Synthesis of Magneto-Controllable Polymer Nanocarrier Based on Poly(N-isopropylacrylamide-co-acrylic Acid) for Doxorubicin Immobilization

In this work, the preparation procedure and properties of anionic magnetic microgels loaded with antitumor drug doxorubicin are described. The functional microgels were produced via the in situ formation of iron nanoparticles in an aqueous dispersion of polymer microgels based on poly(N-isopropylacr...
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Autor*in:	Viktoria S. Kusaia [verfasserIn] Elena Yu. Kozhunova [verfasserIn] Darya A. Stepanova [verfasserIn] Vladislava A. Pigareva [verfasserIn] Andrey V. Sybachin [verfasserIn] Sergey B. Zezin [verfasserIn] Anastasiya V. Bolshakova [verfasserIn] Nikita M. Shchelkunov [verfasserIn] Evgeny S. Vavaev [verfasserIn] Evgeny V. Lyubin [verfasserIn] Andrey A. Fedyanin [verfasserIn] Vasiliy V. Spiridonov [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	microgel magnetosensitivity controlled delivery optical tweezers static light scattering model cell membranes

Übergeordnetes Werk:	In: Polymers - MDPI AG, 2011, 14(2022), 24, p 5440
Übergeordnetes Werk:	volume:14 ; year:2022 ; number:24, p 5440

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/polym14245440

Katalog-ID:	DOAJ082995400

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allfields	10.3390/polym14245440 doi (DE-627)DOAJ082995400 (DE-599)DOAJd877549640144c7aa4244de8cfcf217c DE-627 ger DE-627 rakwb eng QD241-441 Viktoria S. Kusaia verfasserin aut Synthesis of Magneto-Controllable Polymer Nanocarrier Based on Poly(N-isopropylacrylamide-co-acrylic Acid) for Doxorubicin Immobilization 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this work, the preparation procedure and properties of anionic magnetic microgels loaded with antitumor drug doxorubicin are described. The functional microgels were produced via the in situ formation of iron nanoparticles in an aqueous dispersion of polymer microgels based on poly(N-isopropylacrylamide-co-acrylic acid) (PNIPAM-PAA). The composition and morphology of the resulting composite microgels were studied by means of X-ray diffraction, Mössbauer spectroscopy, IR spectroscopy, scanning electron microscopy, atomic-force microscopy, laser microelectrophoresis, and static and dynamic light scattering. The forming nanoparticles were found to be β-FeO(OH). In physiological pH and ionic strength, the obtained composite microgels were shown to possess high colloid stability. The average size of the composites was 200 nm, while the zeta-potential was −27.5 mV. An optical tweezers study has demonstrated the possibility of manipulation with microgel using external magnetic fields. Loading of the composite microgel with doxorubicin did not lead to any change in particle size and colloidal stability. Magnetic-driven interaction of the drug-loaded microgel with model cell membranes was demonstrated by fluorescence microscopy. The described magnetic microgels demonstrate the potential for the controlled delivery of biologically active substances. microgel magnetosensitivity controlled delivery optical tweezers static light scattering model cell membranes Organic chemistry Elena Yu. Kozhunova verfasserin aut Darya A. Stepanova verfasserin aut Vladislava A. Pigareva verfasserin aut Andrey V. Sybachin verfasserin aut Sergey B. Zezin verfasserin aut Anastasiya V. Bolshakova verfasserin aut Nikita M. Shchelkunov verfasserin aut Evgeny S. Vavaev verfasserin aut Evgeny V. Lyubin verfasserin aut Andrey A. Fedyanin verfasserin aut Vasiliy V. Spiridonov verfasserin aut In Polymers MDPI AG, 2011 14(2022), 24, p 5440 (DE-627)61409612X (DE-600)2527146-5 20734360 nnns volume:14 year:2022 number:24, p 5440 https://doi.org/10.3390/polym14245440 kostenfrei https://doaj.org/article/d877549640144c7aa4244de8cfcf217c kostenfrei https://www.mdpi.com/2073-4360/14/24/5440 kostenfrei https://doaj.org/toc/2073-4360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 24, p 5440
