Hyaluronic acid-based nanofibers: Electrospun synthesis and their medical applications; recent developments and future perspective
Hyaluronan is a biodegradable, biopolymer that represents a major part of the extracellular matrix and has the potential to be fabricated in a fibrous form conjugated with other polymers via electrospinning. Unique physicochemical features such as viscoelasticity, conductivity, and biological activi...
Ausführliche Beschreibung
Autor*in: |
Humaira [verfasserIn] Sayyad Ali Raza Bukhari [verfasserIn] Hafiz Abdullah Shakir [verfasserIn] Muhammad Khan [verfasserIn] Shagufta Saeed [verfasserIn] Irfan Ahmad [verfasserIn] Khursheed Muzammil [verfasserIn] Marcelo Franco [verfasserIn] Muhammad Irfan [verfasserIn] Kun Li [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2022 |
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Übergeordnetes Werk: |
In: Frontiers in Chemistry - Frontiers Media S.A., 2014, 10(2022) |
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Übergeordnetes Werk: |
volume:10 ; year:2022 |
Links: |
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DOI / URN: |
10.3389/fchem.2022.1092123 |
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Katalog-ID: |
DOAJ082928150 |
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10.3389/fchem.2022.1092123 doi (DE-627)DOAJ082928150 (DE-599)DOAJ8de502be42f34f8eb98e3517a786ddfc DE-627 ger DE-627 rakwb eng QD1-999 Humaira verfasserin aut Hyaluronic acid-based nanofibers: Electrospun synthesis and their medical applications; recent developments and future perspective 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hyaluronan is a biodegradable, biopolymer that represents a major part of the extracellular matrix and has the potential to be fabricated in a fibrous form conjugated with other polymers via electrospinning. Unique physicochemical features such as viscoelasticity, conductivity, and biological activity mainly affected by molecular weight attracted the attention of biomedical researchers to utilize hyaluronan for designing novel HA-based nano-devices. Particularly HA-based nanofibers get focused on a diverse range of applications in medical like tissue implants for regeneration of damaged tissue or organ repair, wound dressings, and drug delivery carriers to treat various disorders. Currently, electrospinning represents an effective available method for designing highly porous, 3D, HA-based nanofibers with features similar to that of the extra-cellular matrix making them a promising candidate for designing advanced regenerative medicines. This review highlights the structural and physicochemical features of HA, recently cited protocols in literature for HA production via microbial fermentation with particular focus on electrospun fabrication of HA-based nanofibers and parameters affecting its synthesis, current progress in medical applications of these electrospun HA-based nanofibers, their limitations and future perspective about the potential of these HA-based nanofibers in medical field. hyaluronic acid nanofibers electrospinning tissue engineering wound healing Chemistry Sayyad Ali Raza Bukhari verfasserin aut Hafiz Abdullah Shakir verfasserin aut Muhammad Khan verfasserin aut Shagufta Saeed verfasserin aut Irfan Ahmad verfasserin aut Khursheed Muzammil verfasserin aut Marcelo Franco verfasserin aut Muhammad Irfan verfasserin aut Kun Li verfasserin aut In Frontiers in Chemistry Frontiers Media S.A., 2014 10(2022) (DE-627)742224538 (DE-600)2711776-5 22962646 nnns volume:10 year:2022 https://doi.org/10.3389/fchem.2022.1092123 kostenfrei https://doaj.org/article/8de502be42f34f8eb98e3517a786ddfc kostenfrei https://www.frontiersin.org/articles/10.3389/fchem.2022.1092123/full kostenfrei https://doaj.org/toc/2296-2646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2022 |
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10.3389/fchem.2022.1092123 doi (DE-627)DOAJ082928150 (DE-599)DOAJ8de502be42f34f8eb98e3517a786ddfc DE-627 ger DE-627 rakwb eng QD1-999 Humaira verfasserin aut Hyaluronic acid-based nanofibers: Electrospun synthesis and their medical applications; recent developments and future perspective 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hyaluronan is a biodegradable, biopolymer that represents a major part of the extracellular matrix and has the potential to be fabricated in a fibrous form conjugated with other polymers via electrospinning. Unique physicochemical features such as viscoelasticity, conductivity, and biological activity mainly affected by molecular weight attracted the attention of biomedical researchers to utilize hyaluronan for designing novel HA-based nano-devices. Particularly HA-based nanofibers get focused on a diverse range of applications in medical like tissue implants for regeneration of damaged tissue or organ repair, wound dressings, and drug delivery carriers to treat various disorders. Currently, electrospinning represents an effective available method for designing highly porous, 3D, HA-based nanofibers with features similar to that of the extra-cellular matrix making them a promising candidate for designing advanced regenerative medicines. This review highlights the structural and physicochemical features of HA, recently cited protocols in literature for HA production via microbial fermentation with particular focus on electrospun fabrication of HA-based nanofibers and parameters affecting its synthesis, current progress in medical applications of these electrospun HA-based nanofibers, their