Prevalence, risk, and outcomes of venous thromboembolic events in kidney transplant recipients: a nested case-control study

AbstractIntroduction Thromboembolism is more common in kidney transplant recipients (KTRs) than in the general population. Studies evaluating arterial and venous thromboembolism (VTE) in KTRs are scarce and the magnitude and risk factors are mostly undefined.Methods A nested control study was conduc...
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Autor*in:	Vinant Bhargava [verfasserIn] Priti Meena [verfasserIn] Anil Kumar Bhalla [verfasserIn] Devinder Singh Rana [verfasserIn] Ashwani Gupta [verfasserIn] Manish Malik [verfasserIn] Anurag Gupta [verfasserIn] Vaibhav Tiwari [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Chemoprophylaxis deep vein thrombosis kidney transplant recipient venous thromboembolic events

Übergeordnetes Werk:	In: Renal Failure - Taylor & Francis Group, 2018, 45(2023), 1
Übergeordnetes Werk:	volume:45 ; year:2023 ; number:1

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1080/0886022X.2022.2161395

Katalog-ID:	DOAJ081612176

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520			\|a AbstractIntroduction Thromboembolism is more common in kidney transplant recipients (KTRs) than in the general population. Studies evaluating arterial and venous thromboembolism (VTE) in KTRs are scarce and the magnitude and risk factors are mostly undefined.Methods A nested control study was conducted from January 1, 2007, to December 31, 2019. Adult KTRs who were detected to have VTE events during this period were included. The primary outcome was to assess the prevalence of VTE in this population. Secondary outcomes were the assessment of the time to occurrence of the thromboembolic events after transplantation and assessing the risk factors and patient survival. For each subject studied, 4 controls were matched from the data set.Results Amongst 2158 patients, 97 (4.5%) were found to have VTE. The median follow-up time was 3.9 years (6–156 months). A total of 101 VTE events were recorded. The most common site of VTE was the lower limb deep vein thrombosis in 79 patients (0.03%)). In multivariate Cox regression analysis, serum creatinine of more than 3 mg/dl [HR 1.30, 95% CI (1.03–1.38)] was independently associated with increased VTE risk. Patients who developed a VTE had higher mortality as compared to patients who did not develop VTE. No increased risk of graft failure was found in VTE patients.Conclusion This study suggests that kidney transplantation surgery is a moderate risk factor for VTE, and VTE is associated with higher morbidity and mortality. However, prospective studies are needed to establish a definite role of VTE in outcomes in KTRs.
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allfields	10.1080/0886022X.2022.2161395 doi (DE-627)DOAJ081612176 (DE-599)DOAJ8d174034c6754ab288548b95834cd5eb DE-627 ger DE-627 rakwb eng RC870-923 Vinant Bhargava verfasserin aut Prevalence, risk, and outcomes of venous thromboembolic events in kidney transplant recipients: a nested case-control study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier AbstractIntroduction Thromboembolism is more common in kidney transplant recipients (KTRs) than in the general population. Studies evaluating arterial and venous thromboembolism (VTE) in KTRs are scarce and the magnitude and risk factors are mostly undefined.Methods A nested control study was conducted from January 1, 2007, to December 31, 2019. Adult KTRs who were detected to have VTE events during this period were included. The primary outcome was to assess the prevalence of VTE in this population. Secondary outcomes were the assessment of the time to occurrence of the thromboembolic events after transplantation and assessing the risk factors and patient survival. For each subject studied, 4 controls were matched from the data set.Results Amongst 2158 patients, 97 (4.5%) were found to have VTE. The median follow-up time was 3.9 years (6–156 months). A total of 101 VTE events were recorded. The most common site of VTE was the lower limb deep vein thrombosis in 79 patients (0.03%)). In multivariate Cox regression analysis, serum creatinine of more than 3 mg/dl [HR 1.30, 95% CI (1.03–1.38)] was independently associated with increased VTE risk. Patients who developed a VTE had higher mortality as compared to patients who did not develop VTE. No increased risk of graft failure was found in VTE patients.Conclusion This study suggests that kidney transplantation