Association of Vasopressors Dose Trajectories with Enteral Nutrition Tolerance in Patients with Shock: A Prospective Observational Study

(1) Background: Studies on the long-term patterns of using vasopressors in patients with shock and their correlations with the risk of feeding intolerance (FI) are limited. This study aimed to characterize the norepinephrine equivalent dose (NEQ) trajectories and explore its correlations with FI in...
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Autor*in:	Luping Wang [verfasserIn] Tao Zhang [verfasserIn] Hua Yao [verfasserIn] Qian Xu [verfasserIn] Xin Fu [verfasserIn] Jing Yang [verfasserIn] Bo Wang [verfasserIn] Zhongwei Zhang [verfasserIn] Xiaodong Jin [verfasserIn] Yan Kang [verfasserIn] Qin Wu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	NEQ trajectory shock enteral nutrition feeding intolerance

Übergeordnetes Werk:	In: Nutrients - MDPI AG, 2009, 14(2022), 24, p 5393
Übergeordnetes Werk:	volume:14 ; year:2022 ; number:24, p 5393

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/nu14245393

Katalog-ID:	DOAJ083007806

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520			\|a (1) Background: Studies on the long-term patterns of using vasopressors in patients with shock and their correlations with the risk of feeding intolerance (FI) are limited. This study aimed to characterize the norepinephrine equivalent dose (NEQ) trajectories and explore its correlations with FI in patients with shock. (2) Methods: This study prospectively enrolled patients with shock, who received vasopressors from August 2020 to June 2022. The Growth Mixed Model (GMM) was used to traverse longitudinal NEQ data at six-hour intervals and identify the latent trajectories of NEQ use in these patients. Cox proportional hazards regression models were used to examine the correlations of NEQ trajectories with FI. (3) Results: This study included a total of 210 patients with shock recruited from August 2020 to June 2022. Four trajectories of NEQ dose were identified and characterized by low-dose stable NEQ (L-NEQ, <i<n</i< = 98), moderate-dose stable NEQ (M-NEQ, <i<n</i< = 74), high-dose stable NEQ (H-NEQ, <i<n</i< = 21), and rapidly rising NEQ (R-NEQ, <i<n</i< = 17), with NEQ doses of 0.2, 0.4, 0.4, and 0.5 µg/kg/min at enteral nutrition (EN) initiation, respectively. The incidences of FI were 37.76%, 67.57%, 80.95%, and 76.47% in the L-NEQ, M-NEQ, H-NEQ, and R-NEQ groups, respectively (<i<p</i< < 0.001). As compared to the L-NEQ group, the risk of FI occurrence increased in the M-NEQ, H-NEQ, and R-NEQ groups (all <i<p</i< < 0.05). (4) Conclusions: The risk of FI was significantly associated with NEQ trajectories. It might be appropriate to initiate EN when the NEQ dose is stabilized below 0.2 µg/kg/min in patients with shock.
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allfields	10.3390/nu14245393 doi (DE-627)DOAJ083007806 (DE-599)DOAJf0ab8e8a0a2b446a826887bea0e107d8 DE-627 ger DE-627 rakwb eng TX341-641 Luping Wang verfasserin aut Association of Vasopressors Dose Trajectories with Enteral Nutrition Tolerance in Patients with Shock: A Prospective Observational Study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier (1) Background: Studies on the long-term patterns of using vasopressors in patients with shock and their correlations with the risk of feeding intolerance (FI) are limited. This study aimed to characterize the norepinephrine equivalent dose (NEQ) trajectories and explore its correlations with FI in patients with shock. (2) Methods: This study prospectively enrolled patients with shock, who received vasopressors from August 2020 to June 2022. The Growth Mixed Model (GMM) was used to traverse longitudinal NEQ data at six-hour intervals and identify the latent trajectories of NEQ use in these patients. Cox proportional hazards regression models were used to examine the correlations of NEQ trajectories with FI. (3) Results: This study included a total of 210 patients with shock recruited from August 2020 to June 2022. Four trajectories of NEQ dose were identified and characterized by low-dose stable NEQ (L-NEQ, <i<n</i< = 98), moderate-dose stable NEQ (M-NEQ, <i<n</i< = 