Responsive Accumulation of Nanohybrids to Boost NIR‐Phototheranostics for Specific Tumor Imaging and Glutathione Depletion‐Enhanced Synergistic Therapy

Abstract Dynamic regulation of nanoparticles in a controllable manner has great potential in various areas. Compared to the individual nanoparticles, the assembled nanoparticles exhibit superior properties and functions, which can be applied to achieve desirable performances. Here, a pH‐responsive i...
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Autor*in:	Liangcan He [verfasserIn] Nannan Zheng [verfasserIn] Qinghui Wang [verfasserIn] Jiarui Du [verfasserIn] Shumin Wang [verfasserIn] Zhiyue Cao [verfasserIn] Zhantong Wang [verfasserIn] Guanying Chen [verfasserIn] Jing Mu [verfasserIn] Shaoqin Liu [verfasserIn] Xiaoyuan Chen [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	acidic‐responsive glutathione depletion metal‐organic frameworks NIR‐II imaging synergistic therapy

Übergeordnetes Werk:	In: Advanced Science - Wiley, 2015, 10(2023), 1, Seite n/a-n/a
Übergeordnetes Werk:	volume:10 ; year:2023 ; number:1 ; pages:n/a-n/a

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1002/advs.202205208

Katalog-ID:	DOAJ082782164

Internformat


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245	1	0	\|a Responsive Accumulation of Nanohybrids to Boost NIR‐Phototheranostics for Specific Tumor Imaging and Glutathione Depletion‐Enhanced Synergistic Therapy
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520			\|a Abstract Dynamic regulation of nanoparticles in a controllable manner has great potential in various areas. Compared to the individual nanoparticles, the assembled nanoparticles exhibit superior properties and functions, which can be applied to achieve desirable performances. Here, a pH‐responsive i‐motif DNA‐mediated strategy to tailor the programmable behaviors of erbium‐based rare‐earth nanoparticles (ErNPs) decorated copper doped metal‐organic framework (CPM) nanohybrids (ECPM) under physiological conditions is reported. Within the acidic tumor microenvironment, the i‐motif DNA strands are able to form quadruplex structures, resulting in the assembly of nanohybrids and selective tumor accumulation, which further amplify the ErNPs downconversion emission (1550 nm) signal for imaging. Meanwhile, the ECPM matrix acts as a near‐infrared (NIR) photon‐activated reactive oxygen species (ROS) amplifier through the singlet oxygen generation of the matrix in combination with its ability of intracellular glutathione depletion upon irradiation. In short, this work displays a classical example of engineering of nanoparticles, which will manifest the importance of developing nanohybrids with structural programmability in biomedical applications.
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allfields	10.1002/advs.202205208 doi (DE-627)DOAJ082782164 (DE-599)DOAJ48df9c476d004eac8214ba1553d756a6 DE-627 ger DE-627 rakwb eng Liangcan He verfasserin aut Responsive Accumulation of Nanohybrids to Boost NIR‐Phototheranostics for Specific Tumor Imaging and Glutathione Depletion‐Enhanced Synergistic Therapy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Dynamic regulation of nanoparticles in a controllable manner has great potential in various areas. Compared to the individual nanoparticles, the assembled nanoparticles exhibit superior properties and functions, which can be applied to achieve desirable performances. Here, a pH‐responsive i‐motif DNA‐mediated strategy to tailor the programmable behaviors of erbium‐based rare‐earth nanoparticles (ErNPs) decorated copper doped metal‐organic framework (CPM) nanohybrids (ECPM) under physiological conditions is reported. Within the acidic tumor microenvironment, the i‐motif DNA strands are able to form quadruplex structures, resulting in the assembly of nanohybrids and selective tumor accumulation, which further amplify the ErNPs downconversion emission (1550 nm) signal for imaging. Meanwhile, the ECPM matrix acts as a near‐infrared (NIR) photon‐activated reactive oxygen species (ROS) amplifier through the singlet oxygen generation of the matrix in combination with its ability of intracellular glutathione depletion upon irradiation. In short, this work displays a classical example of engineering of nanoparticles, which will manifest the importance of developing nanohybrids with structural programmability in biomedical applications. acidic‐responsive glutathione depletion metal‐organic frameworks NIR‐II imaging synergistic therapy Science Q Nannan Zheng verfasserin aut Qinghui Wang verfasserin aut Jiarui Du verfasserin aut Shumin Wang verfasserin aut Zhiyue Cao verfasserin aut Zhantong Wang verfasserin aut Guanying Chen verfasserin aut Jing Mu verfasserin aut Shaoqin Liu verfasserin aut Xiaoyuan Chen verfasserin aut In Advanced Science Wiley, 2015 10(2023), 1, Seite n/a-n/a (DE-627)817357777 (DE-600)2808093-2 21983844 nnns volume:10 year:2023 number:1 pages:n/a-n/a https://doi.org/10.1002/advs.202205208 kostenfrei https://doaj.org/article/48df9c476d004eac8214ba1553d756a6 kostenfrei https://doi.org/10.1002/advs.202205208 kostenfrei https://doaj.org/toc/2198-3844 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2023 1 n/a-n/a