surgery is a moderate risk factor for VTE, and VTE is associated with higher morbidity and mortality. However, prospective studies are needed to establish a definite role of VTE in outcomes in KTRs. Chemoprophylaxis deep vein thrombosis kidney transplant recipient venous thromboembolic events Diseases of the genitourinary system. Urology Priti Meena verfasserin aut Anil Kumar Bhalla verfasserin aut Devinder Singh Rana verfasserin aut Ashwani Gupta verfasserin aut Manish Malik verfasserin aut Anurag Gupta verfasserin aut Vaibhav Tiwari verfasserin aut In Renal Failure Taylor & Francis Group, 2018 45(2023), 1 (DE-627)320528421 (DE-600)2015459-8 15256049 nnns volume:45 year:2023 number:1 https://doi.org/10.1080/0886022X.2022.2161395 kostenfrei https://doaj.org/article/8d174034c6754ab288548b95834cd5eb kostenfrei https://www.tandfonline.com/doi/10.1080/0886022X.2022.2161395 kostenfrei https://doaj.org/toc/0886-022X Journal toc kostenfrei https://doaj.org/toc/1525-6049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 45 2023 1
spelling	10.1080/0886022X.2022.2161395 doi (DE-627)DOAJ081612176 (DE-599)DOAJ8d174034c6754ab288548b95834cd5eb DE-627 ger DE-627 rakwb eng RC870-923 Vinant Bhargava verfasserin aut Prevalence, risk, and outcomes of venous thromboembolic events in kidney transplant recipients: a nested case-control study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier AbstractIntroduction Thromboembolism is more common in kidney transplant recipients (KTRs) than in the general population. Studies evaluating arterial and venous thromboembolism (VTE) in KTRs are scarce and the magnitude and risk factors are mostly undefined.Methods A nested control study was conducted from January 1, 2007, to December 31, 2019. Adult KTRs who were detected to have VTE events during this period were included. The primary outcome was to assess the prevalence of VTE in this population. Secondary outcomes were the assessment of the time to occurrence of the thromboembolic events after transplantation and assessing the risk factors and patient survival. For each subject studied, 4 controls were matched from the data set.Results Amongst 2158 patients, 97 (4.5%) were found to have VTE. The median follow-up time was 3.9 years (6–156 months). A total of 101 VTE events were recorded. The most common site of VTE was the lower limb deep vein thrombosis in 79 patients (0.03%)). In multivariate Cox regression analysis, serum creatinine of more than 3 mg/dl [HR 1.30, 95% CI (1.03–1.38)] was independently associated with increased VTE risk. Patients who developed a VTE had higher mortality as compared to patients who did not develop VTE. No increased risk of graft failure was found in VTE patients.Conclusion This study suggests that kidney transplantation surgery is a moderate risk factor for VTE, and VTE is associated with higher morbidity and mortality. However, prospective studies are needed to establish a definite role of VTE in outcomes in KTRs. Chemoprophylaxis deep vein thrombosis kidney transplant recipient venous thromboembolic events Diseases of the genitourinary system. Urology Priti Meena verfasserin aut Anil Kumar Bhalla verfasserin aut Devinder Singh Rana verfasserin aut Ashwani Gupta verfasserin aut Manish Malik verfasserin aut Anurag Gupta verfasserin aut Vaibhav Tiwari verfasserin aut In Renal Failure Taylor & Francis Group, 2018 45(2023), 1 (DE-627)320528421 (DE-600)2015459-8 15256049 nnns volume:45 year:2023 number:1 https://doi.org/10.1080/0886022X.2022.2161395 kostenfrei https://doaj.org/article/8d174034c6754ab288548b95834cd5eb kostenfrei https://www.tandfonline.com/doi/10.1080/0886022X.2022.2161395 kostenfrei https://doaj.org/toc/0886-022X Journal toc kostenfrei https://doaj.org/toc/1525-6049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 45 2023 1
allfields_unstemmed	10.1080/0886022X.2022.2161395 doi (DE-627)DOAJ081612176 (DE-599)DOAJ8d174034c6754ab288548b95834cd5eb DE-627 ger DE-627 rakwb eng RC870-923 Vinant Bhargava verfasserin aut Prevalence, risk, and outcomes of venous thromboembolic events in kidney transplant recipients: a nested case-control study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier AbstractIntroduction Thromboembolism is more common in kidney transplant recipients (KTRs) than in the general population. Studies evaluating arterial and venous thromboembolism (VTE) in KTRs are scarce and the magnitude and risk factors are mostly undefined.Methods A nested control study was conducted from January 1, 2007, to December 31, 