spelling	10.3390/polym14245440 doi (DE-627)DOAJ082995400 (DE-599)DOAJd877549640144c7aa4244de8cfcf217c DE-627 ger DE-627 rakwb eng QD241-441 Viktoria S. Kusaia verfasserin aut Synthesis of Magneto-Controllable Polymer Nanocarrier Based on Poly(N-isopropylacrylamide-co-acrylic Acid) for Doxorubicin Immobilization 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this work, the preparation procedure and properties of anionic magnetic microgels loaded with antitumor drug doxorubicin are described. The functional microgels were produced via the in situ formation of iron nanoparticles in an aqueous dispersion of polymer microgels based on poly(N-isopropylacrylamide-co-acrylic acid) (PNIPAM-PAA). The composition and morphology of the resulting composite microgels were studied by means of X-ray diffraction, Mössbauer spectroscopy, IR spectroscopy, scanning electron microscopy, atomic-force microscopy, laser microelectrophoresis, and static and dynamic light scattering. The forming nanoparticles were found to be β-FeO(OH). In physiological pH and ionic strength, the obtained composite microgels were shown to possess high colloid stability. The average size of the composites was 200 nm, while the zeta-potential was −27.5 mV. An optical tweezers study has demonstrated the possibility of manipulation with microgel using external magnetic fields. Loading of the composite microgel with doxorubicin did not lead to any change in particle size and colloidal stability. Magnetic-driven interaction of the drug-loaded microgel with model cell membranes was demonstrated by fluorescence microscopy. The described magnetic microgels demonstrate the potential for the controlled delivery of biologically active substances. microgel magnetosensitivity controlled delivery optical tweezers static light scattering model cell membranes Organic chemistry Elena Yu. Kozhunova verfasserin aut Darya A. Stepanova verfasserin aut Vladislava A. Pigareva verfasserin aut Andrey V. Sybachin verfasserin aut Sergey B. Zezin verfasserin aut Anastasiya V. Bolshakova verfasserin aut Nikita M. Shchelkunov verfasserin aut Evgeny S. Vavaev verfasserin aut Evgeny V. Lyubin verfasserin aut Andrey A. Fedyanin verfasserin aut Vasiliy V. Spiridonov verfasserin aut In Polymers MDPI AG, 2011 14(2022), 24, p 5440 (DE-627)61409612X (DE-600)2527146-5 20734360 nnns volume:14 year:2022 number:24, p 5440 https://doi.org/10.3390/polym14245440 kostenfrei https://doaj.org/article/d877549640144c7aa4244de8cfcf217c kostenfrei https://www.mdpi.com/2073-4360/14/24/5440 kostenfrei https://doaj.org/toc/2073-4360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 24, p 5440
allfields_unstemmed	10.3390/polym14245440 doi (DE-627)DOAJ082995400 (DE-599)DOAJd877549640144c7aa4244de8cfcf217c DE-627 ger DE-627 rakwb eng QD241-441 Viktoria S. Kusaia verfasserin aut Synthesis of Magneto-Controllable Polymer Nanocarrier Based on Poly(N-isopropylacrylamide-co-acrylic Acid) for Doxorubicin Immobilization 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this work, the preparation procedure and properties of anionic magnetic microgels loaded with antitumor drug doxorubicin are described. The functional microgels were produced via the in situ formation of iron nanoparticles in an aqueous dispersion of polymer microgels based on poly(N-isopropylacrylamide-co-acrylic acid) (PNIPAM-PAA). The composition and morphology of the resulting composite microgels were studied by means of X-ray diffraction, Mössbauer spectroscopy, IR spectroscopy, scanning electron microscopy, atomic-force microscopy, laser microelectrophoresis, and static and dynamic light scattering. The forming nanoparticles were found to be β-FeO(OH). In physiological pH and ionic strength, the obtained composite microgels were shown to possess high colloid stability. The average size of the composites was 200 nm, while the zeta-potential was −27.5 mV. An optical tweezers study has demonstrated the possibility of manipulation with microgel using external magnetic fields. Loading of the composite microgel with doxorubicin did not lead to any change in particle size and colloidal stability. Magnetic-driven interaction of the drug-loaded microgel with model cell membranes was demonstrated by fluorescence microscopy. The described magnetic microgels demonstrate the potential for the controlled delivery of biologically active substances. microgel magnetosensitivity controlled delivery optical tweezers static light scattering model cell membranes Organic chemistry Elena Yu. Kozhunova verfasserin aut Darya A. Stepanova verfasserin aut Vladislava A. Pigareva verfasserin aut Andrey V. Sybachin verfasserin aut Sergey B. Zezin verfasserin aut Anastasiya V. Bolshakova verfasserin aut Nikita M. Shchelkunov verfasserin aut Evgeny S. Vavaev verfasserin aut Evgeny V. Lyubin verfasserin aut Andrey A. Fedyanin verfasserin aut Vasiliy V. Spiridonov verfasserin aut In Polymers MDPI AG, 2011 14(2022), 24, p 5440 (DE-627)61409612X (DE-600)2527146-5 20734360 nnns volume:14 year:2022 number:24, p 5440 https://doi.org/10.3390/polym14245440 kostenfrei https://doaj.org/article/d877549640144c7aa4244de8cfcf217c kostenfrei https://www.mdpi.com/2073-4360/14/24/5440 kostenfrei https://doaj.org/toc/2073-4360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 24, p 5440
