Profiling Microbial Communities in Idiopathic Granulomatous Mastitis
Idiopathic granulomatous mastitis (IGM) is a rare and benign inflammatory breast disease with ambiguous aetiology. Contrastingly, lactational mastitis (LM) is commonly diagnosed in breastfeeding women. To investigate IGM aetiology, we profiled the microbial flora of pus and skin in patients with IGM...
Ausführliche Beschreibung
Autor*in: |
Seeu Si Ong [verfasserIn] Jia Xu [verfasserIn] Choon Kiat Sim [verfasserIn] Alexis Jiaying Khng [verfasserIn] Peh Joo Ho [verfasserIn] Philip Kam Weng Kwan [verfasserIn] Aarthi Ravikrishnan [verfasserIn] Kiat-Tee Benita Tan [verfasserIn] Qing Ting Tan [verfasserIn] Ern Yu Tan [verfasserIn] Su-Ming Tan [verfasserIn] Thomas Choudary Putti [verfasserIn] Swee Ho Lim [verfasserIn] Ee Ling Serene Tang [verfasserIn] Niranjan Nagarajan [verfasserIn] Neerja Karnani [verfasserIn] Jingmei Li [verfasserIn] Mikael Hartman [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
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2023 |
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Übergeordnetes Werk: |
In: International Journal of Molecular Sciences - MDPI AG, 2003, 24(2023), 2, p 1042 |
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Übergeordnetes Werk: |
volume:24 ; year:2023 ; number:2, p 1042 |
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DOI / URN: |
10.3390/ijms24021042 |
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DOAJ08178421X |
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520 | |a Idiopathic granulomatous mastitis (IGM) is a rare and benign inflammatory breast disease with ambiguous aetiology. Contrastingly, lactational mastitis (LM) is commonly diagnosed in breastfeeding women. To investigate IGM aetiology, we profiled the microbial flora of pus and skin in patients with IGM and LM. A total of 26 patients with IGM and 6 patients with LM were included in the study. The 16S rRNA sequencing libraries were constructed from 16S rRNA gene amplified from total DNA extracted from pus and skin swabs in patients with IGM and LM controls. Constructed libraries were multiplexed and paired-end sequenced on HiSeq4000. Metagenomic analysis was conducted using modified microbiome abundance analysis suite customised R-resource for paired pus and skin samples. Microbiome multivariable association analyses were performed using linear models. A total of 21 IGM and 3 LM paired pus and skin samples underwent metagenomic analysis. Bray−Curtis ecological dissimilarity distance showed dissimilarity across four sample types (IGM pus, IGM skin, LM pus, and LM skin; PERMANOVA, <i<p</i< < 0.001). No characteristic dominant genus was observed across the IGM samples. The IGM pus samples were more diverse than corresponding IGM skin samples (Shannon and Simpson index; Wilcoxon paired signed-rank tests, <i<p</i< = 0.022 and <i<p</i< = 0.07). <i<Corynebacterium kroppenstedtii</i<, reportedly associated with IGM in the literature, was higher in IGM pus samples than paired skin samples (Wilcoxon, <i<p</i< = 0.022). Three other species and nineteen genera were statistically significant in paired IGM pus–skin comparison after antibiotic treatment adjustment and multiple comparisons correction. Microbial profiles are unique between patients with IGM and LM. Inter-patient variability and polymicrobial IGM pus samples cannot implicate specific genus or species as an infectious cause for IGM. | ||
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10.3390/ijms24021042 doi (DE-627)DOAJ08178421X (DE-599)DOAJ2049130e9512420db439bba516c66098 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Seeu Si Ong verfasserin aut Profiling Microbial Communities in Idiopathic Granulomatous Mastitis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Idiopathic granulomatous mastitis (IGM) is a rare and benign inflammatory breast disease with ambiguous aetiology. Contrastingly, lactational mastitis (LM) is commonly diagnosed in breastfeeding women. To investigate IGM aetiology, we profiled the microbial flora of pus and skin in patients with IGM and LM. A total of 26 patients with IGM and 6 patients with LM were included in the study. The 16S rRNA sequencing libraries were constructed from 16S rRNA gene amplified from total DNA extracted from pus and skin swabs in patients with IGM and LM controls. Constructed libraries were multiplexed and paired-end sequenced on HiSeq4000. Metagenomic analysis was conducted using modified microbiome abundance analysis suite customised R-resource for paired pus and skin samples. Microbiome multivariable association analyses were performed using linear models. A total of 21 IGM and 3 LM paired pus and skin samples underwent metagenomic analysis. Bray−Curtis ecological dissimilarity distance showed dissimilarity across four sample types (IGM pus, IGM skin, LM pus, and LM skin; PERMANOVA, <i<p</i< < 