SARS-CoV-2 Breakthrough Infections in Health Care Workers: An Italian Retrospective Cohort Study on Characteristics, Clinical Course and Outcomes
Background: The aim of this study was to determine the characteristics, clinical course and outcomes of COVID-19 breakthrough infections (BIs) among healthcare workers (HCWs) of an Italian University Hospital. Methods: A retrospective observational study was conducted on 6111 HCWs, from January 2021...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Luigi De Maria [verfasserIn] Stefania Sponselli [verfasserIn] Antonio Caputi [verfasserIn] Pasquale Stefanizzi [verfasserIn] Antonella Pipoli [verfasserIn] Gianmarco Giannelli [verfasserIn] Giuseppe Delvecchio [verfasserIn] Silvio Tafuri [verfasserIn] Francesco Inchingolo [verfasserIn] Giovanni Migliore [verfasserIn] Francesco Paolo Bianchi [verfasserIn] Paolo Boffetta [verfasserIn] Luigi Vimercati [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Journal of Clinical Medicine - MDPI AG, 2013, 12(2023), 2, p 628 |
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| Übergeordnetes Werk: |
volume:12 ; year:2023 ; number:2, p 628 |
| Links: |
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| DOI / URN: |
10.3390/jcm12020628 |
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| Katalog-ID: |
DOAJ081771649 |
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| 520 | |a Background: The aim of this study was to determine the characteristics, clinical course and outcomes of COVID-19 breakthrough infections (BIs) among healthcare workers (HCWs) of an Italian University Hospital. Methods: A retrospective observational study was conducted on 6111 HCWs, from January 2021 to February 2022. The study population was offered the full vaccination with BNT162b2 mRNA COVID-19 vaccine. To allow return to work after BI, the protocol required one negative nasopharyngeal RT-PCR swab followed by a medical examination to assess the HCW’s health status. Laboratory tests, instrumental tests and specialist evaluations were carried out if necessary. Results. The cases of BIs observed numbered 582 (9.7%). The frequency of BIs was significantly higher in females than in males (67% vs. 33%; <i<p</i< = 0.03), and in nurses than in all other professional categories (<i<p</i< = 0.001). A total of 88% of the HCWs affected by BI were still symptomatic after the negative swab. None of the instrumental tests carried out showed any new findings of pathological significance. All cases showed progressive disappearance of symptoms, such that no cases of long COVID and no hospitalization or deaths were recorded. Conclusions. Our results confirm that SARS-CoV-2 infections occur even after a full vaccination course; however, the clinical course is favorable and severe outcomes are reduced. | ||
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10.3390/jcm12020628 doi (DE-627)DOAJ081771649 (DE-599)DOAJd398bdd7e5db4339a9f3e11fd9b8427b DE-627 ger DE-627 rakwb eng Luigi De Maria verfasserin aut SARS-CoV-2 Breakthrough Infections in Health Care Workers: An Italian Retrospective Cohort Study on Characteristics, Clinical Course and Outcomes 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The aim of this study was to determine the characteristics, clinical course and outcomes of COVID-19 breakthrough infections (BIs) among healthcare workers (HCWs) of an Italian University Hospital. Methods: A retrospective observational study was conducted on 6111 HCWs, from January 2021 to February 2022. The study population was offered the full vaccination with BNT162b2 mRNA COVID-19 vaccine. To allow return to work after BI, the protocol required one negative nasopharyngeal RT-PCR swab followed by a medical examination to assess the HCW’s health status. Laboratory tests, instrumental tests and specialist evaluations were carried out if necessary. Results. The cases of BIs observed numbered 582 (9.7%). The frequency of BIs was significantly higher in females than in males (67% vs. 33%; <i<p</i< = 0.03), and in nurses than in all other professional categories (<i<p</i< = 0.001). A total of 88% of the HCWs affected by BI were still symptomatic after the negative swab. None of the instrumental tests carried out showed any new findings of pathological significance. All cases showed progressive