Hypoglycemic and H2O2-induced oxidative injury protective effects and the phytochemical profiles of the ethyl acetate fraction from Radix Paeoniae Alba

Radix Paeonia Alba (RPA) is often used as food and medicine. This study aimed to enrich and identify the antioxidant and hypoglycemic bioactive compounds from RPA. The results indicated that the ethyl acetate fraction (EAF) showed the highest total phenolic content, DPPH, ABTS+ scavenging ability, a...
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Gespeichert in:

Autor*in:	Lu Zhang [verfasserIn] Chun-yan Peng [verfasserIn] Pei-xin Wang [verfasserIn] Linju Xu [verfasserIn] Jia-hui Liu [verfasserIn] Xing Xie [verfasserIn] Ling Lu [verfasserIn] Zong-cai Tu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Radix Paeoniae Alba hypoglycemic activity polyphenols HPLC-QTOF-MS/MS oxidative stress

Übergeordnetes Werk:	In: Frontiers in Nutrition - Frontiers Media S.A., 2014, 10(2023)
Übergeordnetes Werk:	volume:10 ; year:2023

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fnut.2023.1126359

Katalog-ID:	DOAJ081864329

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spelling	10.3389/fnut.2023.1126359 doi (DE-627)DOAJ081864329 (DE-599)DOAJe73e5434831949f2ae48623e4f4bad09 DE-627 ger DE-627 rakwb eng TX341-641 Lu Zhang verfasserin aut Hypoglycemic and H2O2-induced oxidative injury protective effects and the phytochemical profiles of the ethyl acetate fraction from Radix Paeoniae Alba 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Radix Paeonia Alba (RPA) is often used as food and medicine. This study aimed to enrich and identify the antioxidant and hypoglycemic bioactive compounds from RPA. The results indicated that the ethyl acetate fraction (EAF) showed the highest total phenolic content, DPPH, ABTS+ scavenging ability, and α-glucosidase inhibition ability (IC50 = 7.27 μg/ml). The EAF could alleviate H2O2-induced oxidative stress in HepG2 cells by decreasing the MDA and ROS levels, improving cell apoptosis, increasing the enzyme activity of GPX-Px, CAT, SOD, Na+/K+-ATP, and Ca2+/Mg2+-ATP, and stimulating T-AOC expression, which also enhanced the glucose uptake of insulin-resistant HepG2 cells. In addition, the EAF significantly reduced the fasting blood glucose level and improved glucose tolerance in diabetic mice. An HPLC-QTOF-MS/MS analysis displayed that procyanidin, digallic acid isomer, methyl gallate, tetragalloylglucose isomer, dimethyl gallic acid, and paeoniflorin were the major compounds in the EAF. These findings are meaningful for the application of the EAF in the medicinal or food industry to prevent and treat oxidative stress and diabetes mellitus. Radix Paeoniae Alba hypoglycemic activity polyphenols HPLC-QTOF-MS/MS oxidative stress Nutrition. Foods and food supply Lu Zhang verfasserin aut Chun-yan Peng verfasserin aut Pei-xin Wang verfasserin aut Linju Xu verfasserin aut Jia-hui Liu verfasserin aut Xing Xie verfasserin aut Ling Lu verfasserin aut Zong-cai Tu verfasserin aut Zong-cai Tu verfasserin aut In Frontiers in Nutrition Frontiers Media S.A., 2014 10(2023) (DE-627)790231158 (DE-600)2776676-7 2296861X nnns volume:10 year:2023 https://doi.org/10.3389/fnut.2023.1126359 kostenfrei https://doaj.org/article/e73e5434831949f2ae48623e4f4bad09 kostenfrei https://www.frontiersin.org/articles/10.3389/fnut.2023.1126359/full kostenfrei https://doaj.org/toc/2296-861X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4367 GBV_ILN_4700 AR 10 2023