2019. Adult KTRs who were detected to have VTE events during this period were included. The primary outcome was to assess the prevalence of VTE in this population. Secondary outcomes were the assessment of the time to occurrence of the thromboembolic events after transplantation and assessing the risk factors and patient survival. For each subject studied, 4 controls were matched from the data set.Results Amongst 2158 patients, 97 (4.5%) were found to have VTE. The median follow-up time was 3.9 years (6–156 months). A total of 101 VTE events were recorded. The most common site of VTE was the lower limb deep vein thrombosis in 79 patients (0.03%)). In multivariate Cox regression analysis, serum creatinine of more than 3 mg/dl [HR 1.30, 95% CI (1.03–1.38)] was independently associated with increased VTE risk. Patients who developed a VTE had higher mortality as compared to patients who did not develop VTE. No increased risk of graft failure was found in VTE patients.Conclusion This study suggests that kidney transplantation surgery is a moderate risk factor for VTE, and VTE is associated with higher morbidity and mortality. However, prospective studies are needed to establish a definite role of VTE in outcomes in KTRs. Chemoprophylaxis deep vein thrombosis kidney transplant recipient venous thromboembolic events Diseases of the genitourinary system. Urology Priti Meena verfasserin aut Anil Kumar Bhalla verfasserin aut Devinder Singh Rana verfasserin aut Ashwani Gupta verfasserin aut Manish Malik verfasserin aut Anurag Gupta verfasserin aut Vaibhav Tiwari verfasserin aut In Renal Failure Taylor & Francis Group, 2018 45(2023), 1 (DE-627)320528421 (DE-600)2015459-8 15256049 nnns volume:45 year:2023 number:1 https://doi.org/10.1080/0886022X.2022.2161395 kostenfrei https://doaj.org/article/8d174034c6754ab288548b95834cd5eb kostenfrei https://www.tandfonline.com/doi/10.1080/0886022X.2022.2161395 kostenfrei https://doaj.org/toc/0886-022X Journal toc kostenfrei https://doaj.org/toc/1525-6049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 45 2023 1
allfieldsGer	10.1080/0886022X.2022.2161395 doi (DE-627)DOAJ081612176 (DE-599)DOAJ8d174034c6754ab288548b95834cd5eb DE-627 ger DE-627 rakwb eng RC870-923 Vinant Bhargava verfasserin aut Prevalence, risk, and outcomes of venous thromboembolic events in kidney transplant recipients: a nested case-control study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier AbstractIntroduction Thromboembolism is more common in kidney transplant recipients (KTRs) than in the general population. Studies evaluating arterial and venous thromboembolism (VTE) in KTRs are scarce and the magnitude and risk factors are mostly undefined.Methods A nested control study was conducted from January 1, 2007, to December 31, 2019. Adult KTRs who were detected to have VTE events during this period were included. The primary outcome was to assess the prevalence of VTE in this population. Secondary outcomes were the assessment of the time to occurrence of the thromboembolic events after transplantation and assessing the risk factors and patient survival. For each subject studied, 4 controls were matched from the data set.Results Amongst 2158 patients, 97 (4.5%) were found to have VTE. The median follow-up time was 3.9 years (6–156 months). A total of 101 VTE events were recorded. The most common site of VTE was the lower limb deep vein thrombosis in 79 patients (0.03%)). In multivariate Cox regression analysis, serum creatinine of more than 3 mg/dl [HR 1.30, 95% CI (1.03–1.38)] was independently associated with increased VTE risk. Patients who developed a VTE had higher mortality as compared to patients who did not develop VTE. No increased risk of graft failure was found in VTE patients.Conclusion This study suggests that kidney transplantation surgery is a moderate risk factor for VTE, and VTE is associated with higher morbidity and mortality. However, prospective studies are needed to establish a definite role of VTE in outcomes in KTRs. Chemoprophylaxis deep vein thrombosis kidney transplant recipient venous thromboembolic events Diseases of the genitourinary system. Urology Priti Meena verfasserin aut Anil Kumar Bhalla verfasserin aut Devinder Singh Rana verfasserin aut Ashwani Gupta verfasserin aut Manish Malik verfasserin aut Anurag Gupta verfasserin aut Vaibhav Tiwari verfasserin aut In Renal Failure Taylor & Francis Group, 2018 45(2023), 1 (DE-627)320528421 (DE-600)2015459-8 15256049 nnns volume:45 year:2023 number:1 https://doi.org/10.1080/0886022X.2022.2161395 kostenfrei https://doaj.org/article/8d174034c6754ab288548b95834cd5eb kostenfrei https://www.tandfonline.com/doi/10.1080/0886022X.2022.2161395 kostenfrei https://doaj.org/toc/0886-022X Journal toc kostenfrei https://doaj.org/toc/1525-6049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 45 2023 1
