A multicenter real‐life study to determine the efficacy of corticosteroids and olfactory training in improving persistent COVID‐19‐related olfactory dysfunction

Abstract Background No definitive treatment exists to effectively restore function in patients with persistent post‐infectious olfactory dysfunction (OD). Corticosteroids have been considered as a therapeutic option in post‐infectious OD but their benefit in COVID‐19‐related OD remains unexplored. W...
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Gespeichert in:

Autor*in:	Alfonso Luca Pendolino [verfasserIn] Giancarlo Ottaviano [verfasserIn] Juman Nijim [verfasserIn] Bruno Scarpa [verfasserIn] Giulia De Lucia [verfasserIn] Cecilia Berro [verfasserIn] Piero Nicolai [verfasserIn] Peter J. Andrews [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	corticosteroids COVID‐19 olfaction olfactory training smell

Übergeordnetes Werk:	In: Laryngoscope Investigative Otolaryngology - Wiley, 2016, 8(2023), 1, Seite 46-54
Übergeordnetes Werk:	volume:8 ; year:2023 ; number:1 ; pages:46-54

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1002/lio2.989

Katalog-ID:	DOAJ081893477

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520			\|a Abstract Background No definitive treatment exists to effectively restore function in patients with persistent post‐infectious olfactory dysfunction (OD). Corticosteroids have been considered as a therapeutic option in post‐infectious OD but their benefit in COVID‐19‐related OD remains unexplored. We aim to determine the role of the combination of corticosteroids plus olfactory training (OT) in improving persistent COVID‐19‐related OD. Methods A multicenter real‐life cohort study was conducted between December 2020 and April 2022 on patients with reported COVID‐19‐related OD. Only patients with confirmed OD at Sniffin' Sticks (S'S) and those who attended their 6‐month follow‐up were included. Patients were started on a combined treatment of corticosteroids and OT. Patients refusing corticosteroids or not doing any treatment formed the control groups. Visual analogue scale (VAS) for sense of smell and SNOT‐22 were used to assess patients reported symptoms. Results Sixty‐seven subjects with reported COVID‐19‐related OD were initially seen. Normosmic patients at S'S (n = 14) and those not attending their follow‐up (n = 9) were excluded. Of the 44 patients included in the analysis, 19 patients had the combined treatment (group A), 16 patients refused to take corticosteroids and did the OT alone (group B) whereas 9 patients did not do any treatment (group C). An improvement of threshold + discrimination + identification (TDI) score (p = .01) and VAS for smell (p = .01) was found in group A whereas only the TDI score improved in group B (p = .04). Presence of comorbidities, age, sex (male), and length of OD negatively influenced olfactory recovery. Conclusions Our study confirms the importance of OT in long‐term OD suggesting that the addition of corticosteroids may give a benefit in terms of patient's perceived olfaction. Level of Evidence 2b
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650		4	\|a olfaction
650		4	\|a olfactory training
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700	0		\|a Cecilia Berro \|e verfasserin \|4 aut
700	0		\|a Piero Nicolai \|e verfasserin \|4 aut
700	0		\|a Peter J. Andrews \|e verfasserin \|4 aut
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allfields	10.1002/lio2.989 doi (DE-627)DOAJ081893477 (DE-599)DOAJ991d5c5f979d4983a86862e132344b81 DE-627 ger DE-627 rakwb eng RF1-547 RD1-811 Alfonso Luca Pendolino verfasserin aut A multicenter real‐life study to determine the efficacy of corticosteroids and olfactory training in improving persistent COVID‐19‐related olfactory dysfunction 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background No definitive treatment exists to effectively restore function in patients with persistent post‐infectious olfactory dysfunction (OD). Corticosteroids have been considered as a therapeutic option in post‐infectious OD but their benefit in COVID‐19‐related OD remains unexplored. We aim to determine the role of the combination of corticosteroids plus olfactory training (OT) in improving persistent COVID‐19‐related OD. Methods A multicenter real‐life cohort study was conducted between December 2020 and April 2022 on patients with reported COVID‐19‐related OD. Only patients with confirmed OD at Sniffin' Sticks (S'S) and those who attended their 6‐month follow‐up were included. Patients were started on a combined treatment of corticosteroids and OT. Patients refusing corticosteroids or not doing any treatment formed the control groups. Visual analogue scale (VAS) for sense of smell and SNOT‐22 were used to