74), high-dose stable NEQ (H-NEQ, <i<n</i< = 21), and rapidly rising NEQ (R-NEQ, <i<n</i< = 17), with NEQ doses of 0.2, 0.4, 0.4, and 0.5 µg/kg/min at enteral nutrition (EN) initiation, respectively. The incidences of FI were 37.76%, 67.57%, 80.95%, and 76.47% in the L-NEQ, M-NEQ, H-NEQ, and R-NEQ groups, respectively (<i<p</i< < 0.001). As compared to the L-NEQ group, the risk of FI occurrence increased in the M-NEQ, H-NEQ, and R-NEQ groups (all <i<p</i< < 0.05). (4) Conclusions: The risk of FI was significantly associated with NEQ trajectories. It might be appropriate to initiate EN when the NEQ dose is stabilized below 0.2 µg/kg/min in patients with shock. NEQ trajectory shock enteral nutrition feeding intolerance Nutrition. Foods and food supply Tao Zhang verfasserin aut Hua Yao verfasserin aut Qian Xu verfasserin aut Xin Fu verfasserin aut Jing Yang verfasserin aut Bo Wang verfasserin aut Zhongwei Zhang verfasserin aut Xiaodong Jin verfasserin aut Yan Kang verfasserin aut Qin Wu verfasserin aut In Nutrients MDPI AG, 2009 14(2022), 24, p 5393 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:14 year:2022 number:24, p 5393 https://doi.org/10.3390/nu14245393 kostenfrei https://doaj.org/article/f0ab8e8a0a2b446a826887bea0e107d8 kostenfrei https://www.mdpi.com/2072-6643/14/24/5393 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 24, p 5393
spelling	10.3390/nu14245393 doi (DE-627)DOAJ083007806 (DE-599)DOAJf0ab8e8a0a2b446a826887bea0e107d8 DE-627 ger DE-627 rakwb eng TX341-641 Luping Wang verfasserin aut Association of Vasopressors Dose Trajectories with Enteral Nutrition Tolerance in Patients with Shock: A Prospective Observational Study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier (1) Background: Studies on the long-term patterns of using vasopressors in patients with shock and their correlations with the risk of feeding intolerance (FI) are limited. This study aimed to characterize the norepinephrine equivalent dose (NEQ) trajectories and explore its correlations with FI in patients with shock. (2) Methods: This study prospectively enrolled patients with shock, who received vasopressors from August 2020 to June 2022. The Growth Mixed Model (GMM) was used to traverse longitudinal NEQ data at six-hour intervals and identify the latent trajectories of NEQ use in these patients. Cox proportional hazards regression models were used to examine the correlations of NEQ trajectories with FI. (3) Results: This study included a total of 210 patients with shock recruited from August 2020 to June 2022. Four trajectories of NEQ dose were identified and characterized by low-dose stable NEQ (L-NEQ, <i<n</i< = 98), moderate-dose stable NEQ (M-NEQ, <i<n</i< = 74), high-dose stable NEQ (H-NEQ, <i<n</i< = 21), and rapidly rising NEQ (R-NEQ, <i<n</i< = 17), with NEQ doses of 0.2, 0.4, 0.4, and 0.5 µg/kg/min at enteral nutrition (EN) initiation, respectively. The incidences of FI were 37.76%, 67.57%, 80.95%, and 76.47% in the L-NEQ, M-NEQ, H-NEQ, and R-NEQ groups, respectively (<i<p</i< < 0.001). As compared to the L-NEQ group, the risk of FI occurrence increased in the M-NEQ, H-NEQ, and R-NEQ groups (all <i<p</i< < 0.05). (4) Conclusions: The risk of FI was significantly associated with NEQ trajectories. It might be appropriate to initiate EN when the NEQ dose is stabilized below 0.2 µg/kg/min in patients with shock. NEQ trajectory shock enteral nutrition feeding intolerance Nutrition. Foods and food supply Tao Zhang verfasserin aut Hua Yao verfasserin aut Qian Xu verfasserin aut Xin Fu verfasserin aut Jing Yang verfasserin aut Bo Wang verfasserin aut Zhongwei Zhang verfasserin aut Xiaodong Jin verfasserin aut Yan Kang verfasserin aut Qin Wu verfasserin aut In Nutrients MDPI AG, 2009 14(2022), 24, p 5393 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:14 year:2022 number:24, p 5393 https://doi.org/10.3390/nu14245393 kostenfrei https://doaj.org/article/f0ab8e8a0a2b446a826887bea0e107d8 kostenfrei https://www.mdpi.com/2072-6643/14/24/5393 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 24, p 5393