disappearance of symptoms, such that no cases of long COVID and no hospitalization or deaths were recorded. Conclusions. Our results confirm that SARS-CoV-2 infections occur even after a full vaccination course; however, the clinical course is favorable and severe outcomes are reduced. COVID-19 SARS-CoV-2 vaccination breakthrough infections health workers Medicine R Stefania Sponselli verfasserin aut Antonio Caputi verfasserin aut Pasquale Stefanizzi verfasserin aut Antonella Pipoli verfasserin aut Gianmarco Giannelli verfasserin aut Giuseppe Delvecchio verfasserin aut Silvio Tafuri verfasserin aut Francesco Inchingolo verfasserin aut Giovanni Migliore verfasserin aut Francesco Paolo Bianchi verfasserin aut Paolo Boffetta verfasserin aut Luigi Vimercati verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 12(2023), 2, p 628 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:12 year:2023 number:2, p 628 https://doi.org/10.3390/jcm12020628 kostenfrei https://doaj.org/article/d398bdd7e5db4339a9f3e11fd9b8427b kostenfrei https://www.mdpi.com/2077-0383/12/2/628 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 2, p 628 |
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10.3390/jcm12020628 doi (DE-627)DOAJ081771649 (DE-599)DOAJd398bdd7e5db4339a9f3e11fd9b8427b DE-627 ger DE-627 rakwb eng Luigi De Maria verfasserin aut SARS-CoV-2 Breakthrough Infections in Health Care Workers: An Italian Retrospective Cohort Study on Characteristics, Clinical Course and Outcomes 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The aim of this study was to determine the characteristics, clinical course and outcomes of COVID-19 breakthrough infections (BIs) among healthcare workers (HCWs) of an Italian University Hospital. Methods: A retrospective observational study was conducted on 6111 HCWs, from January 2021 to February 2022. The study population was offered the full vaccination with BNT162b2 mRNA COVID-19 vaccine. To allow return to work after BI, the protocol required one negative nasopharyngeal RT-PCR swab followed by a medical examination to assess the HCW’s health status. Laboratory tests, instrumental tests and specialist evaluations were carried out if necessary. Results. The cases of BIs observed numbered 582 (9.7%). The frequency of BIs was significantly higher in females than in males (67% vs. 33%; <i<p</i< = 0.03), and in nurses than in all other professional categories (<i<p</i< = 0.001). A total of 88% of the HCWs affected by BI were still symptomatic after the negative swab. None of the instrumental tests carried out showed any new findings of pathological significance. All cases showed progressive disappearance of symptoms, such that no cases of long COVID and no hospitalization or deaths were recorded. Conclusions. Our results confirm that SARS-CoV-2 infections occur even after a full vaccination course; however, the clinical course is favorable and severe outcomes are reduced. COVID-19 SARS-CoV-2 vaccination breakthrough infections health workers Medicine R Stefania Sponselli verfasserin aut Antonio Caputi verfasserin aut Pasquale Stefanizzi verfasserin aut Antonella Pipoli verfasserin aut Gianmarco Giannelli verfasserin aut Giuseppe Delvecchio verfasserin aut Silvio Tafuri verfasserin aut Francesco Inchingolo verfasserin aut Giovanni Migliore verfasserin aut Francesco Paolo Bianchi verfasserin aut Paolo Boffetta verfasserin aut Luigi Vimercati verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 12(2023), 2, p 628 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:12 year:2023 number:2, p 628 https://doi.org/10.3390/jcm12020628 kostenfrei https://doaj.org/article/d398bdd7e5db4339a9f3e11fd9b8427b kostenfrei https://www.mdpi.com/2077-0383/12/2/628 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 2, p 628 |
| allfields_unstemmed |