0.001). No characteristic dominant genus was observed across the IGM samples. The IGM pus samples were more diverse than corresponding IGM skin samples (Shannon and Simpson index; Wilcoxon paired signed-rank tests, <i<p</i< = 0.022 and <i<p</i< = 0.07). <i<Corynebacterium kroppenstedtii</i<, reportedly associated with IGM in the literature, was higher in IGM pus samples than paired skin samples (Wilcoxon, <i<p</i< = 0.022). Three other species and nineteen genera were statistically significant in paired IGM pus–skin comparison after antibiotic treatment adjustment and multiple comparisons correction. Microbial profiles are unique between patients with IGM and LM. Inter-patient variability and polymicrobial IGM pus samples cannot implicate specific genus or species as an infectious cause for IGM. idiopathic granulomatous mastitis metagenomic sequencing microbiota 16S rRNA <i<Corynebacterium</i< MaAsLin 2 Biology (General) Chemistry Jia Xu verfasserin aut Choon Kiat Sim verfasserin aut Alexis Jiaying Khng verfasserin aut Peh Joo Ho verfasserin aut Philip Kam Weng Kwan verfasserin aut Aarthi Ravikrishnan verfasserin aut Kiat-Tee Benita Tan verfasserin aut Qing Ting Tan verfasserin aut Ern Yu Tan verfasserin aut Su-Ming Tan verfasserin aut Thomas Choudary Putti verfasserin aut Swee Ho Lim verfasserin aut Ee Ling Serene Tang verfasserin aut Niranjan Nagarajan verfasserin aut Neerja Karnani verfasserin aut Jingmei Li verfasserin aut Mikael Hartman verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 2, p 1042 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:2, p 1042 https://doi.org/10.3390/ijms24021042 kostenfrei https://doaj.org/article/2049130e9512420db439bba516c66098 kostenfrei https://www.mdpi.com/1422-0067/24/2/1042 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 2, p 1042 |
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10.3390/ijms24021042 doi (DE-627)DOAJ08178421X (DE-599)DOAJ2049130e9512420db439bba516c66098 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Seeu Si Ong verfasserin aut Profiling Microbial Communities in Idiopathic Granulomatous Mastitis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Idiopathic granulomatous mastitis (IGM) is a rare and benign inflammatory breast disease with ambiguous aetiology. Contrastingly, lactational mastitis (LM) is commonly diagnosed in breastfeeding women. To investigate IGM aetiology, we profiled the microbial flora of pus and skin in patients with IGM and LM. A total of 26 patients with IGM and 6 patients with LM were included in the study. The 16S rRNA sequencing libraries were constructed from 16S rRNA gene amplified from total DNA extracted from pus and skin swabs in patients with IGM and LM controls. Constructed libraries were multiplexed and paired-end sequenced on HiSeq4000. Metagenomic analysis was conducted using modified microbiome abundance analysis suite customised R-resource for paired pus and skin samples. Microbiome multivariable association analyses were performed using linear models. A total of 21 IGM and 3 LM paired pus and skin samples underwent metagenomic analysis. Bray−Curtis ecological dissimilarity distance showed dissimilarity across four sample types (IGM pus, IGM skin, LM pus, and LM skin; PERMANOVA, <i<p</i< < 0.001). No characteristic dominant genus was observed across the IGM samples. The IGM pus samples were more diverse than corresponding IGM skin samples (Shannon and Simpson index; Wilcoxon paired signed-rank tests, <i<p</i< = 0.022 and <i<p</i< = 0.07). <i<Corynebacterium kroppenstedtii</i<, reportedly associated with IGM in the literature, was higher in IGM pus samples than paired skin samples (Wilcoxon, <i<p</i< = 0.022). Three other species and nineteen genera were statistically significant in paired IGM pus–skin comparison after antibiotic treatment adjustment and multiple comparisons correction. Microbial profiles are unique between patients with IGM and LM. Inter-patient variability and polymicrobial IGM pus samples cannot implicate specific genus or species as an infectious cause for IGM. idiopathic granulomatous mastitis metagenomic sequencing microbiota 16S rRNA <i<Corynebacterium</i< MaAsLin 2 Biology (General) Chemistry Jia Xu verfasserin aut Choon Kiat Sim verfasserin aut Alexis Jiaying Khng verfasserin aut Peh Joo Ho verfasserin aut Philip Kam Weng Kwan verfasserin aut Aarthi Ravikrishnan verfasserin aut Kiat-Tee Benita Tan verfasserin aut Qing Ting Tan verfasserin aut Ern Yu Tan verfasserin aut Su-Ming Tan verfasserin aut Thomas Choudary Putti verfasserin aut Swee Ho Lim verfasserin aut Ee Ling Serene Tang verfasserin aut Niranjan Nagarajan verfasserin aut Neerja Karnani verfasserin aut Jingmei Li verfasserin aut Mikael Hartman verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 2, p 1042 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:2, p 1042 https://doi.org/10.3390/ijms24021042 kostenfrei https://doaj.org/article/2049130e9512420db439bba516c66098 kostenfrei https://www.mdpi.com/1422-0067/24/2/1042 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 2, p 1042 |