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allfieldsSound	10.3389/fnut.2023.1126359 doi (DE-627)DOAJ081864329 (DE-599)DOAJe73e5434831949f2ae48623e4f4bad09 DE-627 ger DE-627 rakwb eng TX341-641 Lu Zhang verfasserin aut Hypoglycemic and H2O2-induced oxidative injury protective effects and the phytochemical profiles of the ethyl acetate fraction from Radix Paeoniae Alba 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Radix Paeonia Alba (RPA) is often used as food and medicine. This study aimed to enrich and identify the antioxidant and hypoglycemic bioactive compounds from RPA. The results indicated that the ethyl acetate fraction (EAF) showed the highest total phenolic content, DPPH, ABTS+ scavenging ability, and α-glucosidase inhibition ability (IC50 = 7.27 μg/ml). The EAF could alleviate H2O2-induced oxidative stress in HepG2 cells by decreasing the MDA and ROS levels, improving cell apoptosis, increasing the enzyme activity of GPX-Px, CAT, SOD, Na+/K+-ATP, and Ca2+/Mg2+-ATP, and stimulating T-AOC expression, which also enhanced the glucose uptake of insulin-resistant HepG2 cells. In addition, the EAF significantly reduced the fasting blood glucose level and improved glucose tolerance in diabetic mice. An HPLC-QTOF-MS/MS analysis displayed that procyanidin, digallic acid isomer, methyl gallate, tetragalloylglucose isomer, dimethyl gallic acid, and paeoniflorin were the major compounds in the EAF. These findings are meaningful for the application of the EAF in the medicinal or food industry to prevent and treat oxidative stress and diabetes mellitus. Radix Paeoniae Alba hypoglycemic activity polyphenols HPLC-QTOF-MS/MS oxidative stress Nutrition. Foods and food supply Lu Zhang verfasserin aut Chun-yan Peng verfasserin aut Pei-xin Wang verfasserin aut Linju Xu verfasserin aut Jia-hui Liu verfasserin aut Xing Xie verfasserin aut Ling Lu verfasserin aut Zong-cai Tu verfasserin aut Zong-cai Tu verfasserin aut In Frontiers in Nutrition Frontiers Media S.A., 2014 10(2023) (DE-627)790231158 (DE-600)2776676-7 2296861X nnns volume:10 year:2023 https://doi.org/10.3389/fnut.2023.1126359 kostenfrei https://doaj.org/article/e73e5434831949f2ae48623e4f4bad09 kostenfrei https://www.frontiersin.org/articles/10.3389/fnut.2023.1126359/full kostenfrei https://doaj.org/toc/2296-861X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4367 GBV_ILN_4700 AR 10 2023
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callnumber-first	T - Technology
author	Lu Zhang
spellingShingle	Lu Zhang misc TX341-641 misc Radix Paeoniae Alba misc hypoglycemic activity misc polyphenols misc HPLC-QTOF-MS/MS misc oxidative stress misc Nutrition. Foods and food supply Hypoglycemic and H2O2-induced oxidative injury protective effects and the phytochemical profiles of the ethyl acetate fraction from Radix Paeoniae Alba
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topic_title	TX341-641 Hypoglycemic and H2O2-induced oxidative injury protective effects and the phytochemical profiles of the ethyl acetate fraction from Radix Paeoniae Alba Radix Paeoniae Alba hypoglycemic activity polyphenols HPLC-QTOF-MS/MS oxidative stress
topic	misc TX341-641 misc Radix Paeoniae Alba misc hypoglycemic activity misc polyphenols misc HPLC-QTOF-MS/MS misc oxidative stress misc Nutrition. Foods and food supply
topic_unstemmed	misc TX341-641 misc Radix Paeoniae Alba misc hypoglycemic activity misc polyphenols misc HPLC-QTOF-MS/MS misc oxidative stress misc Nutrition. Foods and food supply
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title	Hypoglycemic and H2O2-induced oxidative injury protective effects and the phytochemical profiles of the ethyl acetate fraction from Radix Paeoniae Alba
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title_full	Hypoglycemic and H2O2-induced oxidative injury protective effects and the phytochemical profiles of the ethyl acetate fraction from Radix Paeoniae Alba
author_sort	Lu Zhang
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title_sort	hypoglycemic and h2o2-induced oxidative injury protective effects and the phytochemical profiles of the ethyl acetate fraction from radix paeoniae alba
callnumber	TX341-641
title_auth	Hypoglycemic and H2O2-induced oxidative injury protective effects and the phytochemical profiles of the ethyl acetate fraction from Radix Paeoniae Alba