spelling	10.1002/advs.202205208 doi (DE-627)DOAJ082782164 (DE-599)DOAJ48df9c476d004eac8214ba1553d756a6 DE-627 ger DE-627 rakwb eng Liangcan He verfasserin aut Responsive Accumulation of Nanohybrids to Boost NIR‐Phototheranostics for Specific Tumor Imaging and Glutathione Depletion‐Enhanced Synergistic Therapy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Dynamic regulation of nanoparticles in a controllable manner has great potential in various areas. Compared to the individual nanoparticles, the assembled nanoparticles exhibit superior properties and functions, which can be applied to achieve desirable performances. Here, a pH‐responsive i‐motif DNA‐mediated strategy to tailor the programmable behaviors of erbium‐based rare‐earth nanoparticles (ErNPs) decorated copper doped metal‐organic framework (CPM) nanohybrids (ECPM) under physiological conditions is reported. Within the acidic tumor microenvironment, the i‐motif DNA strands are able to form quadruplex structures, resulting in the assembly of nanohybrids and selective tumor accumulation, which further amplify the ErNPs downconversion emission (1550 nm) signal for imaging. Meanwhile, the ECPM matrix acts as a near‐infrared (NIR) photon‐activated reactive oxygen species (ROS) amplifier through the singlet oxygen generation of the matrix in combination with its ability of intracellular glutathione depletion upon irradiation. In short, this work displays a classical example of engineering of nanoparticles, which will manifest the importance of developing nanohybrids with structural programmability in biomedical applications. acidic‐responsive glutathione depletion metal‐organic frameworks NIR‐II imaging synergistic therapy Science Q Nannan Zheng verfasserin aut Qinghui Wang verfasserin aut Jiarui Du verfasserin aut Shumin Wang verfasserin aut Zhiyue Cao verfasserin aut Zhantong Wang verfasserin aut Guanying Chen verfasserin aut Jing Mu verfasserin aut Shaoqin Liu verfasserin aut Xiaoyuan Chen verfasserin aut In Advanced Science Wiley, 2015 10(2023), 1, Seite n/a-n/a (DE-627)817357777 (DE-600)2808093-2 21983844 nnns volume:10 year:2023 number:1 pages:n/a-n/a https://doi.org/10.1002/advs.202205208 kostenfrei https://doaj.org/article/48df9c476d004eac8214ba1553d756a6 kostenfrei https://doi.org/10.1002/advs.202205208 kostenfrei https://doaj.org/toc/2198-3844 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2023 1 n/a-n/a
allfields_unstemmed	10.1002/advs.202205208 doi (DE-627)DOAJ082782164 (DE-599)DOAJ48df9c476d004eac8214ba1553d756a6 DE-627 ger DE-627 rakwb eng Liangcan He verfasserin aut Responsive Accumulation of Nanohybrids to Boost NIR‐Phototheranostics for Specific Tumor Imaging and Glutathione Depletion‐Enhanced Synergistic Therapy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Dynamic regulation of nanoparticles in a controllable manner has great potential in various areas. Compared to the individual nanoparticles, the assembled nanoparticles exhibit superior properties and functions, which can be applied to achieve desirable performances. Here, a pH‐responsive i‐motif DNA‐mediated strategy to tailor the programmable behaviors of erbium‐based rare‐earth nanoparticles (ErNPs) decorated copper doped metal‐organic framework (CPM) nanohybrids (ECPM) under physiological conditions is reported. Within the acidic tumor microenvironment, the i‐motif DNA strands are able to form quadruplex structures, resulting in the assembly of nanohybrids and selective tumor accumulation, which further amplify the ErNPs downconversion emission (1550 nm) signal for imaging. Meanwhile, the ECPM matrix acts as a near‐infrared (NIR) photon‐activated reactive oxygen species (ROS) amplifier through the singlet oxygen generation of the matrix in combination with its ability of intracellular glutathione depletion upon irradiation. In short, this work displays a classical example of engineering of nanoparticles, which will manifest the importance of developing nanohybrids with structural programmability in biomedical applications. acidic‐responsive glutathione depletion metal‐organic frameworks NIR‐II imaging synergistic therapy Science Q Nannan Zheng verfasserin aut Qinghui Wang verfasserin aut Jiarui Du verfasserin aut Shumin Wang verfasserin aut Zhiyue Cao verfasserin aut Zhantong Wang verfasserin aut Guanying Chen verfasserin aut Jing Mu verfasserin aut Shaoqin Liu verfasserin aut Xiaoyuan Chen verfasserin aut In Advanced Science Wiley, 2015 10(2023), 1, Seite n/a-n/a (DE-627)817357777 (DE-600)2808093-2 21983844 nnns volume:10 year:2023 number:1 pages:n/a-n/a https://doi.org/10.1002/advs.202205208 kostenfrei https://doaj.org/article/48df9c476d004eac8214ba1553d756a6 kostenfrei https://doi.org/10.1002/advs.202205208 kostenfrei https://doaj.org/toc/2198-3844 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2023 1 n/a-n/a