allfieldsSound	10.1080/0886022X.2022.2161395 doi (DE-627)DOAJ081612176 (DE-599)DOAJ8d174034c6754ab288548b95834cd5eb DE-627 ger DE-627 rakwb eng RC870-923 Vinant Bhargava verfasserin aut Prevalence, risk, and outcomes of venous thromboembolic events in kidney transplant recipients: a nested case-control study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier AbstractIntroduction Thromboembolism is more common in kidney transplant recipients (KTRs) than in the general population. Studies evaluating arterial and venous thromboembolism (VTE) in KTRs are scarce and the magnitude and risk factors are mostly undefined.Methods A nested control study was conducted from January 1, 2007, to December 31, 2019. Adult KTRs who were detected to have VTE events during this period were included. The primary outcome was to assess the prevalence of VTE in this population. Secondary outcomes were the assessment of the time to occurrence of the thromboembolic events after transplantation and assessing the risk factors and patient survival. For each subject studied, 4 controls were matched from the data set.Results Amongst 2158 patients, 97 (4.5%) were found to have VTE. The median follow-up time was 3.9 years (6–156 months). A total of 101 VTE events were recorded. The most common site of VTE was the lower limb deep vein thrombosis in 79 patients (0.03%)). In multivariate Cox regression analysis, serum creatinine of more than 3 mg/dl [HR 1.30, 95% CI (1.03–1.38)] was independently associated with increased VTE risk. Patients who developed a VTE had higher mortality as compared to patients who did not develop VTE. No increased risk of graft failure was found in VTE patients.Conclusion This study suggests that kidney transplantation surgery is a moderate risk factor for VTE, and VTE is associated with higher morbidity and mortality. However, prospective studies are needed to establish a definite role of VTE in outcomes in KTRs. Chemoprophylaxis deep vein thrombosis kidney transplant recipient venous thromboembolic events Diseases of the genitourinary system. Urology Priti Meena verfasserin aut Anil Kumar Bhalla verfasserin aut Devinder Singh Rana verfasserin aut Ashwani Gupta verfasserin aut Manish Malik verfasserin aut Anurag Gupta verfasserin aut Vaibhav Tiwari verfasserin aut In Renal Failure Taylor & Francis Group, 2018 45(2023), 1 (DE-627)320528421 (DE-600)2015459-8 15256049 nnns volume:45 year:2023 number:1 https://doi.org/10.1080/0886022X.2022.2161395 kostenfrei https://doaj.org/article/8d174034c6754ab288548b95834cd5eb kostenfrei https://www.tandfonline.com/doi/10.1080/0886022X.2022.2161395 kostenfrei https://doaj.org/toc/0886-022X Journal toc kostenfrei https://doaj.org/toc/1525-6049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 45 2023 1
language	English
source	In Renal Failure 45(2023), 1 volume:45 year:2023 number:1
sourceStr	In Renal Failure 45(2023), 1 volume:45 year:2023 number:1
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Chemoprophylaxis deep vein thrombosis kidney transplant recipient venous thromboembolic events Diseases of the genitourinary system. Urology
isfreeaccess_bool	true
container_title	Renal Failure
authorswithroles_txt_mv	Vinant Bhargava @@aut@@ Priti Meena @@aut@@ Anil Kumar Bhalla @@aut@@ Devinder Singh Rana @@aut@@ Ashwani Gupta @@aut@@ Manish Malik @@aut@@ Anurag Gupta @@aut@@ Vaibhav Tiwari @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	320528421
id	DOAJ081612176
language_de	englisch
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Studies evaluating arterial and venous thromboembolism (VTE) in KTRs are scarce and the magnitude and risk factors are mostly undefined.Methods A nested control study was conducted from January 1, 2007, to December 31, 2019. Adult KTRs who were detected to have VTE events during this period were included. The primary outcome was to assess the prevalence of VTE in this population. Secondary outcomes were the assessment of the time to occurrence of the thromboembolic events after transplantation and assessing the risk factors and patient survival. For each subject studied, 4 controls were matched from the data set.Results Amongst 2158 patients, 97 (4.5%) were found to