<i<Agaricus bisporus</i< Polysaccharides Ameliorates Behavioural Deficits in D-Galactose-Induced Aging Mice: Mediated by Gut Microbiota

White button mushroom polysaccharide (WMP) has various health-promoting functions. However, whether these functions are mediated by gut microbiota has not been well explored. Therefore, this study evaluated the anti-aging capacity of WMP and its effects on the diversity and composition of gut microb...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Hui Duan [verfasserIn] Jinwei Li [verfasserIn] Liuping Fan [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	polysaccharides gut microbiota Bacteroides SCFAs anti-aging effect

Übergeordnetes Werk:	In: Foods - MDPI AG, 2013, 12(2023), 2, p 424
Übergeordnetes Werk:	volume:12 ; year:2023 ; number:2, p 424

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/foods12020424

Katalog-ID:	DOAJ081803125

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520			\|a White button mushroom polysaccharide (WMP) has various health-promoting functions. However, whether these functions are mediated by gut microbiota has not been well explored. Therefore, this study evaluated the anti-aging capacity of WMP and its effects on the diversity and composition of gut microbiota in D-galactose-induced aging mice. WMP significantly improved locomotor activity and the spatial and recognition memory of the aging mice. It also alleviated oxidative stress and decreased the pro-inflammatory cytokine levels in the brain. Moreover, WMP increased α-diversity, the short-chain fatty acid (SCFA) level and the abundance of beneficial genera, such as <i<Bacteroides</i< and <i<Parabacteroides</i<. Moreover, its effect on <i<Bacteroides</i< at the species level was further determined, and the enrichments of <i<B. acidifaciens, B. sartorii</i< and <i<B. stercorirosoris</i< were found. A PICRUSt analysis revealed that WMP had a greater impact on the metabolism of carbon, fatty acid and amino acid, as well as the MAPK and PPAR signaling pathway. In addition, there was a strong correlation between the behavioral improvements and changes in SCFA levels and the abundance of <i<Bacteroides</i<, <i<Parabacteroides, Mucispirillum</i< and <i<Desulfovibrio</i< and <i<Helicobacter</i<. Therefore, WMP might be suitable as a functional foods to prevent or delay aging via the directed enrichment of specific species in <i<Bacteroides</i<.
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callnumber-first	T - Technology
author	Hui Duan
spellingShingle	Hui Duan misc TP1-1185 misc <i<Agaricus bisporus</i< misc polysaccharides misc gut microbiota misc Bacteroides misc SCFAs misc anti-aging effect misc Chemical technology <i<Agaricus bisporus</i< Polysaccharides Ameliorates Behavioural Deficits in D-Galactose-Induced Aging Mice: Mediated by Gut Microbiota
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topic_title	TP1-1185 <i<Agaricus bisporus</i< Polysaccharides Ameliorates Behavioural Deficits in D-Galactose-Induced Aging Mice: Mediated by Gut Microbiota <i<Agaricus bisporus</i< polysaccharides gut microbiota Bacteroides SCFAs anti-aging effect
topic	misc TP1-1185 misc <i<Agaricus bisporus</i< misc polysaccharides misc gut microbiota misc Bacteroides misc SCFAs misc anti-aging effect misc Chemical technology
topic_unstemmed	misc TP1-1185 misc <i<Agaricus bisporus</i< misc polysaccharides misc gut microbiota misc Bacteroides misc SCFAs misc anti-aging effect misc Chemical technology
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title	<i<Agaricus bisporus</i< Polysaccharides Ameliorates Behavioural Deficits in D-Galactose-Induced Aging Mice: Mediated by Gut Microbiota
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title_full	<i<Agaricus bisporus</i< Polysaccharides Ameliorates Behavioural Deficits in D-Galactose-Induced Aging Mice: Mediated by Gut Microbiota
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title_sort	<i<agaricus bisporus</i< polysaccharides ameliorates behavioural deficits in d-galactose-induced aging mice: mediated by gut microbiota
callnumber	TP1-1185
title_auth	<i<Agaricus bisporus</i< Polysaccharides Ameliorates Behavioural Deficits in D-Galactose-Induced Aging Mice: Mediated by Gut Microbiota