assess patients reported symptoms. Results Sixty‐seven subjects with reported COVID‐19‐related OD were initially seen. Normosmic patients at S'S (n = 14) and those not attending their follow‐up (n = 9) were excluded. Of the 44 patients included in the analysis, 19 patients had the combined treatment (group A), 16 patients refused to take corticosteroids and did the OT alone (group B) whereas 9 patients did not do any treatment (group C). An improvement of threshold + discrimination + identification (TDI) score (p = .01) and VAS for smell (p = .01) was found in group A whereas only the TDI score improved in group B (p = .04). Presence of comorbidities, age, sex (male), and length of OD negatively influenced olfactory recovery. Conclusions Our study confirms the importance of OT in long‐term OD suggesting that the addition of corticosteroids may give a benefit in terms of patient's perceived olfaction. Level of Evidence 2b corticosteroids COVID‐19 olfaction olfactory training smell Otorhinolaryngology Surgery Giancarlo Ottaviano verfasserin aut Juman Nijim verfasserin aut Bruno Scarpa verfasserin aut Giulia De Lucia verfasserin aut Cecilia Berro verfasserin aut Piero Nicolai verfasserin aut Peter J. Andrews verfasserin aut In Laryngoscope Investigative Otolaryngology Wiley, 2016 8(2023), 1, Seite 46-54 (DE-627)856388947 (DE-600)2851702-7 23788038 nnns volume:8 year:2023 number:1 pages:46-54 https://doi.org/10.1002/lio2.989 kostenfrei https://doaj.org/article/991d5c5f979d4983a86862e132344b81 kostenfrei https://doi.org/10.1002/lio2.989 kostenfrei https://doaj.org/toc/2378-8038 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2023 1 46-54
spelling	10.1002/lio2.989 doi (DE-627)DOAJ081893477 (DE-599)DOAJ991d5c5f979d4983a86862e132344b81 DE-627 ger DE-627 rakwb eng RF1-547 RD1-811 Alfonso Luca Pendolino verfasserin aut A multicenter real‐life study to determine the efficacy of corticosteroids and olfactory training in improving persistent COVID‐19‐related olfactory dysfunction 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background No definitive treatment exists to effectively restore function in patients with persistent post‐infectious olfactory dysfunction (OD). Corticosteroids have been considered as a therapeutic option in post‐infectious OD but their benefit in COVID‐19‐related OD remains unexplored. We aim to determine the role of the combination of corticosteroids plus olfactory training (OT) in improving persistent COVID‐19‐related OD. Methods A multicenter real‐life cohort study was conducted between December 2020 and April 2022 on patients with reported COVID‐19‐related OD. Only patients with confirmed OD at Sniffin' Sticks (S'S) and those who attended their 6‐month follow‐up were included. Patients were started on a combined treatment of corticosteroids and OT. Patients refusing corticosteroids or not doing any treatment formed the control groups. Visual analogue scale (VAS) for sense of smell and SNOT‐22 were used to assess patients reported symptoms. Results Sixty‐seven subjects with reported COVID‐19‐related OD were initially seen. Normosmic patients at S'S (n = 14) and those not attending their follow‐up (n = 9) were excluded. Of the 44 patients included in the analysis, 19 patients had the combined treatment (group A), 16 patients refused to take corticosteroids and did the OT alone (group B) whereas 9 patients did not do any treatment (group C). An improvement of threshold + discrimination + identification (TDI) score (p = .01) and VAS for smell (p = .01) was found in group A whereas only the TDI score improved in group B (p = .04). Presence of comorbidities, age, sex (male), and length of OD negatively influenced olfactory recovery. Conclusions Our study confirms the importance of OT in long‐term OD suggesting that the addition of corticosteroids may give a benefit in terms of patient's perceived olfaction. Level of Evidence 2b corticosteroids COVID‐19 olfaction olfactory training smell Otorhinolaryngology Surgery Giancarlo Ottaviano verfasserin aut Juman Nijim verfasserin aut Bruno Scarpa verfasserin aut Giulia De Lucia verfasserin aut Cecilia Berro verfasserin aut Piero Nicolai verfasserin aut Peter J. Andrews verfasserin aut In Laryngoscope Investigative Otolaryngology Wiley, 2016 8(2023), 1, Seite 46-54 (DE-627)856388947 (DE-600)2851702-7 23788038 nnns volume:8 year:2023 number:1 pages:46-54 https://doi.org/10.1002/lio2.989 kostenfrei https://doaj.org/article/991d5c5f979d4983a86862e132344b81 kostenfrei https://doi.org/10.1002/lio2.989 kostenfrei https://doaj.org/toc/2378-8038 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2023 1 46-54
