Primary ChAdOx1 vaccination does not reactivate pre-existing, cross-reactive immunity
Currently available COVID-19 vaccines include inactivated virus, live attenuated virus, mRNA-based, viral vectored and adjuvanted protein-subunit-based vaccines. All of them contain the spike glycoprotein as the main immunogen and result in reduced disease severity upon SARS-CoV-2 infection. While w...
Ausführliche Beschreibung
Autor*in: |
Larissa Henze [verfasserIn] Julian Braun [verfasserIn] Lil Meyer-Arndt [verfasserIn] Karsten Jürchott [verfasserIn] Maike Schlotz [verfasserIn] Janine Michel [verfasserIn] Marica Grossegesse [verfasserIn] Maike Mangold [verfasserIn] Manuela Dingeldey [verfasserIn] Beate Kruse [verfasserIn] Pavlo Holenya [verfasserIn] Norbert Mages [verfasserIn] Ulf Reimer [verfasserIn] Maren Eckey [verfasserIn] Karsten Schnatbaum [verfasserIn] Holger Wenschuh [verfasserIn] Bernd Timmermann [verfasserIn] Florian Klein [verfasserIn] Andreas Nitsche [verfasserIn] Claudia Giesecke-Thiel [verfasserIn] Lucie Loyal [verfasserIn] Andreas Thiel [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2023 |
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Übergeordnetes Werk: |
In: Frontiers in Immunology - Frontiers Media S.A., 2011, 14(2023) |
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Übergeordnetes Werk: |
volume:14 ; year:2023 |
Links: |
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DOI / URN: |
10.3389/fimmu.2023.1056525 |
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Katalog-ID: |
DOAJ081293356 |
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520 | |a Currently available COVID-19 vaccines include inactivated virus, live attenuated virus, mRNA-based, viral vectored and adjuvanted protein-subunit-based vaccines. All of them contain the spike glycoprotein as the main immunogen and result in reduced disease severity upon SARS-CoV-2 infection. While we and others have shown that mRNA-based vaccination reactivates pre-existing, cross-reactive immunity, the effect of vector vaccines in this regard is unknown. Here, we studied cellular and humoral responses in heterologous adenovirus-vector-based ChAdOx1 nCOV-19 (AZ; Vaxzeria, AstraZeneca) and mRNA-based BNT162b2 (BNT; Comirnaty, BioNTech/Pfizer) vaccination and compared it to a homologous BNT vaccination regimen. AZ primary vaccination did not lead to measurable reactivation of cross-reactive cellular and humoral immunity compared to BNT primary vaccination. Moreover, humoral immunity induced by primary vaccination with AZ displayed differences in linear spike peptide epitope coverage and a lack of anti-S2 IgG antibodies. Contrary to primary AZ vaccination, secondary vaccination with BNT reactivated pre-existing, cross-reactive immunity, comparable to homologous primary and secondary mRNA vaccination. While induced anti-S1 IgG antibody titers were higher after heterologous vaccination, induced CD4+ T cell responses were highest in homologous vaccinated. However, the overall TCR repertoire breadth was comparable between heterologous AZ-BNT-vaccinated and homologous BNT-BNT-vaccinated individuals, matching TCR repertoire breadths after SARS-CoV-2 infection, too. The reasons why AZ and BNT primary vaccination elicits different immune response patterns to essentially the same antigen, and the associated benefits and risks, need further investigation to inform vaccine and vaccination schedule development. | ||
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10.3389/fimmu.2023.1056525 doi (DE-627)DOAJ081293356 (DE-599)DOAJ8d30110c924e4be5beac3a8eb0a4da1f DE-627 ger DE-627 rakwb eng RC581-607 Larissa Henze verfasserin aut Primary ChAdOx1 vaccination does not reactivate pre-existing, cross-reactive immunity 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Currently available COVID-19 vaccines include inactivated virus, live attenuated virus, mRNA-based, viral vectored and adjuvanted protein-subunit-based vaccines. All of them contain the spike glycoprotein as the main immunogen and result in reduced disease severity upon SARS-CoV-2 infection. While we and others have shown that mRNA-based vaccination reactivates pre-existing, cross-reactive immunity, the effect of vector vaccines