Myeloid masquerade: Microglial transcriptional signatures in retinal development and disease

Microglia are dynamic guardians of neural tissue and the resident immune cells of the central nervous system (CNS). The disease-associated microglial signature (DAM), also known as the microglial neurodegenerative phenotype (MGnD), has gained significant attention in recent years as a fundamental mi...
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Autor*in:	Kristen M. Pitts [verfasserIn] Milica A. Margeta [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	microglia monocytes retina retinal development neurodegeneration single cell RNA sequencing

Übergeordnetes Werk:	In: Frontiers in Cellular Neuroscience - Frontiers Media S.A., 2008, 17(2023)
Übergeordnetes Werk:	volume:17 ; year:2023

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fncel.2023.1106547

Katalog-ID:	DOAJ081500238

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source	In Frontiers in Cellular Neuroscience 17(2023) volume:17 year:2023
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topic_facet	microglia monocytes retina retinal development neurodegeneration single cell RNA sequencing Neurosciences. Biological psychiatry. Neuropsychiatry
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authorswithroles_txt_mv	Kristen M. Pitts @@aut@@ Milica A. Margeta @@aut@@
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author	Kristen M. Pitts
spellingShingle	Kristen M. Pitts misc RC321-571 misc microglia misc monocytes misc retina misc retinal development misc neurodegeneration misc single cell RNA sequencing misc Neurosciences. Biological psychiatry. Neuropsychiatry Myeloid masquerade: Microglial transcriptional signatures in retinal development and disease
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topic_title	RC321-571 Myeloid masquerade: Microglial transcriptional signatures in retinal development and disease microglia monocytes retina retinal development neurodegeneration single cell RNA sequencing
topic	misc RC321-571 misc microglia misc monocytes misc retina misc retinal development misc neurodegeneration misc single cell RNA sequencing misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc microglia misc monocytes misc retina misc retinal development misc neurodegeneration misc single cell RNA sequencing misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Myeloid masquerade: Microglial transcriptional signatures in retinal development and disease
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title_sort	myeloid masquerade: microglial transcriptional signatures in retinal development and disease
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title_auth	Myeloid masquerade: Microglial transcriptional signatures in retinal development and disease
abstract	Microglia are dynamic guardians of neural tissue and the resident immune cells of the central nervous system (CNS). The disease-associated microglial signature (DAM), also known as the microglial neurodegenerative phenotype (MGnD), has gained significant attention in recent years as a fundamental microglial response common to various neurodegenerative disease pathologies. Interestingly, this signature shares many features in common with developmental microglia, suggesting the existence of recycled gene programs which play a role both in early neural circuit formation as well as in response to aging and disease. In addition, recent advances in single cell RNA sequencing have revealed significant heterogeneity within the original DAM signature, with contributions from both yolk sac-derived microglia as well as bone marrow-derived macrophages. In this review, we examine the role of the DAM signature in retinal development and disease, highlighting crosstalk between resident microglia and infiltrating monocytes which may critically contribute to the underlying mechanisms of age-related neurodegeneration.
abstractGer	Microglia are dynamic guardians of neural tissue and the resident immune cells of the central nervous system (CNS). The disease-associated microglial signature (DAM), also known as the microglial neurodegenerative phenotype (MGnD), has gained significant attention in recent years as a fundamental microglial response common to various neurodegenerative disease pathologies. Interestingly, this signature shares many features in common with developmental microglia, suggesting the existence of recycled gene programs which play a role both in early neural circuit formation as well as in response to aging and disease. In addition, recent advances in single cell RNA sequencing have revealed significant heterogeneity within the original DAM signature, with contributions from both yolk sac-derived microglia as well as bone marrow-derived macrophages. In this review, we examine the role of the DAM signature in retinal development and disease, highlighting crosstalk between resident microglia and infiltrating monocytes which may critically contribute to the underlying mechanisms of age-related neurodegeneration.
abstract_unstemmed	Microglia are dynamic guardians of neural tissue and the resident immune cells of the central nervous system (CNS). The disease-associated microglial signature (DAM), also known as the microglial neurodegenerative phenotype (MGnD), has gained significant attention in recent years as a fundamental microglial response common to various neurodegenerative disease pathologies. Interestingly, this signature shares many features in common with developmental microglia, suggesting the existence of recycled gene programs which play a role both in early neural circuit formation as well as in response to aging and disease. In addition, recent advances in single cell RNA sequencing have revealed significant heterogeneity within the original DAM signature, with contributions from both yolk sac-derived microglia as well as bone marrow-derived macrophages. In this review, we examine the role of the DAM signature in retinal development and disease, highlighting crosstalk between resident microglia and infiltrating monocytes which may critically contribute to the underlying mechanisms of age-related neurodegeneration.
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title_short	Myeloid masquerade: Microglial transcriptional signatures in retinal development and disease
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Myeloid masquerade: Microglial transcriptional signatures in retinal development and disease

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