024	7		\|a 10.3390/antiox12020471 \|2 doi
035			\|a (DE-627)DOAJ08102424X
035			\|a (DE-599)DOAJcf106dacbe13428894a6e6ca094090b3
040			\|a DE-627 \|b ger \|c DE-627 \|e rakwb
041			\|a eng
050		0	\|a RM1-950
100	0		\|a Arce Defeo Bellere \|e verfasserin \|4 aut
245	1	0	\|a Antiperiodontitis Effects of <i<Siegesbeckia glabrescens</i< In Vitro
264		1	\|c 2023
336			\|a Text \|b txt \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
520			\|a <i<Siegesbeckia glabrescens</i< is generally grown in fields or roadsides in Korea and used for the treatment of inflammatory diseases. The effects of <i<S. glabrescens</i< on periodontitis are unknown. In this study, we determined the effects of an <i<S. glabrescens</i< 30% EtOH extract (SGE) on periodontitis and analyzed the antioxidant activity (DPPH, ABTS, and SOD), antimicrobial (disc diffusion, MIC, and MBC), inhibition of GTFs, biofilm formation, and the anti-inflammation of lipopolysaccharide from <i<P. gingivalis</i< (LPS-PG)-induced primary equine periodontal ligament fibroblasts (PDLFs). We report that SGE increased DPPH, ABTS, and SOD antioxidant activities in a dose-dependent manner. SGE caused a clear zone with a diameter of 15 mm or more against periodontal pathogens. SGE (2.50 mg/mL) inhibited GTFs and biofilm by 89.07% and 85.40%, respectively. SGE treatment (100 µg/mL) also significantly decreased the secretion of inflammatory mediators in sensitized PDLF, including cytokines and matrix metalloproteinase (MMP)-3, -8, -9, and -13. Overall, we confirmed that SGE had excellent antioxidant, antimicrobial, and anti-inflammatory effects against periodontal pathogens. These results suggest that it has the potential to develop as a prophylactic agent for periodontitis.
650		4	\|a <i<Siegesbeckia glabrescens</i<
650		4	\|a periodontitis
650		4	\|a <i<Porphyromonas gingivalis</i<
650		4	\|a antioxidants
650		4	\|a biofilms
653		0	\|a Therapeutics. Pharmacology
700	0		\|a Duna Yu \|e verfasserin \|4 aut
700	0		\|a Sarang Oh \|e verfasserin \|4 aut
700	0		\|a Myeongju Kim \|e verfasserin \|4 aut
700	0		\|a Jeyong Jung \|e verfasserin \|4 aut
700	0		\|a Minzhe Fang \|e verfasserin \|4 aut
700	0		\|a Shengdao Zheng \|e verfasserin \|4 aut
700	0		\|a Tae-Hoo Yi \|e verfasserin \|4 aut
773	0	8	\|i In \|t Antioxidants \|d MDPI AG, 2013 \|g 12(2023), 2, p 471 \|w (DE-627)737287578 \|w (DE-600)2704216-9 \|x 20763921 \|7 nnns
773	1	8	\|g volume:12 \|g year:2023 \|g number:2, p 471
856	4	0	\|u https://doi.org/10.3390/antiox12020471 \|z kostenfrei
856	4	0	\|u https://doaj.org/article/cf106dacbe13428894a6e6ca094090b3 \|z kostenfrei
856	4	0	\|u https://www.mdpi.com/2076-3921/12/2/471 \|z kostenfrei
856	4	2	\|u https://doaj.org/toc/2076-3921 \|y Journal toc \|z kostenfrei
912			\|a GBV_USEFLAG_A
912			\|a SYSFLAG_A
912			\|a GBV_DOAJ
912			\|a GBV_ILN_20
912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_95
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_206
912			\|a GBV_ILN_213
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_602
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4700
951			\|a AR
952			\|d 12 \|j 2023 \|e 2, p 471

Indexfelder

author_variant	a d b adb d y dy s o so m k mk j j jj m f mf s z sz t h y thy
matchkey_str	article:20763921:2023----::nieidniiefcsfseebciga
hierarchy_sort_str	2023
callnumber-subject-code	RM
publishDate	2023