allfieldsGer	10.3390/polym14245440 doi (DE-627)DOAJ082995400 (DE-599)DOAJd877549640144c7aa4244de8cfcf217c DE-627 ger DE-627 rakwb eng QD241-441 Viktoria S. Kusaia verfasserin aut Synthesis of Magneto-Controllable Polymer Nanocarrier Based on Poly(N-isopropylacrylamide-co-acrylic Acid) for Doxorubicin Immobilization 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this work, the preparation procedure and properties of anionic magnetic microgels loaded with antitumor drug doxorubicin are described. The functional microgels were produced via the in situ formation of iron nanoparticles in an aqueous dispersion of polymer microgels based on poly(N-isopropylacrylamide-co-acrylic acid) (PNIPAM-PAA). The composition and morphology of the resulting composite microgels were studied by means of X-ray diffraction, Mössbauer spectroscopy, IR spectroscopy, scanning electron microscopy, atomic-force microscopy, laser microelectrophoresis, and static and dynamic light scattering. The forming nanoparticles were found to be β-FeO(OH). In physiological pH and ionic strength, the obtained composite microgels were shown to possess high colloid stability. The average size of the composites was 200 nm, while the zeta-potential was −27.5 mV. An optical tweezers study has demonstrated the possibility of manipulation with microgel using external magnetic fields. Loading of the composite microgel with doxorubicin did not lead to any change in particle size and colloidal stability. Magnetic-driven interaction of the drug-loaded microgel with model cell membranes was demonstrated by fluorescence microscopy. The described magnetic microgels demonstrate the potential for the controlled delivery of biologically active substances. microgel magnetosensitivity controlled delivery optical tweezers static light scattering model cell membranes Organic chemistry Elena Yu. Kozhunova verfasserin aut Darya A. Stepanova verfasserin aut Vladislava A. Pigareva verfasserin aut Andrey V. Sybachin verfasserin aut Sergey B. Zezin verfasserin aut Anastasiya V. Bolshakova verfasserin aut Nikita M. Shchelkunov verfasserin aut Evgeny S. Vavaev verfasserin aut Evgeny V. Lyubin verfasserin aut Andrey A. Fedyanin verfasserin aut Vasiliy V. Spiridonov verfasserin aut In Polymers MDPI AG, 2011 14(2022), 24, p 5440 (DE-627)61409612X (DE-600)2527146-5 20734360 nnns volume:14 year:2022 number:24, p 5440 https://doi.org/10.3390/polym14245440 kostenfrei https://doaj.org/article/d877549640144c7aa4244de8cfcf217c kostenfrei https://www.mdpi.com/2073-4360/14/24/5440 kostenfrei https://doaj.org/toc/2073-4360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 24, p 5440
allfieldsSound	10.3390/polym14245440 doi (DE-627)DOAJ082995400 (DE-599)DOAJd877549640144c7aa4244de8cfcf217c DE-627 ger DE-627 rakwb eng QD241-441 Viktoria S. Kusaia verfasserin aut Synthesis of Magneto-Controllable Polymer Nanocarrier Based on Poly(N-isopropylacrylamide-co-acrylic Acid) for Doxorubicin Immobilization 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this work, the preparation procedure and properties of anionic magnetic microgels loaded with antitumor drug doxorubicin are described. The functional microgels were produced via the in situ formation of iron nanoparticles in an aqueous dispersion of polymer microgels based on poly(N-isopropylacrylamide-co-acrylic acid) (PNIPAM-PAA). The composition and morphology of the resulting composite microgels were studied by means of X-ray diffraction, Mössbauer spectroscopy, IR spectroscopy, scanning electron microscopy, atomic-force microscopy, laser microelectrophoresis, and static and dynamic light scattering. The forming nanoparticles were found to be β-FeO(OH). In physiological pH and ionic strength, the obtained composite microgels were shown to possess high colloid stability. The average size of the composites was 200 nm, while the zeta-potential was −27.5 mV. An optical tweezers study has demonstrated the possibility of manipulation with microgel using external magnetic fields. Loading of the composite microgel with doxorubicin did not lead to any change in particle size and colloidal stability. Magnetic-driven interaction of the drug-loaded microgel with model cell membranes was demonstrated by fluorescence microscopy. The