Autism Spectrum Disorder from the Womb to Adulthood: Suggestions for a Paradigm Shift

The wide spectrum of unique needs and strengths of Autism Spectrum Disorders (ASD) is a challenge for the worldwide healthcare system. With the plethora of information from research, a common thread is required to conceptualize an exhaustive pathogenetic paradigm. The epidemiological and clinical fi...
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Autor*in:	Cristina Panisi [verfasserIn] Franca Rosa Guerini [verfasserIn] Provvidenza Maria Abruzzo [verfasserIn] Federico Balzola [verfasserIn] Pier Mario Biava [verfasserIn] Alessandra Bolotta [verfasserIn] Marco Brunero [verfasserIn] Ernesto Burgio [verfasserIn] Alberto Chiara [verfasserIn] Mario Clerici [verfasserIn] Luigi Croce [verfasserIn] Carla Ferreri [verfasserIn] Niccolò Giovannini [verfasserIn] Alessandro Ghezzo [verfasserIn] Enzo Grossi [verfasserIn] Roberto Keller [verfasserIn] Andrea Manzotti [verfasserIn] Marina Marini [verfasserIn] Lucia Migliore [verfasserIn] Lucio Moderato [verfasserIn] Davide Moscone [verfasserIn] Michele Mussap [verfasserIn] Antonia Parmeggiani [verfasserIn] Valentina Pasin [verfasserIn] Monica Perotti [verfasserIn] Cristina Piras [verfasserIn] Marina Saresella [verfasserIn] Andrea Stoccoro [verfasserIn] Tiziana Toso [verfasserIn] Rosa Anna Vacca [verfasserIn] David Vagni [verfasserIn] Salvatore Vendemmia [verfasserIn] Laura Villa [verfasserIn] Pierluigi Politi [verfasserIn] Vassilios Fanos [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Autism Spectrum Disorder (ASD) pathogenesis prevention epigenetics immune activation gut dysbiosis

Übergeordnetes Werk:	In: Journal of Personalized Medicine - MDPI AG, 2012, 11(2021), 2, p 70
Übergeordnetes Werk:	volume:11 ; year:2021 ; number:2, p 70

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jpm11020070

Katalog-ID:	DOAJ081180284

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allfields	10.3390/jpm11020070 doi (DE-627)DOAJ081180284 (DE-599)DOAJdf75712aa9414fbfb75d5ee6be7c84b6 DE-627 ger DE-627 rakwb eng Cristina Panisi verfasserin aut Autism Spectrum Disorder from the Womb to Adulthood: Suggestions for a Paradigm Shift 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The wide spectrum of unique needs and strengths of Autism Spectrum Disorders (ASD) is a challenge for the worldwide healthcare system. With the plethora of information from research, a common thread is required to conceptualize an exhaustive pathogenetic paradigm. The epidemiological and clinical findings in ASD cannot be explained by the traditional linear genetic model, hence the need to move towards a more fluid conception, integrating genetics, environment, and epigenetics as a whole. The embryo-fetal period and the first two years of life (the so-called ‘First 1000 Days’) are the crucial time window for neurodevelopment. In particular, the interplay and the vicious loop between immune activation, gut dysbiosis, and mitochondrial impairment/oxidative stress significantly affects neurodevelopment during pregnancy and undermines the health of ASD people throughout life. Consequently, the most effective intervention in ASD is expected by primary prevention aimed at pregnancy and at early control of the main effector molecular pathways. We will reason here on a comprehensive and exhaustive pathogenetic paradigm in ASD, viewed not just as a theoretical issue, but as a tool to provide suggestions for effective preventive strategies and personalized, dynamic (from womb to adulthood), systemic, and interdisciplinary healthcare approach. Autism Spectrum Disorder (ASD) pathogenesis prevention epigenetics immune activation gut dysbiosis Medicine R Franca Rosa Guerini verfasserin aut Provvidenza Maria Abruzzo verfasserin aut Federico Balzola verfasserin aut Pier Mario Biava verfasserin aut Alessandra Bolotta verfasserin aut Marco Brunero verfasserin aut Ernesto Burgio verfasserin aut