in this regard is unknown. Here, we studied cellular and humoral responses in heterologous adenovirus-vector-based ChAdOx1 nCOV-19 (AZ; Vaxzeria, AstraZeneca) and mRNA-based BNT162b2 (BNT; Comirnaty, BioNTech/Pfizer) vaccination and compared it to a homologous BNT vaccination regimen. AZ primary vaccination did not lead to measurable reactivation of cross-reactive cellular and humoral immunity compared to BNT primary vaccination. Moreover, humoral immunity induced by primary vaccination with AZ displayed differences in linear spike peptide epitope coverage and a lack of anti-S2 IgG antibodies. Contrary to primary AZ vaccination, secondary vaccination with BNT reactivated pre-existing, cross-reactive immunity, comparable to homologous primary and secondary mRNA vaccination. While induced anti-S1 IgG antibody titers were higher after heterologous vaccination, induced CD4+ T cell responses were highest in homologous vaccinated. However, the overall TCR repertoire breadth was comparable between heterologous AZ-BNT-vaccinated and homologous BNT-BNT-vaccinated individuals, matching TCR repertoire breadths after SARS-CoV-2 infection, too. The reasons why AZ and BNT primary vaccination elicits different immune response patterns to essentially the same antigen, and the associated benefits and risks, need further investigation to inform vaccine and vaccination schedule development. SARS-CoV-2 antigen-specific T-cells cross-reactivity heterologous vaccination humoral response Immunologic diseases. Allergy Larissa Henze verfasserin aut Julian Braun verfasserin aut Julian Braun verfasserin aut Lil Meyer-Arndt verfasserin aut Lil Meyer-Arndt verfasserin aut Lil Meyer-Arndt verfasserin aut Lil Meyer-Arndt verfasserin aut Karsten Jürchott verfasserin aut Karsten Jürchott verfasserin aut Maike Schlotz verfasserin aut Janine Michel verfasserin aut Marica Grossegesse verfasserin aut Maike Mangold verfasserin aut Maike Mangold verfasserin aut Manuela Dingeldey verfasserin aut Manuela Dingeldey verfasserin aut Beate Kruse verfasserin aut Beate Kruse verfasserin aut Pavlo Holenya verfasserin aut Norbert Mages verfasserin aut Norbert Mages verfasserin aut Norbert Mages verfasserin aut Ulf Reimer verfasserin aut Maren Eckey verfasserin aut Karsten Schnatbaum verfasserin aut Holger Wenschuh verfasserin aut Bernd Timmermann verfasserin aut Florian Klein verfasserin aut Florian Klein verfasserin aut Florian Klein verfasserin aut Andreas Nitsche verfasserin aut Claudia Giesecke-Thiel verfasserin aut Lucie Loyal verfasserin aut Lucie Loyal verfasserin aut Andreas Thiel verfasserin aut Andreas Thiel verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 14(2023) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:14 year:2023 https://doi.org/10.3389/fimmu.2023.1056525 kostenfrei https://doaj.org/article/8d30110c924e4be5beac3a8eb0a4da1f kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2023.1056525/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 |
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10.3389/fimmu.2023.1056525 doi (DE-627)DOAJ081293356 (DE-599)DOAJ8d30110c924e4be5beac3a8eb0a4da1f DE-627 ger DE-627 rakwb eng RC581-607 Larissa Henze verfasserin aut Primary ChAdOx1 vaccination does not reactivate pre-existing, cross-reactive immunity 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Currently available COVID-19 vaccines include inactivated virus, live attenuated virus, mRNA-based, viral vectored and adjuvanted protein-subunit-based vaccines. All of them contain the spike glycoprotein as the main immunogen and result in reduced disease severity upon SARS-CoV-2 infection. While we and others have shown that mRNA-based vaccination reactivates pre-existing, cross-reactive immunity, the effect of vector vaccines in this regard is unknown. Here, we studied cellular and humoral responses in heterologous adenovirus-vector-based ChAdOx1 nCOV-19 (AZ; Vaxzeria, AstraZeneca) and mRNA-based BNT162b2 (BNT; Comirnaty, BioNTech/Pfizer) vaccination and compared it to a homologous BNT vaccination regimen. AZ primary vaccination did not lead to measurable reactivation of cross-reactive cellular and humoral immunity compared to BNT primary vaccination. Moreover, humoral immunity