HLA-A*01:01 allele diminishing in COVID-19 patients population associated with non-structural epitope abundance in CD8+ T-cell repertoire

In mid-2021, the SARS-CoV-2 Delta variant caused the third wave of the COVID-19 pandemic in several countries worldwide. The pivotal studies were aimed at studying changes in the efficiency of neutralizing antibodies to the spike protein. However, much less attention was paid to the T-cell response...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Maxim Shkurnikov [verfasserIn] Stepan Nersisyan [verfasserIn] Darya Averinskaya [verfasserIn] Milena Chekova [verfasserIn] Fedor Polyakov [verfasserIn] Aleksei Titov [verfasserIn] Dmitriy Doroshenko [verfasserIn] Valery Vechorko [verfasserIn] Alexander Tonevitsky [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	COVID-19 MHC-I HLA-A*01:01 T-cell immune response ELISpot

Übergeordnetes Werk:	In: PeerJ - PeerJ Inc., 2013, 11, p e14707(2023)
Übergeordnetes Werk:	volume:11, p e14707 ; year:2023

Links:	Link aufrufen Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.7717/peerj.14707

Katalog-ID:	DOAJ081772971

Internformat


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allfieldsSound	10.7717/peerj.14707 doi (DE-627)DOAJ081772971 (DE-599)DOAJ88e9b0482c404d02ab62ea3d6f50d781 DE-627 ger DE-627 rakwb eng QH301-705.5 Maxim Shkurnikov verfasserin aut HLA-A01:01 allele diminishing in COVID-19 patients population associated with non-structural epitope abundance in CD8+ T-cell repertoire 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In mid-2021, the SARS-CoV-2 Delta variant caused the third wave of the COVID-19 pandemic in several countries worldwide. The pivotal studies were aimed at studying changes in the efficiency of neutralizing antibodies to the spike protein. However, much less attention was paid to the T-cell response and the presentation of virus peptides by MHC-I molecules. In this study, we compared the features of the HLA-I genotype in symptomatic patients with COVID-19 in the first and third waves of the pandemic. As a result, we could identify the diminishing of carriers of the HLA-A01:01 allele in the third wave and demonstrate the unique properties of this allele. Thus, HLA-A01:01-binding immunoprevalent epitopes are mostly derived from ORF1ab. A set of epitopes from ORF1ab was tested, and their high immunogenicity was confirmed. Moreover, analysis of the results of single-cell phenotyping of T-cells in recovered patients showed that the predominant phenotype in HLA-A01:01 carriers is central memory T-cells. The predominance of T-lymphocytes of this phenotype may contribute to forming long-term T-cell immunity in carriers of this allele. Our results can be the basis for highly effective vaccines based on ORF1ab peptides. COVID-19 MHC-I HLA-A*01:01 T-cell immune response ELISpot Medicine R Biology (General) Stepan Nersisyan verfasserin aut Darya Averinskaya verfasserin aut Milena Chekova verfasserin aut Fedor Polyakov verfasserin aut Aleksei Titov verfasserin aut Dmitriy Doroshenko verfasserin aut Valery Vechorko verfasserin aut Alexander Tonevitsky verfasserin aut In PeerJ PeerJ Inc., 2013 11, p e14707(2023) (DE-627)736558624 (DE-600)2703241-3 21678359 nnns volume:11, p e14707 year:2023 https://doi.org/10.7717/peerj.14707 kostenfrei https://doaj.org/article/88e9b0482c404d02ab62ea3d6f50d781 kostenfrei https://peerj.com/articles/14707.pdf kostenfrei https://peerj.com/articles/14707/ kostenfrei https://doaj.org/toc/2167-8359 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11, p e14707 2023
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callnumber-first	Q - Science
author	Maxim Shkurnikov
spellingShingle	Maxim Shkurnikov misc QH301-705.5 misc COVID-19 misc MHC-I misc HLA-A01:01 misc T-cell immune response misc ELISpot misc Medicine misc R misc Biology (General) HLA-A01:01 allele diminishing in COVID-19 patients population associated with non-structural epitope abundance in CD8+ T-cell repertoire
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topic_title	QH301-705.5 HLA-A01:01 allele diminishing in COVID-19 patients population associated with non-structural epitope abundance in CD8+ T-cell repertoire COVID-19 MHC-I HLA-A01:01 T-cell immune response ELISpot
topic	misc QH301-705.5 misc COVID-19 misc MHC-I misc HLA-A*01:01 misc T-cell immune response misc ELISpot misc Medicine misc R misc Biology (General)
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title	HLA-A*01:01 allele diminishing in COVID-19 patients population associated with non-structural epitope abundance in CD8+ T-cell repertoire
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title_full	HLA-A*01:01 allele diminishing in COVID-19 patients population associated with non-structural epitope abundance in CD8+ T-cell repertoire
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author_browse	Maxim Shkurnikov Stepan Nersisyan Darya Averinskaya Milena Chekova Fedor Polyakov Aleksei Titov Dmitriy Doroshenko Valery Vechorko Alexander Tonevitsky
