Rhanteriol, a New <i<Rhanterium suaveolens</i< Desf. Lignan with Pharmacological Potential as an Inhibitor of Enzymes Involved in Neurodegeneration and Type 2 Diabetes

Several specialized plant metabolites are reported to be enzyme inhibitors. In this investigation, the phytochemical composition and the biological activity of <i<Rhanterium suaveolens</i< Desf. were studied. One new lignan (rhanteriol 1) and seven known secondary metabolites were isolat...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Soumia Belaabed [verfasserIn] Ayoub Khalfaoui [verfasserIn] Valentina Parisi [verfasserIn] Valentina Santoro [verfasserIn] Daniela Russo [verfasserIn] Maria Ponticelli [verfasserIn] Magnus Monné [verfasserIn] Khellaf Rebbas [verfasserIn] Luigi Milella [verfasserIn] Giuliana Donadio [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	rhanteriol 1 NMR cholinesterases inhibition

Übergeordnetes Werk:	In: Plants - MDPI AG, 2013, 12(2023), 2, p 301
Übergeordnetes Werk:	volume:12 ; year:2023 ; number:2, p 301

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/plants12020301

Katalog-ID:	DOAJ081721005

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spellingShingle	Soumia Belaabed misc QK1-989 misc <i<Rhanterium suaveolens</i< Desf. misc rhanteriol 1 misc NMR misc <i<α</i<-amylase inhibition misc <i<α</i<-glucosidase inhibition misc cholinesterases inhibition misc Botany Rhanteriol, a New <i<Rhanterium suaveolens</i< Desf. Lignan with Pharmacological Potential as an Inhibitor of Enzymes Involved in Neurodegeneration and Type 2 Diabetes
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topic_title	QK1-989 Rhanteriol, a New <i<Rhanterium suaveolens</i< Desf. Lignan with Pharmacological Potential as an Inhibitor of Enzymes Involved in Neurodegeneration and Type 2 Diabetes <i<Rhanterium suaveolens</i< Desf rhanteriol 1 NMR <i<α</i<-amylase inhibition <i<α</i<-glucosidase inhibition cholinesterases inhibition
topic	misc QK1-989 misc <i<Rhanterium suaveolens</i< Desf. misc rhanteriol 1 misc NMR misc <i<α</i<-amylase inhibition misc <i<α</i<-glucosidase inhibition misc cholinesterases inhibition misc Botany
topic_unstemmed	misc QK1-989 misc <i<Rhanterium suaveolens</i< Desf. misc rhanteriol 1 misc NMR misc <i<α</i<-amylase inhibition misc <i<α</i<-glucosidase inhibition misc cholinesterases inhibition misc Botany
topic_browse	misc QK1-989 misc <i<Rhanterium suaveolens</i< Desf. misc rhanteriol 1 misc NMR misc <i<α</i<-amylase inhibition misc <i<α</i<-glucosidase inhibition misc cholinesterases inhibition misc Botany
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title	Rhanteriol, a New <i<Rhanterium suaveolens</i< Desf. Lignan with Pharmacological Potential as an Inhibitor of Enzymes Involved in Neurodegeneration and Type 2 Diabetes
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title_full	Rhanteriol, a New <i<Rhanterium suaveolens</i< Desf. Lignan with Pharmacological Potential as an Inhibitor of Enzymes Involved in Neurodegeneration and Type 2 Diabetes
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author_browse	Soumia Belaabed Ayoub Khalfaoui Valentina Parisi Valentina Santoro Daniela Russo Maria Ponticelli Magnus Monné Khellaf Rebbas Luigi Milella Giuliana Donadio
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title_sort	rhanteriol, a new <i<rhanterium suaveolens</i< desf. lignan with pharmacological potential as an inhibitor of enzymes involved in neurodegeneration and type 2 diabetes
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title_auth	Rhanteriol, a New <i<Rhanterium suaveolens</i< Desf. Lignan with Pharmacological Potential as an Inhibitor of Enzymes Involved in Neurodegeneration and Type 2 Diabetes
abstract	Several specialized plant metabolites are reported to be enzyme inhibitors. In this investigation, the phytochemical composition and the biological activity of <i<Rhanterium suaveolens</i< Desf. were studied. One new lignan (rhanteriol 1) and seven known secondary metabolites were isolated from the aerial parts of <i<R. suaveolens</i< by using different chromatographic procedures. The biological properties of the <i<R. suaveolens</i< extracts and the new compound were evaluated by measuring their ability to inhibit the cholinesterase and carbohydrate-hydrolyzing enzymes, using cell-free in vitro methods. The new lignan, rhanteriol, was shown to inhibit <i<α</i<-amylase and <i<α</i<-glucosidase (IC<sub<50</sub< = 46.42 <i<±</i< 3.25 μM and 26.76 ± 3.29 μM, respectively), as well as butyrylcholinesterase (IC<sub<50</sub< = 10.41 ± 0.03 μM), with an effect comparable to that of the respective standards, acarbose and galantamine. Furthermore, docking studies were performed suggesting the interaction mode of rhanteriol with the active sites of the investigated enzymes. The obtained data demonstrated that the aerial part of <i<R. suaveolens</i< could represent a source of active molecules, such as rhanteriol, usable in the development of treatments for preventing or treating type 2 diabetes mellitus and neurodegeneration.
