Comprehensive Analysis of the lncRNA–miRNA–mRNA Regulatory Network for Intramuscular Fat in Pigs

Intramuscular fat (IMF) is an essential trait closely related to meat quality. The IMF trait is a complex quantitative trait that is regulated by multiple genes. In order to better understand the process of IMF and explore the key factors affecting IMF deposition, we identified differentially expres...
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Autor*in:	Yanhui Zhao [verfasserIn] Shaokang Chen [verfasserIn] Jiani Yuan [verfasserIn] Yumei Shi [verfasserIn] Yan Wang [verfasserIn] Yufei Xi [verfasserIn] Xiaolong Qi [verfasserIn] Yong Guo [verfasserIn] Xihui Sheng [verfasserIn] Jianfeng Liu [verfasserIn] Lei Zhou [verfasserIn] Chuduan Wang [verfasserIn] Kai Xing [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	intramuscular fat fatty acid regulatory network

Übergeordnetes Werk:	In: Genes - MDPI AG, 2010, 14(2023), 1, p 168
Übergeordnetes Werk:	volume:14 ; year:2023 ; number:1, p 168

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/genes14010168

Katalog-ID:	DOAJ081797656

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520			\|a Intramuscular fat (IMF) is an essential trait closely related to meat quality. The IMF trait is a complex quantitative trait that is regulated by multiple genes. In order to better understand the process of IMF and explore the key factors affecting IMF deposition, we identified differentially expressed mRNA, miRNA, and lncRNA in the <i<longissimus dorsi</i< muscle (LD) between Songliao Black (SL) pigs and Landrace pigs. We obtained 606 differentially expressed genes (DEGs), 55 differentially expressed miRNAs (DEMs), and 30 differentially expressed lncRNAs (DELs) between the SL pig and Landrace pig. Enrichment results from GO and KEGG indicate that DEGs are involved in fatty acid metabolism and some pathways related to glycogen synthesis. We constructed an lncRNA–miRNA–mRNA interaction network with 18 DELs, 11 DEMs, and 42 DEGs. Finally, the research suggests that <i<ARID5B</i<, <i<CPT1B</i<, <i<ACSL1</i<, <i<LPIN1</i<, <i<HSP90AA1</i<, <i<IRS1</i<, <i<IRS2</i<, <i<PIK3CA</i<, <i<PIK3CB</i<, and <i<PLIN2</i< may be the key genes affecting IMF deposition. The LncRNAs MSTRG.19948.1, MSTRG.13120.1, MSTRG.20210.1, and MSTRG.10023.1, and the miRNAs ssc-miRNA-429 and ssc-miRNA-7-1, may play a regulatory role in IMF deposition through their respective target genes. Our research provides a reference for further understanding the regulatory mechanism of IMF.
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allfields	10.3390/genes14010168 doi (DE-627)DOAJ081797656 (DE-599)DOAJ6985be5317424e67aa6b81d6f282b0db DE-627 ger DE-627 rakwb eng QH426-470 Yanhui Zhao verfasserin aut Comprehensive Analysis of the lncRNA–miRNA–mRNA Regulatory Network for Intramuscular Fat in Pigs 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Intramuscular fat (IMF) is an essential trait closely related to meat quality. The IMF trait is a complex quantitative trait that is regulated by multiple genes. In order to better understand the process of IMF and explore the key factors affecting IMF deposition, we identified differentially expressed mRNA, miRNA, and lncRNA in the <i<longissimus dorsi</i< muscle (LD) between Songliao Black (SL) pigs and Landrace pigs. We obtained 606 differentially expressed genes (DEGs), 55 differentially expressed miRNAs (DEMs), and 30 differentially expressed lncRNAs (DELs) between the SL pig and Landrace pig. Enrichment results from GO and KEGG indicate that DEGs are involved in fatty acid metabolism and some pathways related to glycogen synthesis. We constructed an lncRNA–miRNA–mRNA interaction network with 18 DELs, 11 DEMs, and 42 DEGs. Finally, the research suggests that <i<ARID5B</i<, <i<CPT1B</i<, <i<ACSL1</i<, <i<LPIN1</i<, <i<HSP90AA1</i<, <i<IRS1</i<, <i<IRS2</i<, <i<PIK3CA</i<, <i<PIK3CB</i<, and <i<PLIN2</i< may be the key genes affecting IMF deposition. The LncRNAs MSTRG.19948.1, MSTRG.13120.1, MSTRG.20210.1, and MSTRG.10023.1, and the miRNAs ssc-miRNA-429 and ssc-miRNA-7-1, may play a regulatory role in IMF deposition through their respective target genes. Our research provides a reference for further understanding the regulatory mechanism of IMF. intramuscular fat fatty acid regulatory network Genetics Shaokang Chen verfasserin aut Jiani Yuan verfasserin aut Yumei Shi verfasserin aut Yan Wang verfasserin aut Yufei Xi verfasserin aut Xiaolong Qi verfasserin aut Yong Guo verfasserin aut Xihui Sheng verfasserin aut Jianfeng Liu verfasserin aut Lei Zhou verfasserin aut Chuduan Wang verfasserin aut Kai Xing verfasserin aut In Genes MDPI AG, 2010 14(2023), 1, p 168 (DE-627)614096537 (DE-600)2527218-4 20734425 nnns volume:14 year:2023 number:1, p 168 https://doi.org/10.3390/genes14010168 kostenfrei https://doaj.org/article/6985be5317424e67aa6b81d6f282b0db kostenfrei https://www.mdpi.com/2073-4425/14/1/168 kostenfrei https://doaj.org/toc/2073-4425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 1, p 168
spelling	10.3390/genes14010168 doi (DE-627)DOAJ081797656 (DE-599)DOAJ6985be5317424e67aa6b81d6f282b0db DE-627 ger DE-627 rakwb eng QH426-470 Yanhui Zhao verfasserin aut Comprehensive Analysis of the lncRNA–miRNA–mRNA Regulatory Network for Intramuscular Fat in Pigs 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Intramuscular fat (IMF) is an essential trait closely related to meat quality. The IMF trait is a complex quantitative trait that is regulated by multiple genes. In order to better understand the process of IMF and explore the key factors affecting IMF deposition, we identified differentially expressed mRNA, miRNA, and lncRNA in the <i<longissimus dorsi</i< muscle (LD) between Songliao Black (SL) pigs and Landrace pigs. We obtained 606 differentially expressed genes (DEGs), 55 differentially expressed miRNAs (DEMs), and 30 differentially expressed lncRNAs (DELs) between the SL pig and Landrace pig. Enrichment results from GO and KEGG indicate that DEGs are involved in fatty acid metabolism and some pathways related to glycogen synthesis. We constructed an lncRNA–miRNA–mRNA interaction network with 18 DELs, 11 DEMs, and 42 DEGs. Finally, the research suggests that <i<ARID5B</i<, <i<CPT1B</i<, <i<ACSL1</i<, <i<LPIN1</i<, <i<HSP90AA1</i<, <i<IRS1</i<, <i<IRS2</i<, <i<PIK3CA</i<, <i<PIK3CB</i<, and <i<PLIN2</i< may be the key genes affecting IMF deposition. The LncRNAs MSTRG.19948.1, MSTRG.13120.1, MSTRG.20210.1, and MSTRG.10023.1, and the miRNAs ssc-miRNA-429 and ssc-miRNA-7-1, may play a regulatory role in IMF deposition through their respective target genes. Our research provides a reference for further understanding the regulatory mechanism of IMF. intramuscular fat fatty acid regulatory network Genetics Shaokang Chen verfasserin aut Jiani Yuan verfasserin aut Yumei Shi verfasserin aut Yan Wang verfasserin aut Yufei Xi verfasserin aut Xiaolong Qi verfasserin aut Yong Guo verfasserin aut Xihui Sheng verfasserin aut Jianfeng Liu verfasserin aut Lei Zhou verfasserin aut Chuduan Wang verfasserin aut Kai Xing verfasserin aut In Genes MDPI AG, 2010 14(2023), 1, p 168 (DE-627)614096537 (DE-600)2527218-4 20734425 nnns volume:14 year:2023 number:1, p 168 https://doi.org/10.3390/genes14010168 kostenfrei https://doaj.org/article/6985be5317424e67aa6b81d6f282b0db kostenfrei https://www.mdpi.com/2073-4425/14/1/168 kostenfrei https://doaj.org/toc/2073-4425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 1, p 168