10.3390/jcm12020628 doi (DE-627)DOAJ081771649 (DE-599)DOAJd398bdd7e5db4339a9f3e11fd9b8427b DE-627 ger DE-627 rakwb eng Luigi De Maria verfasserin aut SARS-CoV-2 Breakthrough Infections in Health Care Workers: An Italian Retrospective Cohort Study on Characteristics, Clinical Course and Outcomes 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The aim of this study was to determine the characteristics, clinical course and outcomes of COVID-19 breakthrough infections (BIs) among healthcare workers (HCWs) of an Italian University Hospital. Methods: A retrospective observational study was conducted on 6111 HCWs, from January 2021 to February 2022. The study population was offered the full vaccination with BNT162b2 mRNA COVID-19 vaccine. To allow return to work after BI, the protocol required one negative nasopharyngeal RT-PCR swab followed by a medical examination to assess the HCW’s health status. Laboratory tests, instrumental tests and specialist evaluations were carried out if necessary. Results. The cases of BIs observed numbered 582 (9.7%). The frequency of BIs was significantly higher in females than in males (67% vs. 33%; <i<p</i< = 0.03), and in nurses than in all other professional categories (<i<p</i< = 0.001). A total of 88% of the HCWs affected by BI were still symptomatic after the negative swab. None of the instrumental tests carried out showed any new findings of pathological significance. All cases showed progressive disappearance of symptoms, such that no cases of long COVID and no hospitalization or deaths were recorded. Conclusions. Our results confirm that SARS-CoV-2 infections occur even after a full vaccination course; however, the clinical course is favorable and severe outcomes are reduced. COVID-19 SARS-CoV-2 vaccination breakthrough infections health workers Medicine R Stefania Sponselli verfasserin aut Antonio Caputi verfasserin aut Pasquale Stefanizzi verfasserin aut Antonella Pipoli verfasserin aut Gianmarco Giannelli verfasserin aut Giuseppe Delvecchio verfasserin aut Silvio Tafuri verfasserin aut Francesco Inchingolo verfasserin aut Giovanni Migliore verfasserin aut Francesco Paolo Bianchi verfasserin aut Paolo Boffetta verfasserin aut Luigi Vimercati verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 12(2023), 2, p 628 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:12 year:2023 number:2, p 628 https://doi.org/10.3390/jcm12020628 kostenfrei https://doaj.org/article/d398bdd7e5db4339a9f3e11fd9b8427b kostenfrei https://www.mdpi.com/2077-0383/12/2/628 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 2, p 628 |
| allfieldsGer |
10.3390/jcm12020628 doi (DE-627)DOAJ081771649 (DE-599)DOAJd398bdd7e5db4339a9f3e11fd9b8427b DE-627 ger DE-627 rakwb eng Luigi De Maria verfasserin aut SARS-CoV-2 Breakthrough Infections in Health Care Workers: An Italian Retrospective Cohort Study on Characteristics, Clinical Course and Outcomes 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The aim of this study was to determine the characteristics, clinical course and outcomes of COVID-19 breakthrough infections (BIs) among healthcare workers (HCWs) of an Italian University Hospital. Methods: A retrospective observational study was conducted on 6111 HCWs, from January 2021 to February 2022. The study population was offered the full vaccination with BNT162b2 mRNA COVID-19 vaccine. To allow return to work after BI, the protocol required one negative nasopharyngeal RT-PCR swab followed by a medical examination to assess the HCW’s health status. Laboratory tests, instrumental tests and specialist evaluations were carried out if necessary. Results. The cases of BIs observed numbered 582 (9.7%). The frequency of BIs was significantly higher in females than in males (67% vs. 33%; <i<p</i< = 0.03), and in nurses than in all other professional categories (<i<p</i< = 0.001). A total of 88% of the HCWs affected by BI were still symptomatic after the negative swab. None of the instrumental tests carried out showed any new findings of pathological significance. All cases showed progressive disappearance of symptoms, such that no cases of long COVID and no hospitalization or deaths were recorded. Conclusions. Our results confirm that SARS-CoV-2 infections occur even after a full vaccination course; however, the clinical course is favorable and severe outcomes are reduced. COVID-19 SARS-CoV-2 vaccination breakthrough infections health workers Medicine R Stefania Sponselli verfasserin aut Antonio Caputi verfasserin aut Pasquale Stefanizzi verfasserin aut Antonella Pipoli verfasserin aut Gianmarco Giannelli verfasserin aut Giuseppe Delvecchio verfasserin aut Silvio Tafuri verfasserin aut Francesco Inchingolo verfasserin aut Giovanni Migliore verfasserin aut Francesco Paolo Bianchi verfasserin aut Paolo Boffetta verfasserin aut Luigi Vimercati verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 12(2023), 2, p 628 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:12 year:2023 number:2, p 628 https://doi.org/10.3390/jcm12020628 kostenfrei https://doaj.org/article/d398bdd7e5db4339a9f3e11fd9b8427b kostenfrei https://www.mdpi.com/2077-0383/12/2/628 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 2, p 628 |
