Pharmacokinetic parameters and optimal dosage of a florfenicol and tylosin mixture in beagle dogs

The aims of this study were to evaluate the in vitro antibacterial activity of a florfenicol and tylosin mixture and to determine the pharmacokinetic parameters of each drug following administration of the 2 : 1 florfenicol and tylosin mixture in beagle dogs. The antibacterial activity of the two an...
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Gespeichert in:

Autor*in:	A.F. Mechesso [verfasserIn] S.J. Lee [verfasserIn] N.H. Park [verfasserIn] S.C. Park [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	antibacterial activity drug combination serum concentration synergistic interaction

Übergeordnetes Werk:	In: Veterinární Medicína - Czech Academy of Agricultural Sciences, 2003, 63(2018), 7, Seite 329-334
Übergeordnetes Werk:	volume:63 ; year:2018 ; number:7 ; pages:329-334

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.17221/165/2017-VETMED

Katalog-ID:	DOAJ082796149

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spelling	10.17221/165/2017-VETMED doi (DE-627)DOAJ082796149 (DE-599)DOAJb8ceaeaa20f54c3583dbaaa662e41723 DE-627 ger DE-627 rakwb eng SF600-1100 A.F. Mechesso verfasserin aut Pharmacokinetic parameters and optimal dosage of a florfenicol and tylosin mixture in beagle dogs 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aims of this study were to evaluate the in vitro antibacterial activity of a florfenicol and tylosin mixture and to determine the pharmacokinetic parameters of each drug following administration of the 2 : 1 florfenicol and tylosin mixture in beagle dogs. The antibacterial activity of the two antibiotics, both singly and as a mixture, was investigated in bacteria isolated from 119 beagle dogs. Minimum inhibitory concentrations were determined using the broth dilution method, whereas the checkerboard assay was used to evaluate the antibacterial effects of the combination of florfenicol and tylosin. The pharmacokinetic parameters of the two antibiotics were determined following administration of the mixture in beagle dogs. Serum concentrations of both drugs were analysed using high-performance liquid chromatography. Pharmacokinetics parameters such as area under the concentration-time curve, absolute bioavailability and systemic clearance were determined using non-compartmental analysis. The results showed that tylosin and florfenicol exerted varying degrees of antibacterial activity against the tested isolates. The combination of florfenicol and tylosin produced a synergistic and additive antibacterial effect. Analysis of the serum samples revealed a rapid and almost complete absorption of florfenicol and tylosin with mean bioavailabilities of 92.7% and 106.1%, respectively. The times needed to reach maximum concentration for florfenicol and tylosin were 1.5 and 3 h, respectively. Moreover, intramuscular injection of the mixture to beagle dogs resulted in serum concentrations that were higher than the corresponding minimum inhibitory concentrations in beagle dogs. This is the first study to report optimisation of florfenicol and tylosin doses following administration of a combination of the two drugs to beagle dogs. antibacterial activity drug combination serum concentration synergistic interaction Veterinary medicine S.J. Lee verfasserin aut N.H. Park verfasserin aut S.C. Park verfasserin aut In Veterinární Medicína Czech Academy of Agricultural Sciences, 2003 63(2018), 7, Seite 329-334 (DE-627)381843106 (DE-600)2138934-2 18059392 nnns volume:63 year:2018 number:7 pages:329-334 https://doi.org/10.17221/165/2017-VETMED kostenfrei https://doaj.org/article/b8ceaeaa20f54c3583dbaaa662e41723 kostenfrei https://vetmed.agriculturejournals.cz/artkey/vet-201807-0005_pharmacokinetic-parameters-and-optimal-dosage-of-a-florfenicol-and-tylosin-mixture-in-beagle-dogs.php kostenfrei https://doaj.org/toc/0375-8427 Journal toc kostenfrei https://doaj.org/toc/1805-9392 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 63 2018 7 329-334
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author	A.F. Mechesso
spellingShingle	A.F. Mechesso misc SF600-1100 misc antibacterial activity misc drug combination misc serum concentration misc synergistic interaction misc Veterinary medicine Pharmacokinetic parameters and optimal dosage of a florfenicol and tylosin mixture in beagle dogs
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topic_title	SF600-1100 Pharmacokinetic parameters and optimal dosage of a florfenicol and tylosin mixture in beagle dogs antibacterial activity drug combination serum concentration synergistic interaction
topic	misc SF600-1100 misc antibacterial activity misc drug combination misc serum concentration misc synergistic interaction misc Veterinary medicine
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title	Pharmacokinetic parameters and optimal dosage of a florfenicol and tylosin mixture in beagle dogs
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title_sort	pharmacokinetic parameters and optimal dosage of a florfenicol and tylosin mixture in beagle dogs
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title_auth	Pharmacokinetic parameters and optimal dosage of a florfenicol and tylosin mixture in beagle dogs