Alberto Chiara verfasserin aut Mario Clerici verfasserin aut Luigi Croce verfasserin aut Carla Ferreri verfasserin aut Niccolò Giovannini verfasserin aut Alessandro Ghezzo verfasserin aut Enzo Grossi verfasserin aut Roberto Keller verfasserin aut Andrea Manzotti verfasserin aut Marina Marini verfasserin aut Lucia Migliore verfasserin aut Lucio Moderato verfasserin aut Davide Moscone verfasserin aut Michele Mussap verfasserin aut Antonia Parmeggiani verfasserin aut Valentina Pasin verfasserin aut Monica Perotti verfasserin aut Cristina Piras verfasserin aut Marina Saresella verfasserin aut Andrea Stoccoro verfasserin aut Tiziana Toso verfasserin aut Rosa Anna Vacca verfasserin aut David Vagni verfasserin aut Salvatore Vendemmia verfasserin aut Laura Villa verfasserin aut Pierluigi Politi verfasserin aut Vassilios Fanos verfasserin aut In Journal of Personalized Medicine MDPI AG, 2012 11(2021), 2, p 70 (DE-627)71862713X (DE-600)2662248-8 20754426 nnns volume:11 year:2021 number:2, p 70 https://doi.org/10.3390/jpm11020070 kostenfrei https://doaj.org/article/df75712aa9414fbfb75d5ee6be7c84b6 kostenfrei https://www.mdpi.com/2075-4426/11/2/70 kostenfrei https://doaj.org/toc/2075-4426 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 2, p 70
spelling	10.3390/jpm11020070 doi (DE-627)DOAJ081180284 (DE-599)DOAJdf75712aa9414fbfb75d5ee6be7c84b6 DE-627 ger DE-627 rakwb eng Cristina Panisi verfasserin aut Autism Spectrum Disorder from the Womb to Adulthood: Suggestions for a Paradigm Shift 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The wide spectrum of unique needs and strengths of Autism Spectrum Disorders (ASD) is a challenge for the worldwide healthcare system. With the plethora of information from research, a common thread is required to conceptualize an exhaustive pathogenetic paradigm. The epidemiological and clinical findings in ASD cannot be explained by the traditional linear genetic model, hence the need to move towards a more fluid conception, integrating genetics, environment, and epigenetics as a whole. The embryo-fetal period and the first two years of life (the so-called ‘First 1000 Days’) are the crucial time window for neurodevelopment. In particular, the interplay and the vicious loop between immune activation, gut dysbiosis, and mitochondrial impairment/oxidative stress significantly affects neurodevelopment during pregnancy and undermines the health of ASD people throughout life. Consequently, the most effective intervention in ASD is expected by primary prevention aimed at pregnancy and at early control of the main effector molecular pathways. We will reason here on a comprehensive and exhaustive pathogenetic paradigm in ASD, viewed not just as a theoretical issue, but as a tool to provide suggestions for effective preventive strategies and personalized, dynamic (from womb to adulthood), systemic, and interdisciplinary healthcare approach. Autism Spectrum Disorder (ASD) pathogenesis prevention epigenetics immune activation gut dysbiosis Medicine R Franca Rosa Guerini verfasserin aut Provvidenza Maria Abruzzo verfasserin aut Federico Balzola verfasserin aut Pier Mario Biava verfasserin aut Alessandra Bolotta verfasserin aut Marco Brunero verfasserin aut Ernesto Burgio verfasserin aut Alberto Chiara verfasserin aut Mario Clerici verfasserin aut Luigi Croce verfasserin aut Carla Ferreri verfasserin aut Niccolò Giovannini verfasserin aut Alessandro Ghezzo verfasserin aut Enzo Grossi verfasserin aut Roberto Keller verfasserin aut Andrea Manzotti verfasserin aut Marina Marini verfasserin aut Lucia Migliore verfasserin aut Lucio Moderato verfasserin aut Davide Moscone verfasserin aut Michele Mussap verfasserin aut Antonia Parmeggiani verfasserin aut Valentina Pasin verfasserin aut Monica Perotti verfasserin aut Cristina Piras verfasserin aut Marina Saresella verfasserin aut Andrea Stoccoro verfasserin aut Tiziana Toso verfasserin aut Rosa Anna Vacca verfasserin aut David Vagni verfasserin aut Salvatore Vendemmia verfasserin aut Laura Villa verfasserin aut Pierluigi Politi verfasserin aut Vassilios Fanos verfasserin aut In Journal of Personalized Medicine MDPI AG, 2012 11(2021), 2, p 70 (DE-627)71862713X (DE-600)2662248-8 20754426 nnns volume:11 year:2021 number:2, p 70 https://doi.org/10.3390/jpm11020070 kostenfrei https://doaj.org/article/df75712aa9414fbfb75d5ee6be7c84b6 kostenfrei https://www.mdpi.com/2075-4426/11/2/70 kostenfrei https://doaj.org/toc/2075-4426 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 2, p 70