allfields	10.3390/antiox12020471 doi (DE-627)DOAJ08102424X (DE-599)DOAJcf106dacbe13428894a6e6ca094090b3 DE-627 ger DE-627 rakwb eng RM1-950 Arce Defeo Bellere verfasserin aut Antiperiodontitis Effects of <i<Siegesbeckia glabrescens</i< In Vitro 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Siegesbeckia glabrescens</i< is generally grown in fields or roadsides in Korea and used for the treatment of inflammatory diseases. The effects of <i<S. glabrescens</i< on periodontitis are unknown. In this study, we determined the effects of an <i<S. glabrescens</i< 30% EtOH extract (SGE) on periodontitis and analyzed the antioxidant activity (DPPH, ABTS, and SOD), antimicrobial (disc diffusion, MIC, and MBC), inhibition of GTFs, biofilm formation, and the anti-inflammation of lipopolysaccharide from <i<P. gingivalis</i< (LPS-PG)-induced primary equine periodontal ligament fibroblasts (PDLFs). We report that SGE increased DPPH, ABTS, and SOD antioxidant activities in a dose-dependent manner. SGE caused a clear zone with a diameter of 15 mm or more against periodontal pathogens. SGE (2.50 mg/mL) inhibited GTFs and biofilm by 89.07% and 85.40%, respectively. SGE treatment (100 µg/mL) also significantly decreased the secretion of inflammatory mediators in sensitized PDLF, including cytokines and matrix metalloproteinase (MMP)-3, -8, -9, and -13. Overall, we confirmed that SGE had excellent antioxidant, antimicrobial, and anti-inflammatory effects against periodontal pathogens. These results suggest that it has the potential to develop as a prophylactic agent for periodontitis. <i<Siegesbeckia glabrescens</i< periodontitis <i<Porphyromonas gingivalis</i< antioxidants biofilms Therapeutics. Pharmacology Duna Yu verfasserin aut Sarang Oh verfasserin aut Myeongju Kim verfasserin aut Jeyong Jung verfasserin aut Minzhe Fang verfasserin aut Shengdao Zheng verfasserin aut Tae-Hoo Yi verfasserin aut In Antioxidants MDPI AG, 2013 12(2023), 2, p 471 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:12 year:2023 number:2, p 471 https://doi.org/10.3390/antiox12020471 kostenfrei https://doaj.org/article/cf106dacbe13428894a6e6ca094090b3 kostenfrei https://www.mdpi.com/2076-3921/12/2/471 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 2, p 471
spelling	10.3390/antiox12020471 doi (DE-627)DOAJ08102424X (DE-599)DOAJcf106dacbe13428894a6e6ca094090b3 DE-627 ger DE-627 rakwb eng RM1-950 Arce Defeo Bellere verfasserin aut Antiperiodontitis Effects of <i<Siegesbeckia glabrescens</i< In Vitro 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Siegesbeckia glabrescens</i< is generally grown in fields or roadsides in Korea and used for the treatment of inflammatory diseases. The effects of <i<S. glabrescens</i< on periodontitis are unknown. In this study, we determined the effects of an <i<S. glabrescens</i< 30% EtOH extract (SGE) on periodontitis and analyzed the antioxidant activity (DPPH, ABTS, and SOD), antimicrobial (disc diffusion, MIC, and MBC), inhibition of GTFs, biofilm formation, and the anti-inflammation of lipopolysaccharide from <i<P. gingivalis</i< (LPS-PG)-induced primary equine periodontal ligament fibroblasts (PDLFs). We report that SGE increased DPPH, ABTS, and SOD antioxidant activities in a dose-dependent manner. SGE caused a clear zone with a diameter of 15 mm or more against periodontal pathogens. SGE (2.50 mg/mL) inhibited GTFs and biofilm by 89.07% and 85.40%, respectively. SGE treatment (100 µg/mL) also significantly decreased the secretion of inflammatory mediators in sensitized PDLF, including cytokines and matrix metalloproteinase (MMP)-3, -8, -9, and -13. Overall, we confirmed that SGE had excellent antioxidant, antimicrobial, and anti-inflammatory effects against periodontal pathogens. These results suggest that it has the potential to develop as a prophylactic agent for periodontitis. <i<Siegesbeckia glabrescens</i< periodontitis <i<Porphyromonas gingivalis</i< antioxidants biofilms Therapeutics. Pharmacology Duna Yu verfasserin aut Sarang Oh verfasserin aut Myeongju Kim verfasserin aut Jeyong Jung verfasserin aut Minzhe Fang verfasserin aut Shengdao Zheng verfasserin aut Tae-Hoo Yi verfasserin aut In Antioxidants MDPI AG, 2013 12(2023), 2, p 471 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:12 year:2023 number:2, p 471 https://doi.org/10.3390/antiox12020471 kostenfrei https://doaj.org/article/cf106dacbe13428894a6e6ca094090b3 kostenfrei https://www.mdpi.com/2076-3921/12/2/471 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 2, p 471
