Tryptophan metabolites predict response after cognitive behavioral therapy for depression: A single-arm trial.

Background: Cognitive behavioral therapy (CBT) is one of the most prominent standard treatments for depression. However, like with antidepressant drugs, a subgroup of patients remains unresponsive. Since an imbalance in serotonin and kynurenine pathway metabolites are involved in the pathophysiology...
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Autor*in:	Maria S Simon [verfasserIn] Elif Weidinger [verfasserIn] Bianka Burger [verfasserIn] Yasemin Kisla [verfasserIn] Julia Niedeggen [verfasserIn] Petra Thaler [verfasserIn] Michael Zaudig [verfasserIn] Ulrich Voderholzer [verfasserIn] Markus Schwarz [verfasserIn] Norbert Müller [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Depressive episode Psychotherapy Kynurenine Serotonin Inflammation 5-HIAA

Übergeordnetes Werk:	In: Journal of Affective Disorders Reports - Elsevier, 2021, 11(2023), Seite 100464-
Übergeordnetes Werk:	volume:11 ; year:2023 ; pages:100464-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.jadr.2023.100464

Katalog-ID:	DOAJ081670885

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520			\|a Background: Cognitive behavioral therapy (CBT) is one of the most prominent standard treatments for depression. However, like with antidepressant drugs, a subgroup of patients remains unresponsive. Since an imbalance in serotonin and kynurenine pathway metabolites are involved in the pathophysiology of depression, this study investigates whether those may be useful biomarkers to predict therapy response. Methods: Adult drug-free patients with a diagnosed depressive episode underwent six weeks of cognitive behavioral therapy in a multimodal setting. Levels of biological parameters were measured at baseline and endpoint using Ultra Performance Liquid Chromatography. Similarly, depression severity was measured by MADRS. Results: Levels of the serotonin metabolite 5-HIAA, kynurenine, the kynurenine metabolite 3-HK, and the kynurenine-tryptophan-ratio (Kyn/Trp) significantly increased until endpoint. Higher baseline levels of all four parameters were predictive for better response at endpoint. However, 3-HK levels were predictive for the continuous outcome of MADRS score change, while kynurenine and 5-HIAA levels were predictive for the binary outcome of response versus non-response, and Kyn/Trp and 5-HIAA for remission status. Limitations: With this single-arm design, results are preliminary and effects at endpoint cannot causally be linked to the CBT intervention. Conclusions: This study shows that tryptophan metabolites may serve as biomarkers for treatment response to CBT to foster individualized treatment choices. However, classifying absolute levels as low or high in relation to other biomarkers is not possible. Controlled studies are needed.
650		4	\|a Depressive episode
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700	0		\|a Ulrich Voderholzer \|e verfasserin \|4 aut
700	0		\|a Markus Schwarz \|e verfasserin \|4 aut
700	0		\|a Norbert Müller \|e verfasserin \|4 aut
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spelling	10.1016/j.jadr.2023.100464 doi (DE-627)DOAJ081670885 (DE-599)DOAJb993b696de634b9fb805e7361dcda67f DE-627 ger DE-627 rakwb eng RZ400-408 Maria S Simon verfasserin aut Tryptophan metabolites predict response after cognitive behavioral therapy for depression: A single-arm trial. 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Cognitive behavioral therapy (CBT) is one of the most prominent standard treatments for depression. However, like with antidepressant drugs, a subgroup of patients remains unresponsive. Since an imbalance in serotonin and kynurenine pathway metabolites are involved in the pathophysiology of depression, this study investigates whether those may be useful biomarkers to predict therapy response. Methods: Adult drug-free patients with a diagnosed depressive episode underwent six weeks of cognitive behavioral therapy in a multimodal setting. Levels of biological parameters were measured at baseline and endpoint using Ultra Performance Liquid Chromatography. Similarly, depression severity was measured by MADRS. Results: Levels of the serotonin metabolite 5-HIAA, kynurenine, the kynurenine