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allfieldsGer	10.3390/jpm11020070 doi (DE-627)DOAJ081180284 (DE-599)DOAJdf75712aa9414fbfb75d5ee6be7c84b6 DE-627 ger DE-627 rakwb eng Cristina Panisi verfasserin aut Autism Spectrum Disorder from the Womb to Adulthood: Suggestions for a Paradigm Shift 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The wide spectrum of unique needs and strengths of Autism Spectrum Disorders (ASD) is a challenge for the worldwide healthcare system. With the plethora of information from research, a common thread is required to conceptualize an exhaustive pathogenetic paradigm. The epidemiological and clinical findings in ASD cannot be explained by the traditional linear genetic model, hence the need to move towards a more fluid conception, integrating genetics, environment, and epigenetics as a whole. The embryo-fetal period and the first two years of life (the so-called ‘First 1000 Days’) are the crucial time window for neurodevelopment. In particular, the interplay and the vicious loop between immune activation, gut dysbiosis, and mitochondrial impairment/oxidative stress significantly affects neurodevelopment during pregnancy and undermines the health of ASD people throughout life. Consequently, the most effective intervention in ASD is expected by primary prevention aimed at pregnancy and at early control of the main effector molecular pathways. We will reason here on a comprehensive and exhaustive pathogenetic paradigm in ASD, viewed not just as a theoretical issue, but as a tool to provide suggestions for effective preventive strategies and personalized, dynamic (from womb to adulthood), systemic, and interdisciplinary healthcare approach. Autism Spectrum Disorder (ASD) pathogenesis prevention epigenetics immune activation gut dysbiosis Medicine R Franca Rosa Guerini verfasserin aut Provvidenza Maria Abruzzo verfasserin aut Federico Balzola verfasserin aut Pier Mario Biava verfasserin aut Alessandra Bolotta verfasserin aut Marco Brunero verfasserin aut Ernesto Burgio verfasserin aut Alberto Chiara verfasserin aut Mario Clerici verfasserin aut Luigi Croce verfasserin aut Carla Ferreri verfasserin aut Niccolò Giovannini verfasserin aut Alessandro Ghezzo verfasserin aut Enzo Grossi verfasserin aut Roberto Keller verfasserin aut Andrea Manzotti verfasserin aut Marina Marini verfasserin aut Lucia Migliore verfasserin aut Lucio Moderato verfasserin aut Davide Moscone verfasserin aut Michele Mussap verfasserin aut Antonia Parmeggiani verfasserin aut Valentina Pasin verfasserin aut Monica Perotti verfasserin aut Cristina Piras verfasserin aut Marina Saresella verfasserin aut Andrea Stoccoro verfasserin aut Tiziana Toso verfasserin aut Rosa Anna Vacca verfasserin aut David Vagni verfasserin aut Salvatore Vendemmia verfasserin aut Laura Villa verfasserin aut Pierluigi Politi verfasserin aut Vassilios Fanos verfasserin aut In Journal of Personalized Medicine MDPI AG, 2012 11(2021), 2, p 70 (DE-627)71862713X (DE-600)2662248-8 20754426 nnns volume:11 year:2021 number:2, p 70 https://doi.org/10.3390/jpm11020070 kostenfrei https://doaj.org/article/df75712aa9414fbfb75d5ee6be7c84b6 kostenfrei https://www.mdpi.com/2075-4426/11/2/70 kostenfrei https://doaj.org/toc/2075-4426 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 2, p 70