have VTE. The median follow-up time was 3.9 years (6–156 months). A total of 101 VTE events were recorded. The most common site of VTE was the lower limb deep vein thrombosis in 79 patients (0.03%)). In multivariate Cox regression analysis, serum creatinine of more than 3 mg/dl [HR 1.30, 95% CI (1.03–1.38)] was independently associated with increased VTE risk. Patients who developed a VTE had higher mortality as compared to patients who did not develop VTE. No increased risk of graft failure was found in VTE patients.Conclusion This study suggests that kidney transplantation surgery is a moderate risk factor for VTE, and VTE is associated with higher morbidity and mortality. 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callnumber-first	R - Medicine
author	Vinant Bhargava
spellingShingle	Vinant Bhargava misc RC870-923 misc Chemoprophylaxis misc deep vein thrombosis misc kidney transplant recipient misc venous thromboembolic events misc Diseases of the genitourinary system. Urology Prevalence, risk, and outcomes of venous thromboembolic events in kidney transplant recipients: a nested case-control study
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topic_title	RC870-923 Prevalence, risk, and outcomes of venous thromboembolic events in kidney transplant recipients: a nested case-control study Chemoprophylaxis deep vein thrombosis kidney transplant recipient venous thromboembolic events
topic	misc RC870-923 misc Chemoprophylaxis misc deep vein thrombosis misc kidney transplant recipient misc venous thromboembolic events misc Diseases of the genitourinary system. Urology
topic_unstemmed	misc RC870-923 misc Chemoprophylaxis misc deep vein thrombosis misc kidney transplant recipient misc venous thromboembolic events misc Diseases of the genitourinary system. Urology
topic_browse	misc RC870-923 misc Chemoprophylaxis misc deep vein thrombosis misc kidney transplant recipient misc venous thromboembolic events misc Diseases of the genitourinary system. Urology
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title	Prevalence, risk, and outcomes of venous thromboembolic events in kidney transplant recipients: a nested case-control study
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title_full	Prevalence, risk, and outcomes of venous thromboembolic events in kidney transplant recipients: a nested case-control study
author_sort	Vinant Bhargava
journal	Renal Failure
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author_browse	Vinant Bhargava Priti Meena Anil Kumar Bhalla Devinder Singh Rana Ashwani Gupta Manish Malik Anurag Gupta Vaibhav Tiwari
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title_sort	prevalence, risk, and outcomes of venous thromboembolic events in kidney transplant recipients: a nested case-control study
callnumber	RC870-923
title_auth	Prevalence, risk, and outcomes of venous thromboembolic events in kidney transplant recipients: a nested case-control study
abstract	AbstractIntroduction Thromboembolism is more common in kidney transplant recipients (KTRs) than in the general population. Studies evaluating arterial and venous thromboembolism (VTE) in KTRs are scarce and the magnitude and risk factors are mostly undefined.Methods A nested control study was conducted from January 1, 2007, to December 31, 2019. Adult KTRs who were detected to have VTE events during this period were included. The primary outcome was to assess the prevalence of VTE in this population. Secondary outcomes were the assessment of the time to occurrence of the thromboembolic events after transplantation and assessing the risk factors and patient survival. For each subject studied, 4 controls were matched from the data set.Results Amongst 2158 patients, 97 (4.5%) were found to have VTE. The median follow-up time was 3.9 years (6–156 months). A total of 101 VTE events were recorded. The most common site of VTE was the lower limb deep vein thrombosis in 79 patients (0.03%)). In multivariate Cox regression analysis, serum creatinine of more than 3 mg/dl [HR 1.30, 95% CI (1.03–1.38)] was independently associated with increased VTE risk. Patients who developed a VTE had higher mortality as compared to patients who did not develop VTE. No increased risk of graft failure was found in VTE patients.Conclusion This study suggests that kidney transplantation surgery is a moderate risk factor for VTE, and VTE is associated with higher morbidity and mortality. However, prospective studies are needed to establish a definite role of VTE in outcomes in KTRs.
