Presence of CagA Gene and Its Antibiotic Resistance Pattern in Helicobacter Pylori Isolates
Background and purpose: Helicobacter pylori is one of the most prevalent agents causing gastric infection. Most of the type I strains genome containing cag pathogenicity island (i.e. cagA) result in peptic ulcer and gastric cancer. Antibiotics are amongst the main treatments but drug resistance may...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Mohammad Shokrzadeh [verfasserIn] Ismail Fattahi [verfasserIn] Abbas Mohammadpour [verfasserIn] Amir Hosein Mashhadban [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch ; Persisch |
| Erschienen: |
2017 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Journal of Mazandaran University of Medical Sciences - Mazandaran University of Medical Sciences, 2018, 27(2017), 154, Seite 60-72 |
|---|---|
| Übergeordnetes Werk: |
volume:27 ; year:2017 ; number:154 ; pages:60-72 |
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DOAJ081545010 |
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| 520 | |a Background and purpose: Helicobacter pylori is one of the most prevalent agents causing gastric infection. Most of the type I strains genome containing cag pathogenicity island (i.e. cagA) result in peptic ulcer and gastric cancer. Antibiotics are amongst the main treatments but drug resistance may cause treatment failure. The aim of current research was to investigate the presence of cagA in H. pylori samples and their antibiotic resistance patterns. Materials and methods: A descriptive study was performed in 86 patients. The endoscopy specimen was used fosr rapid urease test and culture and preparation of paraffin blocks to observe lam of tissue and performing PCR method. Samples were grown in standard media and grown colonies in culture medium were identified using catalase and oxidase tests. Antibiotic susceptibility tests were performed by antibiogram. Results: In this study, the rapid urease test, tissue lam observation, culture results and PCR analysis were positive in 45.3%, 53.4%, and 55.9%, and 80.2%, respectively. CagA gene was detected in 69.56% of the samples. Among patients with positive culture, highest rates of resistance were found to metronidazole, amoxicillin, ciprofloxacin, clarithromycin, and furazolidone, while the lowest rate of resistance was to tetracycline. Conclusion: Compared with other methods, PCR analysis was found to be more appropriate. Current study showed that H. pylori strains in Iran are increasingly resistant to clarithromycin, and furazolidone, and metronidazole. | ||
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(DE-627)DOAJ081545010 (DE-599)DOAJb28be29d179f4869b33e12459ee2a2d5 DE-627 ger DE-627 rakwb eng per R5-920 Mohammad Shokrzadeh verfasserin aut Presence of CagA Gene and Its Antibiotic Resistance Pattern in Helicobacter Pylori Isolates 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and purpose: Helicobacter pylori is one of the most prevalent agents causing gastric infection. Most of the type I strains genome containing cag pathogenicity island (i.e. cagA) result in peptic ulcer and gastric cancer. Antibiotics are amongst the main treatments but drug resistance may cause treatment failure. The aim of current research was to investigate the presence of cagA in H. pylori samples and their antibiotic resistance patterns. Materials and methods: A descriptive study was performed in 86 patients. The endoscopy specimen was used fosr rapid urease test and culture and preparation of paraffin blocks to observe lam of tissue and performing PCR method. Samples were grown in standard media and grown colonies in culture medium were identified using catalase and oxidase tests. Antibiotic susceptibility tests were performed by antibiogram. Results: In this study, the rapid urease test, tissue lam observation, culture results and PCR analysis were positive in 45.3%, 53.4%, and 55.9%, and 80.2%, respectively. CagA gene was detected in 69.56% of the samples. Among patients with positive culture, highest rates of resistance were found to metronidazole, amoxicillin, ciprofloxacin, clarithromycin, and furazolidone, while the lowest rate of resistance was to tetracycline. Conclusion: Compared with other methods, PCR analysis was found to be more appropriate. Current study showed that H. pylori strains in Iran are increasingly resistant to clarithromycin, and furazolidone, and metronidazole. gastric cancer antibiotic resistance microaerophile helicobacter pylori caga Medicine R Medicine (General) Ismail Fattahi verfasserin aut Abbas Mohammadpour verfasserin aut Amir Hosein Mashhadban verfasserin aut In Journal of Mazandaran University of Medical Sciences Mazandaran University of Medical Sciences, 2018 27(2017), 154, Seite 60-72 (DE-627)59095623X (DE-600)2476989-7 17359279 nnns volume:27 year:2017 number:154 pages:60-72 https://doaj.org/article/b28be29d179f4869b33e12459ee2a2d5 kostenfrei http://jmums.mazums.ac.ir/article-1-9398-en.html kostenfrei https://doaj.org/toc/1735-9260 Journal toc kostenfrei https://doaj.org/toc/1735-9279 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2017 154 60-72 |