allfieldsSound	10.3390/jpm11020070 doi (DE-627)DOAJ081180284 (DE-599)DOAJdf75712aa9414fbfb75d5ee6be7c84b6 DE-627 ger DE-627 rakwb eng Cristina Panisi verfasserin aut Autism Spectrum Disorder from the Womb to Adulthood: Suggestions for a Paradigm Shift 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The wide spectrum of unique needs and strengths of Autism Spectrum Disorders (ASD) is a challenge for the worldwide healthcare system. With the plethora of information from research, a common thread is required to conceptualize an exhaustive pathogenetic paradigm. The epidemiological and clinical findings in ASD cannot be explained by the traditional linear genetic model, hence the need to move towards a more fluid conception, integrating genetics, environment, and epigenetics as a whole. The embryo-fetal period and the first two years of life (the so-called ‘First 1000 Days’) are the crucial time window for neurodevelopment. In particular, the interplay and the vicious loop between immune activation, gut dysbiosis, and mitochondrial impairment/oxidative stress significantly affects neurodevelopment during pregnancy and undermines the health of ASD people throughout life. Consequently, the most effective intervention in ASD is expected by primary prevention aimed at pregnancy and at early control of the main effector molecular pathways. We will reason here on a comprehensive and exhaustive pathogenetic paradigm in ASD, viewed not just as a theoretical issue, but as a tool to provide suggestions for effective preventive strategies and personalized, dynamic (from womb to adulthood), systemic, and interdisciplinary healthcare approach. Autism Spectrum Disorder (ASD) pathogenesis prevention epigenetics immune activation gut dysbiosis Medicine R Franca Rosa Guerini verfasserin aut Provvidenza Maria Abruzzo verfasserin aut Federico Balzola verfasserin aut Pier Mario Biava verfasserin aut Alessandra Bolotta verfasserin aut Marco Brunero verfasserin aut Ernesto Burgio verfasserin aut Alberto Chiara verfasserin aut Mario Clerici verfasserin aut Luigi Croce verfasserin aut Carla Ferreri verfasserin aut Niccolò Giovannini verfasserin aut Alessandro Ghezzo verfasserin aut Enzo Grossi verfasserin aut Roberto Keller verfasserin aut Andrea Manzotti verfasserin aut Marina Marini verfasserin aut Lucia Migliore verfasserin aut Lucio Moderato verfasserin aut Davide Moscone verfasserin aut Michele Mussap verfasserin aut Antonia Parmeggiani verfasserin aut Valentina Pasin verfasserin aut Monica Perotti verfasserin aut Cristina Piras verfasserin aut Marina Saresella verfasserin aut Andrea Stoccoro verfasserin aut Tiziana Toso verfasserin aut Rosa Anna Vacca verfasserin aut David Vagni verfasserin aut Salvatore Vendemmia verfasserin aut Laura Villa verfasserin aut Pierluigi Politi verfasserin aut Vassilios Fanos verfasserin aut In Journal of Personalized Medicine MDPI AG, 2012 11(2021), 2, p 70 (DE-627)71862713X (DE-600)2662248-8 20754426 nnns volume:11 year:2021 number:2, p 70 https://doi.org/10.3390/jpm11020070 kostenfrei https://doaj.org/article/df75712aa9414fbfb75d5ee6be7c84b6 kostenfrei https://www.mdpi.com/2075-4426/11/2/70 kostenfrei https://doaj.org/toc/2075-4426 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 2, p 70
language	English
source	In Journal of Personalized Medicine 11(2021), 2, p 70 volume:11 year:2021 number:2, p 70
sourceStr	In Journal of Personalized Medicine 11(2021), 2, p 70 volume:11 year:2021 number:2, p 70
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Autism Spectrum Disorder (ASD) pathogenesis prevention epigenetics immune activation gut dysbiosis Medicine R
isfreeaccess_bool	true
container_title	Journal of Personalized Medicine