induced by primary vaccination with AZ displayed differences in linear spike peptide epitope coverage and a lack of anti-S2 IgG antibodies. Contrary to primary AZ vaccination, secondary vaccination with BNT reactivated pre-existing, cross-reactive immunity, comparable to homologous primary and secondary mRNA vaccination. While induced anti-S1 IgG antibody titers were higher after heterologous vaccination, induced CD4+ T cell responses were highest in homologous vaccinated. However, the overall TCR repertoire breadth was comparable between heterologous AZ-BNT-vaccinated and homologous BNT-BNT-vaccinated individuals, matching TCR repertoire breadths after SARS-CoV-2 infection, too. The reasons why AZ and BNT primary vaccination elicits different immune response patterns to essentially the same antigen, and the associated benefits and risks, need further investigation to inform vaccine and vaccination schedule development. SARS-CoV-2 antigen-specific T-cells cross-reactivity heterologous vaccination humoral response Immunologic diseases. Allergy Larissa Henze verfasserin aut Julian Braun verfasserin aut Julian Braun verfasserin aut Lil Meyer-Arndt verfasserin aut Lil Meyer-Arndt verfasserin aut Lil Meyer-Arndt verfasserin aut Lil Meyer-Arndt verfasserin aut Karsten Jürchott verfasserin aut Karsten Jürchott verfasserin aut Maike Schlotz verfasserin aut Janine Michel verfasserin aut Marica Grossegesse verfasserin aut Maike Mangold verfasserin aut Maike Mangold verfasserin aut Manuela Dingeldey verfasserin aut Manuela Dingeldey verfasserin aut Beate Kruse verfasserin aut Beate Kruse verfasserin aut Pavlo Holenya verfasserin aut Norbert Mages verfasserin aut Norbert Mages verfasserin aut Norbert Mages verfasserin aut Ulf Reimer verfasserin aut Maren Eckey verfasserin aut Karsten Schnatbaum verfasserin aut Holger Wenschuh verfasserin aut Bernd Timmermann verfasserin aut Florian Klein verfasserin aut Florian Klein verfasserin aut Florian Klein verfasserin aut Andreas Nitsche verfasserin aut Claudia Giesecke-Thiel verfasserin aut Lucie Loyal verfasserin aut Lucie Loyal verfasserin aut Andreas Thiel verfasserin aut Andreas Thiel verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 14(2023) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:14 year:2023 https://doi.org/10.3389/fimmu.2023.1056525 kostenfrei https://doaj.org/article/8d30110c924e4be5beac3a8eb0a4da1f kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2023.1056525/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 |
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10.3389/fimmu.2023.1056525 doi (DE-627)DOAJ081293356 (DE-599)DOAJ8d30110c924e4be5beac3a8eb0a4da1f DE-627 ger DE-627 rakwb eng RC581-607 Larissa Henze verfasserin aut Primary ChAdOx1 vaccination does not reactivate pre-existing, cross-reactive immunity 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Currently available COVID-19 vaccines include inactivated virus, live attenuated virus, mRNA-based, viral vectored and adjuvanted protein-subunit-based vaccines. All of them contain the spike glycoprotein as the main immunogen and result in reduced disease severity upon SARS-CoV-2 infection. While we and others have shown that mRNA-based vaccination reactivates pre-existing, cross-reactive immunity, the effect of vector vaccines in this regard is unknown. Here, we studied cellular and humoral responses in heterologous adenovirus-vector-based ChAdOx1 nCOV-19 (AZ; Vaxzeria, AstraZeneca) and mRNA-based BNT162b2 (BNT; Comirnaty, BioNTech/Pfizer) vaccination and compared it to a homologous BNT vaccination regimen. AZ primary vaccination did not lead to measurable reactivation of cross-reactive cellular and humoral immunity compared to BNT primary vaccination. Moreover, humoral immunity induced by primary vaccination with AZ displayed differences in linear spike peptide epitope coverage and a lack of anti-S2 IgG antibodies. Contrary to primary AZ vaccination, secondary vaccination with BNT reactivated pre-existing, cross-reactive immunity, comparable to homologous primary and secondary mRNA vaccination. While induced anti-S1 IgG antibody titers were higher after heterologous vaccination, induced CD4+ T cell responses were highest in homologous