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(DE-627)DOAJ081545010 (DE-599)DOAJb28be29d179f4869b33e12459ee2a2d5 DE-627 ger DE-627 rakwb eng per R5-920 Mohammad Shokrzadeh verfasserin aut Presence of CagA Gene and Its Antibiotic Resistance Pattern in Helicobacter Pylori Isolates 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and purpose: Helicobacter pylori is one of the most prevalent agents causing gastric infection. Most of the type I strains genome containing cag pathogenicity island (i.e. cagA) result in peptic ulcer and gastric cancer. Antibiotics are amongst the main treatments but drug resistance may cause treatment failure. The aim of current research was to investigate the presence of cagA in H. pylori samples and their antibiotic resistance patterns. Materials and methods: A descriptive study was performed in 86 patients. The endoscopy specimen was used fosr rapid urease test and culture and preparation of paraffin blocks to observe lam of tissue and performing PCR method. Samples were grown in standard media and grown colonies in culture medium were identified using catalase and oxidase tests. Antibiotic susceptibility tests were performed by antibiogram. Results: In this study, the rapid urease test, tissue lam observation, culture results and PCR analysis were positive in 45.3%, 53.4%, and 55.9%, and 80.2%, respectively. CagA gene was detected in 69.56% of the samples. Among patients with positive culture, highest rates of resistance were found to metronidazole, amoxicillin, ciprofloxacin, clarithromycin, and furazolidone, while the lowest rate of resistance was to tetracycline. Conclusion: Compared with other methods, PCR analysis was found to be more appropriate. Current study showed that H. pylori strains in Iran are increasingly resistant to clarithromycin, and furazolidone, and metronidazole. gastric cancer antibiotic resistance microaerophile helicobacter pylori caga Medicine R Medicine (General) Ismail Fattahi verfasserin aut Abbas Mohammadpour verfasserin aut Amir Hosein Mashhadban verfasserin aut In Journal of Mazandaran University of Medical Sciences Mazandaran University of Medical Sciences, 2018 27(2017), 154, Seite 60-72 (DE-627)59095623X (DE-600)2476989-7 17359279 nnns volume:27 year:2017 number:154 pages:60-72 https://doaj.org/article/b28be29d179f4869b33e12459ee2a2d5 kostenfrei http://jmums.mazums.ac.ir/article-1-9398-en.html kostenfrei https://doaj.org/toc/1735-9260 Journal toc kostenfrei https://doaj.org/toc/1735-9279 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2017 154 60-72 |
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(DE-627)DOAJ081545010 (DE-599)DOAJb28be29d179f4869b33e12459ee2a2d5 DE-627 ger DE-627 rakwb eng per R5-920 Mohammad Shokrzadeh verfasserin aut Presence of CagA Gene and Its Antibiotic Resistance Pattern in Helicobacter Pylori Isolates 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and purpose: Helicobacter pylori is one of the most prevalent agents causing gastric infection. Most of the type I strains genome containing cag pathogenicity island (i.e. cagA) result in peptic ulcer and gastric cancer. Antibiotics are amongst the main treatments but drug resistance may cause treatment failure. The aim of current research was to investigate the presence of cagA in H. pylori samples and their antibiotic resistance patterns. Materials and methods: A descriptive study was performed in 86 patients. The endoscopy specimen was used fosr rapid urease test and culture and preparation of paraffin blocks to observe lam of tissue and performing PCR method. Samples were grown in standard media and grown colonies in culture medium were identified using catalase and oxidase tests. Antibiotic susceptibility tests were performed by antibiogram. Results: In this study, the rapid urease test, tissue lam observation, culture results and PCR analysis were positive in 45.3%, 53.4%, and 55.9%, and 80.2%, respectively. CagA gene was detected in 69.56% of the samples. Among patients with positive culture, highest rates of resistance were found to metronidazole, amoxicillin, ciprofloxacin, clarithromycin, and furazolidone, while the lowest rate of resistance was to tetracycline. Conclusion: Compared with other methods, PCR analysis was found to be more appropriate. Current study showed that H. pylori strains in Iran are increasingly resistant to clarithromycin, and furazolidone, and metronidazole. gastric cancer antibiotic resistance microaerophile helicobacter pylori caga Medicine R Medicine (General) Ismail Fattahi verfasserin aut Abbas Mohammadpour verfasserin aut Amir Hosein Mashhadban verfasserin aut In Journal of Mazandaran University of Medical Sciences Mazandaran University of Medical Sciences, 2018 27(2017), 154, Seite 60-72 (DE-627)59095623X (DE-600)2476989-7 17359279 nnns volume:27 year:2017 number:154 pages:60-72 https://doaj.org/article/b28be29d179f4869b33e12459ee2a2d5 kostenfrei http://jmums.mazums.ac.ir/article-1-9398-en.html kostenfrei https://doaj.org/toc/1735-9260 Journal toc kostenfrei https://doaj.org/toc/1735-9279 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2017 154 60-72 |