limitations and future perspective about the potential of these HA-based nanofibers in medical field. hyaluronic acid nanofibers electrospinning tissue engineering wound healing Chemistry Sayyad Ali Raza Bukhari verfasserin aut Hafiz Abdullah Shakir verfasserin aut Muhammad Khan verfasserin aut Shagufta Saeed verfasserin aut Irfan Ahmad verfasserin aut Khursheed Muzammil verfasserin aut Marcelo Franco verfasserin aut Muhammad Irfan verfasserin aut Kun Li verfasserin aut In Frontiers in Chemistry Frontiers Media S.A., 2014 10(2022) (DE-627)742224538 (DE-600)2711776-5 22962646 nnns volume:10 year:2022 https://doi.org/10.3389/fchem.2022.1092123 kostenfrei https://doaj.org/article/8de502be42f34f8eb98e3517a786ddfc kostenfrei https://www.frontiersin.org/articles/10.3389/fchem.2022.1092123/full kostenfrei https://doaj.org/toc/2296-2646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2022 |
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Hyaluronic acid-based nanofibers: Electrospun synthesis and their medical applications; recent developments and future perspective |
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Hyaluronan is a biodegradable, biopolymer that represents a major part of the extracellular matrix and has the potential to be fabricated in a fibrous form conjugated with other polymers via electrospinning. Unique physicochemical features such as viscoelasticity, conductivity, and biological activity mainly affected by molecular weight attracted the attention of biomedical researchers to utilize hyaluronan for designing novel HA-based nano-devices. Particularly HA-based nanofibers get focused on a diverse range of applications in medical like tissue implants for regeneration of damaged tissue or organ repair, wound dressings, and drug delivery carriers to treat various disorders. Currently, electrospinning represents an effective available method for designing highly porous, 3D, HA-based nanofibers with features similar to that of the extra-cellular matrix making them a promising candidate for designing advanced regenerative medicines. This review highlights the structural and physicochemical features of HA, recently cited protocols in literature for HA production via microbial fermentation with particular focus on electrospun fabrication of HA-based nanofibers and parameters affecting its synthesis, current progress in medical applications of these electrospun HA-based nanofibers, their limitations and future perspective about the potential of these HA-based nanofibers in medical field. |
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Hyaluronan is a biodegradable, biopolymer that represents a major part of the extracellular matrix and has the potential to be fabricated in a fibrous form conjugated with other polymers via electrospinning. Unique physicochemical features such as viscoelasticity, conductivity, and biological activity mainly affected by molecular weight attracted the attention of biomedical researchers to utilize hyaluronan for designing novel HA-based nano-devices. Particularly HA-based nanofibers get focused on a diverse range of applications in medical like tissue implants for regeneration of damaged tissue or organ repair, wound dressings, and drug delivery carriers to treat various disorders. Currently, electrospinning represents an effective available method for designing highly porous, 3D, HA-based nanofibers with features similar to that of the extra-cellular matrix making them a promising candidate for designing advanced regenerative medicines. This review highlights the structural and physicochemical features of HA, recently cited protocols in literature for HA production via microbial fermentation with particular focus on electrospun fabrication of HA-based nanofibers and parameters affecting its synthesis, current progress in medical applications of these electrospun HA-based nanofibers, their limitations and future perspective about the potential of these HA-based nanofibers in medical field. |
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Hyaluronan is a biodegradable, biopolymer that represents a major part of the extracellular matrix and has the potential to be fabricated in a fibrous form conjugated with other polymers via electrospinning. Unique physicochemical features such as viscoelasticity, conductivity, and biological activity mainly affected by molecular weight attracted the attention of biomedical researchers to utilize hyaluronan for designing novel HA-based nano-devices. Particularly HA-based nanofibers get focused on a diverse range of applications in medical like tissue implants for regeneration of damaged tissue or organ repair, wound dressings, and drug delivery carriers to treat various disorders. Currently, electrospinning represents an effective available method for designing highly porous, 3D, HA-based nanofibers with features similar to that of the extra-cellular matrix making them a promising candidate for designing advanced regenerative medicines. This review highlights the structural and physicochemical features of HA, recently cited protocols in literature for HA production via microbial fermentation with particular focus on electrospun fabrication of HA-based nanofibers and parameters affecting its synthesis, current progress in medical applications of these electrospun HA-based nanofibers, their limitations and future perspective about the potential of these HA-based nanofibers in medical field. |
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7.399315 |