metabolite 3-HK, and the kynurenine-tryptophan-ratio (Kyn/Trp) significantly increased until endpoint. Higher baseline levels of all four parameters were predictive for better response at endpoint. However, 3-HK levels were predictive for the continuous outcome of MADRS score change, while kynurenine and 5-HIAA levels were predictive for the binary outcome of response versus non-response, and Kyn/Trp and 5-HIAA for remission status. Limitations: With this single-arm design, results are preliminary and effects at endpoint cannot causally be linked to the CBT intervention. Conclusions: This study shows that tryptophan metabolites may serve as biomarkers for treatment response to CBT to foster individualized treatment choices. However, classifying absolute levels as low or high in relation to other biomarkers is not possible. Controlled studies are needed. Depressive episode Psychotherapy Kynurenine Serotonin Inflammation 5-HIAA Mental healing Elif Weidinger verfasserin aut Bianka Burger verfasserin aut Yasemin Kisla verfasserin aut Julia Niedeggen verfasserin aut Petra Thaler verfasserin aut Michael Zaudig verfasserin aut Ulrich Voderholzer verfasserin aut Markus Schwarz verfasserin aut Norbert Müller verfasserin aut In Journal of Affective Disorders Reports Elsevier, 2021 11(2023), Seite 100464- (DE-627)1747967335 26669153 nnns volume:11 year:2023 pages:100464- https://doi.org/10.1016/j.jadr.2023.100464 kostenfrei https://doaj.org/article/b993b696de634b9fb805e7361dcda67f kostenfrei http://www.sciencedirect.com/science/article/pii/S2666915323000033 kostenfrei https://doaj.org/toc/2666-9153 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 11 2023 100464-
allfields_unstemmed	10.1016/j.jadr.2023.100464 doi (DE-627)DOAJ081670885 (DE-599)DOAJb993b696de634b9fb805e7361dcda67f DE-627 ger DE-627 rakwb eng RZ400-408 Maria S Simon verfasserin aut Tryptophan metabolites predict response after cognitive behavioral therapy for depression: A single-arm trial. 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Cognitive behavioral therapy (CBT) is one of the most prominent standard treatments for depression. However, like with antidepressant drugs, a subgroup of patients remains unresponsive. Since an imbalance in serotonin and kynurenine pathway metabolites are involved in the pathophysiology of depression, this study investigates whether those may be useful biomarkers to predict therapy response. Methods: Adult drug-free patients with a diagnosed depressive episode underwent six weeks of cognitive behavioral therapy in a multimodal setting. Levels of biological parameters were measured at baseline and endpoint using Ultra Performance Liquid Chromatography. Similarly, depression severity was measured by MADRS. Results: Levels of the serotonin metabolite 5-HIAA, kynurenine, the kynurenine metabolite 3-HK, and the kynurenine-tryptophan-ratio (Kyn/Trp) significantly increased until endpoint. Higher baseline levels of all four parameters were predictive for better response at endpoint. However, 3-HK levels were predictive for the continuous outcome of MADRS score change, while kynurenine and 5-HIAA levels were predictive for the binary outcome of response versus non-response, and Kyn/Trp and 5-HIAA for remission status. Limitations: With this single-arm design, results are preliminary and effects at endpoint cannot causally be linked to the CBT intervention. Conclusions: This study shows that tryptophan metabolites may serve as biomarkers for treatment response to CBT to foster individualized treatment choices. However, classifying absolute levels as low or high in relation to other biomarkers is not possible. Controlled studies are needed. Depressive episode Psychotherapy Kynurenine Serotonin Inflammation 5-HIAA Mental healing Elif Weidinger verfasserin aut Bianka Burger verfasserin aut Yasemin Kisla verfasserin aut Julia Niedeggen verfasserin aut Petra Thaler verfasserin aut Michael Zaudig verfasserin aut Ulrich Voderholzer verfasserin aut Markus Schwarz verfasserin aut Norbert Müller verfasserin aut In Journal of Affective Disorders Reports Elsevier, 2021 11(2023), Seite 100464- (DE-627)1747967335 26669153 nnns volume:11 year:2023 pages:100464- https://doi.org/10.1016/j.jadr.2023.100464 kostenfrei https://doaj.org/article/b993b696de634b9fb805e7361dcda67f kostenfrei http://www.sciencedirect.com/science/article/pii/S2666915323000033 kostenfrei https://doaj.org/toc/2666-9153 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 11 2023 100464-