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10.3390/ijms24021042 doi (DE-627)DOAJ08178421X (DE-599)DOAJ2049130e9512420db439bba516c66098 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Seeu Si Ong verfasserin aut Profiling Microbial Communities in Idiopathic Granulomatous Mastitis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Idiopathic granulomatous mastitis (IGM) is a rare and benign inflammatory breast disease with ambiguous aetiology. Contrastingly, lactational mastitis (LM) is commonly diagnosed in breastfeeding women. To investigate IGM aetiology, we profiled the microbial flora of pus and skin in patients with IGM and LM. A total of 26 patients with IGM and 6 patients with LM were included in the study. The 16S rRNA sequencing libraries were constructed from 16S rRNA gene amplified from total DNA extracted from pus and skin swabs in patients with IGM and LM controls. Constructed libraries were multiplexed and paired-end sequenced on HiSeq4000. Metagenomic analysis was conducted using modified microbiome abundance analysis suite customised R-resource for paired pus and skin samples. Microbiome multivariable association analyses were performed using linear models. A total of 21 IGM and 3 LM paired pus and skin samples underwent metagenomic analysis. Bray−Curtis ecological dissimilarity distance showed dissimilarity across four sample types (IGM pus, IGM skin, LM pus, and LM skin; PERMANOVA, <i<p</i< < 0.001). No characteristic dominant genus was observed across the IGM samples. The IGM pus samples were more diverse than corresponding IGM skin samples (Shannon and Simpson index; Wilcoxon paired signed-rank tests, <i<p</i< = 0.022 and <i<p</i< = 0.07). <i<Corynebacterium kroppenstedtii</i<, reportedly associated with IGM in the literature, was higher in IGM pus samples than paired skin samples (Wilcoxon, <i<p</i< = 0.022). Three other species and nineteen genera were statistically significant in paired IGM pus–skin comparison after antibiotic treatment adjustment and multiple comparisons correction. Microbial profiles are unique between patients with IGM and LM. Inter-patient variability and polymicrobial IGM pus samples cannot implicate specific genus or species as an infectious cause for IGM. idiopathic granulomatous mastitis metagenomic sequencing microbiota 16S rRNA <i<Corynebacterium</i< MaAsLin 2 Biology (General) Chemistry Jia Xu verfasserin aut Choon Kiat Sim verfasserin aut Alexis Jiaying Khng verfasserin aut Peh Joo Ho verfasserin aut Philip Kam Weng Kwan verfasserin aut Aarthi Ravikrishnan verfasserin aut Kiat-Tee Benita Tan verfasserin aut Qing Ting Tan verfasserin aut Ern Yu Tan verfasserin aut Su-Ming Tan verfasserin aut Thomas Choudary Putti verfasserin aut Swee Ho Lim verfasserin aut Ee Ling Serene Tang verfasserin aut Niranjan Nagarajan verfasserin aut Neerja Karnani verfasserin aut Jingmei Li verfasserin aut Mikael Hartman verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 2, p 1042 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:2, p 1042 https://doi.org/10.3390/ijms24021042 kostenfrei https://doaj.org/article/2049130e9512420db439bba516c66098 kostenfrei https://www.mdpi.com/1422-0067/24/2/1042 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 2, p 1042 |
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QH301-705.5 QD1-999 Profiling Microbial Communities in Idiopathic Granulomatous Mastitis idiopathic granulomatous mastitis metagenomic sequencing microbiota 16S rRNA <i<Corynebacterium</i< MaAsLin 2 |
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profiling microbial communities in idiopathic granulomatous mastitis |
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Profiling Microbial Communities in Idiopathic Granulomatous Mastitis |
abstract |
Idiopathic granulomatous mastitis (IGM) is a rare and benign inflammatory breast disease with ambiguous aetiology. Contrastingly, lactational mastitis (LM) is commonly diagnosed in breastfeeding women. To investigate IGM aetiology, we profiled the microbial flora of pus and skin in patients with IGM and LM. A total of 26 patients with IGM and 6 patients with LM were included in the study. The 16S rRNA sequencing libraries were constructed from 16S rRNA gene amplified from total DNA extracted from pus and skin swabs in patients with IGM and LM controls. Constructed libraries were multiplexed and paired-end sequenced on HiSeq4000. Metagenomic analysis was conducted using modified microbiome abundance analysis suite customised R-resource for paired pus and skin samples. Microbiome multivariable association analyses were performed using linear models. A total of 21 IGM and 3 LM paired pus and skin samples underwent