Antioxidant and Hepatoprotective Properties of Vicia cracca Against Carbon Tetrachloride Induced Oxidative Stress in Mice

Background and purpose: Vicia cracca (Papilionaceae) has 45 species in Iran. Vicia spp. are known medicinal plants. Some species in this family are well known with distinctive antioxidant activity. This investigation was designed to evaluate the antioxidant activities and hepatoprorective properties...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Mohammad Shokrzadeh [verfasserIn] Farshid Rahimi [verfasserIn] Ali Ziar [verfasserIn] Mohammad Ali Ebrahimzadeh [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch ; Persisch

Erschienen:	2018

Schlagwörter:	vicia cracca antioxidant phenol ﬂavonoids hepatoprotection glutathion hepatic enzymes ccl4

Übergeordnetes Werk:	In: Journal of Mazandaran University of Medical Sciences - Mazandaran University of Medical Sciences, 2018, 27(2018), 156, Seite 50-65
Übergeordnetes Werk:	volume:27 ; year:2018 ; number:156 ; pages:50-65

Links:	Link aufrufen Link aufrufen Journal toc Journal toc

Katalog-ID:	DOAJ081545622

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520			\|a Background and purpose: Vicia cracca (Papilionaceae) has 45 species in Iran. Vicia spp. are known medicinal plants. Some species in this family are well known with distinctive antioxidant activity. This investigation was designed to evaluate the antioxidant activities and hepatoprorective properties of V. cracca in mice. Materials and methods: The aerial parts were extracted by maceration method using methanol as solvent. Antioxidative capacity was assessed by utilizing three different methods: DPPH, nitric oxide (NO) free radicals scavenging, and reducing power. Hepatoprotective activity was evaluated in 50, 100 and 200 mg/kg in CCl4 induced oxidative toxicity. Also, the levels of serum ALT, AST and ALP and hepatic glutathione were measured. Results: Total phenolic content was 17.2 ± 0.9 mg GAE and flavonoid content was 9.78 ± 0.25 mg QE. In DPPH radical scavenging activity, the IC50 value was 1.98 ± 0.25 mg ml-1. The extract showed good reducing power activity indicating significant difference with that of the positive controls (P< 0.05). The extract increased liver glutation content and decreased ALT, AST and ALP levels in mice serum. These effects were dose dependent. The results of histopathology showed a significant decrease in inflammation and necrosis in liver tissues. Conclusion: The findings clearly indicated moderately good antioxidant capacities and potent hepatoprotective properties of the Vicia cracca extract.
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allfields	(DE-627)DOAJ081545622 (DE-599)DOAJf43bf22be04a4a73a00c9c65a56fff49 DE-627 ger DE-627 rakwb eng per R5-920 Mohammad Shokrzadeh verfasserin aut Antioxidant and Hepatoprotective Properties of Vicia cracca Against Carbon Tetrachloride Induced Oxidative Stress in Mice 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and purpose: Vicia cracca (Papilionaceae) has 45 species in Iran. Vicia spp. are known medicinal plants. Some species in this family are well known with distinctive antioxidant activity. This investigation was designed to evaluate the antioxidant activities and hepatoprorective properties of V. cracca in mice. Materials and methods: The aerial parts were extracted by maceration method using methanol as solvent. Antioxidative capacity was assessed by utilizing three different methods: DPPH, nitric oxide (NO) free radicals scavenging, and reducing power. Hepatoprotective activity was evaluated in 50, 100 and 200 mg/kg in CCl4 induced oxidative toxicity. Also, the levels of serum ALT, AST and ALP and hepatic glutathione were measured. Results: Total phenolic content was 17.2 ± 0.9 mg GAE and flavonoid content was 9.78 ± 0.25 mg QE. In DPPH radical scavenging activity, the IC50 value was 1.98 ± 0.25 mg ml-1. The extract showed good reducing power activity indicating significant difference with that of the positive controls (P< 0.05). The extract increased liver glutation content and decreased ALT, AST and ALP levels in mice serum. These effects were dose dependent. The results of histopathology showed a significant decrease in inflammation and necrosis in liver tissues. Conclusion: The findings clearly indicated moderately good antioxidant capacities and potent hepatoprotective properties of the Vicia cracca extract. vicia cracca antioxidant phenol ﬂavonoids hepatoprotection glutathion hepatic enzymes ccl4 Medicine R Medicine (General) Farshid Rahimi verfasserin aut Ali Ziar verfasserin aut Mohammad Ali Ebrahimzadeh verfasserin aut In Journal of Mazandaran University of Medical Sciences Mazandaran University of Medical Sciences, 2018 27(2018), 156, Seite 50-65 (DE-627)59095623X (DE-600)2476989-7 17359279 nnns volume:27 year:2018 number:156 pages:50-65 https://doaj.org/article/f43bf22be04a4a73a00c9c65a56fff49 kostenfrei http://jmums.mazums.ac.ir/article-1-10123-en.html kostenfrei https://doaj.org/toc/1735-9260 Journal toc kostenfrei https://doaj.org/toc/1735-9279 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2018 156 50-65