allfields_unstemmed	10.3390/genes14010168 doi (DE-627)DOAJ081797656 (DE-599)DOAJ6985be5317424e67aa6b81d6f282b0db DE-627 ger DE-627 rakwb eng QH426-470 Yanhui Zhao verfasserin aut Comprehensive Analysis of the lncRNA–miRNA–mRNA Regulatory Network for Intramuscular Fat in Pigs 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Intramuscular fat (IMF) is an essential trait closely related to meat quality. The IMF trait is a complex quantitative trait that is regulated by multiple genes. In order to better understand the process of IMF and explore the key factors affecting IMF deposition, we identified differentially expressed mRNA, miRNA, and lncRNA in the <i<longissimus dorsi</i< muscle (LD) between Songliao Black (SL) pigs and Landrace pigs. We obtained 606 differentially expressed genes (DEGs), 55 differentially expressed miRNAs (DEMs), and 30 differentially expressed lncRNAs (DELs) between the SL pig and Landrace pig. Enrichment results from GO and KEGG indicate that DEGs are involved in fatty acid metabolism and some pathways related to glycogen synthesis. We constructed an lncRNA–miRNA–mRNA interaction network with 18 DELs, 11 DEMs, and 42 DEGs. Finally, the research suggests that <i<ARID5B</i<, <i<CPT1B</i<, <i<ACSL1</i<, <i<LPIN1</i<, <i<HSP90AA1</i<, <i<IRS1</i<, <i<IRS2</i<, <i<PIK3CA</i<, <i<PIK3CB</i<, and <i<PLIN2</i< may be the key genes affecting IMF deposition. The LncRNAs MSTRG.19948.1, MSTRG.13120.1, MSTRG.20210.1, and MSTRG.10023.1, and the miRNAs ssc-miRNA-429 and ssc-miRNA-7-1, may play a regulatory role in IMF deposition through their respective target genes. Our research provides a reference for further understanding the regulatory mechanism of IMF. intramuscular fat fatty acid regulatory network Genetics Shaokang Chen verfasserin aut Jiani Yuan verfasserin aut Yumei Shi verfasserin aut Yan Wang verfasserin aut Yufei Xi verfasserin aut Xiaolong Qi verfasserin aut Yong Guo verfasserin aut Xihui Sheng verfasserin aut Jianfeng Liu verfasserin aut Lei Zhou verfasserin aut Chuduan Wang verfasserin aut Kai Xing verfasserin aut In Genes MDPI AG, 2010 14(2023), 1, p 168 (DE-627)614096537 (DE-600)2527218-4 20734425 nnns volume:14 year:2023 number:1, p 168 https://doi.org/10.3390/genes14010168 kostenfrei https://doaj.org/article/6985be5317424e67aa6b81d6f282b0db kostenfrei https://www.mdpi.com/2073-4425/14/1/168 kostenfrei https://doaj.org/toc/2073-4425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 1, p 168
allfieldsGer	10.3390/genes14010168 doi (DE-627)DOAJ081797656 (DE-599)DOAJ6985be5317424e67aa6b81d6f282b0db DE-627 ger DE-627 rakwb eng QH426-470 Yanhui Zhao verfasserin aut Comprehensive Analysis of the lncRNA–miRNA–mRNA Regulatory Network for Intramuscular Fat in Pigs 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Intramuscular fat (IMF) is an essential trait closely related to meat quality. The IMF trait is a complex quantitative trait that is regulated by multiple genes. In order to better understand the process of IMF and explore the key factors affecting IMF deposition, we identified differentially expressed mRNA, miRNA, and lncRNA in the <i<longissimus dorsi</i< muscle (LD) between Songliao Black (SL) pigs and Landrace pigs. We obtained 606 differentially expressed genes (DEGs), 55 differentially expressed miRNAs (DEMs), and 30 differentially expressed lncRNAs (DELs) between the SL pig and Landrace pig. Enrichment results from GO and KEGG indicate that DEGs are involved in fatty acid metabolism and some pathways related to glycogen synthesis. We constructed an lncRNA–miRNA–mRNA interaction network with 18 DELs, 11 DEMs, and 42 DEGs. Finally, the research suggests that <i<ARID5B</i<, <i<CPT1B</i<, <i<ACSL1</i<, <i<LPIN1</i<, <i<HSP90AA1</i<, <i<IRS1</i<, <i<IRS2</i<, <i<PIK3CA</i<, <i<PIK3CB</i<, and <i<PLIN2</i< may be the key genes affecting IMF deposition. The LncRNAs MSTRG.19948.1, MSTRG.13120.1, MSTRG.20210.1, and MSTRG.10023.1, and the miRNAs ssc-miRNA-429 and ssc-miRNA-7-1, may play a regulatory role in IMF deposition through their respective target genes. Our research provides a reference for further understanding the regulatory mechanism of IMF. intramuscular fat fatty