vaccinated. However, the overall TCR repertoire breadth was comparable between heterologous AZ-BNT-vaccinated and homologous BNT-BNT-vaccinated individuals, matching TCR repertoire breadths after SARS-CoV-2 infection, too. The reasons why AZ and BNT primary vaccination elicits different immune response patterns to essentially the same antigen, and the associated benefits and risks, need further investigation to inform vaccine and vaccination schedule development. SARS-CoV-2 antigen-specific T-cells cross-reactivity heterologous vaccination humoral response Immunologic diseases. Allergy Larissa Henze verfasserin aut Julian Braun verfasserin aut Julian Braun verfasserin aut Lil Meyer-Arndt verfasserin aut Lil Meyer-Arndt verfasserin aut Lil Meyer-Arndt verfasserin aut Lil Meyer-Arndt verfasserin aut Karsten Jürchott verfasserin aut Karsten Jürchott verfasserin aut Maike Schlotz verfasserin aut Janine Michel verfasserin aut Marica Grossegesse verfasserin aut Maike Mangold verfasserin aut Maike Mangold verfasserin aut Manuela Dingeldey verfasserin aut Manuela Dingeldey verfasserin aut Beate Kruse verfasserin aut Beate Kruse verfasserin aut Pavlo Holenya verfasserin aut Norbert Mages verfasserin aut Norbert Mages verfasserin aut Norbert Mages verfasserin aut Ulf Reimer verfasserin aut Maren Eckey verfasserin aut Karsten Schnatbaum verfasserin aut Holger Wenschuh verfasserin aut Bernd Timmermann verfasserin aut Florian Klein verfasserin aut Florian Klein verfasserin aut Florian Klein verfasserin aut Andreas Nitsche verfasserin aut Claudia Giesecke-Thiel verfasserin aut Lucie Loyal verfasserin aut Lucie Loyal verfasserin aut Andreas Thiel verfasserin aut Andreas Thiel verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 14(2023) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:14 year:2023 https://doi.org/10.3389/fimmu.2023.1056525 kostenfrei https://doaj.org/article/8d30110c924e4be5beac3a8eb0a4da1f kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2023.1056525/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 |
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10.3389/fimmu.2023.1056525 doi (DE-627)DOAJ081293356 (DE-599)DOAJ8d30110c924e4be5beac3a8eb0a4da1f DE-627 ger DE-627 rakwb eng RC581-607 Larissa Henze verfasserin aut Primary ChAdOx1 vaccination does not reactivate pre-existing, cross-reactive immunity 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Currently available COVID-19 vaccines include inactivated virus, live attenuated virus, mRNA-based, viral vectored and adjuvanted protein-subunit-based vaccines. All of them contain the spike glycoprotein as the main immunogen and result in reduced disease severity upon SARS-CoV-2 infection. While we and others have shown that mRNA-based vaccination reactivates pre-existing, cross-reactive immunity, the effect of vector vaccines in this regard is unknown. Here, we studied cellular and humoral responses in heterologous adenovirus-vector-based ChAdOx1 nCOV-19 (AZ; Vaxzeria, AstraZeneca) and mRNA-based BNT162b2 (BNT; Comirnaty, BioNTech/Pfizer) vaccination and compared it to a homologous BNT vaccination regimen. AZ primary vaccination did not lead to measurable reactivation of cross-reactive cellular and humoral immunity compared to BNT primary vaccination. Moreover, humoral immunity induced by primary vaccination with AZ displayed differences in linear spike peptide epitope coverage and a lack of anti-S2 IgG antibodies. Contrary to primary AZ vaccination, secondary vaccination with BNT reactivated pre-existing, cross-reactive immunity, comparable to homologous primary and secondary mRNA vaccination. While induced anti-S1 IgG antibody titers were higher after heterologous vaccination, induced CD4+ T cell responses were highest in homologous vaccinated. However, the overall TCR repertoire breadth was comparable between heterologous AZ-BNT-vaccinated and homologous BNT-BNT-vaccinated individuals, matching TCR repertoire breadths after SARS-CoV-2 infection, too. The reasons why AZ and BNT primary vaccination elicits different immune response patterns to essentially the same antigen, and the associated benefits and risks, need further investigation to inform vaccine and vaccination schedule