spelling	(DE-627)DOAJ081545622 (DE-599)DOAJf43bf22be04a4a73a00c9c65a56fff49 DE-627 ger DE-627 rakwb eng per R5-920 Mohammad Shokrzadeh verfasserin aut Antioxidant and Hepatoprotective Properties of Vicia cracca Against Carbon Tetrachloride Induced Oxidative Stress in Mice 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and purpose: Vicia cracca (Papilionaceae) has 45 species in Iran. Vicia spp. are known medicinal plants. Some species in this family are well known with distinctive antioxidant activity. This investigation was designed to evaluate the antioxidant activities and hepatoprorective properties of V. cracca in mice. Materials and methods: The aerial parts were extracted by maceration method using methanol as solvent. Antioxidative capacity was assessed by utilizing three different methods: DPPH, nitric oxide (NO) free radicals scavenging, and reducing power. Hepatoprotective activity was evaluated in 50, 100 and 200 mg/kg in CCl4 induced oxidative toxicity. Also, the levels of serum ALT, AST and ALP and hepatic glutathione were measured. Results: Total phenolic content was 17.2 ± 0.9 mg GAE and flavonoid content was 9.78 ± 0.25 mg QE. In DPPH radical scavenging activity, the IC50 value was 1.98 ± 0.25 mg ml-1. The extract showed good reducing power activity indicating significant difference with that of the positive controls (P< 0.05). The extract increased liver glutation content and decreased ALT, AST and ALP levels in mice serum. These effects were dose dependent. The results of histopathology showed a significant decrease in inflammation and necrosis in liver tissues. Conclusion: The findings clearly indicated moderately good antioxidant capacities and potent hepatoprotective properties of the Vicia cracca extract. vicia cracca antioxidant phenol ﬂavonoids hepatoprotection glutathion hepatic enzymes ccl4 Medicine R Medicine (General) Farshid Rahimi verfasserin aut Ali Ziar verfasserin aut Mohammad Ali Ebrahimzadeh verfasserin aut In Journal of Mazandaran University of Medical Sciences Mazandaran University of Medical Sciences, 2018 27(2018), 156, Seite 50-65 (DE-627)59095623X (DE-600)2476989-7 17359279 nnns volume:27 year:2018 number:156 pages:50-65 https://doaj.org/article/f43bf22be04a4a73a00c9c65a56fff49 kostenfrei http://jmums.mazums.ac.ir/article-1-10123-en.html kostenfrei https://doaj.org/toc/1735-9260 Journal toc kostenfrei https://doaj.org/toc/1735-9279 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2018 156 50-65
allfields_unstemmed	(DE-627)DOAJ081545622 (DE-599)DOAJf43bf22be04a4a73a00c9c65a56fff49 DE-627 ger DE-627 rakwb eng per R5-920 Mohammad Shokrzadeh verfasserin aut Antioxidant and Hepatoprotective Properties of Vicia cracca Against Carbon Tetrachloride Induced Oxidative Stress in Mice 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and purpose: Vicia cracca (Papilionaceae) has 45 species in Iran. Vicia spp. are known medicinal plants. Some species in this family are well known with distinctive antioxidant activity. This investigation was designed to evaluate the antioxidant activities and hepatoprorective properties of V. cracca in mice. Materials and methods: The aerial parts were extracted by maceration method using methanol as solvent. Antioxidative capacity was assessed by utilizing three different methods: DPPH, nitric oxide (NO) free radicals scavenging, and reducing power. Hepatoprotective activity was evaluated in 50, 100 and 200 mg/kg in CCl4 induced oxidative toxicity. Also, the levels of serum ALT, AST and ALP and hepatic glutathione were measured. Results: Total phenolic content was 17.2 ± 0.9 mg GAE and flavonoid content was 9.78 ± 0.25 mg QE. In DPPH radical scavenging activity, the IC50 value was 1.98 ± 0.25 mg ml-1. The extract showed good reducing power activity indicating significant difference with that of the positive controls (P< 0.05). The extract increased liver glutation content and decreased ALT, AST and ALP levels in mice serum. These effects were dose dependent. The results of histopathology showed a significant decrease in inflammation and necrosis in liver tissues. Conclusion: The findings clearly indicated