allfieldsGer	10.1002/advs.202205208 doi (DE-627)DOAJ082782164 (DE-599)DOAJ48df9c476d004eac8214ba1553d756a6 DE-627 ger DE-627 rakwb eng Liangcan He verfasserin aut Responsive Accumulation of Nanohybrids to Boost NIR‐Phototheranostics for Specific Tumor Imaging and Glutathione Depletion‐Enhanced Synergistic Therapy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Dynamic regulation of nanoparticles in a controllable manner has great potential in various areas. Compared to the individual nanoparticles, the assembled nanoparticles exhibit superior properties and functions, which can be applied to achieve desirable performances. Here, a pH‐responsive i‐motif DNA‐mediated strategy to tailor the programmable behaviors of erbium‐based rare‐earth nanoparticles (ErNPs) decorated copper doped metal‐organic framework (CPM) nanohybrids (ECPM) under physiological conditions is reported. Within the acidic tumor microenvironment, the i‐motif DNA strands are able to form quadruplex structures, resulting in the assembly of nanohybrids and selective tumor accumulation, which further amplify the ErNPs downconversion emission (1550 nm) signal for imaging. Meanwhile, the ECPM matrix acts as a near‐infrared (NIR) photon‐activated reactive oxygen species (ROS) amplifier through the singlet oxygen generation of the matrix in combination with its ability of intracellular glutathione depletion upon irradiation. In short, this work displays a classical example of engineering of nanoparticles, which will manifest the importance of developing nanohybrids with structural programmability in biomedical applications. acidic‐responsive glutathione depletion metal‐organic frameworks NIR‐II imaging synergistic therapy Science Q Nannan Zheng verfasserin aut Qinghui Wang verfasserin aut Jiarui Du verfasserin aut Shumin Wang verfasserin aut Zhiyue Cao verfasserin aut Zhantong Wang verfasserin aut Guanying Chen verfasserin aut Jing Mu verfasserin aut Shaoqin Liu verfasserin aut Xiaoyuan Chen verfasserin aut In Advanced Science Wiley, 2015 10(2023), 1, Seite n/a-n/a (DE-627)817357777 (DE-600)2808093-2 21983844 nnns volume:10 year:2023 number:1 pages:n/a-n/a https://doi.org/10.1002/advs.202205208 kostenfrei https://doaj.org/article/48df9c476d004eac8214ba1553d756a6 kostenfrei https://doi.org/10.1002/advs.202205208 kostenfrei https://doaj.org/toc/2198-3844 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2023 1 n/a-n/a
allfieldsSound	10.1002/advs.202205208 doi (DE-627)DOAJ082782164 (DE-599)DOAJ48df9c476d004eac8214ba1553d756a6 DE-627 ger DE-627 rakwb eng Liangcan He verfasserin aut Responsive Accumulation of Nanohybrids to Boost NIR‐Phototheranostics for Specific Tumor Imaging and Glutathione Depletion‐Enhanced Synergistic Therapy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Dynamic regulation of nanoparticles in a controllable manner has great potential in various areas. Compared to the individual nanoparticles, the assembled nanoparticles exhibit superior properties and functions, which can be applied to achieve desirable performances. Here, a pH‐responsive i‐motif DNA‐mediated strategy to tailor the programmable behaviors of erbium‐based rare‐earth nanoparticles (ErNPs) decorated copper doped metal‐organic framework (CPM) nanohybrids (ECPM) under physiological conditions is reported. Within the acidic tumor microenvironment, the i‐motif DNA strands are able to form quadruplex structures, resulting in the assembly of nanohybrids and selective tumor accumulation, which further amplify the ErNPs downconversion emission (1550 nm) signal for imaging. Meanwhile, the ECPM matrix acts as a near‐infrared (NIR) photon‐activated reactive oxygen species (ROS) amplifier through the singlet oxygen generation of the matrix in combination with its ability of intracellular glutathione depletion upon irradiation. In short, this work displays a classical example of engineering of nanoparticles, which will manifest the importance of developing nanohybrids with structural programmability in biomedical applications. acidic‐responsive glutathione depletion