abstract	White button mushroom polysaccharide (WMP) has various health-promoting functions. However, whether these functions are mediated by gut microbiota has not been well explored. Therefore, this study evaluated the anti-aging capacity of WMP and its effects on the diversity and composition of gut microbiota in D-galactose-induced aging mice. WMP significantly improved locomotor activity and the spatial and recognition memory of the aging mice. It also alleviated oxidative stress and decreased the pro-inflammatory cytokine levels in the brain. Moreover, WMP increased α-diversity, the short-chain fatty acid (SCFA) level and the abundance of beneficial genera, such as <i<Bacteroides</i< and <i<Parabacteroides</i<. Moreover, its effect on <i<Bacteroides</i< at the species level was further determined, and the enrichments of <i<B. acidifaciens, B. sartorii</i< and <i<B. stercorirosoris</i< were found. A PICRUSt analysis revealed that WMP had a greater impact on the metabolism of carbon, fatty acid and amino acid, as well as the MAPK and PPAR signaling pathway. In addition, there was a strong correlation between the behavioral improvements and changes in SCFA levels and the abundance of <i<Bacteroides</i<, <i<Parabacteroides, Mucispirillum</i< and <i<Desulfovibrio</i< and <i<Helicobacter</i<. Therefore, WMP might be suitable as a functional foods to prevent or delay aging via the directed enrichment of specific species in <i<Bacteroides</i<.
abstractGer	White button mushroom polysaccharide (WMP) has various health-promoting functions. However, whether these functions are mediated by gut microbiota has not been well explored. Therefore, this study evaluated the anti-aging capacity of WMP and its effects on the diversity and composition of gut microbiota in D-galactose-induced aging mice. WMP significantly improved locomotor activity and the spatial and recognition memory of the aging mice. It also alleviated oxidative stress and decreased the pro-inflammatory cytokine levels in the brain. Moreover, WMP increased α-diversity, the short-chain fatty acid (SCFA) level and the abundance of beneficial genera, such as <i<Bacteroides</i< and <i<Parabacteroides</i<. Moreover, its effect on <i<Bacteroides</i< at the species level was further determined, and the enrichments of <i<B. acidifaciens, B. sartorii</i< and <i<B. stercorirosoris</i< were found. A PICRUSt analysis revealed that WMP had a greater impact on the metabolism of carbon, fatty acid and amino acid, as well as the MAPK and PPAR signaling pathway. In addition, there was a strong correlation between the behavioral improvements and changes in SCFA levels and the abundance of <i<Bacteroides</i<, <i<Parabacteroides, Mucispirillum</i< and <i<Desulfovibrio</i< and <i<Helicobacter</i<. Therefore, WMP might be suitable as a functional foods to prevent or delay aging via the directed enrichment of specific species in <i<Bacteroides</i<.
abstract_unstemmed	White button mushroom polysaccharide (WMP) has various health-promoting functions. However, whether these functions are mediated by gut microbiota has not been well explored. Therefore, this study evaluated the anti-aging capacity of WMP and its effects on the diversity and composition of gut microbiota in D-galactose-induced aging mice. WMP significantly improved locomotor activity and the spatial and recognition memory of the aging mice. It also alleviated oxidative stress and decreased the pro-inflammatory cytokine levels in the brain. Moreover, WMP increased α-diversity, the short-chain fatty acid (SCFA) level and the abundance of beneficial genera, such as <i<Bacteroides</i< and <i<Parabacteroides</i<. Moreover, its effect on <i<Bacteroides</i< at the species level was further determined, and the enrichments of <i<B. acidifaciens, B. sartorii</i< and <i<B. stercorirosoris</i< were found. A PICRUSt analysis revealed that WMP had a greater impact on the metabolism of carbon, fatty acid and amino acid, as well as the MAPK and PPAR signaling pathway. In addition, there was a strong correlation between the behavioral improvements and changes in SCFA levels and the abundance of <i<Bacteroides</i<, <i<Parabacteroides, Mucispirillum</i< and <i<Desulfovibrio</i< and <i<Helicobacter</i<. Therefore, WMP might be suitable as a functional foods to prevent or delay aging via the directed enrichment of specific species in <i<Bacteroides</i<.
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title_short	<i<Agaricus bisporus</i< Polysaccharides Ameliorates Behavioural Deficits in D-Galactose-Induced Aging Mice: Mediated by Gut Microbiota
url	https://doi.org/10.3390/foods12020424 https://doaj.org/article/293a77c937a044cf82b0423593f0a4d9 https://www.mdpi.com/2304-8158/12/2/424 https://doaj.org/toc/2304-8158
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<i<Agaricus bisporus</i< Polysaccharides Ameliorates Behavioural Deficits in D-Galactose-Induced Aging Mice: Mediated by Gut Microbiota

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