described magnetic microgels demonstrate the potential for the controlled delivery of biologically active substances. microgel magnetosensitivity controlled delivery optical tweezers static light scattering model cell membranes Organic chemistry Elena Yu. Kozhunova verfasserin aut Darya A. Stepanova verfasserin aut Vladislava A. Pigareva verfasserin aut Andrey V. Sybachin verfasserin aut Sergey B. Zezin verfasserin aut Anastasiya V. Bolshakova verfasserin aut Nikita M. Shchelkunov verfasserin aut Evgeny S. Vavaev verfasserin aut Evgeny V. Lyubin verfasserin aut Andrey A. Fedyanin verfasserin aut Vasiliy V. Spiridonov verfasserin aut In Polymers MDPI AG, 2011 14(2022), 24, p 5440 (DE-627)61409612X (DE-600)2527146-5 20734360 nnns volume:14 year:2022 number:24, p 5440 https://doi.org/10.3390/polym14245440 kostenfrei https://doaj.org/article/d877549640144c7aa4244de8cfcf217c kostenfrei https://www.mdpi.com/2073-4360/14/24/5440 kostenfrei https://doaj.org/toc/2073-4360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 24, p 5440
language	English
source	In Polymers 14(2022), 24, p 5440 volume:14 year:2022 number:24, p 5440
sourceStr	In Polymers 14(2022), 24, p 5440 volume:14 year:2022 number:24, p 5440
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	microgel magnetosensitivity controlled delivery optical tweezers static light scattering model cell membranes Organic chemistry
isfreeaccess_bool	true
container_title	Polymers
authorswithroles_txt_mv	Viktoria S. Kusaia @@aut@@ Elena Yu. Kozhunova @@aut@@ Darya A. Stepanova @@aut@@ Vladislava A. Pigareva @@aut@@ Andrey V. Sybachin @@aut@@ Sergey B. Zezin @@aut@@ Anastasiya V. Bolshakova @@aut@@ Nikita M. Shchelkunov @@aut@@ Evgeny S. Vavaev @@aut@@ Evgeny V. Lyubin @@aut@@ Andrey A. Fedyanin @@aut@@ Vasiliy V. Spiridonov @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	61409612X
id	DOAJ082995400
language_de	englisch
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callnumber-first	Q - Science
author	Viktoria S. Kusaia
spellingShingle	Viktoria S. Kusaia misc QD241-441 misc microgel misc magnetosensitivity misc controlled delivery misc optical tweezers misc static light scattering misc model cell membranes misc Organic chemistry Synthesis of Magneto-Controllable Polymer Nanocarrier Based on Poly(N-isopropylacrylamide-co-acrylic Acid) for Doxorubicin Immobilization
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topic_title	QD241-441 Synthesis of Magneto-Controllable Polymer Nanocarrier Based on Poly(N-isopropylacrylamide-co-acrylic Acid) for Doxorubicin Immobilization microgel magnetosensitivity controlled delivery optical tweezers static light scattering model cell membranes
topic	misc QD241-441 misc microgel misc magnetosensitivity misc controlled delivery misc optical tweezers misc static light scattering misc model cell membranes misc Organic chemistry
topic_unstemmed	misc QD241-441 misc microgel misc magnetosensitivity misc controlled delivery misc optical tweezers misc static light scattering misc model cell membranes misc Organic chemistry
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title	Synthesis of Magneto-Controllable Polymer Nanocarrier Based on Poly(N-isopropylacrylamide-co-acrylic Acid) for Doxorubicin Immobilization
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title_full	Synthesis of Magneto-Controllable Polymer Nanocarrier Based on Poly(N-isopropylacrylamide-co-acrylic Acid) for Doxorubicin Immobilization
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author_browse	Viktoria S. Kusaia Elena Yu. Kozhunova Darya A. Stepanova Vladislava A. Pigareva Andrey V. Sybachin Sergey B. Zezin Anastasiya V. Bolshakova Nikita M. Shchelkunov Evgeny S. Vavaev Evgeny V. Lyubin Andrey A. Fedyanin Vasiliy V. Spiridonov
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author-letter	Viktoria S. Kusaia
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title_sort	synthesis of magneto-controllable polymer nanocarrier based on poly(n-isopropylacrylamide-co-acrylic acid) for doxorubicin immobilization
callnumber	QD241-441
title_auth	Synthesis of Magneto-Controllable Polymer Nanocarrier Based on Poly(N-isopropylacrylamide-co-acrylic Acid) for Doxorubicin Immobilization
