Pharmacological screening of silibinin for antischizophrenic activity along with its acute toxicity evaluation in experimental animals

Silibinin (SIL), a flavolignan extracted from the medicinal plant “silybum marianum (milk thistle)”, has traditionally been used to treat liver disease. This phytochemical has displayed neuroprotective properties, its activity against schizophrenia is not elucidated. The present study was designed t...
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Gespeichert in:

Autor*in:	Qurat Ul Ain [verfasserIn] Uzma Saleem [verfasserIn] Bashir Ahmad [verfasserIn] Iqra Khalid [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	silibinin acute oral toxicity schizophrenia ketamine oxidative stress

Übergeordnetes Werk:	In: Frontiers in Pharmacology - Frontiers Media S.A., 2010, 14(2023)
Übergeordnetes Werk:	volume:14 ; year:2023

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fphar.2023.1111915

Katalog-ID:	DOAJ081132387

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520			\|a Silibinin (SIL), a flavolignan extracted from the medicinal plant “silybum marianum (milk thistle)”, has traditionally been used to treat liver disease. This phytochemical has displayed neuroprotective properties, its activity against schizophrenia is not elucidated. The present study was designed to evaluate the antipsychotic potential of silibinin and probe its toxic potential. The acute oral toxicity study was assessed as per OECD 425 guidelines. Animals were divided into two groups of female rats (n = 6): one group served as the normal control and the other group received a 2,000 mg/kg dose of SIL. We also evaluated the antipsychotic potential of SIL. To this end, animals were divided into six groups (n = 10) of mice for both the preventive and curative protocols. Group I (CMC 1 mL/kg) served as the normal control and received CMC 1 mL/kg; group II was the diseased group treated with ketamine (10 mg/kg) i.p; group III was the standard group treated with clozapine 1 mg/kg; groups IV, V, and VI served as the treatment groups, receiving SIL 50, 100, and 200 mg/kg, respectively, orally for both protocols. Improvement in positive symptoms of the disease was evaluated by stereotypy and hyperlocomotion, while negative symptoms (behavioral despair) were determined by a forced swim test and a tail suspension test in the mice models. The results suggested that the LD50 of SIL was greater than 2,000 mg/kg. Moreover, SIL prevented and reversed ketamine-induced increase in stereotypy (p < 0.001) and behavioral despair in the forced swim and tail suspension tests (p < 0.001). Taken together, the findings suggest that silibinin is a safe drug with low toxicity which demonstrates significant antipsychotic activity against the positive and negative symptoms of schizophrenia.
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allfieldsSound	10.3389/fphar.2023.1111915 doi (DE-627)DOAJ081132387 (DE-599)DOAJ121cdfd3652940b4a99988462eb7b1ed DE-627 ger DE-627 rakwb eng RM1-950 Qurat Ul Ain verfasserin aut Pharmacological screening of silibinin for antischizophrenic activity along with its acute toxicity evaluation in experimental animals 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Silibinin (SIL), a flavolignan extracted from the medicinal plant “silybum marianum (milk thistle)”, has traditionally been used to treat liver disease. This phytochemical has displayed neuroprotective properties, its activity against schizophrenia is not elucidated. The present study was designed to evaluate the antipsychotic potential of silibinin and probe its toxic potential. The acute oral toxicity study was assessed as per OECD 425 guidelines. Animals were divided into two groups of female rats (n = 6): one group served as the normal control and the other group received a 2,000 mg/kg dose of SIL. We also evaluated the antipsychotic potential of SIL. To this end, animals were divided into six groups (n = 10) of mice for both the preventive and curative protocols. Group I (CMC 1 mL/kg) served as the normal control and received CMC 1 mL/kg; group II was the diseased group treated with ketamine (10 mg/kg) i.p; group III was the standard group treated with clozapine 1 mg/kg; groups IV, V, and VI served as the treatment groups, receiving SIL 50, 100, and 200 mg/kg, respectively, orally for both protocols. Improvement in positive symptoms of the disease was evaluated by stereotypy and hyperlocomotion, while negative symptoms (behavioral