acid regulatory network Genetics Shaokang Chen verfasserin aut Jiani Yuan verfasserin aut Yumei Shi verfasserin aut Yan Wang verfasserin aut Yufei Xi verfasserin aut Xiaolong Qi verfasserin aut Yong Guo verfasserin aut Xihui Sheng verfasserin aut Jianfeng Liu verfasserin aut Lei Zhou verfasserin aut Chuduan Wang verfasserin aut Kai Xing verfasserin aut In Genes MDPI AG, 2010 14(2023), 1, p 168 (DE-627)614096537 (DE-600)2527218-4 20734425 nnns volume:14 year:2023 number:1, p 168 https://doi.org/10.3390/genes14010168 kostenfrei https://doaj.org/article/6985be5317424e67aa6b81d6f282b0db kostenfrei https://www.mdpi.com/2073-4425/14/1/168 kostenfrei https://doaj.org/toc/2073-4425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 1, p 168
allfieldsSound	10.3390/genes14010168 doi (DE-627)DOAJ081797656 (DE-599)DOAJ6985be5317424e67aa6b81d6f282b0db DE-627 ger DE-627 rakwb eng QH426-470 Yanhui Zhao verfasserin aut Comprehensive Analysis of the lncRNA–miRNA–mRNA Regulatory Network for Intramuscular Fat in Pigs 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Intramuscular fat (IMF) is an essential trait closely related to meat quality. The IMF trait is a complex quantitative trait that is regulated by multiple genes. In order to better understand the process of IMF and explore the key factors affecting IMF deposition, we identified differentially expressed mRNA, miRNA, and lncRNA in the <i<longissimus dorsi</i< muscle (LD) between Songliao Black (SL) pigs and Landrace pigs. We obtained 606 differentially expressed genes (DEGs), 55 differentially expressed miRNAs (DEMs), and 30 differentially expressed lncRNAs (DELs) between the SL pig and Landrace pig. Enrichment results from GO and KEGG indicate that DEGs are involved in fatty acid metabolism and some pathways related to glycogen synthesis. We constructed an lncRNA–miRNA–mRNA interaction network with 18 DELs, 11 DEMs, and 42 DEGs. Finally, the research suggests that <i<ARID5B</i<, <i<CPT1B</i<, <i<ACSL1</i<, <i<LPIN1</i<, <i<HSP90AA1</i<, <i<IRS1</i<, <i<IRS2</i<, <i<PIK3CA</i<, <i<PIK3CB</i<, and <i<PLIN2</i< may be the key genes affecting IMF deposition. The LncRNAs MSTRG.19948.1, MSTRG.13120.1, MSTRG.20210.1, and MSTRG.10023.1, and the miRNAs ssc-miRNA-429 and ssc-miRNA-7-1, may play a regulatory role in IMF deposition through their respective target genes. Our research provides a reference for further understanding the regulatory mechanism of IMF. intramuscular fat fatty acid regulatory network Genetics Shaokang Chen verfasserin aut Jiani Yuan verfasserin aut Yumei Shi verfasserin aut Yan Wang verfasserin aut Yufei Xi verfasserin aut Xiaolong Qi verfasserin aut Yong Guo verfasserin aut Xihui Sheng verfasserin aut Jianfeng Liu verfasserin aut Lei Zhou verfasserin aut Chuduan Wang verfasserin aut Kai Xing verfasserin aut In Genes MDPI AG, 2010 14(2023), 1, p 168 (DE-627)614096537 (DE-600)2527218-4 20734425 nnns volume:14 year:2023 number:1, p 168 https://doi.org/10.3390/genes14010168 kostenfrei https://doaj.org/article/6985be5317424e67aa6b81d6f282b0db kostenfrei https://www.mdpi.com/2073-4425/14/1/168 kostenfrei https://doaj.org/toc/2073-4425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 1, p 168
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source	In Genes 14(2023), 1, p 168 volume:14 year:2023 number:1, p 168
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callnumber-first	Q - Science
author	Yanhui Zhao
spellingShingle	Yanhui Zhao misc QH426-470 misc intramuscular fat misc fatty acid misc regulatory network misc Genetics Comprehensive Analysis of the lncRNA–miRNA–mRNA Regulatory Network for Intramuscular Fat in Pigs
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topic_title	QH426-470 Comprehensive Analysis of the lncRNA–miRNA–mRNA Regulatory Network for Intramuscular Fat in Pigs intramuscular fat fatty acid regulatory network