allfieldsGer	10.1016/j.jadr.2023.100464 doi (DE-627)DOAJ081670885 (DE-599)DOAJb993b696de634b9fb805e7361dcda67f DE-627 ger DE-627 rakwb eng RZ400-408 Maria S Simon verfasserin aut Tryptophan metabolites predict response after cognitive behavioral therapy for depression: A single-arm trial. 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Cognitive behavioral therapy (CBT) is one of the most prominent standard treatments for depression. However, like with antidepressant drugs, a subgroup of patients remains unresponsive. Since an imbalance in serotonin and kynurenine pathway metabolites are involved in the pathophysiology of depression, this study investigates whether those may be useful biomarkers to predict therapy response. Methods: Adult drug-free patients with a diagnosed depressive episode underwent six weeks of cognitive behavioral therapy in a multimodal setting. Levels of biological parameters were measured at baseline and endpoint using Ultra Performance Liquid Chromatography. Similarly, depression severity was measured by MADRS. Results: Levels of the serotonin metabolite 5-HIAA, kynurenine, the kynurenine metabolite 3-HK, and the kynurenine-tryptophan-ratio (Kyn/Trp) significantly increased until endpoint. Higher baseline levels of all four parameters were predictive for better response at endpoint. However, 3-HK levels were predictive for the continuous outcome of MADRS score change, while kynurenine and 5-HIAA levels were predictive for the binary outcome of response versus non-response, and Kyn/Trp and 5-HIAA for remission status. Limitations: With this single-arm design, results are preliminary and effects at endpoint cannot causally be linked to the CBT intervention. Conclusions: This study shows that tryptophan metabolites may serve as biomarkers for treatment response to CBT to foster individualized treatment choices. However, classifying absolute levels as low or high in relation to other biomarkers is not possible. Controlled studies are needed. Depressive episode Psychotherapy Kynurenine Serotonin Inflammation 5-HIAA Mental healing Elif Weidinger verfasserin aut Bianka Burger verfasserin aut Yasemin Kisla verfasserin aut Julia Niedeggen verfasserin aut Petra Thaler verfasserin aut Michael Zaudig verfasserin aut Ulrich Voderholzer verfasserin aut Markus Schwarz verfasserin aut Norbert Müller verfasserin aut In Journal of Affective Disorders Reports Elsevier, 2021 11(2023), Seite 100464- (DE-627)1747967335 26669153 nnns volume:11 year:2023 pages:100464- https://doi.org/10.1016/j.jadr.2023.100464 kostenfrei https://doaj.org/article/b993b696de634b9fb805e7361dcda67f kostenfrei http://www.sciencedirect.com/science/article/pii/S2666915323000033 kostenfrei https://doaj.org/toc/2666-9153 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 11 2023 100464-
allfieldsSound	10.1016/j.jadr.2023.100464 doi (DE-627)DOAJ081670885 (DE-599)DOAJb993b696de634b9fb805e7361dcda67f DE-627 ger DE-627 rakwb eng RZ400-408 Maria S Simon verfasserin aut Tryptophan metabolites predict response after cognitive behavioral therapy for depression: A single-arm trial. 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Cognitive behavioral therapy (CBT) is one of the most prominent standard treatments for depression. However, like with antidepressant drugs, a subgroup of patients remains unresponsive. Since an imbalance in serotonin and kynurenine pathway metabolites are involved in the pathophysiology of depression, this study investigates whether those may be useful biomarkers to predict therapy response. Methods: Adult drug-free patients with a diagnosed depressive episode underwent six weeks of cognitive behavioral therapy in a multimodal setting. Levels of biological parameters were measured at baseline and endpoint using Ultra Performance Liquid Chromatography. Similarly, depression severity was measured by MADRS. Results: Levels of the serotonin metabolite 5-HIAA, kynurenine, the kynurenine metabolite 3-HK, and the kynurenine-tryptophan-ratio (Kyn/Trp) significantly increased until endpoint. Higher baseline levels of all four parameters