Hyaluronic acid-based nanofibers: Electrospun synthesis and their medical applications; recent developments and future perspective

Hyaluronan is a biodegradable, biopolymer that represents a major part of the extracellular matrix and has the potential to be fabricated in a fibrous form conjugated with other polymers via electrospinning. Unique physicochemical features such as viscoelasticity, conductivity, and biological activi...
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Autor*in:	Humaira [verfasserIn] Sayyad Ali Raza Bukhari [verfasserIn] Hafiz Abdullah Shakir [verfasserIn] Muhammad Khan [verfasserIn] Shagufta Saeed [verfasserIn] Irfan Ahmad [verfasserIn] Khursheed Muzammil [verfasserIn] Marcelo Franco [verfasserIn] Muhammad Irfan [verfasserIn] Kun Li [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	hyaluronic acid nanofibers electrospinning tissue engineering wound healing

Übergeordnetes Werk:	In: Frontiers in Chemistry - Frontiers Media S.A., 2014, 10(2022)
Übergeordnetes Werk:	volume:10 ; year:2022

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fchem.2022.1092123

Katalog-ID:	DOAJ082928150

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spellingShingle	Humaira misc QD1-999 misc hyaluronic acid misc nanofibers misc electrospinning misc tissue engineering misc wound healing misc Chemistry Hyaluronic acid-based nanofibers: Electrospun synthesis and their medical applications; recent developments and future perspective
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topic_title	QD1-999 Hyaluronic acid-based nanofibers: Electrospun synthesis and their medical applications; recent developments and future perspective hyaluronic acid nanofibers electrospinning tissue engineering wound healing
topic	misc QD1-999 misc hyaluronic acid misc nanofibers misc electrospinning misc tissue engineering misc wound healing misc Chemistry
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title	Hyaluronic acid-based nanofibers: Electrospun synthesis and their medical applications; recent developments and future perspective
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title_auth	Hyaluronic acid-based nanofibers: Electrospun synthesis and their medical applications; recent developments and future perspective
abstract	Hyaluronan is a biodegradable, biopolymer that represents a major part of the extracellular matrix and has the potential to be fabricated in a fibrous form conjugated with other polymers via electrospinning. Unique physicochemical features such as viscoelasticity, conductivity, and biological activity mainly affected by molecular weight attracted the attention of biomedical researchers to utilize hyaluronan for designing novel HA-based nano-devices. Particularly HA-based nanofibers get focused on a diverse range of applications in medical like tissue implants for regeneration of damaged tissue or organ repair, wound dressings, and drug delivery carriers to treat various disorders. Currently, electrospinning represents an effective available method for designing highly porous, 3D, HA-based nanofibers with features similar to that of the extra-cellular matrix making them a promising candidate for designing advanced regenerative medicines. This review highlights the structural and physicochemical features of HA, recently cited protocols in literature for HA production via microbial fermentation with particular focus on electrospun fabrication of HA-based nanofibers and parameters affecting its synthesis, current progress in medical applications of these electrospun HA-based nanofibers, their limitations and future perspective about the potential of these HA-based nanofibers in medical field.
abstractGer	Hyaluronan is a biodegradable, biopolymer that represents a major part of the extracellular matrix and has the potential to be fabricated in a fibrous form conjugated with other polymers via electrospinning. Unique physicochemical features such as viscoelasticity, conductivity, and biological activity mainly affected by molecular weight attracted the attention of biomedical researchers to utilize hyaluronan for designing novel HA-based nano-devices. Particularly HA-based nanofibers get focused on a diverse range of applications in medical like tissue implants for regeneration of damaged tissue or organ repair, wound dressings, and drug delivery carriers to treat various disorders. Currently, electrospinning represents an effective available method for designing highly porous, 3D, HA-based nanofibers with features similar to that of the extra-cellular matrix making them a promising candidate for designing advanced regenerative medicines. This review highlights the structural and physicochemical features of HA, recently cited protocols in literature for HA production via microbial fermentation with particular focus on electrospun fabrication of HA-based nanofibers and parameters affecting its synthesis, current progress in medical applications of these electrospun HA-based nanofibers, their limitations and future perspective about the potential of these HA-based nanofibers in medical field.
abstract_unstemmed	Hyaluronan is a biodegradable, biopolymer that represents a major part of the extracellular matrix and has the potential to be fabricated in a fibrous form conjugated with other polymers via electrospinning. Unique physicochemical features such as viscoelasticity, conductivity, and biological activity mainly affected by molecular weight attracted the attention of biomedical researchers to utilize hyaluronan for designing novel HA-based nano-devices. Particularly HA-based nanofibers get focused on a diverse range of applications in medical like tissue implants for regeneration of damaged tissue or organ repair, wound dressings, and drug delivery carriers to treat various disorders. Currently, electrospinning represents an effective available method for designing highly porous, 3D, HA-based nanofibers with features similar to that of the extra-cellular matrix making them a promising candidate for designing advanced regenerative medicines. This review highlights the structural and physicochemical features of HA, recently cited protocols in literature for HA production via microbial fermentation with particular focus on electrospun fabrication of HA-based nanofibers and parameters affecting its synthesis, current progress in medical applications of these electrospun HA-based nanofibers, their limitations and future perspective about the potential of these HA-based nanofibers in medical field.
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title_short	Hyaluronic acid-based nanofibers: Electrospun synthesis and their medical applications; recent developments and future perspective
url	https://doi.org/10.3389/fchem.2022.1092123 https://doaj.org/article/8de502be42f34f8eb98e3517a786ddfc https://www.frontiersin.org/articles/10.3389/fchem.2022.1092123/full https://doaj.org/toc/2296-2646
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up_date	2024-07-03T14:34:30.149Z
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Hyaluronic acid-based nanofibers: Electrospun synthesis and their medical applications; recent developments and future perspective

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