authorswithroles_txt_mv	Cristina Panisi @@aut@@ Franca Rosa Guerini @@aut@@ Provvidenza Maria Abruzzo @@aut@@ Federico Balzola @@aut@@ Pier Mario Biava @@aut@@ Alessandra Bolotta @@aut@@ Marco Brunero @@aut@@ Ernesto Burgio @@aut@@ Alberto Chiara @@aut@@ Mario Clerici @@aut@@ Luigi Croce @@aut@@ Carla Ferreri @@aut@@ Niccolò Giovannini @@aut@@ Alessandro Ghezzo @@aut@@ Enzo Grossi @@aut@@ Roberto Keller @@aut@@ Andrea Manzotti @@aut@@ Marina Marini @@aut@@ Lucia Migliore @@aut@@ Lucio Moderato @@aut@@ Davide Moscone @@aut@@ Michele Mussap @@aut@@ Antonia Parmeggiani @@aut@@ Valentina Pasin @@aut@@ Monica Perotti @@aut@@ Cristina Piras @@aut@@ Marina Saresella @@aut@@ Andrea Stoccoro @@aut@@ Tiziana Toso @@aut@@ Rosa Anna Vacca @@aut@@ David Vagni @@aut@@ Salvatore Vendemmia @@aut@@ Laura Villa @@aut@@ Pierluigi Politi @@aut@@ Vassilios Fanos @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	71862713X
id	DOAJ081180284
language_de	englisch
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author	Cristina Panisi
spellingShingle	Cristina Panisi misc Autism Spectrum Disorder (ASD) misc pathogenesis misc prevention misc epigenetics misc immune activation misc gut dysbiosis misc Medicine misc R Autism Spectrum Disorder from the Womb to Adulthood: Suggestions for a Paradigm Shift
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topic_title	Autism Spectrum Disorder from the Womb to Adulthood: Suggestions for a Paradigm Shift Autism Spectrum Disorder (ASD) pathogenesis prevention epigenetics immune activation gut dysbiosis
topic	misc Autism Spectrum Disorder (ASD) misc pathogenesis misc prevention misc epigenetics misc immune activation misc gut dysbiosis misc Medicine misc R
topic_unstemmed	misc Autism Spectrum Disorder (ASD) misc pathogenesis misc prevention misc epigenetics misc immune activation misc gut dysbiosis misc Medicine misc R
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title	Autism Spectrum Disorder from the Womb to Adulthood: Suggestions for a Paradigm Shift
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author_browse	Cristina Panisi Franca Rosa Guerini Provvidenza Maria Abruzzo Federico Balzola Pier Mario Biava Alessandra Bolotta Marco Brunero Ernesto Burgio Alberto Chiara Mario Clerici Luigi Croce Carla Ferreri Niccolò Giovannini Alessandro Ghezzo Enzo Grossi Roberto Keller Andrea Manzotti Marina Marini Lucia Migliore Lucio Moderato Davide Moscone Michele Mussap Antonia Parmeggiani Valentina Pasin Monica Perotti Cristina Piras Marina Saresella Andrea Stoccoro Tiziana Toso Rosa Anna Vacca David Vagni Salvatore Vendemmia Laura Villa Pierluigi Politi Vassilios Fanos
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title_sort	autism spectrum disorder from the womb to adulthood: suggestions for a paradigm shift
title_auth	Autism Spectrum Disorder from the Womb to Adulthood: Suggestions for a Paradigm Shift
abstract	The wide spectrum of unique needs and strengths of Autism Spectrum Disorders (ASD) is a challenge for the worldwide healthcare system. With the plethora of information from research, a common thread is required to conceptualize an exhaustive pathogenetic paradigm. The epidemiological and clinical findings in ASD cannot be explained by the traditional linear genetic model, hence the need to move towards a more fluid conception, integrating genetics, environment, and epigenetics as a whole. The embryo-fetal period and the first two years of life (the so-called ‘First 1000 Days’) are the crucial time window for neurodevelopment. In particular, the interplay and the vicious loop between immune activation, gut dysbiosis, and mitochondrial impairment/oxidative stress significantly affects neurodevelopment during pregnancy and undermines the health of ASD people throughout life. Consequently, the most effective intervention in ASD is expected by primary prevention aimed at pregnancy and at early control of the main effector molecular pathways. We will reason here on a comprehensive and exhaustive pathogenetic paradigm in ASD, viewed not just as a theoretical issue, but as a tool to provide suggestions for effective preventive strategies and personalized, dynamic (from womb to adulthood), systemic, and interdisciplinary healthcare approach.