despair) were determined by a forced swim test and a tail suspension test in the mice models. The results suggested that the LD50 of SIL was greater than 2,000 mg/kg. Moreover, SIL prevented and reversed ketamine-induced increase in stereotypy (p < 0.001) and behavioral despair in the forced swim and tail suspension tests (p < 0.001). Taken together, the findings suggest that silibinin is a safe drug with low toxicity which demonstrates significant antipsychotic activity against the positive and negative symptoms of schizophrenia. silibinin acute oral toxicity schizophrenia ketamine oxidative stress Therapeutics. Pharmacology Uzma Saleem verfasserin aut Bashir Ahmad verfasserin aut Iqra Khalid verfasserin aut In Frontiers in Pharmacology Frontiers Media S.A., 2010 14(2023) (DE-627)642889392 (DE-600)2587355-6 16639812 nnns volume:14 year:2023 https://doi.org/10.3389/fphar.2023.1111915 kostenfrei https://doaj.org/article/121cdfd3652940b4a99988462eb7b1ed kostenfrei https://www.frontiersin.org/articles/10.3389/fphar.2023.1111915/full kostenfrei https://doaj.org/toc/1663-9812 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023
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callnumber-first	R - Medicine
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spellingShingle	Qurat Ul Ain misc RM1-950 misc silibinin misc acute oral toxicity misc schizophrenia misc ketamine misc oxidative stress misc Therapeutics. Pharmacology Pharmacological screening of silibinin for antischizophrenic activity along with its acute toxicity evaluation in experimental animals
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topic_title	RM1-950 Pharmacological screening of silibinin for antischizophrenic activity along with its acute toxicity evaluation in experimental animals silibinin acute oral toxicity schizophrenia ketamine oxidative stress
topic	misc RM1-950 misc silibinin misc acute oral toxicity misc schizophrenia misc ketamine misc oxidative stress misc Therapeutics. Pharmacology
topic_unstemmed	misc RM1-950 misc silibinin misc acute oral toxicity misc schizophrenia misc ketamine misc oxidative stress misc Therapeutics. Pharmacology
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title	Pharmacological screening of silibinin for antischizophrenic activity along with its acute toxicity evaluation in experimental animals
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title_full	Pharmacological screening of silibinin for antischizophrenic activity along with its acute toxicity evaluation in experimental animals
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title_sort	pharmacological screening of silibinin for antischizophrenic activity along with its acute toxicity evaluation in experimental animals
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title_auth	Pharmacological screening of silibinin for antischizophrenic activity along with its acute toxicity evaluation in experimental animals
abstract	Silibinin (SIL), a flavolignan extracted from the medicinal plant “silybum marianum (milk thistle)”, has traditionally been used to treat liver disease. This phytochemical has displayed neuroprotective properties, its activity against schizophrenia is not elucidated. The present study was designed to evaluate the antipsychotic potential of silibinin and probe its toxic potential. The acute oral toxicity study was assessed as per OECD 425 guidelines. Animals were divided into two groups of female rats (n = 6): one group served as the normal control and the other group received a 2,000 mg/kg dose of SIL. We also evaluated the antipsychotic potential of SIL. To this end, animals were divided into six groups (n = 10) of mice for both the preventive and curative protocols. Group I (CMC 1 mL/kg) served as the normal control and received CMC 1 mL/kg; group II was the diseased group treated with ketamine (10 mg/kg) i.p; group III was the standard group treated with clozapine 1 mg/kg; groups IV, V, and VI served as the treatment groups, receiving SIL 50, 100, and 200 mg/kg, respectively, orally for both protocols. Improvement in positive symptoms of the disease was evaluated by stereotypy and hyperlocomotion, while negative symptoms (behavioral despair) were determined by a forced swim test and a tail suspension test in the mice models. The results suggested that the LD50 of SIL was greater than 2,000 mg/kg. Moreover, SIL prevented and reversed ketamine-induced increase in stereotypy (p < 0.001) and behavioral despair in the forced swim and tail suspension tests (p < 0.001). Taken together, the findings suggest that silibinin is a safe drug with low toxicity which demonstrates significant antipsychotic activity against the positive and negative symptoms of schizophrenia.
