Targeting Pim kinases in hematological cancers: molecular and clinical review

Abstract Decades of research has recognized a solid role for Pim kinases in lymphoproliferative disorders. Often up-regulated following JAK/STAT and tyrosine kinase receptor signaling, Pim kinases regulate cell proliferation, survival, metabolism, cellular trafficking and signaling. Targeting Pim ki...
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Gespeichert in:

Autor*in:	Marcia Bellon [verfasserIn] Christophe Nicot [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Pim1 Pim2 Pim3 Leukemia Lymphoma PIM

Übergeordnetes Werk:	In: Molecular Cancer - BMC, 2003, 22(2023), 1, Seite 25
Übergeordnetes Werk:	volume:22 ; year:2023 ; number:1 ; pages:25

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12943-023-01721-1

Katalog-ID:	DOAJ081403151

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allfieldsGer	10.1186/s12943-023-01721-1 doi (DE-627)DOAJ081403151 (DE-599)DOAJ7c593544b2064139a0fd938d142a1f96 DE-627 ger DE-627 rakwb eng RC254-282 Marcia Bellon verfasserin aut Targeting Pim kinases in hematological cancers: molecular and clinical review 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Decades of research has recognized a solid role for Pim kinases in lymphoproliferative disorders. Often up-regulated following JAK/STAT and tyrosine kinase receptor signaling, Pim kinases regulate cell proliferation, survival, metabolism, cellular trafficking and signaling. Targeting Pim kinases represents an interesting approach since knock-down of Pim kinases leads to non-fatal phenotypes in vivo suggesting clinical inhibition of Pim may have less side effects. In addition, the ATP binding site offers unique characteristics that can be used for the development of small inhibitors targeting one or all Pim isoforms. This review takes a closer look at Pim kinase expression and involvement in hematopoietic cancers. Current and past clinical trials and in vitro characterization of Pim kinase inhibitors are examined and future directions are discussed. Current studies suggest that Pim kinase inhibition may be most valuable when accompanied by multi-drug targeting therapy. Pim1 Pim2 Pim3 Leukemia Lymphoma PIM Neoplasms. Tumors. Oncology. Including cancer and carcinogens Christophe Nicot verfasserin aut In Molecular Cancer BMC, 2003 22(2023), 1, Seite 25 (DE-627)355987619 (DE-600)2091373-4 14764598 nnns volume:22 year:2023 number:1 pages:25 https://doi.org/10.1186/s12943-023-01721-1 kostenfrei https://doaj.org/article/7c593544b2064139a0fd938d142a1f96 kostenfrei https://doi.org/10.1186/s12943-023-01721-1 kostenfrei https://doaj.org/toc/1476-4598 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2023 1 25
allfieldsSound	10.1186/s12943-023-01721-1 doi (DE-627)DOAJ081403151 (DE-599)DOAJ7c593544b2064139a0fd938d142a1f96 DE-627 ger DE-627 rakwb eng RC254-282 Marcia Bellon verfasserin aut Targeting Pim kinases in hematological cancers: molecular and clinical review 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Decades of research has recognized a solid role for Pim kinases in lymphoproliferative disorders. Often up-regulated following JAK/STAT and tyrosine kinase receptor signaling, Pim kinases regulate cell proliferation, survival, metabolism, cellular trafficking and signaling. Targeting Pim kinases represents an interesting approach since knock-down of Pim kinases leads to non-fatal phenotypes in vivo suggesting clinical inhibition of Pim may have less side effects. In addition, the ATP binding site offers unique characteristics that can be used for the development of small inhibitors targeting one or all Pim isoforms. This review takes a closer look at Pim kinase expression and involvement in hematopoietic cancers. Current and past clinical trials and in vitro characterization of Pim kinase inhibitors are examined and future directions are discussed. Current studies suggest that Pim kinase inhibition may be most valuable when accompanied by multi-drug targeting therapy. Pim1 Pim2 Pim3 Leukemia Lymphoma PIM Neoplasms. Tumors. Oncology. Including cancer and carcinogens Christophe Nicot verfasserin aut In Molecular Cancer BMC, 2003 22(2023), 1, Seite 25 (DE-627)355987619 (DE-600)2091373-4 14764598 nnns volume:22 year:2023 number:1 pages:25 https://doi.org/10.1186/s12943-023-01721-1 kostenfrei https://doaj.org/article/7c593544b2064139a0fd938d142a1f96 kostenfrei https://doi.org/10.1186/s12943-023-01721-1 kostenfrei https://doaj.org/toc/1476-4598 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2023 1 25
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container_title	Molecular Cancer
