Time-restricted feeding ameliorates dextran sulfate sodium-induced colitis via reducing intestinal inflammation

Time-restricted feeding (TRF) is an emerging dietary intervention that improves metabolic disorders such as obesity, insulin resistance and dyslipidemia. Inflammatory bowel disease (IBD) is a chronic inflammatory disorder affecting the gastrointestinal tract, where nutrition plays an important role...
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Gespeichert in:

Autor*in:	Shuo Song [verfasserIn] Lingling Chen [verfasserIn] Meijuan Bai [verfasserIn] Shuo Wang [verfasserIn] Xiaoyi Ye [verfasserIn] Yijun Lin [verfasserIn] Xuemei Luo [verfasserIn] Zixuan Li [verfasserIn] Lingling Zhang [verfasserIn] Xinyu Zhu [verfasserIn] Zinan Wang [verfasserIn] Yan Chen [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	inflammatory bowel disease time-restricted feeding intestine inflammation T cells

Übergeordnetes Werk:	In: Frontiers in Nutrition - Frontiers Media S.A., 2014, 9(2022)
Übergeordnetes Werk:	volume:9 ; year:2022

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fnut.2022.1043783

Katalog-ID:	DOAJ082933383

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spelling	10.3389/fnut.2022.1043783 doi (DE-627)DOAJ082933383 (DE-599)DOAJ794998c403fe4aea8b9a40ff60e0335b DE-627 ger DE-627 rakwb eng TX341-641 Shuo Song verfasserin aut Time-restricted feeding ameliorates dextran sulfate sodium-induced colitis via reducing intestinal inflammation 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Time-restricted feeding (TRF) is an emerging dietary intervention that improves metabolic disorders such as obesity, insulin resistance and dyslipidemia. Inflammatory bowel disease (IBD) is a chronic inflammatory disorder affecting the gastrointestinal tract, where nutrition plays an important role in its pathogenesis. Although numerous strategies of nutritional intervention have been reported, whether TRF can improve IBD has been elusive. In this study, we investigated the effect of two cycles of 7-day TRF intervention in a dextran sulfate sodium-induced IBD mouse model. We found that TRF was able to reduce the disease activity index and ameliorate the IBD-associated symptoms, as well as increase the number of colonic crypts and decrease the histological score in the colon. Furthermore, TRF lowered the percentage of CD4+ T cells in the peripheral blood and mesenteric lymph node, and increased the number of CD4+CD25+ T cells in the mesenteric lymph nodes. Additionally, TRF reduced the infiltration of leukocytes and macrophages around the crypt base in the colon. However, unlike the intermittent caloric restriction with fasting-mimicking diet, TRF was not able to increase the markers of progenitor and cell proliferation in the colon. Collectively, these results demonstrated that TRF is able to improve IBD in mice via reduction in intestinal inflammation. inflammatory bowel disease time-restricted feeding intestine inflammation T cells Nutrition. Foods and food supply Shuo Song verfasserin aut Lingling Chen verfasserin aut Meijuan Bai verfasserin aut Shuo Wang verfasserin aut Xiaoyi Ye verfasserin aut Yijun Lin verfasserin aut Xuemei Luo verfasserin aut Zixuan Li verfasserin aut Lingling Zhang verfasserin aut Xinyu Zhu verfasserin aut Zinan Wang verfasserin aut Yan Chen verfasserin aut Yan Chen verfasserin aut In Frontiers in Nutrition Frontiers Media S.A., 2014 9(2022) (DE-627)790231158 (DE-600)2776676-7 2296861X nnns volume:9 year:2022 https://doi.org/10.3389/fnut.2022.1043783 kostenfrei https://doaj.org/article/794998c403fe4aea8b9a40ff60e0335b kostenfrei https://www.frontiersin.org/articles/10.3389/fnut.2022.1043783/full kostenfrei https://doaj.org/toc/2296-861X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022
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allfieldsSound	10.3389/fnut.2022.1043783 doi (DE-627)DOAJ082933383 (DE-599)DOAJ794998c403fe4aea8b9a40ff60e0335b DE-627 ger DE-627 rakwb eng TX341-641 Shuo Song verfasserin aut Time-restricted feeding ameliorates dextran sulfate sodium-induced colitis via reducing intestinal inflammation 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Time-restricted feeding (TRF) is an emerging dietary intervention that improves metabolic disorders such as obesity, insulin resistance and dyslipidemia. Inflammatory bowel disease (IBD) is a chronic inflammatory disorder affecting the gastrointestinal tract, where nutrition