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10.3390/jcm12020628 doi (DE-627)DOAJ081771649 (DE-599)DOAJd398bdd7e5db4339a9f3e11fd9b8427b DE-627 ger DE-627 rakwb eng Luigi De Maria verfasserin aut SARS-CoV-2 Breakthrough Infections in Health Care Workers: An Italian Retrospective Cohort Study on Characteristics, Clinical Course and Outcomes 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The aim of this study was to determine the characteristics, clinical course and outcomes of COVID-19 breakthrough infections (BIs) among healthcare workers (HCWs) of an Italian University Hospital. Methods: A retrospective observational study was conducted on 6111 HCWs, from January 2021 to February 2022. The study population was offered the full vaccination with BNT162b2 mRNA COVID-19 vaccine. To allow return to work after BI, the protocol required one negative nasopharyngeal RT-PCR swab followed by a medical examination to assess the HCW’s health status. Laboratory tests, instrumental tests and specialist evaluations were carried out if necessary. Results. The cases of BIs observed numbered 582 (9.7%). The frequency of BIs was significantly higher in females than in males (67% vs. 33%; <i<p</i< = 0.03), and in nurses than in all other professional categories (<i<p</i< = 0.001). A total of 88% of the HCWs affected by BI were still symptomatic after the negative swab. None of the instrumental tests carried out showed any new findings of pathological significance. All cases showed progressive disappearance of symptoms, such that no cases of long COVID and no hospitalization or deaths were recorded. Conclusions. Our results confirm that SARS-CoV-2 infections occur even after a full vaccination course; however, the clinical course is favorable and severe outcomes are reduced. COVID-19 SARS-CoV-2 vaccination breakthrough infections health workers Medicine R Stefania Sponselli verfasserin aut Antonio Caputi verfasserin aut Pasquale Stefanizzi verfasserin aut Antonella Pipoli verfasserin aut Gianmarco Giannelli verfasserin aut Giuseppe Delvecchio verfasserin aut Silvio Tafuri verfasserin aut Francesco Inchingolo verfasserin aut Giovanni Migliore verfasserin aut Francesco Paolo Bianchi verfasserin aut Paolo Boffetta verfasserin aut Luigi Vimercati verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 12(2023), 2, p 628 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:12 year:2023 number:2, p 628 https://doi.org/10.3390/jcm12020628 kostenfrei https://doaj.org/article/d398bdd7e5db4339a9f3e11fd9b8427b kostenfrei https://www.mdpi.com/2077-0383/12/2/628 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 2, p 628 |
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SARS-CoV-2 Breakthrough Infections in Health Care Workers: An Italian Retrospective Cohort Study on Characteristics, Clinical Course and Outcomes |
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Background: The aim of this study was to determine the characteristics, clinical course and outcomes of COVID-19 breakthrough infections (BIs) among healthcare workers (HCWs) of an Italian University Hospital. Methods: A retrospective observational study was conducted on 6111 HCWs, from January 2021 to February 2022. The study population was offered the full vaccination with BNT162b2 mRNA COVID-19 vaccine. To allow return to work after BI, the protocol required one negative nasopharyngeal RT-PCR swab followed by a medical examination to assess the HCW’s health status. Laboratory tests, instrumental tests and specialist evaluations were carried out if necessary. Results. The cases of BIs observed numbered 582 (9.7%). The frequency of BIs was significantly higher in females than in males (67% vs. 33%; <i<p</i< = 0.03), and in nurses than in all other professional categories (<i<p</i< = 0.001). A total of 88% of the HCWs affected by BI were still symptomatic after the negative swab. None of the instrumental tests carried out showed any new findings of pathological significance. All cases showed progressive disappearance of symptoms, such that no cases of long COVID and no hospitalization or deaths were recorded. Conclusions. Our results confirm that SARS-CoV-2 infections occur even after a full vaccination course; however, the clinical course is favorable and severe outcomes are reduced. |