authorswithroles_txt_mv	Marcia Bellon @@aut@@ Christophe Nicot @@aut@@
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callnumber-first	R - Medicine
author	Marcia Bellon
spellingShingle	Marcia Bellon misc RC254-282 misc Pim1 misc Pim2 misc Pim3 misc Leukemia misc Lymphoma misc PIM misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Targeting Pim kinases in hematological cancers: molecular and clinical review
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topic_title	RC254-282 Targeting Pim kinases in hematological cancers: molecular and clinical review Pim1 Pim2 Pim3 Leukemia Lymphoma PIM
topic	misc RC254-282 misc Pim1 misc Pim2 misc Pim3 misc Leukemia misc Lymphoma misc PIM misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc Pim1 misc Pim2 misc Pim3 misc Leukemia misc Lymphoma misc PIM misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Targeting Pim kinases in hematological cancers: molecular and clinical review
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title_full	Targeting Pim kinases in hematological cancers: molecular and clinical review
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title_sort	targeting pim kinases in hematological cancers: molecular and clinical review
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title_auth	Targeting Pim kinases in hematological cancers: molecular and clinical review
abstract	Abstract Decades of research has recognized a solid role for Pim kinases in lymphoproliferative disorders. Often up-regulated following JAK/STAT and tyrosine kinase receptor signaling, Pim kinases regulate cell proliferation, survival, metabolism, cellular trafficking and signaling. Targeting Pim kinases represents an interesting approach since knock-down of Pim kinases leads to non-fatal phenotypes in vivo suggesting clinical inhibition of Pim may have less side effects. In addition, the ATP binding site offers unique characteristics that can be used for the development of small inhibitors targeting one or all Pim isoforms. This review takes a closer look at Pim kinase expression and involvement in hematopoietic cancers. Current and past clinical trials and in vitro characterization of Pim kinase inhibitors are examined and future directions are discussed. Current studies suggest that Pim kinase inhibition may be most valuable when accompanied by multi-drug targeting therapy.
abstractGer	Abstract Decades of research has recognized a solid role for Pim kinases in lymphoproliferative disorders. Often up-regulated following JAK/STAT and tyrosine kinase receptor signaling, Pim kinases regulate cell proliferation, survival, metabolism, cellular trafficking and signaling. Targeting Pim kinases represents an interesting approach since knock-down of Pim kinases leads to non-fatal phenotypes in vivo suggesting clinical inhibition of Pim may have less side effects. In addition, the ATP binding site offers unique characteristics that can be used for the development of small inhibitors targeting one or all Pim isoforms. This review takes a closer look at Pim kinase expression and involvement in hematopoietic cancers. Current and past clinical trials and in vitro characterization of Pim kinase inhibitors are examined and future directions are discussed. Current studies suggest that Pim kinase inhibition may be most valuable when accompanied by multi-drug targeting therapy.
abstract_unstemmed	Abstract Decades of research has recognized a solid role for Pim kinases in lymphoproliferative disorders. Often up-regulated following JAK/STAT and tyrosine kinase receptor signaling, Pim kinases regulate cell proliferation, survival, metabolism, cellular trafficking and signaling. Targeting Pim kinases represents an interesting approach since knock-down of Pim kinases leads to non-fatal phenotypes in vivo suggesting clinical inhibition of Pim may have less side effects. In addition, the ATP binding site offers unique characteristics that can be used for the development of small inhibitors targeting one or all Pim isoforms. This review takes a closer look at Pim kinase expression and involvement in hematopoietic cancers. Current and past clinical trials and in vitro characterization of Pim kinase inhibitors are examined and future directions are discussed. Current studies suggest that Pim kinase inhibition may be most valuable when accompanied by multi-drug targeting therapy.
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title_short	Targeting Pim kinases in hematological cancers: molecular and clinical review
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Targeting Pim kinases in hematological cancers: molecular and clinical review

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