moderately good antioxidant capacities and potent hepatoprotective properties of the Vicia cracca extract. vicia cracca antioxidant phenol ﬂavonoids hepatoprotection glutathion hepatic enzymes ccl4 Medicine R Medicine (General) Farshid Rahimi verfasserin aut Ali Ziar verfasserin aut Mohammad Ali Ebrahimzadeh verfasserin aut In Journal of Mazandaran University of Medical Sciences Mazandaran University of Medical Sciences, 2018 27(2018), 156, Seite 50-65 (DE-627)59095623X (DE-600)2476989-7 17359279 nnns volume:27 year:2018 number:156 pages:50-65 https://doaj.org/article/f43bf22be04a4a73a00c9c65a56fff49 kostenfrei http://jmums.mazums.ac.ir/article-1-10123-en.html kostenfrei https://doaj.org/toc/1735-9260 Journal toc kostenfrei https://doaj.org/toc/1735-9279 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2018 156 50-65
allfieldsGer	(DE-627)DOAJ081545622 (DE-599)DOAJf43bf22be04a4a73a00c9c65a56fff49 DE-627 ger DE-627 rakwb eng per R5-920 Mohammad Shokrzadeh verfasserin aut Antioxidant and Hepatoprotective Properties of Vicia cracca Against Carbon Tetrachloride Induced Oxidative Stress in Mice 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and purpose: Vicia cracca (Papilionaceae) has 45 species in Iran. Vicia spp. are known medicinal plants. Some species in this family are well known with distinctive antioxidant activity. This investigation was designed to evaluate the antioxidant activities and hepatoprorective properties of V. cracca in mice. Materials and methods: The aerial parts were extracted by maceration method using methanol as solvent. Antioxidative capacity was assessed by utilizing three different methods: DPPH, nitric oxide (NO) free radicals scavenging, and reducing power. Hepatoprotective activity was evaluated in 50, 100 and 200 mg/kg in CCl4 induced oxidative toxicity. Also, the levels of serum ALT, AST and ALP and hepatic glutathione were measured. Results: Total phenolic content was 17.2 ± 0.9 mg GAE and flavonoid content was 9.78 ± 0.25 mg QE. In DPPH radical scavenging activity, the IC50 value was 1.98 ± 0.25 mg ml-1. The extract showed good reducing power activity indicating significant difference with that of the positive controls (P< 0.05). The extract increased liver glutation content and decreased ALT, AST and ALP levels in mice serum. These effects were dose dependent. The results of histopathology showed a significant decrease in inflammation and necrosis in liver tissues. Conclusion: The findings clearly indicated moderately good antioxidant capacities and potent hepatoprotective properties of the Vicia cracca extract. vicia cracca antioxidant phenol ﬂavonoids hepatoprotection glutathion hepatic enzymes ccl4 Medicine R Medicine (General) Farshid Rahimi verfasserin aut Ali Ziar verfasserin aut Mohammad Ali Ebrahimzadeh verfasserin aut In Journal of Mazandaran University of Medical Sciences Mazandaran University of Medical Sciences, 2018 27(2018), 156, Seite 50-65 (DE-627)59095623X (DE-600)2476989-7 17359279 nnns volume:27 year:2018 number:156 pages:50-65 https://doaj.org/article/f43bf22be04a4a73a00c9c65a56fff49 kostenfrei http://jmums.mazums.ac.ir/article-1-10123-en.html kostenfrei https://doaj.org/toc/1735-9260 Journal toc kostenfrei https://doaj.org/toc/1735-9279 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2018 156 50-65
allfieldsSound	(DE-627)DOAJ081545622 (DE-599)DOAJf43bf22be04a4a73a00c9c65a56fff49 DE-627 ger DE-627 rakwb eng per R5-920 Mohammad Shokrzadeh verfasserin aut Antioxidant and Hepatoprotective Properties of Vicia cracca Against Carbon Tetrachloride Induced Oxidative Stress in Mice 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and purpose: Vicia cracca (Papilionaceae) has 45 species in Iran. Vicia spp. are known medicinal plants. Some species in this family are well known with distinctive antioxidant activity. This investigation was designed to evaluate the antioxidant activities and hepatoprorective properties of V. cracca in mice. Materials and methods: The aerial parts were extracted by maceration method using methanol as solvent. Antioxidative capacity was assessed by utilizing three different methods: DPPH, nitric oxide (NO) free radicals scavenging, and reducing power. Hepatoprotective activity was evaluated in 50, 100 and 200 mg/kg in CCl4 induced oxidative toxicity. Also, the levels of serum ALT, AST and ALP and hepatic glutathione were measured. Results: Total phenolic content was 17.2 ± 0.9 mg GAE and flavonoid content was 9.78 ± 0.25 mg QE. In DPPH radical scavenging activity, the IC50 value was 1.98 ± 0.25 mg ml-1. The extract showed good reducing power activity indicating significant difference