abstractGer	The wide spectrum of unique needs and strengths of Autism Spectrum Disorders (ASD) is a challenge for the worldwide healthcare system. With the plethora of information from research, a common thread is required to conceptualize an exhaustive pathogenetic paradigm. The epidemiological and clinical findings in ASD cannot be explained by the traditional linear genetic model, hence the need to move towards a more fluid conception, integrating genetics, environment, and epigenetics as a whole. The embryo-fetal period and the first two years of life (the so-called ‘First 1000 Days’) are the crucial time window for neurodevelopment. In particular, the interplay and the vicious loop between immune activation, gut dysbiosis, and mitochondrial impairment/oxidative stress significantly affects neurodevelopment during pregnancy and undermines the health of ASD people throughout life. Consequently, the most effective intervention in ASD is expected by primary prevention aimed at pregnancy and at early control of the main effector molecular pathways. We will reason here on a comprehensive and exhaustive pathogenetic paradigm in ASD, viewed not just as a theoretical issue, but as a tool to provide suggestions for effective preventive strategies and personalized, dynamic (from womb to adulthood), systemic, and interdisciplinary healthcare approach.
abstract_unstemmed	The wide spectrum of unique needs and strengths of Autism Spectrum Disorders (ASD) is a challenge for the worldwide healthcare system. With the plethora of information from research, a common thread is required to conceptualize an exhaustive pathogenetic paradigm. The epidemiological and clinical findings in ASD cannot be explained by the traditional linear genetic model, hence the need to move towards a more fluid conception, integrating genetics, environment, and epigenetics as a whole. The embryo-fetal period and the first two years of life (the so-called ‘First 1000 Days’) are the crucial time window for neurodevelopment. In particular, the interplay and the vicious loop between immune activation, gut dysbiosis, and mitochondrial impairment/oxidative stress significantly affects neurodevelopment during pregnancy and undermines the health of ASD people throughout life. Consequently, the most effective intervention in ASD is expected by primary prevention aimed at pregnancy and at early control of the main effector molecular pathways. We will reason here on a comprehensive and exhaustive pathogenetic paradigm in ASD, viewed not just as a theoretical issue, but as a tool to provide suggestions for effective preventive strategies and personalized, dynamic (from womb to adulthood), systemic, and interdisciplinary healthcare approach.
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title_short	Autism Spectrum Disorder from the Womb to Adulthood: Suggestions for a Paradigm Shift
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author2	Franca Rosa Guerini Provvidenza Maria Abruzzo Federico Balzola Pier Mario Biava Alessandra Bolotta Marco Brunero Ernesto Burgio Alberto Chiara Mario Clerici Luigi Croce Carla Ferreri Niccolò Giovannini Alessandro Ghezzo Enzo Grossi Roberto Keller Andrea Manzotti Marina Marini Lucia Migliore Lucio Moderato Davide Moscone Michele Mussap Antonia Parmeggiani Valentina Pasin Monica Perotti Cristina Piras Marina Saresella Andrea Stoccoro Tiziana Toso Rosa Anna Vacca David Vagni Salvatore Vendemmia Laura Villa Pierluigi Politi Vassilios Fanos
author2Str	Franca Rosa Guerini Provvidenza Maria Abruzzo Federico Balzola Pier Mario Biava Alessandra Bolotta Marco Brunero Ernesto Burgio Alberto Chiara Mario Clerici Luigi Croce Carla Ferreri Niccolò Giovannini Alessandro Ghezzo Enzo Grossi Roberto Keller Andrea Manzotti Marina Marini Lucia Migliore Lucio Moderato Davide Moscone Michele Mussap Antonia Parmeggiani Valentina Pasin Monica Perotti Cristina Piras Marina Saresella Andrea Stoccoro Tiziana Toso Rosa Anna Vacca David Vagni Salvatore Vendemmia Laura Villa Pierluigi Politi Vassilios Fanos
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up_date	2024-07-03T18:42:42.125Z
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