allfields_unstemmed	10.3390/antiox12020471 doi (DE-627)DOAJ08102424X (DE-599)DOAJcf106dacbe13428894a6e6ca094090b3 DE-627 ger DE-627 rakwb eng RM1-950 Arce Defeo Bellere verfasserin aut Antiperiodontitis Effects of <i<Siegesbeckia glabrescens</i< In Vitro 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Siegesbeckia glabrescens</i< is generally grown in fields or roadsides in Korea and used for the treatment of inflammatory diseases. The effects of <i<S. glabrescens</i< on periodontitis are unknown. In this study, we determined the effects of an <i<S. glabrescens</i< 30% EtOH extract (SGE) on periodontitis and analyzed the antioxidant activity (DPPH, ABTS, and SOD), antimicrobial (disc diffusion, MIC, and MBC), inhibition of GTFs, biofilm formation, and the anti-inflammation of lipopolysaccharide from <i<P. gingivalis</i< (LPS-PG)-induced primary equine periodontal ligament fibroblasts (PDLFs). We report that SGE increased DPPH, ABTS, and SOD antioxidant activities in a dose-dependent manner. SGE caused a clear zone with a diameter of 15 mm or more against periodontal pathogens. SGE (2.50 mg/mL) inhibited GTFs and biofilm by 89.07% and 85.40%, respectively. SGE treatment (100 µg/mL) also significantly decreased the secretion of inflammatory mediators in sensitized PDLF, including cytokines and matrix metalloproteinase (MMP)-3, -8, -9, and -13. Overall, we confirmed that SGE had excellent antioxidant, antimicrobial, and anti-inflammatory effects against periodontal pathogens. These results suggest that it has the potential to develop as a prophylactic agent for periodontitis. <i<Siegesbeckia glabrescens</i< periodontitis <i<Porphyromonas gingivalis</i< antioxidants biofilms Therapeutics. Pharmacology Duna Yu verfasserin aut Sarang Oh verfasserin aut Myeongju Kim verfasserin aut Jeyong Jung verfasserin aut Minzhe Fang verfasserin aut Shengdao Zheng verfasserin aut Tae-Hoo Yi verfasserin aut In Antioxidants MDPI AG, 2013 12(2023), 2, p 471 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:12 year:2023 number:2, p 471 https://doi.org/10.3390/antiox12020471 kostenfrei https://doaj.org/article/cf106dacbe13428894a6e6ca094090b3 kostenfrei https://www.mdpi.com/2076-3921/12/2/471 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 2, p 471
allfieldsGer	10.3390/antiox12020471 doi (DE-627)DOAJ08102424X (DE-599)DOAJcf106dacbe13428894a6e6ca094090b3 DE-627 ger DE-627 rakwb eng RM1-950 Arce Defeo Bellere verfasserin aut Antiperiodontitis Effects of <i<Siegesbeckia glabrescens</i< In Vitro 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Siegesbeckia glabrescens</i< is generally grown in fields or roadsides in Korea and used for the treatment of inflammatory diseases. The effects of <i<S. glabrescens</i< on periodontitis are unknown. In this study, we determined the effects of an <i<S. glabrescens</i< 30% EtOH extract (SGE) on periodontitis and analyzed the antioxidant activity (DPPH, ABTS, and SOD), antimicrobial (disc diffusion, MIC, and MBC), inhibition of GTFs, biofilm formation, and the anti-inflammation of lipopolysaccharide from <i<P. gingivalis</i< (LPS-PG)-induced primary equine periodontal ligament fibroblasts (PDLFs). We report that SGE increased DPPH, ABTS, and SOD antioxidant activities in a dose-dependent manner. SGE caused a clear zone with a diameter of 15 mm or more against periodontal pathogens. SGE (2.50 mg/mL) inhibited GTFs and biofilm by 89.07% and 85.40%, respectively. SGE treatment (100 µg/mL) also significantly decreased the secretion of inflammatory mediators in sensitized PDLF, including cytokines and matrix metalloproteinase (MMP)-3, -8, -9, and -13. Overall, we confirmed that SGE had