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(DE-627)DOAJ081545010 (DE-599)DOAJb28be29d179f4869b33e12459ee2a2d5 DE-627 ger DE-627 rakwb eng per R5-920 Mohammad Shokrzadeh verfasserin aut Presence of CagA Gene and Its Antibiotic Resistance Pattern in Helicobacter Pylori Isolates 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and purpose: Helicobacter pylori is one of the most prevalent agents causing gastric infection. Most of the type I strains genome containing cag pathogenicity island (i.e. cagA) result in peptic ulcer and gastric cancer. Antibiotics are amongst the main treatments but drug resistance may cause treatment failure. The aim of current research was to investigate the presence of cagA in H. pylori samples and their antibiotic resistance patterns. Materials and methods: A descriptive study was performed in 86 patients. The endoscopy specimen was used fosr rapid urease test and culture and preparation of paraffin blocks to observe lam of tissue and performing PCR method. Samples were grown in standard media and grown colonies in culture medium were identified using catalase and oxidase tests. Antibiotic susceptibility tests were performed by antibiogram. Results: In this study, the rapid urease test, tissue lam observation, culture results and PCR analysis were positive in 45.3%, 53.4%, and 55.9%, and 80.2%, respectively. CagA gene was detected in 69.56% of the samples. Among patients with positive culture, highest rates of resistance were found to metronidazole, amoxicillin, ciprofloxacin, clarithromycin, and furazolidone, while the lowest rate of resistance was to tetracycline. Conclusion: Compared with other methods, PCR analysis was found to be more appropriate. Current study showed that H. pylori strains in Iran are increasingly resistant to clarithromycin, and furazolidone, and metronidazole. gastric cancer antibiotic resistance microaerophile helicobacter pylori caga Medicine R Medicine (General) Ismail Fattahi verfasserin aut Abbas Mohammadpour verfasserin aut Amir Hosein Mashhadban verfasserin aut In Journal of Mazandaran University of Medical Sciences Mazandaran University of Medical Sciences, 2018 27(2017), 154, Seite 60-72 (DE-627)59095623X (DE-600)2476989-7 17359279 nnns volume:27 year:2017 number:154 pages:60-72 https://doaj.org/article/b28be29d179f4869b33e12459ee2a2d5 kostenfrei http://jmums.mazums.ac.ir/article-1-9398-en.html kostenfrei https://doaj.org/toc/1735-9260 Journal toc kostenfrei https://doaj.org/toc/1735-9279 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2017 154 60-72 |
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(DE-627)DOAJ081545010 (DE-599)DOAJb28be29d179f4869b33e12459ee2a2d5 DE-627 ger DE-627 rakwb eng per R5-920 Mohammad Shokrzadeh verfasserin aut Presence of CagA Gene and Its Antibiotic Resistance Pattern in Helicobacter Pylori Isolates 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and purpose: Helicobacter pylori is one of the most prevalent agents causing gastric infection. Most of the type I strains genome containing cag pathogenicity island (i.e. cagA) result in peptic ulcer and gastric cancer. Antibiotics are amongst the main treatments but drug resistance may cause treatment failure. The aim of current research was to investigate the presence of cagA in H. pylori samples and their antibiotic resistance patterns. Materials and methods: A descriptive study was performed in 86 patients. The endoscopy specimen was used fosr rapid urease test and culture and preparation of paraffin blocks to observe lam of tissue and performing PCR method. Samples were grown in standard media and grown colonies in culture medium were identified using catalase and oxidase tests. Antibiotic susceptibility tests were performed by antibiogram. Results: In this study, the rapid urease test, tissue lam observation, culture results and PCR analysis were positive in 45.3%, 53.4%, and 55.9%, and 80.2%, respectively. CagA gene was detected in 69.56% of the samples. Among patients with positive culture, highest rates of resistance were found to metronidazole, amoxicillin, ciprofloxacin, clarithromycin, and furazolidone, while the lowest rate of resistance was to tetracycline. Conclusion: Compared with other methods, PCR analysis was found to be more appropriate. Current study showed that H. pylori strains in Iran are increasingly resistant to clarithromycin, and furazolidone, and metronidazole. gastric cancer antibiotic resistance microaerophile helicobacter pylori caga Medicine R Medicine (General) Ismail Fattahi verfasserin aut Abbas Mohammadpour verfasserin aut Amir Hosein Mashhadban verfasserin aut In Journal of Mazandaran University of Medical Sciences Mazandaran University of Medical Sciences, 2018 27(2017), 154, Seite 60-72 (DE-627)59095623X (DE-600)2476989-7 17359279 nnns volume:27 year:2017 number:154 pages:60-72 https://doaj.org/article/b28be29d179f4869b33e12459ee2a2d5 kostenfrei http://jmums.mazums.ac.ir/article-1-9398-en.html kostenfrei https://doaj.org/toc/1735-9260 Journal toc kostenfrei https://doaj.org/toc/1735-9279 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2017 154 60-72 |