topic	misc QH426-470 misc intramuscular fat misc fatty acid misc regulatory network misc Genetics
topic_unstemmed	misc QH426-470 misc intramuscular fat misc fatty acid misc regulatory network misc Genetics
topic_browse	misc QH426-470 misc intramuscular fat misc fatty acid misc regulatory network misc Genetics
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title	Comprehensive Analysis of the lncRNA–miRNA–mRNA Regulatory Network for Intramuscular Fat in Pigs
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title_full	Comprehensive Analysis of the lncRNA–miRNA–mRNA Regulatory Network for Intramuscular Fat in Pigs
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author_browse	Yanhui Zhao Shaokang Chen Jiani Yuan Yumei Shi Yan Wang Yufei Xi Xiaolong Qi Yong Guo Xihui Sheng Jianfeng Liu Lei Zhou Chuduan Wang Kai Xing
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title_sort	comprehensive analysis of the lncrna–mirna–mrna regulatory network for intramuscular fat in pigs
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title_auth	Comprehensive Analysis of the lncRNA–miRNA–mRNA Regulatory Network for Intramuscular Fat in Pigs
abstract	Intramuscular fat (IMF) is an essential trait closely related to meat quality. The IMF trait is a complex quantitative trait that is regulated by multiple genes. In order to better understand the process of IMF and explore the key factors affecting IMF deposition, we identified differentially expressed mRNA, miRNA, and lncRNA in the <i<longissimus dorsi</i< muscle (LD) between Songliao Black (SL) pigs and Landrace pigs. We obtained 606 differentially expressed genes (DEGs), 55 differentially expressed miRNAs (DEMs), and 30 differentially expressed lncRNAs (DELs) between the SL pig and Landrace pig. Enrichment results from GO and KEGG indicate that DEGs are involved in fatty acid metabolism and some pathways related to glycogen synthesis. We constructed an lncRNA–miRNA–mRNA interaction network with 18 DELs, 11 DEMs, and 42 DEGs. Finally, the research suggests that <i<ARID5B</i<, <i<CPT1B</i<, <i<ACSL1</i<, <i<LPIN1</i<, <i<HSP90AA1</i<, <i<IRS1</i<, <i<IRS2</i<, <i<PIK3CA</i<, <i<PIK3CB</i<, and <i<PLIN2</i< may be the key genes affecting IMF deposition. The LncRNAs MSTRG.19948.1, MSTRG.13120.1, MSTRG.20210.1, and MSTRG.10023.1, and the miRNAs ssc-miRNA-429 and ssc-miRNA-7-1, may play a regulatory role in IMF deposition through their respective target genes. Our research provides a reference for further understanding the regulatory mechanism of IMF.
abstractGer	Intramuscular fat (IMF) is an essential trait closely related to meat quality. The IMF trait is a complex quantitative trait that is regulated by multiple genes. In order to better understand the process of IMF and explore the key factors affecting IMF deposition, we identified differentially expressed mRNA, miRNA, and lncRNA in the <i<longissimus dorsi</i< muscle (LD) between Songliao Black (SL) pigs and Landrace pigs. We obtained 606 differentially expressed genes (DEGs), 55 differentially expressed miRNAs (DEMs), and 30 differentially expressed lncRNAs (DELs) between the SL pig and Landrace pig. Enrichment results from GO and KEGG indicate that DEGs are involved in fatty acid metabolism and some pathways related to glycogen synthesis. We constructed an lncRNA–miRNA–mRNA interaction network with 18 DELs, 11 DEMs, and 42 DEGs. Finally, the research suggests that <i<ARID5B</i<, <i<CPT1B</i<, <i<ACSL1</i<, <i<LPIN1</i<, <i<HSP90AA1</i<, <i<IRS1</i<, <i<IRS2</i<, <i<PIK3CA</i<, <i<PIK3CB</i<, and <i<PLIN2</i< may be the key genes affecting IMF deposition. The LncRNAs MSTRG.19948.1, MSTRG.13120.1, MSTRG.20210.1, and MSTRG.10023.1, and the miRNAs ssc-miRNA-429 and ssc-miRNA-7-1, may play a regulatory role in IMF deposition through their respective target genes. Our research provides a reference for further understanding the regulatory mechanism of IMF.