abstract	In this work, the preparation procedure and properties of anionic magnetic microgels loaded with antitumor drug doxorubicin are described. The functional microgels were produced via the in situ formation of iron nanoparticles in an aqueous dispersion of polymer microgels based on poly(N-isopropylacrylamide-co-acrylic acid) (PNIPAM-PAA). The composition and morphology of the resulting composite microgels were studied by means of X-ray diffraction, Mössbauer spectroscopy, IR spectroscopy, scanning electron microscopy, atomic-force microscopy, laser microelectrophoresis, and static and dynamic light scattering. The forming nanoparticles were found to be β-FeO(OH). In physiological pH and ionic strength, the obtained composite microgels were shown to possess high colloid stability. The average size of the composites was 200 nm, while the zeta-potential was −27.5 mV. An optical tweezers study has demonstrated the possibility of manipulation with microgel using external magnetic fields. Loading of the composite microgel with doxorubicin did not lead to any change in particle size and colloidal stability. Magnetic-driven interaction of the drug-loaded microgel with model cell membranes was demonstrated by fluorescence microscopy. The described magnetic microgels demonstrate the potential for the controlled delivery of biologically active substances.
abstractGer	In this work, the preparation procedure and properties of anionic magnetic microgels loaded with antitumor drug doxorubicin are described. The functional microgels were produced via the in situ formation of iron nanoparticles in an aqueous dispersion of polymer microgels based on poly(N-isopropylacrylamide-co-acrylic acid) (PNIPAM-PAA). The composition and morphology of the resulting composite microgels were studied by means of X-ray diffraction, Mössbauer spectroscopy, IR spectroscopy, scanning electron microscopy, atomic-force microscopy, laser microelectrophoresis, and static and dynamic light scattering. The forming nanoparticles were found to be β-FeO(OH). In physiological pH and ionic strength, the obtained composite microgels were shown to possess high colloid stability. The average size of the composites was 200 nm, while the zeta-potential was −27.5 mV. An optical tweezers study has demonstrated the possibility of manipulation with microgel using external magnetic fields. Loading of the composite microgel with doxorubicin did not lead to any change in particle size and colloidal stability. Magnetic-driven interaction of the drug-loaded microgel with model cell membranes was demonstrated by fluorescence microscopy. The described magnetic microgels demonstrate the potential for the controlled delivery of biologically active substances.
abstract_unstemmed	In this work, the preparation procedure and properties of anionic magnetic microgels loaded with antitumor drug doxorubicin are described. The functional microgels were produced via the in situ formation of iron nanoparticles in an aqueous dispersion of polymer microgels based on poly(N-isopropylacrylamide-co-acrylic acid) (PNIPAM-PAA). The composition and morphology of the resulting composite microgels were studied by means of X-ray diffraction, Mössbauer spectroscopy, IR spectroscopy, scanning electron microscopy, atomic-force microscopy, laser microelectrophoresis, and static and dynamic light scattering. The forming nanoparticles were found to be β-FeO(OH). In physiological pH and ionic strength, the obtained composite microgels were shown to possess high colloid stability. The average size of the composites was 200 nm, while the zeta-potential was −27.5 mV. An optical tweezers study has demonstrated the possibility of manipulation with microgel using external magnetic fields. Loading of the composite microgel with doxorubicin did not lead to any change in particle size and colloidal stability. Magnetic-driven interaction of the drug-loaded microgel with model cell membranes was demonstrated by fluorescence microscopy. The described magnetic microgels demonstrate the potential for the controlled delivery of biologically active substances.
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title_short	Synthesis of Magneto-Controllable Polymer Nanocarrier Based on Poly(N-isopropylacrylamide-co-acrylic Acid) for Doxorubicin Immobilization
url	https://doi.org/10.3390/polym14245440 https://doaj.org/article/d877549640144c7aa4244de8cfcf217c https://www.mdpi.com/2073-4360/14/24/5440 https://doaj.org/toc/2073-4360
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score	7.40199

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Synthesis of Magneto-Controllable Polymer Nanocarrier Based on Poly(N-isopropylacrylamide-co-acrylic Acid) for Doxorubicin Immobilization

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