development. SARS-CoV-2 antigen-specific T-cells cross-reactivity heterologous vaccination humoral response Immunologic diseases. Allergy Larissa Henze verfasserin aut Julian Braun verfasserin aut Julian Braun verfasserin aut Lil Meyer-Arndt verfasserin aut Lil Meyer-Arndt verfasserin aut Lil Meyer-Arndt verfasserin aut Lil Meyer-Arndt verfasserin aut Karsten Jürchott verfasserin aut Karsten Jürchott verfasserin aut Maike Schlotz verfasserin aut Janine Michel verfasserin aut Marica Grossegesse verfasserin aut Maike Mangold verfasserin aut Maike Mangold verfasserin aut Manuela Dingeldey verfasserin aut Manuela Dingeldey verfasserin aut Beate Kruse verfasserin aut Beate Kruse verfasserin aut Pavlo Holenya verfasserin aut Norbert Mages verfasserin aut Norbert Mages verfasserin aut Norbert Mages verfasserin aut Ulf Reimer verfasserin aut Maren Eckey verfasserin aut Karsten Schnatbaum verfasserin aut Holger Wenschuh verfasserin aut Bernd Timmermann verfasserin aut Florian Klein verfasserin aut Florian Klein verfasserin aut Florian Klein verfasserin aut Andreas Nitsche verfasserin aut Claudia Giesecke-Thiel verfasserin aut Lucie Loyal verfasserin aut Lucie Loyal verfasserin aut Andreas Thiel verfasserin aut Andreas Thiel verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 14(2023) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:14 year:2023 https://doi.org/10.3389/fimmu.2023.1056525 kostenfrei https://doaj.org/article/8d30110c924e4be5beac3a8eb0a4da1f kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2023.1056525/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 |
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10.3389/fimmu.2023.1056525 doi (DE-627)DOAJ081293356 (DE-599)DOAJ8d30110c924e4be5beac3a8eb0a4da1f DE-627 ger DE-627 rakwb eng RC581-607 Larissa Henze verfasserin aut Primary ChAdOx1 vaccination does not reactivate pre-existing, cross-reactive immunity 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Currently available COVID-19 vaccines include inactivated virus, live attenuated virus, mRNA-based, viral vectored and adjuvanted protein-subunit-based vaccines. All of them contain the spike glycoprotein as the main immunogen and result in reduced disease severity upon SARS-CoV-2 infection. While we and others have shown that mRNA-based vaccination reactivates pre-existing, cross-reactive immunity, the effect of vector vaccines in this regard is unknown. Here, we studied cellular and humoral responses in heterologous adenovirus-vector-based ChAdOx1 nCOV-19 (AZ; Vaxzeria, AstraZeneca) and mRNA-based BNT162b2 (BNT; Comirnaty, BioNTech/Pfizer) vaccination and compared it to a homologous BNT vaccination regimen. AZ primary vaccination did not lead to measurable reactivation of cross-reactive cellular and humoral immunity compared to BNT primary vaccination. Moreover, humoral immunity induced by primary vaccination with AZ displayed differences in linear spike peptide epitope coverage and a lack of anti-S2 IgG antibodies. Contrary to primary AZ vaccination, secondary vaccination with BNT reactivated pre-existing, cross-reactive immunity, comparable to homologous primary and secondary mRNA vaccination. While induced anti-S1 IgG antibody titers were higher after heterologous vaccination, induced CD4+ T cell responses were highest in homologous vaccinated. However, the overall TCR repertoire breadth was comparable between heterologous AZ-BNT-vaccinated and homologous BNT-BNT-vaccinated individuals, matching TCR repertoire breadths after SARS-CoV-2 infection, too. The reasons why AZ and BNT primary vaccination elicits different immune response patterns to essentially the same antigen, and the associated benefits and risks, need further investigation to inform vaccine and vaccination schedule development. SARS-CoV-2 antigen-specific T-cells cross-reactivity heterologous vaccination humoral response Immunologic diseases. Allergy Larissa Henze verfasserin aut Julian Braun verfasserin aut Julian Braun verfasserin aut Lil Meyer-Arndt verfasserin aut Lil Meyer-Arndt verfasserin aut Lil Meyer-Arndt verfasserin aut Lil Meyer-Arndt verfasserin aut Karsten Jürchott verfasserin aut Karsten Jürchott verfasserin aut Maike Schlotz verfasserin aut Janine Michel