excellent antioxidant, antimicrobial, and anti-inflammatory effects against periodontal pathogens. These results suggest that it has the potential to develop as a prophylactic agent for periodontitis. <i<Siegesbeckia glabrescens</i< periodontitis <i<Porphyromonas gingivalis</i< antioxidants biofilms Therapeutics. Pharmacology Duna Yu verfasserin aut Sarang Oh verfasserin aut Myeongju Kim verfasserin aut Jeyong Jung verfasserin aut Minzhe Fang verfasserin aut Shengdao Zheng verfasserin aut Tae-Hoo Yi verfasserin aut In Antioxidants MDPI AG, 2013 12(2023), 2, p 471 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:12 year:2023 number:2, p 471 https://doi.org/10.3390/antiox12020471 kostenfrei https://doaj.org/article/cf106dacbe13428894a6e6ca094090b3 kostenfrei https://www.mdpi.com/2076-3921/12/2/471 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 2, p 471
allfieldsSound	10.3390/antiox12020471 doi (DE-627)DOAJ08102424X (DE-599)DOAJcf106dacbe13428894a6e6ca094090b3 DE-627 ger DE-627 rakwb eng RM1-950 Arce Defeo Bellere verfasserin aut Antiperiodontitis Effects of <i<Siegesbeckia glabrescens</i< In Vitro 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Siegesbeckia glabrescens</i< is generally grown in fields or roadsides in Korea and used for the treatment of inflammatory diseases. The effects of <i<S. glabrescens</i< on periodontitis are unknown. In this study, we determined the effects of an <i<S. glabrescens</i< 30% EtOH extract (SGE) on periodontitis and analyzed the antioxidant activity (DPPH, ABTS, and SOD), antimicrobial (disc diffusion, MIC, and MBC), inhibition of GTFs, biofilm formation, and the anti-inflammation of lipopolysaccharide from <i<P. gingivalis</i< (LPS-PG)-induced primary equine periodontal ligament fibroblasts (PDLFs). We report that SGE increased DPPH, ABTS, and SOD antioxidant activities in a dose-dependent manner. SGE caused a clear zone with a diameter of 15 mm or more against periodontal pathogens. SGE (2.50 mg/mL) inhibited GTFs and biofilm by 89.07% and 85.40%, respectively. SGE treatment (100 µg/mL) also significantly decreased the secretion of inflammatory mediators in sensitized PDLF, including cytokines and matrix metalloproteinase (MMP)-3, -8, -9, and -13. Overall, we confirmed that SGE had excellent antioxidant, antimicrobial, and anti-inflammatory effects against periodontal pathogens. These results suggest that it has the potential to develop as a prophylactic agent for periodontitis. <i<Siegesbeckia glabrescens</i< periodontitis <i<Porphyromonas gingivalis</i< antioxidants biofilms Therapeutics. Pharmacology Duna Yu verfasserin aut Sarang Oh verfasserin aut Myeongju Kim verfasserin aut Jeyong Jung verfasserin aut Minzhe Fang verfasserin aut Shengdao Zheng verfasserin aut Tae-Hoo Yi verfasserin aut In Antioxidants MDPI AG, 2013 12(2023), 2, p 471 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:12 year:2023 number:2, p 471 https://doi.org/10.3390/antiox12020471 kostenfrei https://doaj.org/article/cf106dacbe13428894a6e6ca094090b3 kostenfrei https://www.mdpi.com/2076-3921/12/2/471 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 2, p 471
language	English
source	In Antioxidants 12(2023), 2, p 471 volume:12 year:2023 number:2, p 471
sourceStr	In Antioxidants 12(2023), 2, p 471 volume:12 year:2023 number:2, p 471
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	<i<Siegesbeckia glabrescens</i< periodontitis <i<Porphyromonas gingivalis</i< antioxidants biofilms Therapeutics. Pharmacology
isfreeaccess_bool	true
container_title	Antioxidants
authorswithroles_txt_mv	Arce Defeo Bellere @@aut@@ Duna Yu @@aut@@ Sarang Oh @@aut@@ Myeongju Kim @@aut@@ Jeyong Jung @@aut@@ Minzhe Fang @@aut@@ Shengdao Zheng @@aut@@ Tae-Hoo Yi @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	737287578
id	DOAJ08102424X