plays an important role in its pathogenesis. Although numerous strategies of nutritional intervention have been reported, whether TRF can improve IBD has been elusive. In this study, we investigated the effect of two cycles of 7-day TRF intervention in a dextran sulfate sodium-induced IBD mouse model. We found that TRF was able to reduce the disease activity index and ameliorate the IBD-associated symptoms, as well as increase the number of colonic crypts and decrease the histological score in the colon. Furthermore, TRF lowered the percentage of CD4+ T cells in the peripheral blood and mesenteric lymph node, and increased the number of CD4+CD25+ T cells in the mesenteric lymph nodes. Additionally, TRF reduced the infiltration of leukocytes and macrophages around the crypt base in the colon. However, unlike the intermittent caloric restriction with fasting-mimicking diet, TRF was not able to increase the markers of progenitor and cell proliferation in the colon. Collectively, these results demonstrated that TRF is able to improve IBD in mice via reduction in intestinal inflammation. inflammatory bowel disease time-restricted feeding intestine inflammation T cells Nutrition. Foods and food supply Shuo Song verfasserin aut Lingling Chen verfasserin aut Meijuan Bai verfasserin aut Shuo Wang verfasserin aut Xiaoyi Ye verfasserin aut Yijun Lin verfasserin aut Xuemei Luo verfasserin aut Zixuan Li verfasserin aut Lingling Zhang verfasserin aut Xinyu Zhu verfasserin aut Zinan Wang verfasserin aut Yan Chen verfasserin aut Yan Chen verfasserin aut In Frontiers in Nutrition Frontiers Media S.A., 2014 9(2022) (DE-627)790231158 (DE-600)2776676-7 2296861X nnns volume:9 year:2022 https://doi.org/10.3389/fnut.2022.1043783 kostenfrei https://doaj.org/article/794998c403fe4aea8b9a40ff60e0335b kostenfrei https://www.frontiersin.org/articles/10.3389/fnut.2022.1043783/full kostenfrei https://doaj.org/toc/2296-861X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022
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callnumber-first	T - Technology
author	Shuo Song
spellingShingle	Shuo Song misc TX341-641 misc inflammatory bowel disease misc time-restricted feeding misc intestine misc inflammation misc T cells misc Nutrition. Foods and food supply Time-restricted feeding ameliorates dextran sulfate sodium-induced colitis via reducing intestinal inflammation
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topic_title	TX341-641 Time-restricted feeding ameliorates dextran sulfate sodium-induced colitis via reducing intestinal inflammation inflammatory bowel disease time-restricted feeding intestine inflammation T cells
topic	misc TX341-641 misc inflammatory bowel disease misc time-restricted feeding misc intestine misc inflammation misc T cells misc Nutrition. Foods and food supply
topic_unstemmed	misc TX341-641 misc inflammatory bowel disease misc time-restricted feeding misc intestine misc inflammation misc T cells misc Nutrition. Foods and food supply
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title	Time-restricted feeding ameliorates dextran sulfate sodium-induced colitis via reducing intestinal inflammation
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title_full	Time-restricted feeding ameliorates dextran sulfate sodium-induced colitis via reducing intestinal inflammation
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author_browse	Shuo Song Lingling Chen Meijuan Bai Shuo Wang Xiaoyi Ye Yijun Lin Xuemei Luo Zixuan Li Lingling Zhang Xinyu Zhu Zinan Wang Yan Chen
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title_sort	time-restricted feeding ameliorates dextran sulfate sodium-induced colitis via reducing intestinal inflammation
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title_auth	Time-restricted feeding ameliorates dextran sulfate sodium-induced colitis via reducing intestinal inflammation