verfasserin aut Marica Grossegesse verfasserin aut Maike Mangold verfasserin aut Maike Mangold verfasserin aut Manuela Dingeldey verfasserin aut Manuela Dingeldey verfasserin aut Beate Kruse verfasserin aut Beate Kruse verfasserin aut Pavlo Holenya verfasserin aut Norbert Mages verfasserin aut Norbert Mages verfasserin aut Norbert Mages verfasserin aut Ulf Reimer verfasserin aut Maren Eckey verfasserin aut Karsten Schnatbaum verfasserin aut Holger Wenschuh verfasserin aut Bernd Timmermann verfasserin aut Florian Klein verfasserin aut Florian Klein verfasserin aut Florian Klein verfasserin aut Andreas Nitsche verfasserin aut Claudia Giesecke-Thiel verfasserin aut Lucie Loyal verfasserin aut Lucie Loyal verfasserin aut Andreas Thiel verfasserin aut Andreas Thiel verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 14(2023) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:14 year:2023 https://doi.org/10.3389/fimmu.2023.1056525 kostenfrei https://doaj.org/article/8d30110c924e4be5beac3a8eb0a4da1f kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2023.1056525/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 |
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Larissa Henze @@aut@@ Julian Braun @@aut@@ Lil Meyer-Arndt @@aut@@ Karsten Jürchott @@aut@@ Maike Schlotz @@aut@@ Janine Michel @@aut@@ Marica Grossegesse @@aut@@ Maike Mangold @@aut@@ Manuela Dingeldey @@aut@@ Beate Kruse @@aut@@ Pavlo Holenya @@aut@@ Norbert Mages @@aut@@ Ulf Reimer @@aut@@ Maren Eckey @@aut@@ Karsten Schnatbaum @@aut@@ Holger Wenschuh @@aut@@ Bernd Timmermann @@aut@@ Florian Klein @@aut@@ Andreas Nitsche @@aut@@ Claudia Giesecke-Thiel @@aut@@ Lucie Loyal @@aut@@ Andreas Thiel @@aut@@ |
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Larissa Henze misc RC581-607 misc SARS-CoV-2 misc antigen-specific T-cells misc cross-reactivity misc heterologous vaccination misc humoral response misc Immunologic diseases. Allergy Primary ChAdOx1 vaccination does not reactivate pre-existing, cross-reactive immunity |
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RC581-607 Primary ChAdOx1 vaccination does not reactivate pre-existing, cross-reactive immunity SARS-CoV-2 antigen-specific T-cells cross-reactivity heterologous vaccination humoral response |
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Primary ChAdOx1 vaccination does not reactivate pre-existing, cross-reactive immunity |
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primary chadox1 vaccination does not reactivate pre-existing, cross-reactive immunity |
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Primary ChAdOx1 vaccination does not reactivate pre-existing, cross-reactive immunity |
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Currently available COVID-19 vaccines include inactivated virus, live attenuated virus, mRNA-based, viral vectored and adjuvanted protein-subunit-based vaccines. All of them contain the spike glycoprotein as the main immunogen and result in reduced disease severity upon SARS-CoV-2 infection. While we and others have shown that mRNA-based vaccination reactivates pre-existing, cross-reactive immunity, the effect of vector vaccines in this regard is unknown. Here, we studied cellular and humoral responses in heterologous adenovirus-vector-based ChAdOx1 nCOV-19 (AZ; Vaxzeria, AstraZeneca) and mRNA-based BNT162b2 (BNT; Comirnaty, BioNTech/Pfizer) vaccination and compared it to a homologous BNT vaccination regimen. AZ primary vaccination did not lead to measurable reactivation of cross-reactive cellular and humoral immunity compared to BNT primary vaccination. Moreover, humoral immunity induced by primary vaccination with AZ displayed differences in linear spike peptide epitope coverage and a lack of anti-S2 IgG antibodies. Contrary to primary AZ vaccination, secondary vaccination with BNT reactivated pre-existing, cross-reactive immunity, comparable to homologous primary and secondary mRNA vaccination. While induced anti-S1 IgG antibody titers were higher after heterologous vaccination, induced CD4+ T cell responses were highest in homologous vaccinated. However, the overall TCR repertoire breadth was comparable between heterologous AZ-BNT-vaccinated and homologous BNT-BNT-vaccinated individuals, matching TCR repertoire breadths after SARS-CoV-2 infection, too. The reasons why AZ and BNT primary vaccination elicits different immune response patterns to essentially the same antigen, and the associated benefits and risks, need further investigation to inform vaccine and vaccination schedule development. |
