Exposure to the Dutch Famine in Early Gestation and Cognitive Function and Decline in Older Age

People exposed to the 1944–1945 Dutch famine in early gestation performed worse on a selective attention task at age 58 and reported more cognitive problems at age 72. We here hypothesized that undernutrition in early gestation is associated with poorer cognitive functioning in older age and a highe...
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Gespeichert in:

Autor*in:	Aline Marileen Wiegersma [verfasserIn] Amber Boots [verfasserIn] Tessa J. Roseboom [verfasserIn] Susanne R. de Rooij [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	prenatal undernutrition prenatal famine cognitive function cognitive decline self-perceived cognitive problems

Übergeordnetes Werk:	In: Nutrients - MDPI AG, 2009, 15(2023), 2, p 293
Übergeordnetes Werk:	volume:15 ; year:2023 ; number:2, p 293

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/nu15020293

Katalog-ID:	DOAJ081730462

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callnumber-first	T - Technology
author	Aline Marileen Wiegersma
spellingShingle	Aline Marileen Wiegersma misc TX341-641 misc prenatal undernutrition misc prenatal famine misc cognitive function misc cognitive decline misc self-perceived cognitive problems misc Nutrition. Foods and food supply Exposure to the Dutch Famine in Early Gestation and Cognitive Function and Decline in Older Age
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topic_title	TX341-641 Exposure to the Dutch Famine in Early Gestation and Cognitive Function and Decline in Older Age prenatal undernutrition prenatal famine cognitive function cognitive decline self-perceived cognitive problems
topic	misc TX341-641 misc prenatal undernutrition misc prenatal famine misc cognitive function misc cognitive decline misc self-perceived cognitive problems misc Nutrition. Foods and food supply
topic_unstemmed	misc TX341-641 misc prenatal undernutrition misc prenatal famine misc cognitive function misc cognitive decline misc self-perceived cognitive problems misc Nutrition. Foods and food supply
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title	Exposure to the Dutch Famine in Early Gestation and Cognitive Function and Decline in Older Age
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title_full	Exposure to the Dutch Famine in Early Gestation and Cognitive Function and Decline in Older Age
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title_sort	exposure to the dutch famine in early gestation and cognitive function and decline in older age
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title_auth	Exposure to the Dutch Famine in Early Gestation and Cognitive Function and Decline in Older Age
abstract	People exposed to the 1944–1945 Dutch famine in early gestation performed worse on a selective attention task at age 58 and reported more cognitive problems at age 72. We here hypothesized that undernutrition in early gestation is associated with poorer cognitive functioning in older age and a higher rate of cognitive decline. We tested this hypothesis in the Dutch famine birth cohort in men and women combined and separately. We assessed cognitive function using a Stroop-like, trail-making and 15-word task (at ages 68 and 74) and the Montreal cognitive assessment as well as self-perceived cognitive problems (at age 74) in 73 men (<i<n</i< = 34) and women (<i<n</i< = 39). We compared cognitive function and decline (change in cognitive function between age 68 and 74) between those exposed in early gestation and those not exposed (born before or conceived after the famine). Although in both men and women cognitive function declined from age 68 to 74, cognitive task scores and the rate of decline did not differ between those exposed or unexposed to famine. At age 74, men exposed to famine in early gestation more often reported cognitive problems, although this was not statistically different from unexposed men (OR 3.1 [95%CI 0.7 to 13.0]). We did not find evidence of increased cognitive decline after prenatal undernutrition. Selective participation and mortality may have hampered our ability to detect potential true effects. The self-perceived cognitive problems among men who had been exposed to famine in early gestation might be an indication of future dementia risk.
abstractGer	People exposed to the 1944–1945 Dutch famine in early gestation performed worse on a selective attention task at age 58 and reported more cognitive problems at age 72. We here hypothesized that undernutrition in early gestation is associated with poorer cognitive functioning in older age and a higher rate of cognitive decline. We tested this hypothesis in the Dutch famine birth cohort in men and women combined and separately. We assessed cognitive function using a Stroop-like, trail-making and 15-word task (at ages 68 and 74) and the Montreal cognitive assessment as well as self-perceived cognitive problems (at age 74) in 73 men (<i<n</i< = 34) and women (<i<n</i< = 39). We compared cognitive function and decline (change in cognitive function between age 68 and 74) between those exposed in early gestation and those not exposed (born before or conceived after the famine). Although in both men and women cognitive function declined from age 68 to 74, cognitive task scores and the rate of decline did not differ between those exposed or unexposed to famine. At age 74, men exposed to famine in early gestation more often reported cognitive problems, although this was not statistically different from unexposed men (OR 3.1 [95%CI 0.7 to 13.0]). We did not find evidence of increased cognitive decline after prenatal undernutrition. Selective participation and mortality may have hampered our ability to detect potential true effects. The self-perceived cognitive problems among men who had been exposed to famine in early gestation might be an indication of future dementia risk.
abstract_unstemmed	People exposed to the 1944–1945 Dutch famine in early gestation performed worse on a selective attention task at age 58 and reported more cognitive problems at age 72. We here hypothesized that undernutrition in early gestation is associated with poorer cognitive functioning in older age and a higher rate of cognitive decline. We tested this hypothesis in the Dutch famine birth cohort in men and women combined and separately. We assessed cognitive function using a Stroop-like, trail-making and 15-word task (at ages 68 and 74) and the Montreal cognitive assessment as well as self-perceived cognitive problems (at age 74) in 73 men (<i<n</i< = 34) and women (<i<n</i< = 39). We compared cognitive function and decline (change in cognitive function between age 68 and 74) between those exposed in early gestation and those not exposed (born before or conceived after the famine). Although in both men and women cognitive function declined from age 68 to 74, cognitive task scores and the rate of decline did not differ between those exposed or unexposed to famine. At age 74, men exposed to famine in early gestation more often reported cognitive problems, although this was not statistically different from unexposed men (OR 3.1 [95%CI 0.7 to 13.0]). We did not find evidence of increased cognitive decline after prenatal undernutrition. Selective participation and mortality may have hampered our ability to detect potential true effects. The self-perceived cognitive problems among men who had been exposed to famine in early gestation might be an indication of future dementia risk.
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title_short	Exposure to the Dutch Famine in Early Gestation and Cognitive Function and Decline in Older Age
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Exposure to the Dutch Famine in Early Gestation and Cognitive Function and Decline in Older Age

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