allfields_unstemmed	10.1002/lio2.989 doi (DE-627)DOAJ081893477 (DE-599)DOAJ991d5c5f979d4983a86862e132344b81 DE-627 ger DE-627 rakwb eng RF1-547 RD1-811 Alfonso Luca Pendolino verfasserin aut A multicenter real‐life study to determine the efficacy of corticosteroids and olfactory training in improving persistent COVID‐19‐related olfactory dysfunction 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background No definitive treatment exists to effectively restore function in patients with persistent post‐infectious olfactory dysfunction (OD). Corticosteroids have been considered as a therapeutic option in post‐infectious OD but their benefit in COVID‐19‐related OD remains unexplored. We aim to determine the role of the combination of corticosteroids plus olfactory training (OT) in improving persistent COVID‐19‐related OD. Methods A multicenter real‐life cohort study was conducted between December 2020 and April 2022 on patients with reported COVID‐19‐related OD. Only patients with confirmed OD at Sniffin' Sticks (S'S) and those who attended their 6‐month follow‐up were included. Patients were started on a combined treatment of corticosteroids and OT. Patients refusing corticosteroids or not doing any treatment formed the control groups. Visual analogue scale (VAS) for sense of smell and SNOT‐22 were used to assess patients reported symptoms. Results Sixty‐seven subjects with reported COVID‐19‐related OD were initially seen. Normosmic patients at S'S (n = 14) and those not attending their follow‐up (n = 9) were excluded. Of the 44 patients included in the analysis, 19 patients had the combined treatment (group A), 16 patients refused to take corticosteroids and did the OT alone (group B) whereas 9 patients did not do any treatment (group C). An improvement of threshold + discrimination + identification (TDI) score (p = .01) and VAS for smell (p = .01) was found in group A whereas only the TDI score improved in group B (p = .04). Presence of comorbidities, age, sex (male), and length of OD negatively influenced olfactory recovery. Conclusions Our study confirms the importance of OT in long‐term OD suggesting that the addition of corticosteroids may give a benefit in terms of patient's perceived olfaction. Level of Evidence 2b corticosteroids COVID‐19 olfaction olfactory training smell Otorhinolaryngology Surgery Giancarlo Ottaviano verfasserin aut Juman Nijim verfasserin aut Bruno Scarpa verfasserin aut Giulia De Lucia verfasserin aut Cecilia Berro verfasserin aut Piero Nicolai verfasserin aut Peter J. Andrews verfasserin aut In Laryngoscope Investigative Otolaryngology Wiley, 2016 8(2023), 1, Seite 46-54 (DE-627)856388947 (DE-600)2851702-7 23788038 nnns volume:8 year:2023 number:1 pages:46-54 https://doi.org/10.1002/lio2.989 kostenfrei https://doaj.org/article/991d5c5f979d4983a86862e132344b81 kostenfrei https://doi.org/10.1002/lio2.989 kostenfrei https://doaj.org/toc/2378-8038 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2023 1 46-54
allfieldsGer	10.1002/lio2.989 doi (DE-627)DOAJ081893477 (DE-599)DOAJ991d5c5f979d4983a86862e132344b81 DE-627 ger DE-627 rakwb eng RF1-547 RD1-811 Alfonso Luca Pendolino verfasserin aut A multicenter real‐life study to determine the efficacy of corticosteroids and olfactory training in improving persistent COVID‐19‐related olfactory dysfunction 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background No definitive treatment exists to effectively restore function in patients with persistent post‐infectious olfactory dysfunction (OD). Corticosteroids have been considered as a therapeutic option in post‐infectious OD but their benefit in COVID‐19‐related OD remains unexplored. We aim to determine the role of the combination of corticosteroids plus olfactory training (OT) in improving persistent COVID‐19‐related OD. Methods A multicenter real‐life cohort study was conducted between December 2020 and April 2022 on patients with reported COVID‐19‐related OD. Only patients with confirmed OD at Sniffin' Sticks (S'S) and those who attended their 6‐month follow‐up were included. Patients were started on a combined treatment of corticosteroids and OT. Patients refusing corticosteroids or not doing any treatment formed the control groups. Visual analogue scale (VAS) for sense of smell and SNOT‐22 were used to assess patients reported symptoms. Results Sixty‐seven subjects with reported COVID‐19‐related OD were initially seen. Normosmic patients at S'S (n = 14) and those not attending their follow‐up (n = 9) were excluded. Of the 44 patients included in the analysis, 19 patients had the combined treatment (group A), 16 patients refused to take corticosteroids and did the OT alone (group B) whereas 9 patients did not do any treatment (group C). An improvement of threshold + discrimination + identification (TDI) score (p = .01) and VAS for smell (p = .01) was found in group