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Presence of CagA Gene and Its Antibiotic Resistance Pattern in Helicobacter Pylori Isolates |
| abstract |
Background and purpose: Helicobacter pylori is one of the most prevalent agents causing gastric infection. Most of the type I strains genome containing cag pathogenicity island (i.e. cagA) result in peptic ulcer and gastric cancer. Antibiotics are amongst the main treatments but drug resistance may cause treatment failure. The aim of current research was to investigate the presence of cagA in H. pylori samples and their antibiotic resistance patterns. Materials and methods: A descriptive study was performed in 86 patients. The endoscopy specimen was used fosr rapid urease test and culture and preparation of paraffin blocks to observe lam of tissue and performing PCR method. Samples were grown in standard media and grown colonies in culture medium were identified using catalase and oxidase tests. Antibiotic susceptibility tests were performed by antibiogram. Results: In this study, the rapid urease test, tissue lam observation, culture results and PCR analysis were positive in 45.3%, 53.4%, and 55.9%, and 80.2%, respectively. CagA gene was detected in 69.56% of the samples. Among patients with positive culture, highest rates of resistance were found to metronidazole, amoxicillin, ciprofloxacin, clarithromycin, and furazolidone, while the lowest rate of resistance was to tetracycline. Conclusion: Compared with other methods, PCR analysis was found to be more appropriate. Current study showed that H. pylori strains in Iran are increasingly resistant to clarithromycin, and furazolidone, and metronidazole. |
| abstractGer |
Background and purpose: Helicobacter pylori is one of the most prevalent agents causing gastric infection. Most of the type I strains genome containing cag pathogenicity island (i.e. cagA) result in peptic ulcer and gastric cancer. Antibiotics are amongst the main treatments but drug resistance may cause treatment failure. The aim of current research was to investigate the presence of cagA in H. pylori samples and their antibiotic resistance patterns. Materials and methods: A descriptive study was performed in 86 patients. The endoscopy specimen was used fosr rapid urease test and culture and preparation of paraffin blocks to observe lam of tissue and performing PCR method. Samples were grown in standard media and grown colonies in culture medium were identified using catalase and oxidase tests. Antibiotic susceptibility tests were performed by antibiogram. Results: In this study, the rapid urease test, tissue lam observation, culture results and PCR analysis were positive in 45.3%, 53.4%, and 55.9%, and 80.2%, respectively. CagA gene was detected in 69.56% of the samples. Among patients with positive culture, highest rates of resistance were found to metronidazole, amoxicillin, ciprofloxacin, clarithromycin, and furazolidone, while the lowest rate of resistance was to tetracycline. Conclusion: Compared with other methods, PCR analysis was found to be more appropriate. Current study showed that H. pylori strains in Iran are increasingly resistant to clarithromycin, and furazolidone, and metronidazole. |
| abstract_unstemmed |
Background and purpose: Helicobacter pylori is one of the most prevalent agents causing gastric infection. Most of the type I strains genome containing cag pathogenicity island (i.e. cagA) result in peptic ulcer and gastric cancer. Antibiotics are amongst the main treatments but drug resistance may cause treatment failure. The aim of current research was to investigate the presence of cagA in H. pylori samples and their antibiotic resistance patterns. Materials and methods: A descriptive study was performed in 86 patients. The endoscopy specimen was used fosr rapid urease test and culture and preparation of paraffin blocks to observe lam of tissue and performing PCR method. Samples were grown in standard media and grown colonies in culture medium were identified using catalase and oxidase tests. Antibiotic susceptibility tests were performed by antibiogram. Results: In this study, the rapid urease test, tissue lam observation, culture results and PCR analysis were positive in 45.3%, 53.4%, and 55.9%, and 80.2%, respectively. CagA gene was detected in 69.56% of the samples. Among patients with positive culture, highest rates of resistance were found to metronidazole, amoxicillin, ciprofloxacin, clarithromycin, and furazolidone, while the lowest rate of resistance was to tetracycline. Conclusion: Compared with other methods, PCR analysis was found to be more appropriate. Current study showed that H. pylori strains in Iran are increasingly resistant to clarithromycin, and furazolidone, and metronidazole. |
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Among patients with positive culture, highest rates of resistance were found to metronidazole, amoxicillin, ciprofloxacin, clarithromycin, and furazolidone, while the lowest rate of resistance was to tetracycline. Conclusion: Compared with other methods, PCR analysis was found to be more appropriate. 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