abstractGer	Silibinin (SIL), a flavolignan extracted from the medicinal plant “silybum marianum (milk thistle)”, has traditionally been used to treat liver disease. This phytochemical has displayed neuroprotective properties, its activity against schizophrenia is not elucidated. The present study was designed to evaluate the antipsychotic potential of silibinin and probe its toxic potential. The acute oral toxicity study was assessed as per OECD 425 guidelines. Animals were divided into two groups of female rats (n = 6): one group served as the normal control and the other group received a 2,000 mg/kg dose of SIL. We also evaluated the antipsychotic potential of SIL. To this end, animals were divided into six groups (n = 10) of mice for both the preventive and curative protocols. Group I (CMC 1 mL/kg) served as the normal control and received CMC 1 mL/kg; group II was the diseased group treated with ketamine (10 mg/kg) i.p; group III was the standard group treated with clozapine 1 mg/kg; groups IV, V, and VI served as the treatment groups, receiving SIL 50, 100, and 200 mg/kg, respectively, orally for both protocols. Improvement in positive symptoms of the disease was evaluated by stereotypy and hyperlocomotion, while negative symptoms (behavioral despair) were determined by a forced swim test and a tail suspension test in the mice models. The results suggested that the LD50 of SIL was greater than 2,000 mg/kg. Moreover, SIL prevented and reversed ketamine-induced increase in stereotypy (p < 0.001) and behavioral despair in the forced swim and tail suspension tests (p < 0.001). Taken together, the findings suggest that silibinin is a safe drug with low toxicity which demonstrates significant antipsychotic activity against the positive and negative symptoms of schizophrenia.
abstract_unstemmed	Silibinin (SIL), a flavolignan extracted from the medicinal plant “silybum marianum (milk thistle)”, has traditionally been used to treat liver disease. This phytochemical has displayed neuroprotective properties, its activity against schizophrenia is not elucidated. The present study was designed to evaluate the antipsychotic potential of silibinin and probe its toxic potential. The acute oral toxicity study was assessed as per OECD 425 guidelines. Animals were divided into two groups of female rats (n = 6): one group served as the normal control and the other group received a 2,000 mg/kg dose of SIL. We also evaluated the antipsychotic potential of SIL. To this end, animals were divided into six groups (n = 10) of mice for both the preventive and curative protocols. Group I (CMC 1 mL/kg) served as the normal control and received CMC 1 mL/kg; group II was the diseased group treated with ketamine (10 mg/kg) i.p; group III was the standard group treated with clozapine 1 mg/kg; groups IV, V, and VI served as the treatment groups, receiving SIL 50, 100, and 200 mg/kg, respectively, orally for both protocols. Improvement in positive symptoms of the disease was evaluated by stereotypy and hyperlocomotion, while negative symptoms (behavioral despair) were determined by a forced swim test and a tail suspension test in the mice models. The results suggested that the LD50 of SIL was greater than 2,000 mg/kg. Moreover, SIL prevented and reversed ketamine-induced increase in stereotypy (p < 0.001) and behavioral despair in the forced swim and tail suspension tests (p < 0.001). Taken together, the findings suggest that silibinin is a safe drug with low toxicity which demonstrates significant antipsychotic activity against the positive and negative symptoms of schizophrenia.
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title_short	Pharmacological screening of silibinin for antischizophrenic activity along with its acute toxicity evaluation in experimental animals
url	https://doi.org/10.3389/fphar.2023.1111915 https://doaj.org/article/121cdfd3652940b4a99988462eb7b1ed https://www.frontiersin.org/articles/10.3389/fphar.2023.1111915/full https://doaj.org/toc/1663-9812
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Pharmacological screening of silibinin for antischizophrenic activity along with its acute toxicity evaluation in experimental animals

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