A whereas only the TDI score improved in group B (p = .04). Presence of comorbidities, age, sex (male), and length of OD negatively influenced olfactory recovery. Conclusions Our study confirms the importance of OT in long‐term OD suggesting that the addition of corticosteroids may give a benefit in terms of patient's perceived olfaction. Level of Evidence 2b corticosteroids COVID‐19 olfaction olfactory training smell Otorhinolaryngology Surgery Giancarlo Ottaviano verfasserin aut Juman Nijim verfasserin aut Bruno Scarpa verfasserin aut Giulia De Lucia verfasserin aut Cecilia Berro verfasserin aut Piero Nicolai verfasserin aut Peter J. Andrews verfasserin aut In Laryngoscope Investigative Otolaryngology Wiley, 2016 8(2023), 1, Seite 46-54 (DE-627)856388947 (DE-600)2851702-7 23788038 nnns volume:8 year:2023 number:1 pages:46-54 https://doi.org/10.1002/lio2.989 kostenfrei https://doaj.org/article/991d5c5f979d4983a86862e132344b81 kostenfrei https://doi.org/10.1002/lio2.989 kostenfrei https://doaj.org/toc/2378-8038 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2023 1 46-54
allfieldsSound	10.1002/lio2.989 doi (DE-627)DOAJ081893477 (DE-599)DOAJ991d5c5f979d4983a86862e132344b81 DE-627 ger DE-627 rakwb eng RF1-547 RD1-811 Alfonso Luca Pendolino verfasserin aut A multicenter real‐life study to determine the efficacy of corticosteroids and olfactory training in improving persistent COVID‐19‐related olfactory dysfunction 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background No definitive treatment exists to effectively restore function in patients with persistent post‐infectious olfactory dysfunction (OD). Corticosteroids have been considered as a therapeutic option in post‐infectious OD but their benefit in COVID‐19‐related OD remains unexplored. We aim to determine the role of the combination of corticosteroids plus olfactory training (OT) in improving persistent COVID‐19‐related OD. Methods A multicenter real‐life cohort study was conducted between December 2020 and April 2022 on patients with reported COVID‐19‐related OD. Only patients with confirmed OD at Sniffin' Sticks (S'S) and those who attended their 6‐month follow‐up were included. Patients were started on a combined treatment of corticosteroids and OT. Patients refusing corticosteroids or not doing any treatment formed the control groups. Visual analogue scale (VAS) for sense of smell and SNOT‐22 were used to assess patients reported symptoms. Results Sixty‐seven subjects with reported COVID‐19‐related OD were initially seen. Normosmic patients at S'S (n = 14) and those not attending their follow‐up (n = 9) were excluded. Of the 44 patients included in the analysis, 19 patients had the combined treatment (group A), 16 patients refused to take corticosteroids and did the OT alone (group B) whereas 9 patients did not do any treatment (group C). An improvement of threshold + discrimination + identification (TDI) score (p = .01) and VAS for smell (p = .01) was found in group A whereas only the TDI score improved in group B (p = .04). Presence of comorbidities, age, sex (male), and length of OD negatively influenced olfactory recovery. Conclusions Our study confirms the importance of OT in long‐term OD suggesting that the addition of corticosteroids may give a benefit in terms of patient's perceived olfaction. Level of Evidence 2b corticosteroids COVID‐19 olfaction olfactory training smell Otorhinolaryngology Surgery Giancarlo Ottaviano verfasserin aut Juman Nijim verfasserin aut Bruno Scarpa verfasserin aut Giulia De Lucia verfasserin aut Cecilia Berro verfasserin aut Piero Nicolai verfasserin aut Peter J. Andrews verfasserin aut In Laryngoscope Investigative Otolaryngology Wiley, 2016 8(2023), 1, Seite 46-54 (DE-627)856388947 (DE-600)2851702-7 23788038 nnns volume:8 year:2023 number:1 pages:46-54 https://doi.org/10.1002/lio2.989 kostenfrei https://doaj.org/article/991d5c5f979d4983a86862e132344b81 kostenfrei https://doi.org/10.1002/lio2.989 kostenfrei https://doaj.org/toc/2378-8038 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2023 1 46-54
language	English
source	In Laryngoscope Investigative Otolaryngology 8(2023), 1, Seite 46-54 volume:8 year:2023 number:1 pages:46-54
sourceStr	In Laryngoscope Investigative Otolaryngology 8(2023), 1, Seite 46-54 volume:8 year:2023 number:1 pages:46-54
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	corticosteroids COVID‐19 olfaction olfactory training smell Otorhinolaryngology Surgery
isfreeaccess_bool	true
container_title	Laryngoscope Investigative Otolaryngology
authorswithroles_txt_mv	Alfonso Luca Pendolino @@aut@@ Giancarlo Ottaviano @@aut@@ Juman Nijim @@aut@@ Bruno Scarpa @@aut@@ Giulia De Lucia @@aut@@ Cecilia Berro @@aut@@ Piero Nicolai @@aut@@ Peter J. Andrews @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	856388947