were predictive for better response at endpoint. However, 3-HK levels were predictive for the continuous outcome of MADRS score change, while kynurenine and 5-HIAA levels were predictive for the binary outcome of response versus non-response, and Kyn/Trp and 5-HIAA for remission status. Limitations: With this single-arm design, results are preliminary and effects at endpoint cannot causally be linked to the CBT intervention. Conclusions: This study shows that tryptophan metabolites may serve as biomarkers for treatment response to CBT to foster individualized treatment choices. However, classifying absolute levels as low or high in relation to other biomarkers is not possible. Controlled studies are needed. Depressive episode Psychotherapy Kynurenine Serotonin Inflammation 5-HIAA Mental healing Elif Weidinger verfasserin aut Bianka Burger verfasserin aut Yasemin Kisla verfasserin aut Julia Niedeggen verfasserin aut Petra Thaler verfasserin aut Michael Zaudig verfasserin aut Ulrich Voderholzer verfasserin aut Markus Schwarz verfasserin aut Norbert Müller verfasserin aut In Journal of Affective Disorders Reports Elsevier, 2021 11(2023), Seite 100464- (DE-627)1747967335 26669153 nnns volume:11 year:2023 pages:100464- https://doi.org/10.1016/j.jadr.2023.100464 kostenfrei https://doaj.org/article/b993b696de634b9fb805e7361dcda67f kostenfrei http://www.sciencedirect.com/science/article/pii/S2666915323000033 kostenfrei https://doaj.org/toc/2666-9153 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 11 2023 100464-
language	English
source	In Journal of Affective Disorders Reports 11(2023), Seite 100464- volume:11 year:2023 pages:100464-
sourceStr	In Journal of Affective Disorders Reports 11(2023), Seite 100464- volume:11 year:2023 pages:100464-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Depressive episode Psychotherapy Kynurenine Serotonin Inflammation 5-HIAA Mental healing
isfreeaccess_bool	true
container_title	Journal of Affective Disorders Reports
authorswithroles_txt_mv	Maria S Simon @@aut@@ Elif Weidinger @@aut@@ Bianka Burger @@aut@@ Yasemin Kisla @@aut@@ Julia Niedeggen @@aut@@ Petra Thaler @@aut@@ Michael Zaudig @@aut@@ Ulrich Voderholzer @@aut@@ Markus Schwarz @@aut@@ Norbert Müller @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	1747967335
id	DOAJ081670885
language_de	englisch
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However, like with antidepressant drugs, a subgroup of patients remains unresponsive. Since an imbalance in serotonin and kynurenine pathway metabolites are involved in the pathophysiology of depression, this study investigates whether those may be useful biomarkers to predict therapy response. Methods: Adult drug-free patients with a diagnosed depressive episode underwent six weeks of cognitive behavioral therapy in a multimodal setting. Levels of biological parameters were measured at baseline and endpoint using Ultra Performance Liquid Chromatography. Similarly, depression severity was measured by MADRS. Results: Levels of the serotonin metabolite 5-HIAA, kynurenine, the kynurenine metabolite 3-HK, and the kynurenine-tryptophan-ratio (Kyn/Trp) significantly increased until endpoint. Higher baseline levels of all four parameters were predictive for better response at endpoint. However, 3-HK levels were predictive for the continuous outcome of MADRS score change, while kynurenine and 5-HIAA levels were predictive for the binary outcome of response versus non-response, and Kyn/Trp and 5-HIAA for remission status. Limitations: With this single-arm design, results are preliminary and effects at endpoint cannot causally be linked to the CBT intervention. Conclusions: This study shows that tryptophan metabolites may serve as biomarkers for treatment response to CBT to foster individualized treatment choices. However, classifying absolute levels as low or high in relation to other biomarkers is not possible. 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callnumber-first	R - Medicine
author	Maria S Simon
spellingShingle	Maria S Simon misc RZ400-408 misc Depressive episode misc Psychotherapy misc Kynurenine misc Serotonin misc Inflammation misc 5-HIAA misc Mental healing Tryptophan metabolites predict response after cognitive behavioral therapy for depression: A single-arm trial.