abstractGer |
Currently available COVID-19 vaccines include inactivated virus, live attenuated virus, mRNA-based, viral vectored and adjuvanted protein-subunit-based vaccines. All of them contain the spike glycoprotein as the main immunogen and result in reduced disease severity upon SARS-CoV-2 infection. While we and others have shown that mRNA-based vaccination reactivates pre-existing, cross-reactive immunity, the effect of vector vaccines in this regard is unknown. Here, we studied cellular and humoral responses in heterologous adenovirus-vector-based ChAdOx1 nCOV-19 (AZ; Vaxzeria, AstraZeneca) and mRNA-based BNT162b2 (BNT; Comirnaty, BioNTech/Pfizer) vaccination and compared it to a homologous BNT vaccination regimen. AZ primary vaccination did not lead to measurable reactivation of cross-reactive cellular and humoral immunity compared to BNT primary vaccination. Moreover, humoral immunity induced by primary vaccination with AZ displayed differences in linear spike peptide epitope coverage and a lack of anti-S2 IgG antibodies. Contrary to primary AZ vaccination, secondary vaccination with BNT reactivated pre-existing, cross-reactive immunity, comparable to homologous primary and secondary mRNA vaccination. While induced anti-S1 IgG antibody titers were higher after heterologous vaccination, induced CD4+ T cell responses were highest in homologous vaccinated. However, the overall TCR repertoire breadth was comparable between heterologous AZ-BNT-vaccinated and homologous BNT-BNT-vaccinated individuals, matching TCR repertoire breadths after SARS-CoV-2 infection, too. The reasons why AZ and BNT primary vaccination elicits different immune response patterns to essentially the same antigen, and the associated benefits and risks, need further investigation to inform vaccine and vaccination schedule development. |
abstract_unstemmed |
Currently available COVID-19 vaccines include inactivated virus, live attenuated virus, mRNA-based, viral vectored and adjuvanted protein-subunit-based vaccines. All of them contain the spike glycoprotein as the main immunogen and result in reduced disease severity upon SARS-CoV-2 infection. While we and others have shown that mRNA-based vaccination reactivates pre-existing, cross-reactive immunity, the effect of vector vaccines in this regard is unknown. Here, we studied cellular and humoral responses in heterologous adenovirus-vector-based ChAdOx1 nCOV-19 (AZ; Vaxzeria, AstraZeneca) and mRNA-based BNT162b2 (BNT; Comirnaty, BioNTech/Pfizer) vaccination and compared it to a homologous BNT vaccination regimen. AZ primary vaccination did not lead to measurable reactivation of cross-reactive cellular and humoral immunity compared to BNT primary vaccination. Moreover, humoral immunity induced by primary vaccination with AZ displayed differences in linear spike peptide epitope coverage and a lack of anti-S2 IgG antibodies. Contrary to primary AZ vaccination, secondary vaccination with BNT reactivated pre-existing, cross-reactive immunity, comparable to homologous primary and secondary mRNA vaccination. While induced anti-S1 IgG antibody titers were higher after heterologous vaccination, induced CD4+ T cell responses were highest in homologous vaccinated. However, the overall TCR repertoire breadth was comparable between heterologous AZ-BNT-vaccinated and homologous BNT-BNT-vaccinated individuals, matching TCR repertoire breadths after SARS-CoV-2 infection, too. The reasons why AZ and BNT primary vaccination elicits different immune response patterns to essentially the same antigen, and the associated benefits and risks, need further investigation to inform vaccine and vaccination schedule development. |
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Primary ChAdOx1 vaccination does not reactivate pre-existing, cross-reactive immunity |
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