id	DOAJ081893477
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">DOAJ081893477</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230310224739.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230310s2023 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1002/lio2.989</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ081893477</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ991d5c5f979d4983a86862e132344b81</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RF1-547</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RD1-811</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Alfonso Luca Pendolino</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="2"><subfield code="a">A multicenter real‐life study to determine the efficacy of corticosteroids and olfactory training in improving persistent COVID‐19‐related olfactory dysfunction</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2023</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Background No definitive treatment exists to effectively restore function in patients with persistent post‐infectious olfactory dysfunction (OD). Corticosteroids have been considered as a therapeutic option in post‐infectious OD but their benefit in COVID‐19‐related OD remains unexplored. We aim to determine the role of the combination of corticosteroids plus olfactory training (OT) in improving persistent COVID‐19‐related OD. Methods A multicenter real‐life cohort study was conducted between December 2020 and April 2022 on patients with reported COVID‐19‐related OD. Only patients with confirmed OD at Sniffin' Sticks (S'S) and those who attended their 6‐month follow‐up were included. Patients were started on a combined treatment of corticosteroids and OT. Patients refusing corticosteroids or not doing any treatment formed the control groups. Visual analogue scale (VAS) for sense of smell and SNOT‐22 were used to assess patients reported symptoms. Results Sixty‐seven subjects with reported COVID‐19‐related OD were initially seen. Normosmic patients at S'S (n = 14) and those not attending their follow‐up (n = 9) were excluded. Of the 44 patients included in the analysis, 19 patients had the combined treatment (group A), 16 patients refused to take corticosteroids and did the OT alone (group B) whereas 9 patients did not do any treatment (group C). An improvement of threshold + discrimination + identification (TDI) score (p = .01) and VAS for smell (p = .01) was found in group A whereas only the TDI score improved in group B (p = .04). Presence of comorbidities, age, sex (male), and length of OD negatively influenced olfactory recovery. Conclusions Our study confirms the importance of OT in long‐term OD suggesting that the addition of corticosteroids may give a benefit in terms of patient's perceived olfaction. 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callnumber-first	R - Medicine
author	Alfonso Luca Pendolino
spellingShingle	Alfonso Luca Pendolino misc RF1-547 misc RD1-811 misc corticosteroids misc COVID‐19 misc olfaction misc olfactory training misc smell misc Otorhinolaryngology misc Surgery A multicenter real‐life study to determine the efficacy of corticosteroids and olfactory training in improving persistent COVID‐19‐related olfactory dysfunction
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topic_title	RF1-547 RD1-811 A multicenter real‐life study to determine the efficacy of corticosteroids and olfactory training in improving persistent COVID‐19‐related olfactory dysfunction corticosteroids COVID‐19 olfaction olfactory training smell
topic	misc RF1-547 misc RD1-811 misc corticosteroids misc COVID‐19 misc olfaction misc olfactory training misc smell misc Otorhinolaryngology misc Surgery
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title	A multicenter real‐life study to determine the efficacy of corticosteroids and olfactory training in improving persistent COVID‐19‐related olfactory dysfunction
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title_full	A multicenter real‐life study to determine the efficacy of corticosteroids and olfactory training in improving persistent COVID‐19‐related olfactory dysfunction
author_sort	Alfonso Luca Pendolino
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author_browse	Alfonso Luca Pendolino Giancarlo Ottaviano Juman Nijim Bruno Scarpa Giulia De Lucia Cecilia Berro Piero Nicolai Peter J. Andrews
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doi_str_mv	10.1002/lio2.989
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title_sort	multicenter real‐life study to determine the efficacy of corticosteroids and olfactory training in improving persistent covid‐19‐related olfactory dysfunction