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topic_title	RZ400-408 Tryptophan metabolites predict response after cognitive behavioral therapy for depression: A single-arm trial Depressive episode Psychotherapy Kynurenine Serotonin Inflammation 5-HIAA
topic	misc RZ400-408 misc Depressive episode misc Psychotherapy misc Kynurenine misc Serotonin misc Inflammation misc 5-HIAA misc Mental healing
topic_unstemmed	misc RZ400-408 misc Depressive episode misc Psychotherapy misc Kynurenine misc Serotonin misc Inflammation misc 5-HIAA misc Mental healing
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title	Tryptophan metabolites predict response after cognitive behavioral therapy for depression: A single-arm trial.
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title_full	Tryptophan metabolites predict response after cognitive behavioral therapy for depression: A single-arm trial
author_sort	Maria S Simon
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author_browse	Maria S Simon Elif Weidinger Bianka Burger Yasemin Kisla Julia Niedeggen Petra Thaler Michael Zaudig Ulrich Voderholzer Markus Schwarz Norbert Müller
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title_sort	tryptophan metabolites predict response after cognitive behavioral therapy for depression: a single-arm trial
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title_auth	Tryptophan metabolites predict response after cognitive behavioral therapy for depression: A single-arm trial.
abstract	Background: Cognitive behavioral therapy (CBT) is one of the most prominent standard treatments for depression. However, like with antidepressant drugs, a subgroup of patients remains unresponsive. Since an imbalance in serotonin and kynurenine pathway metabolites are involved in the pathophysiology of depression, this study investigates whether those may be useful biomarkers to predict therapy response. Methods: Adult drug-free patients with a diagnosed depressive episode underwent six weeks of cognitive behavioral therapy in a multimodal setting. Levels of biological parameters were measured at baseline and endpoint using Ultra Performance Liquid Chromatography. Similarly, depression severity was measured by MADRS. Results: Levels of the serotonin metabolite 5-HIAA, kynurenine, the kynurenine metabolite 3-HK, and the kynurenine-tryptophan-ratio (Kyn/Trp) significantly increased until endpoint. Higher baseline levels of all four parameters were predictive for better response at endpoint. However, 3-HK levels were predictive for the continuous outcome of MADRS score change, while kynurenine and 5-HIAA levels were predictive for the binary outcome of response versus non-response, and Kyn/Trp and 5-HIAA for remission status. Limitations: With this single-arm design, results are preliminary and effects at endpoint cannot causally be linked to the CBT intervention. Conclusions: This study shows that tryptophan metabolites may serve as biomarkers for treatment response to CBT to foster individualized treatment choices. However, classifying absolute levels as low or high in relation to other biomarkers is not possible. Controlled studies are needed.