abstract	Radix Paeonia Alba (RPA) is often used as food and medicine. This study aimed to enrich and identify the antioxidant and hypoglycemic bioactive compounds from RPA. The results indicated that the ethyl acetate fraction (EAF) showed the highest total phenolic content, DPPH, ABTS+ scavenging ability, and α-glucosidase inhibition ability (IC50 = 7.27 μg/ml). The EAF could alleviate H2O2-induced oxidative stress in HepG2 cells by decreasing the MDA and ROS levels, improving cell apoptosis, increasing the enzyme activity of GPX-Px, CAT, SOD, Na+/K+-ATP, and Ca2+/Mg2+-ATP, and stimulating T-AOC expression, which also enhanced the glucose uptake of insulin-resistant HepG2 cells. In addition, the EAF significantly reduced the fasting blood glucose level and improved glucose tolerance in diabetic mice. An HPLC-QTOF-MS/MS analysis displayed that procyanidin, digallic acid isomer, methyl gallate, tetragalloylglucose isomer, dimethyl gallic acid, and paeoniflorin were the major compounds in the EAF. These findings are meaningful for the application of the EAF in the medicinal or food industry to prevent and treat oxidative stress and diabetes mellitus.
abstractGer	Radix Paeonia Alba (RPA) is often used as food and medicine. This study aimed to enrich and identify the antioxidant and hypoglycemic bioactive compounds from RPA. The results indicated that the ethyl acetate fraction (EAF) showed the highest total phenolic content, DPPH, ABTS+ scavenging ability, and α-glucosidase inhibition ability (IC50 = 7.27 μg/ml). The EAF could alleviate H2O2-induced oxidative stress in HepG2 cells by decreasing the MDA and ROS levels, improving cell apoptosis, increasing the enzyme activity of GPX-Px, CAT, SOD, Na+/K+-ATP, and Ca2+/Mg2+-ATP, and stimulating T-AOC expression, which also enhanced the glucose uptake of insulin-resistant HepG2 cells. In addition, the EAF significantly reduced the fasting blood glucose level and improved glucose tolerance in diabetic mice. An HPLC-QTOF-MS/MS analysis displayed that procyanidin, digallic acid isomer, methyl gallate, tetragalloylglucose isomer, dimethyl gallic acid, and paeoniflorin were the major compounds in the EAF. These findings are meaningful for the application of the EAF in the medicinal or food industry to prevent and treat oxidative stress and diabetes mellitus.
abstract_unstemmed	Radix Paeonia Alba (RPA) is often used as food and medicine. This study aimed to enrich and identify the antioxidant and hypoglycemic bioactive compounds from RPA. The results indicated that the ethyl acetate fraction (EAF) showed the highest total phenolic content, DPPH, ABTS+ scavenging ability, and α-glucosidase inhibition ability (IC50 = 7.27 μg/ml). The EAF could alleviate H2O2-induced oxidative stress in HepG2 cells by decreasing the MDA and ROS levels, improving cell apoptosis, increasing the enzyme activity of GPX-Px, CAT, SOD, Na+/K+-ATP, and Ca2+/Mg2+-ATP, and stimulating T-AOC expression, which also enhanced the glucose uptake of insulin-resistant HepG2 cells. In addition, the EAF significantly reduced the fasting blood glucose level and improved glucose tolerance in diabetic mice. An HPLC-QTOF-MS/MS analysis displayed that procyanidin, digallic acid isomer, methyl gallate, tetragalloylglucose isomer, dimethyl gallic acid, and paeoniflorin were the major compounds in the EAF. These findings are meaningful for the application of the EAF in the medicinal or food industry to prevent and treat oxidative stress and diabetes mellitus.
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title_short	Hypoglycemic and H2O2-induced oxidative injury protective effects and the phytochemical profiles of the ethyl acetate fraction from Radix Paeoniae Alba
url	https://doi.org/10.3389/fnut.2023.1126359 https://doaj.org/article/e73e5434831949f2ae48623e4f4bad09 https://www.frontiersin.org/articles/10.3389/fnut.2023.1126359/full https://doaj.org/toc/2296-861X
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author2	Lu Zhang Chun-yan Peng Pei-xin Wang Linju Xu Jia-hui Liu Xing Xie Ling Lu Zong-cai Tu
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up_date	2024-07-03T22:23:16.339Z
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Hypoglycemic and H2O2-induced oxidative injury protective effects and the phytochemical profiles of the ethyl acetate fraction from Radix Paeoniae Alba

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