abstractGer	Several specialized plant metabolites are reported to be enzyme inhibitors. In this investigation, the phytochemical composition and the biological activity of <i<Rhanterium suaveolens</i< Desf. were studied. One new lignan (rhanteriol 1) and seven known secondary metabolites were isolated from the aerial parts of <i<R. suaveolens</i< by using different chromatographic procedures. The biological properties of the <i<R. suaveolens</i< extracts and the new compound were evaluated by measuring their ability to inhibit the cholinesterase and carbohydrate-hydrolyzing enzymes, using cell-free in vitro methods. The new lignan, rhanteriol, was shown to inhibit <i<α</i<-amylase and <i<α</i<-glucosidase (IC<sub<50</sub< = 46.42 <i<±</i< 3.25 μM and 26.76 ± 3.29 μM, respectively), as well as butyrylcholinesterase (IC<sub<50</sub< = 10.41 ± 0.03 μM), with an effect comparable to that of the respective standards, acarbose and galantamine. Furthermore, docking studies were performed suggesting the interaction mode of rhanteriol with the active sites of the investigated enzymes. The obtained data demonstrated that the aerial part of <i<R. suaveolens</i< could represent a source of active molecules, such as rhanteriol, usable in the development of treatments for preventing or treating type 2 diabetes mellitus and neurodegeneration.
abstract_unstemmed	Several specialized plant metabolites are reported to be enzyme inhibitors. In this investigation, the phytochemical composition and the biological activity of <i<Rhanterium suaveolens</i< Desf. were studied. One new lignan (rhanteriol 1) and seven known secondary metabolites were isolated from the aerial parts of <i<R. suaveolens</i< by using different chromatographic procedures. The biological properties of the <i<R. suaveolens</i< extracts and the new compound were evaluated by measuring their ability to inhibit the cholinesterase and carbohydrate-hydrolyzing enzymes, using cell-free in vitro methods. The new lignan, rhanteriol, was shown to inhibit <i<α</i<-amylase and <i<α</i<-glucosidase (IC<sub<50</sub< = 46.42 <i<±</i< 3.25 μM and 26.76 ± 3.29 μM, respectively), as well as butyrylcholinesterase (IC<sub<50</sub< = 10.41 ± 0.03 μM), with an effect comparable to that of the respective standards, acarbose and galantamine. Furthermore, docking studies were performed suggesting the interaction mode of rhanteriol with the active sites of the investigated enzymes. The obtained data demonstrated that the aerial part of <i<R. suaveolens</i< could represent a source of active molecules, such as rhanteriol, usable in the development of treatments for preventing or treating type 2 diabetes mellitus and neurodegeneration.
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title_short	Rhanteriol, a New <i<Rhanterium suaveolens</i< Desf. Lignan with Pharmacological Potential as an Inhibitor of Enzymes Involved in Neurodegeneration and Type 2 Diabetes
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Lignan with Pharmacological Potential as an Inhibitor of Enzymes Involved in Neurodegeneration and Type 2 Diabetes</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2023</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Several specialized plant metabolites are reported to be enzyme inhibitors. In this investigation, the phytochemical composition and the biological activity of <i<Rhanterium suaveolens</i< Desf. were studied. One new lignan (rhanteriol 1) and seven known secondary metabolites were isolated from the aerial parts of <i<R. suaveolens</i< by using different chromatographic procedures. The biological properties of the <i<R. suaveolens</i< extracts and the new compound were evaluated by measuring their ability to inhibit the cholinesterase and carbohydrate-hydrolyzing enzymes, using cell-free in vitro methods. The new lignan, rhanteriol, was shown to inhibit <i<α</i<-amylase and <i<α</i<-glucosidase (IC<sub<50</sub< = 46.42 <i<±</i< 3.25 μM and 26.76 ± 3.29 μM, respectively), as well as butyrylcholinesterase (IC<sub<50</sub< = 10.41 ± 0.03 μM), with an effect comparable to that of the respective standards, acarbose and galantamine. Furthermore, docking studies were performed suggesting the interaction mode of rhanteriol with the active sites of the investigated enzymes. 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Rhanteriol, a New <i<Rhanterium suaveolens</i< Desf. Lignan with Pharmacological Potential as an Inhibitor of Enzymes Involved in Neurodegeneration and Type 2 Diabetes

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