metal‐organic frameworks NIR‐II imaging synergistic therapy Science Q Nannan Zheng verfasserin aut Qinghui Wang verfasserin aut Jiarui Du verfasserin aut Shumin Wang verfasserin aut Zhiyue Cao verfasserin aut Zhantong Wang verfasserin aut Guanying Chen verfasserin aut Jing Mu verfasserin aut Shaoqin Liu verfasserin aut Xiaoyuan Chen verfasserin aut In Advanced Science Wiley, 2015 10(2023), 1, Seite n/a-n/a (DE-627)817357777 (DE-600)2808093-2 21983844 nnns volume:10 year:2023 number:1 pages:n/a-n/a https://doi.org/10.1002/advs.202205208 kostenfrei https://doaj.org/article/48df9c476d004eac8214ba1553d756a6 kostenfrei https://doi.org/10.1002/advs.202205208 kostenfrei https://doaj.org/toc/2198-3844 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2023 1 n/a-n/a
language	English
source	In Advanced Science 10(2023), 1, Seite n/a-n/a volume:10 year:2023 number:1 pages:n/a-n/a
sourceStr	In Advanced Science 10(2023), 1, Seite n/a-n/a volume:10 year:2023 number:1 pages:n/a-n/a
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	acidic‐responsive glutathione depletion metal‐organic frameworks NIR‐II imaging synergistic therapy Science Q
isfreeaccess_bool	true
container_title	Advanced Science
authorswithroles_txt_mv	Liangcan He @@aut@@ Nannan Zheng @@aut@@ Qinghui Wang @@aut@@ Jiarui Du @@aut@@ Shumin Wang @@aut@@ Zhiyue Cao @@aut@@ Zhantong Wang @@aut@@ Guanying Chen @@aut@@ Jing Mu @@aut@@ Shaoqin Liu @@aut@@ Xiaoyuan Chen @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	817357777
id	DOAJ082782164
language_de	englisch
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author	Liangcan He
spellingShingle	Liangcan He misc acidic‐responsive misc glutathione depletion misc metal‐organic frameworks misc NIR‐II imaging misc synergistic therapy misc Science misc Q Responsive Accumulation of Nanohybrids to Boost NIR‐Phototheranostics for Specific Tumor Imaging and Glutathione Depletion‐Enhanced Synergistic Therapy
authorStr	Liangcan He
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topic_title	Responsive Accumulation of Nanohybrids to Boost NIR‐Phototheranostics for Specific Tumor Imaging and Glutathione Depletion‐Enhanced Synergistic Therapy acidic‐responsive glutathione depletion metal‐organic frameworks NIR‐II imaging synergistic therapy
topic	misc acidic‐responsive misc glutathione depletion misc metal‐organic frameworks misc NIR‐II imaging misc synergistic therapy misc Science misc Q
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title	Responsive Accumulation of Nanohybrids to Boost NIR‐Phototheranostics for Specific Tumor Imaging and Glutathione Depletion‐Enhanced Synergistic Therapy
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title_full	Responsive Accumulation of Nanohybrids to Boost NIR‐Phototheranostics for Specific Tumor Imaging and Glutathione Depletion‐Enhanced Synergistic Therapy
author_sort	Liangcan He
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author_browse	Liangcan He Nannan Zheng Qinghui Wang Jiarui Du Shumin Wang Zhiyue Cao Zhantong Wang Guanying Chen Jing Mu Shaoqin Liu Xiaoyuan Chen
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title_sort	responsive accumulation of nanohybrids to boost nir‐phototheranostics for specific tumor imaging and glutathione depletion‐enhanced synergistic therapy
title_auth	Responsive Accumulation of Nanohybrids to Boost NIR‐Phototheranostics for Specific Tumor Imaging and Glutathione Depletion‐Enhanced Synergistic Therapy
abstract	Abstract Dynamic regulation of nanoparticles in a controllable manner has great potential in various areas. Compared to the individual nanoparticles, the assembled nanoparticles exhibit superior properties and functions, which can be applied to achieve desirable performances. Here, a pH‐responsive i‐motif DNA‐mediated strategy to tailor the programmable behaviors of erbium‐based rare‐earth nanoparticles (ErNPs) decorated copper doped metal‐organic framework (CPM) nanohybrids (ECPM) under physiological conditions is reported. Within the acidic tumor microenvironment, the i‐motif DNA strands are able to form quadruplex structures, resulting in the assembly of nanohybrids and selective tumor accumulation, which further amplify the ErNPs downconversion emission (1550 nm) signal for imaging. Meanwhile, the ECPM matrix acts as a near‐infrared (NIR) photon‐activated reactive oxygen species (ROS) amplifier through the singlet oxygen generation of the matrix in combination with its ability of intracellular glutathione depletion upon irradiation. In short, this work displays a classical example of engineering of nanoparticles, which will manifest the importance of developing nanohybrids with structural programmability in biomedical applications.