abstractGer	Background: Cognitive behavioral therapy (CBT) is one of the most prominent standard treatments for depression. However, like with antidepressant drugs, a subgroup of patients remains unresponsive. Since an imbalance in serotonin and kynurenine pathway metabolites are involved in the pathophysiology of depression, this study investigates whether those may be useful biomarkers to predict therapy response. Methods: Adult drug-free patients with a diagnosed depressive episode underwent six weeks of cognitive behavioral therapy in a multimodal setting. Levels of biological parameters were measured at baseline and endpoint using Ultra Performance Liquid Chromatography. Similarly, depression severity was measured by MADRS. Results: Levels of the serotonin metabolite 5-HIAA, kynurenine, the kynurenine metabolite 3-HK, and the kynurenine-tryptophan-ratio (Kyn/Trp) significantly increased until endpoint. Higher baseline levels of all four parameters were predictive for better response at endpoint. However, 3-HK levels were predictive for the continuous outcome of MADRS score change, while kynurenine and 5-HIAA levels were predictive for the binary outcome of response versus non-response, and Kyn/Trp and 5-HIAA for remission status. Limitations: With this single-arm design, results are preliminary and effects at endpoint cannot causally be linked to the CBT intervention. Conclusions: This study shows that tryptophan metabolites may serve as biomarkers for treatment response to CBT to foster individualized treatment choices. However, classifying absolute levels as low or high in relation to other biomarkers is not possible. Controlled studies are needed.
abstract_unstemmed	Background: Cognitive behavioral therapy (CBT) is one of the most prominent standard treatments for depression. However, like with antidepressant drugs, a subgroup of patients remains unresponsive. Since an imbalance in serotonin and kynurenine pathway metabolites are involved in the pathophysiology of depression, this study investigates whether those may be useful biomarkers to predict therapy response. Methods: Adult drug-free patients with a diagnosed depressive episode underwent six weeks of cognitive behavioral therapy in a multimodal setting. Levels of biological parameters were measured at baseline and endpoint using Ultra Performance Liquid Chromatography. Similarly, depression severity was measured by MADRS. Results: Levels of the serotonin metabolite 5-HIAA, kynurenine, the kynurenine metabolite 3-HK, and the kynurenine-tryptophan-ratio (Kyn/Trp) significantly increased until endpoint. Higher baseline levels of all four parameters were predictive for better response at endpoint. However, 3-HK levels were predictive for the continuous outcome of MADRS score change, while kynurenine and 5-HIAA levels were predictive for the binary outcome of response versus non-response, and Kyn/Trp and 5-HIAA for remission status. Limitations: With this single-arm design, results are preliminary and effects at endpoint cannot causally be linked to the CBT intervention. Conclusions: This study shows that tryptophan metabolites may serve as biomarkers for treatment response to CBT to foster individualized treatment choices. However, classifying absolute levels as low or high in relation to other biomarkers is not possible. Controlled studies are needed.
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title_short	Tryptophan metabolites predict response after cognitive behavioral therapy for depression: A single-arm trial.
url	https://doi.org/10.1016/j.jadr.2023.100464 https://doaj.org/article/b993b696de634b9fb805e7361dcda67f http://www.sciencedirect.com/science/article/pii/S2666915323000033 https://doaj.org/toc/2666-9153
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However, like with antidepressant drugs, a subgroup of patients remains unresponsive. Since an imbalance in serotonin and kynurenine pathway metabolites are involved in the pathophysiology of depression, this study investigates whether those may be useful biomarkers to predict therapy response. Methods: Adult drug-free patients with a diagnosed depressive episode underwent six weeks of cognitive behavioral therapy in a multimodal setting. Levels of biological parameters were measured at baseline and endpoint using Ultra Performance Liquid Chromatography. Similarly, depression severity was measured by MADRS. Results: Levels of the serotonin metabolite 5-HIAA, kynurenine, the kynurenine metabolite 3-HK, and the kynurenine-tryptophan-ratio (Kyn/Trp) significantly increased until endpoint. Higher baseline levels of all four parameters were predictive for better response at endpoint. However, 3-HK levels were predictive for the continuous outcome of MADRS score change, while kynurenine and 5-HIAA levels were predictive for the binary outcome of response versus non-response, and Kyn/Trp and 5-HIAA for remission status. Limitations: With this single-arm design, results are preliminary and effects at endpoint cannot causally be linked to the CBT intervention. Conclusions: This study shows that tryptophan metabolites may serve as biomarkers for treatment response to CBT to foster individualized treatment choices. However, classifying absolute levels as low or high in relation to other biomarkers is not possible. 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Tryptophan metabolites predict response after cognitive behavioral therapy for depression: A single-arm trial.

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