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ08102424X</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240413064611.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230310s2023 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3390/antiox12020471</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ08102424X</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJcf106dacbe13428894a6e6ca094090b3</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RM1-950</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Arce Defeo Bellere</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Antiperiodontitis Effects of <i<Siegesbeckia glabrescens</i< In Vitro</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2023</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a"><i<Siegesbeckia glabrescens</i< is generally grown in fields or roadsides in Korea and used for the treatment of inflammatory diseases. The effects of <i<S. glabrescens</i< on periodontitis are unknown. In this study, we determined the effects of an <i<S. glabrescens</i< 30% EtOH extract (SGE) on periodontitis and analyzed the antioxidant activity (DPPH, ABTS, and SOD), antimicrobial (disc diffusion, MIC, and MBC), inhibition of GTFs, biofilm formation, and the anti-inflammation of lipopolysaccharide from <i<P. gingivalis</i< (LPS-PG)-induced primary equine periodontal ligament fibroblasts (PDLFs). We report that SGE increased DPPH, ABTS, and SOD antioxidant activities in a dose-dependent manner. SGE caused a clear zone with a diameter of 15 mm or more against periodontal pathogens. SGE (2.50 mg/mL) inhibited GTFs and biofilm by 89.07% and 85.40%, respectively. SGE treatment (100 µg/mL) also significantly decreased the secretion of inflammatory mediators in sensitized PDLF, including cytokines and matrix metalloproteinase (MMP)-3, -8, -9, and -13. Overall, we confirmed that SGE had excellent antioxidant, antimicrobial, and anti-inflammatory effects against periodontal pathogens. These results suggest that it has the potential to develop as a prophylactic agent for periodontitis.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a"><i<Siegesbeckia glabrescens</i<</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">periodontitis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a"><i<Porphyromonas gingivalis</i<</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">antioxidants</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">biofilms</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Therapeutics. Pharmacology</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Duna Yu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sarang Oh</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Myeongju Kim</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jeyong Jung</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Minzhe Fang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shengdao Zheng</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tae-Hoo Yi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Antioxidants</subfield><subfield code="d">MDPI AG, 2013</subfield><subfield code="g">12(2023), 2, p 471</subfield><subfield code="w">(DE-627)737287578</subfield><subfield code="w">(DE-600)2704216-9</subfield><subfield code="x">20763921</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:12</subfield><subfield code="g">year:2023</subfield><subfield code="g">number:2, p 471</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.3390/antiox12020471</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/cf106dacbe13428894a6e6ca094090b3</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://www.mdpi.com/2076-3921/12/2/471</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2076-3921</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">12</subfield><subfield code="j">2023</subfield><subfield code="e">2, p 471</subfield></datafield></record></collection>