allfields_unstemmed	10.3390/nu14245393 doi (DE-627)DOAJ083007806 (DE-599)DOAJf0ab8e8a0a2b446a826887bea0e107d8 DE-627 ger DE-627 rakwb eng TX341-641 Luping Wang verfasserin aut Association of Vasopressors Dose Trajectories with Enteral Nutrition Tolerance in Patients with Shock: A Prospective Observational Study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier (1) Background: Studies on the long-term patterns of using vasopressors in patients with shock and their correlations with the risk of feeding intolerance (FI) are limited. This study aimed to characterize the norepinephrine equivalent dose (NEQ) trajectories and explore its correlations with FI in patients with shock. (2) Methods: This study prospectively enrolled patients with shock, who received vasopressors from August 2020 to June 2022. The Growth Mixed Model (GMM) was used to traverse longitudinal NEQ data at six-hour intervals and identify the latent trajectories of NEQ use in these patients. Cox proportional hazards regression models were used to examine the correlations of NEQ trajectories with FI. (3) Results: This study included a total of 210 patients with shock recruited from August 2020 to June 2022. Four trajectories of NEQ dose were identified and characterized by low-dose stable NEQ (L-NEQ, <i<n</i< = 98), moderate-dose stable NEQ (M-NEQ, <i<n</i< = 74), high-dose stable NEQ (H-NEQ, <i<n</i< = 21), and rapidly rising NEQ (R-NEQ, <i<n</i< = 17), with NEQ doses of 0.2, 0.4, 0.4, and 0.5 µg/kg/min at enteral nutrition (EN) initiation, respectively. The incidences of FI were 37.76%, 67.57%, 80.95%, and 76.47% in the L-NEQ, M-NEQ, H-NEQ, and R-NEQ groups, respectively (<i<p</i< < 0.001). As compared to the L-NEQ group, the risk of FI occurrence increased in the M-NEQ, H-NEQ, and R-NEQ groups (all <i<p</i< < 0.05). (4) Conclusions: The risk of FI was significantly associated with NEQ trajectories. It might be appropriate to initiate EN when the NEQ dose is stabilized below 0.2 µg/kg/min in patients with shock. NEQ trajectory shock enteral nutrition feeding intolerance Nutrition. Foods and food supply Tao Zhang verfasserin aut Hua Yao verfasserin aut Qian Xu verfasserin aut Xin Fu verfasserin aut Jing Yang verfasserin aut Bo Wang verfasserin aut Zhongwei Zhang verfasserin aut Xiaodong Jin verfasserin aut Yan Kang verfasserin aut Qin Wu verfasserin aut In Nutrients MDPI AG, 2009 14(2022), 24, p 5393 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:14 year:2022 number:24, p 5393 https://doi.org/10.3390/nu14245393 kostenfrei https://doaj.org/article/f0ab8e8a0a2b446a826887bea0e107d8 kostenfrei https://www.mdpi.com/2072-6643/14/24/5393 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 24, p 5393
allfieldsGer	10.3390/nu14245393 doi (DE-627)DOAJ083007806 (DE-599)DOAJf0ab8e8a0a2b446a826887bea0e107d8 DE-627 ger DE-627 rakwb eng TX341-641 Luping Wang verfasserin aut Association of Vasopressors Dose Trajectories with Enteral Nutrition Tolerance in Patients with Shock: A Prospective Observational Study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier (1) Background: Studies on the long-term patterns of using vasopressors in patients with shock and their correlations with the risk of feeding intolerance (FI) are limited. This study aimed to characterize the norepinephrine equivalent dose (NEQ) trajectories and explore its correlations with FI in patients with shock. (2) Methods: This study prospectively enrolled patients with shock, who received vasopressors from August 2020 to June 2022. The Growth Mixed Model (GMM) was used to traverse longitudinal NEQ data at six-hour intervals and identify the latent trajectories of NEQ use in these patients. Cox proportional hazards regression models were used to examine the correlations of NEQ trajectories with FI. (3) Results: This study included a total of 210 patients with shock recruited from August 2020 to June 2022. Four trajectories of NEQ dose were identified and characterized by low-dose stable NEQ (L-NEQ, <i<n</i< = 98), moderate-dose stable NEQ (M-NEQ, <i<n</i< = 74), high-dose stable NEQ (H-NEQ, <i<n</i< = 21), and rapidly rising NEQ (R-NEQ, <i<n</i< = 17), with NEQ doses of 0.2, 0.4, 0.4, and 0.5 µg/kg/min at enteral nutrition (EN) initiation, respectively. The incidences of FI were 37.76%, 67.57%, 