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title_sort	hla-a*01:01 allele diminishing in covid-19 patients population associated with non-structural epitope abundance in cd8+ t-cell repertoire
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title_auth	HLA-A*01:01 allele diminishing in COVID-19 patients population associated with non-structural epitope abundance in CD8+ T-cell repertoire
abstract	In mid-2021, the SARS-CoV-2 Delta variant caused the third wave of the COVID-19 pandemic in several countries worldwide. The pivotal studies were aimed at studying changes in the efficiency of neutralizing antibodies to the spike protein. However, much less attention was paid to the T-cell response and the presentation of virus peptides by MHC-I molecules. In this study, we compared the features of the HLA-I genotype in symptomatic patients with COVID-19 in the first and third waves of the pandemic. As a result, we could identify the diminishing of carriers of the HLA-A01:01 allele in the third wave and demonstrate the unique properties of this allele. Thus, HLA-A01:01-binding immunoprevalent epitopes are mostly derived from ORF1ab. A set of epitopes from ORF1ab was tested, and their high immunogenicity was confirmed. Moreover, analysis of the results of single-cell phenotyping of T-cells in recovered patients showed that the predominant phenotype in HLA-A*01:01 carriers is central memory T-cells. The predominance of T-lymphocytes of this phenotype may contribute to forming long-term T-cell immunity in carriers of this allele. Our results can be the basis for highly effective vaccines based on ORF1ab peptides.
abstractGer	In mid-2021, the SARS-CoV-2 Delta variant caused the third wave of the COVID-19 pandemic in several countries worldwide. The pivotal studies were aimed at studying changes in the efficiency of neutralizing antibodies to the spike protein. However, much less attention was paid to the T-cell response and the presentation of virus peptides by MHC-I molecules. In this study, we compared the features of the HLA-I genotype in symptomatic patients with COVID-19 in the first and third waves of the pandemic. As a result, we could identify the diminishing of carriers of the HLA-A01:01 allele in the third wave and demonstrate the unique properties of this allele. Thus, HLA-A01:01-binding immunoprevalent epitopes are mostly derived from ORF1ab. A set of epitopes from ORF1ab was tested, and their high immunogenicity was confirmed. Moreover, analysis of the results of single-cell phenotyping of T-cells in recovered patients showed that the predominant phenotype in HLA-A*01:01 carriers is central memory T-cells. The predominance of T-lymphocytes of this phenotype may contribute to forming long-term T-cell immunity in carriers of this allele. Our results can be the basis for highly effective vaccines based on ORF1ab peptides.
abstract_unstemmed	In mid-2021, the SARS-CoV-2 Delta variant caused the third wave of the COVID-19 pandemic in several countries worldwide. The pivotal studies were aimed at studying changes in the efficiency of neutralizing antibodies to the spike protein. However, much less attention was paid to the T-cell response and the presentation of virus peptides by MHC-I molecules. In this study, we compared the features of the HLA-I genotype in symptomatic patients with COVID-19 in the first and third waves of the pandemic. As a result, we could identify the diminishing of carriers of the HLA-A01:01 allele in the third wave and demonstrate the unique properties of this allele. Thus, HLA-A01:01-binding immunoprevalent epitopes are mostly derived from ORF1ab. A set of epitopes from ORF1ab was tested, and their high immunogenicity was confirmed. Moreover, analysis of the results of single-cell phenotyping of T-cells in recovered patients showed that the predominant phenotype in HLA-A*01:01 carriers is central memory T-cells. The predominance of T-lymphocytes of this phenotype may contribute to forming long-term T-cell immunity in carriers of this allele. Our results can be the basis for highly effective vaccines based on ORF1ab peptides.
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title_short	HLA-A*01:01 allele diminishing in COVID-19 patients population associated with non-structural epitope abundance in CD8+ T-cell repertoire
url	https://doi.org/10.7717/peerj.14707 https://doaj.org/article/88e9b0482c404d02ab62ea3d6f50d781 https://peerj.com/articles/14707.pdf https://peerj.com/articles/14707/ https://doaj.org/toc/2167-8359
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author2	Stepan Nersisyan Darya Averinskaya Milena Chekova Fedor Polyakov Aleksei Titov Dmitriy Doroshenko Valery Vechorko Alexander Tonevitsky
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up_date	2024-07-03T21:51:42.999Z
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HLA-A*01:01 allele diminishing in COVID-19 patients population associated with non-structural epitope abundance in CD8+ T-cell repertoire

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