abstract	The aims of this study were to evaluate the in vitro antibacterial activity of a florfenicol and tylosin mixture and to determine the pharmacokinetic parameters of each drug following administration of the 2 : 1 florfenicol and tylosin mixture in beagle dogs. The antibacterial activity of the two antibiotics, both singly and as a mixture, was investigated in bacteria isolated from 119 beagle dogs. Minimum inhibitory concentrations were determined using the broth dilution method, whereas the checkerboard assay was used to evaluate the antibacterial effects of the combination of florfenicol and tylosin. The pharmacokinetic parameters of the two antibiotics were determined following administration of the mixture in beagle dogs. Serum concentrations of both drugs were analysed using high-performance liquid chromatography. Pharmacokinetics parameters such as area under the concentration-time curve, absolute bioavailability and systemic clearance were determined using non-compartmental analysis. The results showed that tylosin and florfenicol exerted varying degrees of antibacterial activity against the tested isolates. The combination of florfenicol and tylosin produced a synergistic and additive antibacterial effect. Analysis of the serum samples revealed a rapid and almost complete absorption of florfenicol and tylosin with mean bioavailabilities of 92.7% and 106.1%, respectively. The times needed to reach maximum concentration for florfenicol and tylosin were 1.5 and 3 h, respectively. Moreover, intramuscular injection of the mixture to beagle dogs resulted in serum concentrations that were higher than the corresponding minimum inhibitory concentrations in beagle dogs. This is the first study to report optimisation of florfenicol and tylosin doses following administration of a combination of the two drugs to beagle dogs.
abstractGer	The aims of this study were to evaluate the in vitro antibacterial activity of a florfenicol and tylosin mixture and to determine the pharmacokinetic parameters of each drug following administration of the 2 : 1 florfenicol and tylosin mixture in beagle dogs. The antibacterial activity of the two antibiotics, both singly and as a mixture, was investigated in bacteria isolated from 119 beagle dogs. Minimum inhibitory concentrations were determined using the broth dilution method, whereas the checkerboard assay was used to evaluate the antibacterial effects of the combination of florfenicol and tylosin. The pharmacokinetic parameters of the two antibiotics were determined following administration of the mixture in beagle dogs. Serum concentrations of both drugs were analysed using high-performance liquid chromatography. Pharmacokinetics parameters such as area under the concentration-time curve, absolute bioavailability and systemic clearance were determined using non-compartmental analysis. The results showed that tylosin and florfenicol exerted varying degrees of antibacterial activity against the tested isolates. The combination of florfenicol and tylosin produced a synergistic and additive antibacterial effect. Analysis of the serum samples revealed a rapid and almost complete absorption of florfenicol and tylosin with mean bioavailabilities of 92.7% and 106.1%, respectively. The times needed to reach maximum concentration for florfenicol and tylosin were 1.5 and 3 h, respectively. Moreover, intramuscular injection of the mixture to beagle dogs resulted in serum concentrations that were higher than the corresponding minimum inhibitory concentrations in beagle dogs. This is the first study to report optimisation of florfenicol and tylosin doses following administration of a combination of the two drugs to beagle dogs.
abstract_unstemmed	The aims of this study were to evaluate the in vitro antibacterial activity of a florfenicol and tylosin mixture and to determine the pharmacokinetic parameters of each drug following administration of the 2 : 1 florfenicol and tylosin mixture in beagle dogs. The antibacterial activity of the two antibiotics, both singly and as a mixture, was investigated in bacteria isolated from 119 beagle dogs. Minimum inhibitory concentrations were determined using the broth dilution method, whereas the checkerboard assay was used to evaluate the antibacterial effects of the combination of florfenicol and tylosin. The pharmacokinetic parameters of the two antibiotics were determined following administration of the mixture in beagle dogs. Serum concentrations of both drugs were analysed using high-performance liquid chromatography. Pharmacokinetics parameters such as area under the concentration-time curve, absolute bioavailability and systemic clearance were determined using non-compartmental analysis. The results showed that tylosin and florfenicol exerted varying degrees of antibacterial activity against the tested isolates. The combination of florfenicol and tylosin produced a synergistic and additive antibacterial effect. Analysis of the serum samples revealed a rapid and almost complete absorption of florfenicol and tylosin with mean bioavailabilities of 92.7% and 106.1%, respectively. The times needed to reach maximum concentration for florfenicol and tylosin were 1.5 and 3 h, respectively. Moreover, intramuscular injection of the mixture to beagle dogs resulted in serum concentrations that were higher than the corresponding minimum inhibitory concentrations in beagle dogs. This is the first study to report optimisation of florfenicol and tylosin doses following administration of a combination of the two drugs to beagle dogs.
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title_short	Pharmacokinetic parameters and optimal dosage of a florfenicol and tylosin mixture in beagle dogs
url	https://doi.org/10.17221/165/2017-VETMED https://doaj.org/article/b8ceaeaa20f54c3583dbaaa662e41723 https://vetmed.agriculturejournals.cz/artkey/vet-201807-0005_pharmacokinetic-parameters-and-optimal-dosage-of-a-florfenicol-and-tylosin-mixture-in-beagle-dogs.php https://doaj.org/toc/0375-8427 https://doaj.org/toc/1805-9392
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Pharmacokinetic parameters and optimal dosage of a florfenicol and tylosin mixture in beagle dogs

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