callnumber-first	R - Medicine
author	Arce Defeo Bellere
spellingShingle	Arce Defeo Bellere misc RM1-950 misc <i<Siegesbeckia glabrescens</i< misc periodontitis misc <i<Porphyromonas gingivalis</i< misc antioxidants misc biofilms misc Therapeutics. Pharmacology Antiperiodontitis Effects of <i<Siegesbeckia glabrescens</i< In Vitro
authorStr	Arce Defeo Bellere
ppnlink_with_tag_str_mv	@@773@@(DE-627)737287578
format	electronic Article
delete_txt_mv	keep
author_role	aut aut aut aut aut aut aut aut
collection	DOAJ
remote_str	true
callnumber-label	RM1-950
illustrated	Not Illustrated
issn	20763921
topic_title	RM1-950 Antiperiodontitis Effects of <i<Siegesbeckia glabrescens</i< In Vitro <i<Siegesbeckia glabrescens</i< periodontitis <i<Porphyromonas gingivalis</i< antioxidants biofilms
topic	misc RM1-950 misc <i<Siegesbeckia glabrescens</i< misc periodontitis misc <i<Porphyromonas gingivalis</i< misc antioxidants misc biofilms misc Therapeutics. Pharmacology
topic_unstemmed	misc RM1-950 misc <i<Siegesbeckia glabrescens</i< misc periodontitis misc <i<Porphyromonas gingivalis</i< misc antioxidants misc biofilms misc Therapeutics. Pharmacology
topic_browse	misc RM1-950 misc <i<Siegesbeckia glabrescens</i< misc periodontitis misc <i<Porphyromonas gingivalis</i< misc antioxidants misc biofilms misc Therapeutics. Pharmacology
format_facet	Elektronische Aufsätze Aufsätze Elektronische Ressource
format_main_str_mv	Text Zeitschrift/Artikel
carriertype_str_mv	cr
hierarchy_parent_title	Antioxidants
hierarchy_parent_id	737287578
hierarchy_top_title	Antioxidants
isfreeaccess_txt	true
familylinks_str_mv	(DE-627)737287578 (DE-600)2704216-9
title	Antiperiodontitis Effects of <i<Siegesbeckia glabrescens</i< In Vitro
ctrlnum	(DE-627)DOAJ08102424X (DE-599)DOAJcf106dacbe13428894a6e6ca094090b3
title_full	Antiperiodontitis Effects of <i<Siegesbeckia glabrescens</i< In Vitro
author_sort	Arce Defeo Bellere
journal	Antioxidants
journalStr	Antioxidants
callnumber-first-code	R
lang_code	eng
isOA_bool	true
recordtype	marc
publishDateSort	2023
contenttype_str_mv	txt
author_browse	Arce Defeo Bellere Duna Yu Sarang Oh Myeongju Kim Jeyong Jung Minzhe Fang Shengdao Zheng Tae-Hoo Yi
container_volume	12
class	RM1-950
format_se	Elektronische Aufsätze
author-letter	Arce Defeo Bellere
doi_str_mv	10.3390/antiox12020471
author2-role	verfasserin
title_sort	antiperiodontitis effects of <i<siegesbeckia glabrescens</i< in vitro
callnumber	RM1-950
title_auth	Antiperiodontitis Effects of <i<Siegesbeckia glabrescens</i< In Vitro
abstract	<i<Siegesbeckia glabrescens</i< is generally grown in fields or roadsides in Korea and used for the treatment of inflammatory diseases. The effects of <i<S. glabrescens</i< on periodontitis are unknown. In this study, we determined the effects of an <i<S. glabrescens</i< 30% EtOH extract (SGE) on periodontitis and analyzed the antioxidant activity (DPPH, ABTS, and SOD), antimicrobial (disc diffusion, MIC, and MBC), inhibition of GTFs, biofilm formation, and the anti-inflammation of lipopolysaccharide from <i<P. gingivalis</i< (LPS-PG)-induced primary equine periodontal ligament fibroblasts (PDLFs). We report that SGE increased DPPH, ABTS, and SOD antioxidant activities in a dose-dependent manner. SGE caused a clear zone with a diameter of 15 mm or more against periodontal pathogens. SGE (2.50 mg/mL) inhibited GTFs and biofilm by 89.07% and 85.40%, respectively. SGE treatment (100 µg/mL) also significantly decreased the secretion of inflammatory mediators in sensitized PDLF, including cytokines and matrix metalloproteinase (MMP)-3, -8, -9, and -13. Overall, we confirmed that SGE had excellent antioxidant, antimicrobial, and anti-inflammatory effects against periodontal pathogens. These results suggest that it has the potential to develop as a prophylactic agent for periodontitis.