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Background: The aim of this study was to determine the characteristics, clinical course and outcomes of COVID-19 breakthrough infections (BIs) among healthcare workers (HCWs) of an Italian University Hospital. Methods: A retrospective observational study was conducted on 6111 HCWs, from January 2021 to February 2022. The study population was offered the full vaccination with BNT162b2 mRNA COVID-19 vaccine. To allow return to work after BI, the protocol required one negative nasopharyngeal RT-PCR swab followed by a medical examination to assess the HCW’s health status. Laboratory tests, instrumental tests and specialist evaluations were carried out if necessary. Results. The cases of BIs observed numbered 582 (9.7%). The frequency of BIs was significantly higher in females than in males (67% vs. 33%; <i<p</i< = 0.03), and in nurses than in all other professional categories (<i<p</i< = 0.001). A total of 88% of the HCWs affected by BI were still symptomatic after the negative swab. None of the instrumental tests carried out showed any new findings of pathological significance. All cases showed progressive disappearance of symptoms, such that no cases of long COVID and no hospitalization or deaths were recorded. Conclusions. Our results confirm that SARS-CoV-2 infections occur even after a full vaccination course; however, the clinical course is favorable and severe outcomes are reduced. |
| abstract_unstemmed |
Background: The aim of this study was to determine the characteristics, clinical course and outcomes of COVID-19 breakthrough infections (BIs) among healthcare workers (HCWs) of an Italian University Hospital. Methods: A retrospective observational study was conducted on 6111 HCWs, from January 2021 to February 2022. The study population was offered the full vaccination with BNT162b2 mRNA COVID-19 vaccine. To allow return to work after BI, the protocol required one negative nasopharyngeal RT-PCR swab followed by a medical examination to assess the HCW’s health status. Laboratory tests, instrumental tests and specialist evaluations were carried out if necessary. Results. The cases of BIs observed numbered 582 (9.7%). The frequency of BIs was significantly higher in females than in males (67% vs. 33%; <i<p</i< = 0.03), and in nurses than in all other professional categories (<i<p</i< = 0.001). A total of 88% of the HCWs affected by BI were still symptomatic after the negative swab. None of the instrumental tests carried out showed any new findings of pathological significance. All cases showed progressive disappearance of symptoms, such that no cases of long COVID and no hospitalization or deaths were recorded. Conclusions. Our results confirm that SARS-CoV-2 infections occur even after a full vaccination course; however, the clinical course is favorable and severe outcomes are reduced. |
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SARS-CoV-2 Breakthrough Infections in Health Care Workers: An Italian Retrospective Cohort Study on Characteristics, Clinical Course and Outcomes |
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https://doi.org/10.3390/jcm12020628 https://doaj.org/article/d398bdd7e5db4339a9f3e11fd9b8427b https://www.mdpi.com/2077-0383/12/2/628 https://doaj.org/toc/2077-0383 |
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Stefania Sponselli Antonio Caputi Pasquale Stefanizzi Antonella Pipoli Gianmarco Giannelli Giuseppe Delvecchio Silvio Tafuri Francesco Inchingolo Giovanni Migliore Francesco Paolo Bianchi Paolo Boffetta Luigi Vimercati |
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Stefania Sponselli Antonio Caputi Pasquale Stefanizzi Antonella Pipoli Gianmarco Giannelli Giuseppe Delvecchio Silvio Tafuri Francesco Inchingolo Giovanni Migliore Francesco Paolo Bianchi Paolo Boffetta Luigi Vimercati |
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