80.95%, and 76.47% in the L-NEQ, M-NEQ, H-NEQ, and R-NEQ groups, respectively (<i<p</i< < 0.001). As compared to the L-NEQ group, the risk of FI occurrence increased in the M-NEQ, H-NEQ, and R-NEQ groups (all <i<p</i< < 0.05). (4) Conclusions: The risk of FI was significantly associated with NEQ trajectories. It might be appropriate to initiate EN when the NEQ dose is stabilized below 0.2 µg/kg/min in patients with shock. NEQ trajectory shock enteral nutrition feeding intolerance Nutrition. Foods and food supply Tao Zhang verfasserin aut Hua Yao verfasserin aut Qian Xu verfasserin aut Xin Fu verfasserin aut Jing Yang verfasserin aut Bo Wang verfasserin aut Zhongwei Zhang verfasserin aut Xiaodong Jin verfasserin aut Yan Kang verfasserin aut Qin Wu verfasserin aut In Nutrients MDPI AG, 2009 14(2022), 24, p 5393 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:14 year:2022 number:24, p 5393 https://doi.org/10.3390/nu14245393 kostenfrei https://doaj.org/article/f0ab8e8a0a2b446a826887bea0e107d8 kostenfrei https://www.mdpi.com/2072-6643/14/24/5393 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 24, p 5393
allfieldsSound	10.3390/nu14245393 doi (DE-627)DOAJ083007806 (DE-599)DOAJf0ab8e8a0a2b446a826887bea0e107d8 DE-627 ger DE-627 rakwb eng TX341-641 Luping Wang verfasserin aut Association of Vasopressors Dose Trajectories with Enteral Nutrition Tolerance in Patients with Shock: A Prospective Observational Study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier (1) Background: Studies on the long-term patterns of using vasopressors in patients with shock and their correlations with the risk of feeding intolerance (FI) are limited. This study aimed to characterize the norepinephrine equivalent dose (NEQ) trajectories and explore its correlations with FI in patients with shock. (2) Methods: This study prospectively enrolled patients with shock, who received vasopressors from August 2020 to June 2022. The Growth Mixed Model (GMM) was used to traverse longitudinal NEQ data at six-hour intervals and identify the latent trajectories of NEQ use in these patients. Cox proportional hazards regression models were used to examine the correlations of NEQ trajectories with FI. (3) Results: This study included a total of 210 patients with shock recruited from August 2020 to June 2022. Four trajectories of NEQ dose were identified and characterized by low-dose stable NEQ (L-NEQ, <i<n</i< = 98), moderate-dose stable NEQ (M-NEQ, <i<n</i< = 74), high-dose stable NEQ (H-NEQ, <i<n</i< = 21), and rapidly rising NEQ (R-NEQ, <i<n</i< = 17), with NEQ doses of 0.2, 0.4, 0.4, and 0.5 µg/kg/min at enteral nutrition (EN) initiation, respectively. The incidences of FI were 37.76%, 67.57%, 80.95%, and 76.47% in the L-NEQ, M-NEQ, H-NEQ, and R-NEQ groups, respectively (<i<p</i< < 0.001). As compared to the L-NEQ group, the risk of FI occurrence increased in the M-NEQ, H-NEQ, and R-NEQ groups (all <i<p</i< < 0.05). (4) Conclusions: The risk of FI was significantly associated with NEQ trajectories. It might be appropriate to initiate EN when the NEQ dose is stabilized below 0.2 µg/kg/min in patients with shock. NEQ trajectory shock enteral nutrition feeding intolerance Nutrition. Foods and food supply Tao Zhang verfasserin aut Hua Yao verfasserin aut Qian Xu verfasserin aut Xin Fu verfasserin aut Jing Yang verfasserin aut Bo Wang verfasserin aut Zhongwei Zhang verfasserin aut Xiaodong Jin verfasserin aut Yan Kang verfasserin aut Qin Wu verfasserin aut In Nutrients MDPI AG, 2009 14(2022), 24, p 5393 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:14 year:2022 number:24, p 5393 https://doi.org/10.3390/nu14245393 kostenfrei https://doaj.org/article/f0ab8e8a0a2b446a826887bea0e107d8 kostenfrei https://www.mdpi.com/2072-6643/14/24/5393 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 24, p 5393
language	English
source	In Nutrients 14(2022), 24, p 5393 volume:14 year:2022 number:24, p 5393
sourceStr	In Nutrients 14(2022), 24, p 5393 volume:14 year:2022 number:24, p 5393
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	NEQ trajectory shock enteral nutrition feeding intolerance Nutrition. Foods and food supply