abstract	Time-restricted feeding (TRF) is an emerging dietary intervention that improves metabolic disorders such as obesity, insulin resistance and dyslipidemia. Inflammatory bowel disease (IBD) is a chronic inflammatory disorder affecting the gastrointestinal tract, where nutrition plays an important role in its pathogenesis. Although numerous strategies of nutritional intervention have been reported, whether TRF can improve IBD has been elusive. In this study, we investigated the effect of two cycles of 7-day TRF intervention in a dextran sulfate sodium-induced IBD mouse model. We found that TRF was able to reduce the disease activity index and ameliorate the IBD-associated symptoms, as well as increase the number of colonic crypts and decrease the histological score in the colon. Furthermore, TRF lowered the percentage of CD4+ T cells in the peripheral blood and mesenteric lymph node, and increased the number of CD4+CD25+ T cells in the mesenteric lymph nodes. Additionally, TRF reduced the infiltration of leukocytes and macrophages around the crypt base in the colon. However, unlike the intermittent caloric restriction with fasting-mimicking diet, TRF was not able to increase the markers of progenitor and cell proliferation in the colon. Collectively, these results demonstrated that TRF is able to improve IBD in mice via reduction in intestinal inflammation.
abstractGer	Time-restricted feeding (TRF) is an emerging dietary intervention that improves metabolic disorders such as obesity, insulin resistance and dyslipidemia. Inflammatory bowel disease (IBD) is a chronic inflammatory disorder affecting the gastrointestinal tract, where nutrition plays an important role in its pathogenesis. Although numerous strategies of nutritional intervention have been reported, whether TRF can improve IBD has been elusive. In this study, we investigated the effect of two cycles of 7-day TRF intervention in a dextran sulfate sodium-induced IBD mouse model. We found that TRF was able to reduce the disease activity index and ameliorate the IBD-associated symptoms, as well as increase the number of colonic crypts and decrease the histological score in the colon. Furthermore, TRF lowered the percentage of CD4+ T cells in the peripheral blood and mesenteric lymph node, and increased the number of CD4+CD25+ T cells in the mesenteric lymph nodes. Additionally, TRF reduced the infiltration of leukocytes and macrophages around the crypt base in the colon. However, unlike the intermittent caloric restriction with fasting-mimicking diet, TRF was not able to increase the markers of progenitor and cell proliferation in the colon. Collectively, these results demonstrated that TRF is able to improve IBD in mice via reduction in intestinal inflammation.
abstract_unstemmed	Time-restricted feeding (TRF) is an emerging dietary intervention that improves metabolic disorders such as obesity, insulin resistance and dyslipidemia. Inflammatory bowel disease (IBD) is a chronic inflammatory disorder affecting the gastrointestinal tract, where nutrition plays an important role in its pathogenesis. Although numerous strategies of nutritional intervention have been reported, whether TRF can improve IBD has been elusive. In this study, we investigated the effect of two cycles of 7-day TRF intervention in a dextran sulfate sodium-induced IBD mouse model. We found that TRF was able to reduce the disease activity index and ameliorate the IBD-associated symptoms, as well as increase the number of colonic crypts and decrease the histological score in the colon. Furthermore, TRF lowered the percentage of CD4+ T cells in the peripheral blood and mesenteric lymph node, and increased the number of CD4+CD25+ T cells in the mesenteric lymph nodes. Additionally, TRF reduced the infiltration of leukocytes and macrophages around the crypt base in the colon. However, unlike the intermittent caloric restriction with fasting-mimicking diet, TRF was not able to increase the markers of progenitor and cell proliferation in the colon. Collectively, these results demonstrated that TRF is able to improve IBD in mice via reduction in intestinal inflammation.
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title_short	Time-restricted feeding ameliorates dextran sulfate sodium-induced colitis via reducing intestinal inflammation
url	https://doi.org/10.3389/fnut.2022.1043783 https://doaj.org/article/794998c403fe4aea8b9a40ff60e0335b https://www.frontiersin.org/articles/10.3389/fnut.2022.1043783/full https://doaj.org/toc/2296-861X
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author2	Shuo Song Lingling Chen Meijuan Bai Shuo Wang Xiaoyi Ye Yijun Lin Xuemei Luo Zixuan Li Lingling Zhang Xinyu Zhu Zinan Wang Yan Chen
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up_date	2024-07-03T14:36:18.205Z
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Time-restricted feeding ameliorates dextran sulfate sodium-induced colitis via reducing intestinal inflammation

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