callnumber	RF1-547
title_auth	A multicenter real‐life study to determine the efficacy of corticosteroids and olfactory training in improving persistent COVID‐19‐related olfactory dysfunction
abstract	Abstract Background No definitive treatment exists to effectively restore function in patients with persistent post‐infectious olfactory dysfunction (OD). Corticosteroids have been considered as a therapeutic option in post‐infectious OD but their benefit in COVID‐19‐related OD remains unexplored. We aim to determine the role of the combination of corticosteroids plus olfactory training (OT) in improving persistent COVID‐19‐related OD. Methods A multicenter real‐life cohort study was conducted between December 2020 and April 2022 on patients with reported COVID‐19‐related OD. Only patients with confirmed OD at Sniffin' Sticks (S'S) and those who attended their 6‐month follow‐up were included. Patients were started on a combined treatment of corticosteroids and OT. Patients refusing corticosteroids or not doing any treatment formed the control groups. Visual analogue scale (VAS) for sense of smell and SNOT‐22 were used to assess patients reported symptoms. Results Sixty‐seven subjects with reported COVID‐19‐related OD were initially seen. Normosmic patients at S'S (n = 14) and those not attending their follow‐up (n = 9) were excluded. Of the 44 patients included in the analysis, 19 patients had the combined treatment (group A), 16 patients refused to take corticosteroids and did the OT alone (group B) whereas 9 patients did not do any treatment (group C). An improvement of threshold + discrimination + identification (TDI) score (p = .01) and VAS for smell (p = .01) was found in group A whereas only the TDI score improved in group B (p = .04). Presence of comorbidities, age, sex (male), and length of OD negatively influenced olfactory recovery. Conclusions Our study confirms the importance of OT in long‐term OD suggesting that the addition of corticosteroids may give a benefit in terms of patient's perceived olfaction. Level of Evidence 2b
abstractGer	Abstract Background No definitive treatment exists to effectively restore function in patients with persistent post‐infectious olfactory dysfunction (OD). Corticosteroids have been considered as a therapeutic option in post‐infectious OD but their benefit in COVID‐19‐related OD remains unexplored. We aim to determine the role of the combination of corticosteroids plus olfactory training (OT) in improving persistent COVID‐19‐related OD. Methods A multicenter real‐life cohort study was conducted between December 2020 and April 2022 on patients with reported COVID‐19‐related OD. Only patients with confirmed OD at Sniffin' Sticks (S'S) and those who attended their 6‐month follow‐up were included. Patients were started on a combined treatment of corticosteroids and OT. Patients refusing corticosteroids or not doing any treatment formed the control groups. Visual analogue scale (VAS) for sense of smell and SNOT‐22 were used to assess patients reported symptoms. Results Sixty‐seven subjects with reported COVID‐19‐related OD were initially seen. Normosmic patients at S'S (n = 14) and those not attending their follow‐up (n = 9) were excluded. Of the 44 patients included in the analysis, 19 patients had the combined treatment (group A), 16 patients refused to take corticosteroids and did the OT alone (group B) whereas 9 patients did not do any treatment (group C). An improvement of threshold + discrimination + identification (TDI) score (p = .01) and VAS for smell (p = .01) was found in group A whereas only the TDI score improved in group B (p = .04). Presence of comorbidities, age, sex (male), and length of OD negatively influenced olfactory recovery. Conclusions Our study confirms the importance of OT in long‐term OD suggesting that the addition of corticosteroids may give a benefit in terms of patient's perceived olfaction. Level of Evidence 2b
abstract_unstemmed	Abstract Background No definitive treatment exists to effectively restore function in patients with persistent post‐infectious olfactory dysfunction (OD). Corticosteroids have been considered as a therapeutic option in post‐infectious OD but their benefit in COVID‐19‐related OD remains unexplored. We aim to determine the role of the combination of corticosteroids plus olfactory training (OT) in improving persistent COVID‐19‐related OD. Methods A multicenter real‐life cohort study was conducted between December 2020 and April 2022 on patients with reported COVID‐19‐related OD. Only patients with confirmed OD at Sniffin' Sticks (S'S) and those who attended their 6‐month follow‐up were included. Patients were started on a combined treatment of corticosteroids and OT. Patients