metagenomic analysis. Bray−Curtis ecological dissimilarity distance showed dissimilarity across four sample types (IGM pus, IGM skin, LM pus, and LM skin; PERMANOVA, <i<p</i< < 0.001). No characteristic dominant genus was observed across the IGM samples. The IGM pus samples were more diverse than corresponding IGM skin samples (Shannon and Simpson index; Wilcoxon paired signed-rank tests, <i<p</i< = 0.022 and <i<p</i< = 0.07). <i<Corynebacterium kroppenstedtii</i<, reportedly associated with IGM in the literature, was higher in IGM pus samples than paired skin samples (Wilcoxon, <i<p</i< = 0.022). Three other species and nineteen genera were statistically significant in paired IGM pus–skin comparison after antibiotic treatment adjustment and multiple comparisons correction. Microbial profiles are unique between patients with IGM and LM. Inter-patient variability and polymicrobial IGM pus samples cannot implicate specific genus or species as an infectious cause for IGM. |
abstractGer |
Idiopathic granulomatous mastitis (IGM) is a rare and benign inflammatory breast disease with ambiguous aetiology. Contrastingly, lactational mastitis (LM) is commonly diagnosed in breastfeeding women. To investigate IGM aetiology, we profiled the microbial flora of pus and skin in patients with IGM and LM. A total of 26 patients with IGM and 6 patients with LM were included in the study. The 16S rRNA sequencing libraries were constructed from 16S rRNA gene amplified from total DNA extracted from pus and skin swabs in patients with IGM and LM controls. Constructed libraries were multiplexed and paired-end sequenced on HiSeq4000. Metagenomic analysis was conducted using modified microbiome abundance analysis suite customised R-resource for paired pus and skin samples. Microbiome multivariable association analyses were performed using linear models. A total of 21 IGM and 3 LM paired pus and skin samples underwent metagenomic analysis. Bray−Curtis ecological dissimilarity distance showed dissimilarity across four sample types (IGM pus, IGM skin, LM pus, and LM skin; PERMANOVA, <i<p</i< < 0.001). No characteristic dominant genus was observed across the IGM samples. The IGM pus samples were more diverse than corresponding IGM skin samples (Shannon and Simpson index; Wilcoxon paired signed-rank tests, <i<p</i< = 0.022 and <i<p</i< = 0.07). <i<Corynebacterium kroppenstedtii</i<, reportedly associated with IGM in the literature, was higher in IGM pus samples than paired skin samples (Wilcoxon, <i<p</i< = 0.022). Three other species and nineteen genera were statistically significant in paired IGM pus–skin comparison after antibiotic treatment adjustment and multiple comparisons correction. Microbial profiles are unique between patients with IGM and LM. Inter-patient variability and polymicrobial IGM pus samples cannot implicate specific genus or species as an infectious cause for IGM. |
abstract_unstemmed |
Idiopathic granulomatous mastitis (IGM) is a rare and benign inflammatory breast disease with ambiguous aetiology. Contrastingly, lactational mastitis (LM) is commonly diagnosed in breastfeeding women. To investigate IGM aetiology, we profiled the microbial flora of pus and skin in patients with IGM and LM. A total of 26 patients with IGM and 6 patients with LM were included in the study. The 16S rRNA sequencing libraries were constructed from 16S rRNA gene amplified from total DNA extracted from pus and skin swabs in patients with IGM and LM controls. Constructed libraries were multiplexed and paired-end sequenced on HiSeq4000. Metagenomic analysis was conducted using modified microbiome abundance analysis suite customised R-resource for paired pus and skin samples. Microbiome multivariable association analyses were performed using linear models. A total of 21 IGM and 3 LM paired pus and skin samples underwent metagenomic analysis. Bray−Curtis ecological dissimilarity distance showed dissimilarity across four sample types (IGM pus, IGM skin, LM pus, and LM skin; PERMANOVA, <i<p</i< < 0.001). No characteristic dominant genus was observed across the IGM samples. The IGM pus samples were more diverse than corresponding IGM skin samples (Shannon and Simpson index; Wilcoxon paired signed-rank tests, <i<p</i< = 0.022 and <i<p</i< = 0.07). <i<Corynebacterium kroppenstedtii</i<, reportedly associated with IGM in the literature, was higher in IGM pus samples than paired skin samples (Wilcoxon, <i<p</i< = 0.022). Three other species and nineteen genera were statistically significant in paired IGM pus–skin comparison after antibiotic treatment adjustment and multiple comparisons correction. Microbial profiles are unique between patients with IGM and LM. Inter-patient variability and polymicrobial IGM pus samples cannot implicate specific genus or species as an infectious cause for IGM. |
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