abstractGer	<i<Siegesbeckia glabrescens</i< is generally grown in fields or roadsides in Korea and used for the treatment of inflammatory diseases. The effects of <i<S. glabrescens</i< on periodontitis are unknown. In this study, we determined the effects of an <i<S. glabrescens</i< 30% EtOH extract (SGE) on periodontitis and analyzed the antioxidant activity (DPPH, ABTS, and SOD), antimicrobial (disc diffusion, MIC, and MBC), inhibition of GTFs, biofilm formation, and the anti-inflammation of lipopolysaccharide from <i<P. gingivalis</i< (LPS-PG)-induced primary equine periodontal ligament fibroblasts (PDLFs). We report that SGE increased DPPH, ABTS, and SOD antioxidant activities in a dose-dependent manner. SGE caused a clear zone with a diameter of 15 mm or more against periodontal pathogens. SGE (2.50 mg/mL) inhibited GTFs and biofilm by 89.07% and 85.40%, respectively. SGE treatment (100 µg/mL) also significantly decreased the secretion of inflammatory mediators in sensitized PDLF, including cytokines and matrix metalloproteinase (MMP)-3, -8, -9, and -13. Overall, we confirmed that SGE had excellent antioxidant, antimicrobial, and anti-inflammatory effects against periodontal pathogens. These results suggest that it has the potential to develop as a prophylactic agent for periodontitis.
abstract_unstemmed	<i<Siegesbeckia glabrescens</i< is generally grown in fields or roadsides in Korea and used for the treatment of inflammatory diseases. The effects of <i<S. glabrescens</i< on periodontitis are unknown. In this study, we determined the effects of an <i<S. glabrescens</i< 30% EtOH extract (SGE) on periodontitis and analyzed the antioxidant activity (DPPH, ABTS, and SOD), antimicrobial (disc diffusion, MIC, and MBC), inhibition of GTFs, biofilm formation, and the anti-inflammation of lipopolysaccharide from <i<P. gingivalis</i< (LPS-PG)-induced primary equine periodontal ligament fibroblasts (PDLFs). We report that SGE increased DPPH, ABTS, and SOD antioxidant activities in a dose-dependent manner. SGE caused a clear zone with a diameter of 15 mm or more against periodontal pathogens. SGE (2.50 mg/mL) inhibited GTFs and biofilm by 89.07% and 85.40%, respectively. SGE treatment (100 µg/mL) also significantly decreased the secretion of inflammatory mediators in sensitized PDLF, including cytokines and matrix metalloproteinase (MMP)-3, -8, -9, and -13. Overall, we confirmed that SGE had excellent antioxidant, antimicrobial, and anti-inflammatory effects against periodontal pathogens. These results suggest that it has the potential to develop as a prophylactic agent for periodontitis.