abstractGer	Abstract Dynamic regulation of nanoparticles in a controllable manner has great potential in various areas. Compared to the individual nanoparticles, the assembled nanoparticles exhibit superior properties and functions, which can be applied to achieve desirable performances. Here, a pH‐responsive i‐motif DNA‐mediated strategy to tailor the programmable behaviors of erbium‐based rare‐earth nanoparticles (ErNPs) decorated copper doped metal‐organic framework (CPM) nanohybrids (ECPM) under physiological conditions is reported. Within the acidic tumor microenvironment, the i‐motif DNA strands are able to form quadruplex structures, resulting in the assembly of nanohybrids and selective tumor accumulation, which further amplify the ErNPs downconversion emission (1550 nm) signal for imaging. Meanwhile, the ECPM matrix acts as a near‐infrared (NIR) photon‐activated reactive oxygen species (ROS) amplifier through the singlet oxygen generation of the matrix in combination with its ability of intracellular glutathione depletion upon irradiation. In short, this work displays a classical example of engineering of nanoparticles, which will manifest the importance of developing nanohybrids with structural programmability in biomedical applications.
abstract_unstemmed	Abstract Dynamic regulation of nanoparticles in a controllable manner has great potential in various areas. Compared to the individual nanoparticles, the assembled nanoparticles exhibit superior properties and functions, which can be applied to achieve desirable performances. Here, a pH‐responsive i‐motif DNA‐mediated strategy to tailor the programmable behaviors of erbium‐based rare‐earth nanoparticles (ErNPs) decorated copper doped metal‐organic framework (CPM) nanohybrids (ECPM) under physiological conditions is reported. Within the acidic tumor microenvironment, the i‐motif DNA strands are able to form quadruplex structures, resulting in the assembly of nanohybrids and selective tumor accumulation, which further amplify the ErNPs downconversion emission (1550 nm) signal for imaging. Meanwhile, the ECPM matrix acts as a near‐infrared (NIR) photon‐activated reactive oxygen species (ROS) amplifier through the singlet oxygen generation of the matrix in combination with its ability of intracellular glutathione depletion upon irradiation. In short, this work displays a classical example of engineering of nanoparticles, which will manifest the importance of developing nanohybrids with structural programmability in biomedical applications.
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title_short	Responsive Accumulation of Nanohybrids to Boost NIR‐Phototheranostics for Specific Tumor Imaging and Glutathione Depletion‐Enhanced Synergistic Therapy
url	https://doi.org/10.1002/advs.202205208 https://doaj.org/article/48df9c476d004eac8214ba1553d756a6 https://doaj.org/toc/2198-3844
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author2	Nannan Zheng Qinghui Wang Jiarui Du Shumin Wang Zhiyue Cao Zhantong Wang Guanying Chen Jing Mu Shaoqin Liu Xiaoyuan Chen
author2Str	Nannan Zheng Qinghui Wang Jiarui Du Shumin Wang Zhiyue Cao Zhantong Wang Guanying Chen Jing Mu Shaoqin Liu Xiaoyuan Chen
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up_date	2024-07-03T13:47:49.954Z
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Responsive Accumulation of Nanohybrids to Boost NIR‐Phototheranostics for Specific Tumor Imaging and Glutathione Depletion‐Enhanced Synergistic Therapy

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