with that of the positive controls (P< 0.05). The extract increased liver glutation content and decreased ALT, AST and ALP levels in mice serum. These effects were dose dependent. The results of histopathology showed a significant decrease in inflammation and necrosis in liver tissues. Conclusion: The findings clearly indicated moderately good antioxidant capacities and potent hepatoprotective properties of the Vicia cracca extract. vicia cracca antioxidant phenol ﬂavonoids hepatoprotection glutathion hepatic enzymes ccl4 Medicine R Medicine (General) Farshid Rahimi verfasserin aut Ali Ziar verfasserin aut Mohammad Ali Ebrahimzadeh verfasserin aut In Journal of Mazandaran University of Medical Sciences Mazandaran University of Medical Sciences, 2018 27(2018), 156, Seite 50-65 (DE-627)59095623X (DE-600)2476989-7 17359279 nnns volume:27 year:2018 number:156 pages:50-65 https://doaj.org/article/f43bf22be04a4a73a00c9c65a56fff49 kostenfrei http://jmums.mazums.ac.ir/article-1-10123-en.html kostenfrei https://doaj.org/toc/1735-9260 Journal toc kostenfrei https://doaj.org/toc/1735-9279 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2018 156 50-65
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source	In Journal of Mazandaran University of Medical Sciences 27(2018), 156, Seite 50-65 volume:27 year:2018 number:156 pages:50-65
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callnumber-first	R - Medicine
author	Mohammad Shokrzadeh
spellingShingle	Mohammad Shokrzadeh misc R5-920 misc vicia cracca misc antioxidant misc phenol misc ﬂavonoids misc hepatoprotection misc glutathion misc hepatic enzymes misc ccl4 misc Medicine misc R misc Medicine (General) Antioxidant and Hepatoprotective Properties of Vicia cracca Against Carbon Tetrachloride Induced Oxidative Stress in Mice
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topic_title	R5-920 Antioxidant and Hepatoprotective Properties of Vicia cracca Against Carbon Tetrachloride Induced Oxidative Stress in Mice vicia cracca antioxidant phenol ﬂavonoids hepatoprotection glutathion hepatic enzymes ccl4
topic	misc R5-920 misc vicia cracca misc antioxidant misc phenol misc ﬂavonoids misc hepatoprotection misc glutathion misc hepatic enzymes misc ccl4 misc Medicine misc R misc Medicine (General)
topic_unstemmed	misc R5-920 misc vicia cracca misc antioxidant misc phenol misc ﬂavonoids misc hepatoprotection misc glutathion misc hepatic enzymes misc ccl4 misc Medicine misc R misc Medicine (General)
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title	Antioxidant and Hepatoprotective Properties of Vicia cracca Against Carbon Tetrachloride Induced Oxidative Stress in Mice
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title_full	Antioxidant and Hepatoprotective Properties of Vicia cracca Against Carbon Tetrachloride Induced Oxidative Stress in Mice
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title_sort	antioxidant and hepatoprotective properties of vicia cracca against carbon tetrachloride induced oxidative stress in mice
callnumber	R5-920
title_auth	Antioxidant and Hepatoprotective Properties of Vicia cracca Against Carbon Tetrachloride Induced Oxidative Stress in Mice
abstract	Background and purpose: Vicia cracca (Papilionaceae) has 45 species in Iran. Vicia spp. are known medicinal plants. Some species in this family are well known with distinctive antioxidant activity. This investigation was designed to evaluate the antioxidant activities and hepatoprorective properties of V. cracca in mice. Materials and methods: The aerial parts were extracted by maceration method using methanol as solvent. Antioxidative capacity was assessed by utilizing three different methods: DPPH, nitric oxide (NO) free radicals scavenging, and reducing power. Hepatoprotective activity was evaluated in 50, 100 and 200 mg/kg in CCl4 induced oxidative toxicity. Also, the levels of serum ALT, AST and ALP and hepatic glutathione were measured. Results: Total phenolic content was 17.2 ± 0.9 mg GAE and flavonoid content was 9.78 ± 0.25 mg QE. In DPPH radical scavenging activity, the IC50 value was 1.98 ± 0.25 mg ml-1. The extract showed good reducing power activity indicating significant difference with that of the positive controls (P< 0.05). The extract increased liver glutation content and decreased ALT, AST and ALP levels in mice serum. These effects were dose dependent. The results of histopathology showed a significant decrease in inflammation and necrosis in liver tissues. Conclusion: The findings clearly indicated moderately good antioxidant capacities and potent hepatoprotective properties of the Vicia cracca extract.