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
container_issue	2, p 471
title_short	Antiperiodontitis Effects of <i<Siegesbeckia glabrescens</i< In Vitro
url	https://doi.org/10.3390/antiox12020471 https://doaj.org/article/cf106dacbe13428894a6e6ca094090b3 https://www.mdpi.com/2076-3921/12/2/471 https://doaj.org/toc/2076-3921
remote_bool	true
author2	Duna Yu Sarang Oh Myeongju Kim Jeyong Jung Minzhe Fang Shengdao Zheng Tae-Hoo Yi
author2Str	Duna Yu Sarang Oh Myeongju Kim Jeyong Jung Minzhe Fang Shengdao Zheng Tae-Hoo Yi
ppnlink	737287578
callnumber-subject	RM - Therapeutics and Pharmacology
mediatype_str_mv	c
isOA_txt	true
hochschulschrift_bool	false
doi_str	10.3390/antiox12020471
callnumber-a	RM1-950
up_date	2024-07-03T17:52:48.506Z
_version_	1803581305411076097
fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ08102424X</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240413064611.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230310s2023 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3390/antiox12020471</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ08102424X</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJcf106dacbe13428894a6e6ca094090b3</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RM1-950</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Arce Defeo Bellere</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Antiperiodontitis Effects of <i<Siegesbeckia glabrescens</i< In Vitro</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2023</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a"><i<Siegesbeckia glabrescens</i< is generally grown in fields or roadsides in Korea and used for the treatment of inflammatory diseases. The effects of <i<S. glabrescens</i< on periodontitis are unknown. In this study, we determined the effects of an <i<S. glabrescens</i< 30% EtOH extract (SGE) on periodontitis and analyzed the antioxidant activity (DPPH, ABTS, and SOD), antimicrobial (disc diffusion, MIC, and MBC), inhibition of GTFs, biofilm formation, and the anti-inflammation of lipopolysaccharide from <i<P. gingivalis</i< (LPS-PG)-induced primary equine periodontal ligament fibroblasts (PDLFs). We report that SGE increased DPPH, ABTS, and SOD antioxidant activities in a dose-dependent manner. SGE caused a clear zone with a diameter of 15 mm or more against periodontal pathogens. SGE (2.50 mg/mL) inhibited GTFs and biofilm by 89.07% and 85.40%, respectively. SGE treatment (100 µg/mL) also significantly decreased the secretion of inflammatory mediators in sensitized PDLF, including cytokines and matrix metalloproteinase (MMP)-3, -8, -9, and -13. Overall, we confirmed that SGE had excellent antioxidant, antimicrobial, and anti-inflammatory effects against periodontal pathogens. These results suggest that it has the potential to develop as a prophylactic agent for periodontitis.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a"><i<Siegesbeckia glabrescens</i<</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">periodontitis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a"><i<Porphyromonas gingivalis</i<</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">antioxidants</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">biofilms</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Therapeutics. Pharmacology</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Duna Yu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sarang Oh</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Myeongju Kim</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jeyong Jung</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Minzhe Fang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shengdao Zheng</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tae-Hoo Yi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Antioxidants</subfield><subfield code="d">MDPI AG, 2013</subfield><subfield code="g">12(2023), 2, p 471</subfield><subfield code="w">(DE-627)737287578</subfield><subfield code="w">(DE-600)2704216-9</subfield><subfield code="x">20763921</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:12</subfield><subfield code="g">year:2023</subfield><subfield code="g">number:2, p 471</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.3390/antiox12020471</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/cf106dacbe13428894a6e6ca094090b3</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://www.mdpi.com/2076-3921/12/2/471</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2076-3921</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">12</subfield><subfield code="j">2023</subfield><subfield code="e">2, p 471</subfield></datafield></record></collection>
score	7.4008284

Nicht das Richtige dabei?

Schreiben Sie uns!

Antiperiodontitis Effects of <i<Siegesbeckia glabrescens</i< In Vitro

Nicht das Richtige dabei?

Zugang & Verfügbarkeit

Vorhandene Bände

Nicht das Richtige dabei?