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container_title	Nutrients
authorswithroles_txt_mv	Luping Wang @@aut@@ Tao Zhang @@aut@@ Hua Yao @@aut@@ Qian Xu @@aut@@ Xin Fu @@aut@@ Jing Yang @@aut@@ Bo Wang @@aut@@ Zhongwei Zhang @@aut@@ Xiaodong Jin @@aut@@ Yan Kang @@aut@@ Qin Wu @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
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author	Luping Wang
spellingShingle	Luping Wang misc TX341-641 misc NEQ misc trajectory misc shock misc enteral nutrition misc feeding intolerance misc Nutrition. Foods and food supply Association of Vasopressors Dose Trajectories with Enteral Nutrition Tolerance in Patients with Shock: A Prospective Observational Study
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topic_title	TX341-641 Association of Vasopressors Dose Trajectories with Enteral Nutrition Tolerance in Patients with Shock: A Prospective Observational Study NEQ trajectory shock enteral nutrition feeding intolerance
topic	misc TX341-641 misc NEQ misc trajectory misc shock misc enteral nutrition misc feeding intolerance misc Nutrition. Foods and food supply
topic_unstemmed	misc TX341-641 misc NEQ misc trajectory misc shock misc enteral nutrition misc feeding intolerance misc Nutrition. Foods and food supply
topic_browse	misc TX341-641 misc NEQ misc trajectory misc shock misc enteral nutrition misc feeding intolerance misc Nutrition. Foods and food supply
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title	Association of Vasopressors Dose Trajectories with Enteral Nutrition Tolerance in Patients with Shock: A Prospective Observational Study
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title_full	Association of Vasopressors Dose Trajectories with Enteral Nutrition Tolerance in Patients with Shock: A Prospective Observational Study
author_sort	Luping Wang
journal	Nutrients
journalStr	Nutrients
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author_browse	Luping Wang Tao Zhang Hua Yao Qian Xu Xin Fu Jing Yang Bo Wang Zhongwei Zhang Xiaodong Jin Yan Kang Qin Wu
container_volume	14
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author-letter	Luping Wang
doi_str_mv	10.3390/nu14245393
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title_sort	association of vasopressors dose trajectories with enteral nutrition tolerance in patients with shock: a prospective observational study
callnumber	TX341-641
title_auth	Association of Vasopressors Dose Trajectories with Enteral Nutrition Tolerance in Patients with Shock: A Prospective Observational Study
abstract	(1) Background: Studies on the long-term patterns of using vasopressors in patients with shock and their correlations with the risk of feeding intolerance (FI) are limited. This study aimed to characterize the norepinephrine equivalent dose (NEQ) trajectories and explore its correlations with FI in patients with shock. (2) Methods: This study prospectively enrolled patients with shock, who received vasopressors from August 2020 to June 2022. The Growth Mixed Model (GMM) was used to traverse longitudinal NEQ data at six-hour intervals and identify the latent trajectories of NEQ use in these patients. Cox proportional hazards regression models were used to examine the correlations of NEQ trajectories with FI. (3) Results: This study included a total of 210 patients with shock recruited from August 2020 to June 2022. Four trajectories of NEQ dose were identified and characterized by low-dose stable NEQ (L-NEQ, <i<n</i< = 98), moderate-dose stable NEQ (M-NEQ, <i<n</i< = 74), high-dose stable NEQ (H-NEQ, <i<n</i< = 21), and rapidly rising NEQ (R-NEQ, <i<n</i< = 17), with NEQ doses of 0.2, 0.4, 0.4, and 0.5 µg/kg/min at enteral nutrition (EN) initiation, respectively. The incidences of FI were 37.76%, 67.57%, 80.95%, and 76.47% in the L-NEQ, M-NEQ, H-NEQ, and R-NEQ groups, respectively (<i<p</i< < 0.001). As compared to the L-NEQ group, the risk of FI occurrence increased in the M-NEQ, H-NEQ, and R-NEQ groups (all <i<p</i< < 0.05). (4) Conclusions: The risk of FI was significantly associated with NEQ trajectories. It might be appropriate to initiate EN when the NEQ dose is stabilized below 0.2 µg/kg/min in patients with shock.