abstract_unstemmed	Intramuscular fat (IMF) is an essential trait closely related to meat quality. The IMF trait is a complex quantitative trait that is regulated by multiple genes. In order to better understand the process of IMF and explore the key factors affecting IMF deposition, we identified differentially expressed mRNA, miRNA, and lncRNA in the <i<longissimus dorsi</i< muscle (LD) between Songliao Black (SL) pigs and Landrace pigs. We obtained 606 differentially expressed genes (DEGs), 55 differentially expressed miRNAs (DEMs), and 30 differentially expressed lncRNAs (DELs) between the SL pig and Landrace pig. Enrichment results from GO and KEGG indicate that DEGs are involved in fatty acid metabolism and some pathways related to glycogen synthesis. We constructed an lncRNA–miRNA–mRNA interaction network with 18 DELs, 11 DEMs, and 42 DEGs. Finally, the research suggests that <i<ARID5B</i<, <i<CPT1B</i<, <i<ACSL1</i<, <i<LPIN1</i<, <i<HSP90AA1</i<, <i<IRS1</i<, <i<IRS2</i<, <i<PIK3CA</i<, <i<PIK3CB</i<, and <i<PLIN2</i< may be the key genes affecting IMF deposition. The LncRNAs MSTRG.19948.1, MSTRG.13120.1, MSTRG.20210.1, and MSTRG.10023.1, and the miRNAs ssc-miRNA-429 and ssc-miRNA-7-1, may play a regulatory role in IMF deposition through their respective target genes. Our research provides a reference for further understanding the regulatory mechanism of IMF.
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container_issue	1, p 168
title_short	Comprehensive Analysis of the lncRNA–miRNA–mRNA Regulatory Network for Intramuscular Fat in Pigs
url	https://doi.org/10.3390/genes14010168 https://doaj.org/article/6985be5317424e67aa6b81d6f282b0db https://www.mdpi.com/2073-4425/14/1/168 https://doaj.org/toc/2073-4425
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The IMF trait is a complex quantitative trait that is regulated by multiple genes. In order to better understand the process of IMF and explore the key factors affecting IMF deposition, we identified differentially expressed mRNA, miRNA, and lncRNA in the <i<longissimus dorsi</i< muscle (LD) between Songliao Black (SL) pigs and Landrace pigs. We obtained 606 differentially expressed genes (DEGs), 55 differentially expressed miRNAs (DEMs), and 30 differentially expressed lncRNAs (DELs) between the SL pig and Landrace pig. Enrichment results from GO and KEGG indicate that DEGs are involved in fatty acid metabolism and some pathways related to glycogen synthesis. We constructed an lncRNA–miRNA–mRNA interaction network with 18 DELs, 11 DEMs, and 42 DEGs. Finally, the research suggests that <i<ARID5B</i<, <i<CPT1B</i<, <i<ACSL1</i<, <i<LPIN1</i<, <i<HSP90AA1</i<, <i<IRS1</i<, <i<IRS2</i<, <i<PIK3CA</i<, <i<PIK3CB</i<, and <i<PLIN2</i< may be the key genes affecting IMF deposition. The LncRNAs MSTRG.19948.1, MSTRG.13120.1, MSTRG.20210.1, and MSTRG.10023.1, and the miRNAs ssc-miRNA-429 and ssc-miRNA-7-1, may play a regulatory role in IMF deposition through their respective target genes. 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Comprehensive Analysis of the lncRNA–miRNA–mRNA Regulatory Network for Intramuscular Fat in Pigs

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