abstractGer	AbstractIntroduction Thromboembolism is more common in kidney transplant recipients (KTRs) than in the general population. Studies evaluating arterial and venous thromboembolism (VTE) in KTRs are scarce and the magnitude and risk factors are mostly undefined.Methods A nested control study was conducted from January 1, 2007, to December 31, 2019. Adult KTRs who were detected to have VTE events during this period were included. The primary outcome was to assess the prevalence of VTE in this population. Secondary outcomes were the assessment of the time to occurrence of the thromboembolic events after transplantation and assessing the risk factors and patient survival. For each subject studied, 4 controls were matched from the data set.Results Amongst 2158 patients, 97 (4.5%) were found to have VTE. The median follow-up time was 3.9 years (6–156 months). A total of 101 VTE events were recorded. The most common site of VTE was the lower limb deep vein thrombosis in 79 patients (0.03%)). In multivariate Cox regression analysis, serum creatinine of more than 3 mg/dl [HR 1.30, 95% CI (1.03–1.38)] was independently associated with increased VTE risk. Patients who developed a VTE had higher mortality as compared to patients who did not develop VTE. No increased risk of graft failure was found in VTE patients.Conclusion This study suggests that kidney transplantation surgery is a moderate risk factor for VTE, and VTE is associated with higher morbidity and mortality. However, prospective studies are needed to establish a definite role of VTE in outcomes in KTRs.
abstract_unstemmed	AbstractIntroduction Thromboembolism is more common in kidney transplant recipients (KTRs) than in the general population. Studies evaluating arterial and venous thromboembolism (VTE) in KTRs are scarce and the magnitude and risk factors are mostly undefined.Methods A nested control study was conducted from January 1, 2007, to December 31, 2019. Adult KTRs who were detected to have VTE events during this period were included. The primary outcome was to assess the prevalence of VTE in this population. Secondary outcomes were the assessment of the time to occurrence of the thromboembolic events after transplantation and assessing the risk factors and patient survival. For each subject studied, 4 controls were matched from the data set.Results Amongst 2158 patients, 97 (4.5%) were found to have VTE. The median follow-up time was 3.9 years (6–156 months). A total of 101 VTE events were recorded. The most common site of VTE was the lower limb deep vein thrombosis in 79 patients (0.03%)). In multivariate Cox regression analysis, serum creatinine of more than 3 mg/dl [HR 1.30, 95% CI (1.03–1.38)] was independently associated with increased VTE risk. Patients who developed a VTE had higher mortality as compared to patients who did not develop VTE. No increased risk of graft failure was found in VTE patients.Conclusion This study suggests that kidney transplantation surgery is a moderate risk factor for VTE, and VTE is associated with higher morbidity and mortality. However, prospective studies are needed to establish a definite role of VTE in outcomes in KTRs.
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title_short	Prevalence, risk, and outcomes of venous thromboembolic events in kidney transplant recipients: a nested case-control study
url	https://doi.org/10.1080/0886022X.2022.2161395 https://doaj.org/article/8d174034c6754ab288548b95834cd5eb https://www.tandfonline.com/doi/10.1080/0886022X.2022.2161395 https://doaj.org/toc/0886-022X https://doaj.org/toc/1525-6049
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Prevalence, risk, and outcomes of venous thromboembolic events in kidney transplant recipients: a nested case-control study

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