An <i<O</i<-Demethylation Metabolite of Rabeprazole Sulfide by <i<Cunninghamella blakesleeana</i< 3.970 Biotransformation

To explore the potential metabolites from rabeprazole sulfide, seven strains of filamentous fungi were screened for their biotransformation abilities. Among these strains, <i<Cunninghamella blakesleeana</i< 3.970 exhibited the best result. Four different culture media were screened in or...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Ming Song [verfasserIn] Hongxiang Zhu [verfasserIn] Jian Wang [verfasserIn] Weizhuo Xu [verfasserIn] Wei Xu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	rabeprazole sulfide biotransformation

Übergeordnetes Werk:	In: Catalysts - MDPI AG, 2012, 13(2022), 1, p 15
Übergeordnetes Werk:	volume:13 ; year:2022 ; number:1, p 15

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/catal13010015

Katalog-ID:	DOAJ081832796

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callnumber-first	T - Technology
author	Ming Song
spellingShingle	Ming Song misc TP1-1185 misc QD1-999 misc rabeprazole misc sulfide misc biotransformation misc <i<Cunninghamella blakesleeana</i< 3.970 misc <i<O</i<-demethylation rabeprazole sulfide misc Chemical technology misc Chemistry An <i<O</i<-Demethylation Metabolite of Rabeprazole Sulfide by <i<Cunninghamella blakesleeana</i< 3.970 Biotransformation
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topic_title	TP1-1185 QD1-999 An <i<O</i<-Demethylation Metabolite of Rabeprazole Sulfide by <i<Cunninghamella blakesleeana</i< 3.970 Biotransformation rabeprazole sulfide biotransformation <i<Cunninghamella blakesleeana</i< 3.970 <i<O</i<-demethylation rabeprazole sulfide
topic	misc TP1-1185 misc QD1-999 misc rabeprazole misc sulfide misc biotransformation misc <i<Cunninghamella blakesleeana</i< 3.970 misc <i<O</i<-demethylation rabeprazole sulfide misc Chemical technology misc Chemistry
topic_unstemmed	misc TP1-1185 misc QD1-999 misc rabeprazole misc sulfide misc biotransformation misc <i<Cunninghamella blakesleeana</i< 3.970 misc <i<O</i<-demethylation rabeprazole sulfide misc Chemical technology misc Chemistry
topic_browse	misc TP1-1185 misc QD1-999 misc rabeprazole misc sulfide misc biotransformation misc <i<Cunninghamella blakesleeana</i< 3.970 misc <i<O</i<-demethylation rabeprazole sulfide misc Chemical technology misc Chemistry
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title	An <i<O</i<-Demethylation Metabolite of Rabeprazole Sulfide by <i<Cunninghamella blakesleeana</i< 3.970 Biotransformation
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title_full	An <i<O</i<-Demethylation Metabolite of Rabeprazole Sulfide by <i<Cunninghamella blakesleeana</i< 3.970 Biotransformation
author_sort	Ming Song
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author_browse	Ming Song Hongxiang Zhu Jian Wang Weizhuo Xu Wei Xu
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title_sort	<i<o</i<-demethylation metabolite of rabeprazole sulfide by <i<cunninghamella blakesleeana</i< 3.970 biotransformation
callnumber	TP1-1185
title_auth	An <i<O</i<-Demethylation Metabolite of Rabeprazole Sulfide by <i<Cunninghamella blakesleeana</i< 3.970 Biotransformation
abstract	To explore the potential metabolites from rabeprazole sulfide, seven strains of filamentous fungi were screened for their biotransformation abilities. Among these strains, <i<Cunninghamella blakesleeana</i< 3.970 exhibited the best result. Four different culture media were screened in order to identify the most optimal for subsequent research. Single factors such as the initial pH of culture media, culture time, inoculation volume, and media volume were individually investigated to provide the optimum biotransformation conditions. Then, an orthogonal optimization process using a five-factor, four-level L<sub<16</sub<(4<sup<5</sup<) experiment was designed and performed. Finally, when the substrate concentration is 3 g/L, one major metabolite was detected with a transformation rate of 72.4%. Isolated by semipreparative HPLC, this metabolite was further detected by ESI-MS and NMR. The final data analysis indicated that the metabolite is <i<O</i<-demethylation rabeprazole sulfide.
abstractGer	To explore the potential metabolites from rabeprazole sulfide, seven strains of filamentous fungi were screened for their biotransformation abilities. Among these strains, <i<Cunninghamella blakesleeana</i< 3.970 exhibited the best result. Four different culture media were screened in order to identify the most optimal for subsequent research. Single factors such as the initial pH of culture media, culture time, inoculation volume, and media volume were individually investigated to provide the optimum biotransformation conditions. Then, an orthogonal optimization process using a five-factor, four-level L<sub<16</sub<(4<sup<5</sup<) experiment was designed and performed. Finally, when the substrate concentration is 3 g/L, one major metabolite was detected with a transformation rate of 72.4%. Isolated by semipreparative HPLC, this metabolite was further detected by ESI-MS and NMR. The final data analysis indicated that the metabolite is <i<O</i<-demethylation rabeprazole sulfide.
abstract_unstemmed	To explore the potential metabolites from rabeprazole sulfide, seven strains of filamentous fungi were screened for their biotransformation abilities. Among these strains, <i<Cunninghamella blakesleeana</i< 3.970 exhibited the best result. Four different culture media were screened in order to identify the most optimal for subsequent research. Single factors such as the initial pH of culture media, culture time, inoculation volume, and media volume were individually investigated to provide the optimum biotransformation conditions. Then, an orthogonal optimization process using a five-factor, four-level L<sub<16</sub<(4<sup<5</sup<) experiment was designed and performed. Finally, when the substrate concentration is 3 g/L, one major metabolite was detected with a transformation rate of 72.4%. Isolated by semipreparative HPLC, this metabolite was further detected by ESI-MS and NMR. The final data analysis indicated that the metabolite is <i<O</i<-demethylation rabeprazole sulfide.
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
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title_short	An <i<O</i<-Demethylation Metabolite of Rabeprazole Sulfide by <i<Cunninghamella blakesleeana</i< 3.970 Biotransformation
url	https://doi.org/10.3390/catal13010015 https://doaj.org/article/4fca1bbabb7742ec81238449b2f6f9de https://www.mdpi.com/2073-4344/13/1/15 https://doaj.org/toc/2073-4344
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up_date	2024-07-03T22:12:35.765Z
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An <i<O</i<-Demethylation Metabolite of Rabeprazole Sulfide by <i<Cunninghamella blakesleeana</i< 3.970 Biotransformation

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