abstractGer	Background and purpose: Vicia cracca (Papilionaceae) has 45 species in Iran. Vicia spp. are known medicinal plants. Some species in this family are well known with distinctive antioxidant activity. This investigation was designed to evaluate the antioxidant activities and hepatoprorective properties of V. cracca in mice. Materials and methods: The aerial parts were extracted by maceration method using methanol as solvent. Antioxidative capacity was assessed by utilizing three different methods: DPPH, nitric oxide (NO) free radicals scavenging, and reducing power. Hepatoprotective activity was evaluated in 50, 100 and 200 mg/kg in CCl4 induced oxidative toxicity. Also, the levels of serum ALT, AST and ALP and hepatic glutathione were measured. Results: Total phenolic content was 17.2 ± 0.9 mg GAE and flavonoid content was 9.78 ± 0.25 mg QE. In DPPH radical scavenging activity, the IC50 value was 1.98 ± 0.25 mg ml-1. The extract showed good reducing power activity indicating significant difference with that of the positive controls (P< 0.05). The extract increased liver glutation content and decreased ALT, AST and ALP levels in mice serum. These effects were dose dependent. The results of histopathology showed a significant decrease in inflammation and necrosis in liver tissues. Conclusion: The findings clearly indicated moderately good antioxidant capacities and potent hepatoprotective properties of the Vicia cracca extract.
abstract_unstemmed	Background and purpose: Vicia cracca (Papilionaceae) has 45 species in Iran. Vicia spp. are known medicinal plants. Some species in this family are well known with distinctive antioxidant activity. This investigation was designed to evaluate the antioxidant activities and hepatoprorective properties of V. cracca in mice. Materials and methods: The aerial parts were extracted by maceration method using methanol as solvent. Antioxidative capacity was assessed by utilizing three different methods: DPPH, nitric oxide (NO) free radicals scavenging, and reducing power. Hepatoprotective activity was evaluated in 50, 100 and 200 mg/kg in CCl4 induced oxidative toxicity. Also, the levels of serum ALT, AST and ALP and hepatic glutathione were measured. Results: Total phenolic content was 17.2 ± 0.9 mg GAE and flavonoid content was 9.78 ± 0.25 mg QE. In DPPH radical scavenging activity, the IC50 value was 1.98 ± 0.25 mg ml-1. The extract showed good reducing power activity indicating significant difference with that of the positive controls (P< 0.05). The extract increased liver glutation content and decreased ALT, AST and ALP levels in mice serum. These effects were dose dependent. The results of histopathology showed a significant decrease in inflammation and necrosis in liver tissues. Conclusion: The findings clearly indicated moderately good antioxidant capacities and potent hepatoprotective properties of the Vicia cracca extract.
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title_short	Antioxidant and Hepatoprotective Properties of Vicia cracca Against Carbon Tetrachloride Induced Oxidative Stress in Mice
url	https://doaj.org/article/f43bf22be04a4a73a00c9c65a56fff49 http://jmums.mazums.ac.ir/article-1-10123-en.html https://doaj.org/toc/1735-9260 https://doaj.org/toc/1735-9279
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author2	Farshid Rahimi Ali Ziar Mohammad Ali Ebrahimzadeh
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Antioxidant and Hepatoprotective Properties of Vicia cracca Against Carbon Tetrachloride Induced Oxidative Stress in Mice

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