abstractGer	(1) Background: Studies on the long-term patterns of using vasopressors in patients with shock and their correlations with the risk of feeding intolerance (FI) are limited. This study aimed to characterize the norepinephrine equivalent dose (NEQ) trajectories and explore its correlations with FI in patients with shock. (2) Methods: This study prospectively enrolled patients with shock, who received vasopressors from August 2020 to June 2022. The Growth Mixed Model (GMM) was used to traverse longitudinal NEQ data at six-hour intervals and identify the latent trajectories of NEQ use in these patients. Cox proportional hazards regression models were used to examine the correlations of NEQ trajectories with FI. (3) Results: This study included a total of 210 patients with shock recruited from August 2020 to June 2022. Four trajectories of NEQ dose were identified and characterized by low-dose stable NEQ (L-NEQ, <i<n</i< = 98), moderate-dose stable NEQ (M-NEQ, <i<n</i< = 74), high-dose stable NEQ (H-NEQ, <i<n</i< = 21), and rapidly rising NEQ (R-NEQ, <i<n</i< = 17), with NEQ doses of 0.2, 0.4, 0.4, and 0.5 µg/kg/min at enteral nutrition (EN) initiation, respectively. The incidences of FI were 37.76%, 67.57%, 80.95%, and 76.47% in the L-NEQ, M-NEQ, H-NEQ, and R-NEQ groups, respectively (<i<p</i< < 0.001). As compared to the L-NEQ group, the risk of FI occurrence increased in the M-NEQ, H-NEQ, and R-NEQ groups (all <i<p</i< < 0.05). (4) Conclusions: The risk of FI was significantly associated with NEQ trajectories. It might be appropriate to initiate EN when the NEQ dose is stabilized below 0.2 µg/kg/min in patients with shock.
abstract_unstemmed	(1) Background: Studies on the long-term patterns of using vasopressors in patients with shock and their correlations with the risk of feeding intolerance (FI) are limited. This study aimed to characterize the norepinephrine equivalent dose (NEQ) trajectories and explore its correlations with FI in patients with shock. (2) Methods: This study prospectively enrolled patients with shock, who received vasopressors from August 2020 to June 2022. The Growth Mixed Model (GMM) was used to traverse longitudinal NEQ data at six-hour intervals and identify the latent trajectories of NEQ use in these patients. Cox proportional hazards regression models were used to examine the correlations of NEQ trajectories with FI. (3) Results: This study included a total of 210 patients with shock recruited from August 2020 to June 2022. Four trajectories of NEQ dose were identified and characterized by low-dose stable NEQ (L-NEQ, <i<n</i< = 98), moderate-dose stable NEQ (M-NEQ, <i<n</i< = 74), high-dose stable NEQ (H-NEQ, <i<n</i< = 21), and rapidly rising NEQ (R-NEQ, <i<n</i< = 17), with NEQ doses of 0.2, 0.4, 0.4, and 0.5 µg/kg/min at enteral nutrition (EN) initiation, respectively. The incidences of FI were 37.76%, 67.57%, 80.95%, and 76.47% in the L-NEQ, M-NEQ, H-NEQ, and R-NEQ groups, respectively (<i<p</i< < 0.001). As compared to the L-NEQ group, the risk of FI occurrence increased in the M-NEQ, H-NEQ, and R-NEQ groups (all <i<p</i< < 0.05). (4) Conclusions: The risk of FI was significantly associated with NEQ trajectories. It might be appropriate to initiate EN when the NEQ dose is stabilized below 0.2 µg/kg/min in patients with shock.
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container_issue	24, p 5393
title_short	Association of Vasopressors Dose Trajectories with Enteral Nutrition Tolerance in Patients with Shock: A Prospective Observational Study
url	https://doi.org/10.3390/nu14245393 https://doaj.org/article/f0ab8e8a0a2b446a826887bea0e107d8 https://www.mdpi.com/2072-6643/14/24/5393 https://doaj.org/toc/2072-6643
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author2	Tao Zhang Hua Yao Qian Xu Xin Fu Jing Yang Bo Wang Zhongwei Zhang Xiaodong Jin Yan Kang Qin Wu
author2Str	Tao Zhang Hua Yao Qian Xu Xin Fu Jing Yang Bo Wang Zhongwei Zhang Xiaodong Jin Yan Kang Qin Wu
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up_date	2024-07-03T15:01:59.147Z
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Association of Vasopressors Dose Trajectories with Enteral Nutrition Tolerance in Patients with Shock: A Prospective Observational Study

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