refusing corticosteroids or not doing any treatment formed the control groups. Visual analogue scale (VAS) for sense of smell and SNOT‐22 were used to assess patients reported symptoms. Results Sixty‐seven subjects with reported COVID‐19‐related OD were initially seen. Normosmic patients at S'S (n = 14) and those not attending their follow‐up (n = 9) were excluded. Of the 44 patients included in the analysis, 19 patients had the combined treatment (group A), 16 patients refused to take corticosteroids and did the OT alone (group B) whereas 9 patients did not do any treatment (group C). An improvement of threshold + discrimination + identification (TDI) score (p = .01) and VAS for smell (p = .01) was found in group A whereas only the TDI score improved in group B (p = .04). Presence of comorbidities, age, sex (male), and length of OD negatively influenced olfactory recovery. Conclusions Our study confirms the importance of OT in long‐term OD suggesting that the addition of corticosteroids may give a benefit in terms of patient's perceived olfaction. Level of Evidence 2b
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title_short	A multicenter real‐life study to determine the efficacy of corticosteroids and olfactory training in improving persistent COVID‐19‐related olfactory dysfunction
url	https://doi.org/10.1002/lio2.989 https://doaj.org/article/991d5c5f979d4983a86862e132344b81 https://doaj.org/toc/2378-8038
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author2	Giancarlo Ottaviano Juman Nijim Bruno Scarpa Giulia De Lucia Cecilia Berro Piero Nicolai Peter J. Andrews
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up_date	2024-07-03T22:31:54.159Z
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">DOAJ081893477</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230310224739.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230310s2023 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1002/lio2.989</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ081893477</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ991d5c5f979d4983a86862e132344b81</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RF1-547</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RD1-811</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Alfonso Luca Pendolino</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="2"><subfield code="a">A multicenter real‐life study to determine the efficacy of corticosteroids and olfactory training in improving persistent COVID‐19‐related olfactory dysfunction</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2023</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Background No definitive treatment exists to effectively restore function in patients with persistent post‐infectious olfactory dysfunction (OD). Corticosteroids have been considered as a therapeutic option in post‐infectious OD but their benefit in COVID‐19‐related OD remains unexplored. We aim to determine the role of the combination of corticosteroids plus olfactory training (OT) in improving persistent COVID‐19‐related OD. Methods A multicenter real‐life cohort study was conducted between December 2020 and April 2022 on patients with reported COVID‐19‐related OD. Only patients with confirmed OD at Sniffin' Sticks (S'S) and those who attended their 6‐month follow‐up were included. Patients were started on a combined treatment of corticosteroids and OT. Patients refusing corticosteroids or not doing any treatment formed the control groups. Visual analogue scale (VAS) for sense of smell and SNOT‐22 were used to assess patients reported symptoms. Results Sixty‐seven subjects with reported COVID‐19‐related OD were initially seen. Normosmic patients at S'S (n = 14) and those not attending their follow‐up (n = 9) were excluded. Of the 44 patients included in the analysis, 19 patients had the combined treatment (group A), 16 patients refused to take corticosteroids and did the OT alone (group B) whereas 9 patients did not do any treatment (group C). An improvement of threshold + discrimination + identification (TDI) score (p = .01) and VAS for smell (p = .01) was found in group A whereas only the TDI score improved in group B (p = .04). Presence of comorbidities, age, sex (male), and length of OD negatively influenced olfactory recovery. Conclusions Our study confirms the importance of OT in long‐term OD suggesting that the addition of corticosteroids may give a benefit in terms of patient's perceived olfaction. 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A multicenter real‐life study to determine the efficacy of corticosteroids and olfactory training in improving persistent COVID‐19‐related olfactory dysfunction

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