Real-Life Effectiveness of Subcutaneous Immune Therapy with Carbamylated Monomeric Allergoids on Mite, Grass, and Pellitory Respiratory Allergy: A Retrospective Study
Background: real-life studies are encouraged to evaluate the effectiveness and safety of allergen immunotherapy (AIT). In this context, a retrospective cohort study was conducted to assess the effectiveness and safety of carbamylated monomeric allergoid subcutaneous immunotherapy (MA-SCIT), along wi...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Mario Di Gioacchino [verfasserIn] Loredana Della Valle [verfasserIn] Rocco Mangifesta [verfasserIn] Arianna Lumaca [verfasserIn] Francesco Cipollone [verfasserIn] Franco Frati [verfasserIn] Enrico Compalati [verfasserIn] Eralda Lekli [verfasserIn] Etleva Qirco Loloci [verfasserIn] Francesca Santilli [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Journal of Clinical Medicine - MDPI AG, 2013, 11(2022), 24, p 7384 |
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| Übergeordnetes Werk: |
volume:11 ; year:2022 ; number:24, p 7384 |
| Links: |
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| DOI / URN: |
10.3390/jcm11247384 |
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| Katalog-ID: |
DOAJ083137319 |
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| 520 | |a Background: real-life studies are encouraged to evaluate the effectiveness and safety of allergen immunotherapy (AIT). In this context, a retrospective cohort study was conducted to assess the effectiveness and safety of carbamylated monomeric allergoid subcutaneous immunotherapy (MA-SCIT), along with patient satisfaction. Methods: a total of 291 patients with rhinoconjunctivitis with or without asthma with inhalant (house dust mite, grass, and pellitory) allergies were enrolled in this study. Perceived efficacy and perceived satisfaction with MA-SCIT, symptom score by VAS, ARIA classification of rhinitis, drug consumption, number of asthma worsening episodes, and asthma symptom control were evaluated by questionnaires before, after one year, at the end of treatment, and after one or two years of MA-SCIT. Results: the overall symptom score significantly decreased over the years of MA-SCIT, irrespective of specific sensitization (<i<p</i< < 0.01). There was a substantial amelioration of rhinitis severity, with a significant reduction (<i<p</i< < 0.01) in drug use. A significant reduction was observed in the asthma symptom VAS score and asthma-worsening episodes requiring systemic steroids. None of the patients reported any severe adverse reactions. Finally, 90% of the patients reported full satisfaction with the treatment. Conclusions: the study showed that AIT with carbamylated monomeric allergoids of grass, pellitory, and mites was effective and well tolerated by patients. | ||
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10.3390/jcm11247384 doi (DE-627)DOAJ083137319 (DE-599)DOAJ77046e25e8094240bd11620d534939ca DE-627 ger DE-627 rakwb eng Mario Di Gioacchino verfasserin aut Real-Life Effectiveness of Subcutaneous Immune Therapy with Carbamylated Monomeric Allergoids on Mite, Grass, and Pellitory Respiratory Allergy: A Retrospective Study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: real-life studies are encouraged to evaluate the effectiveness and safety of allergen immunotherapy (AIT). In this context, a retrospective cohort study was conducted to assess the effectiveness and safety of carbamylated monomeric allergoid subcutaneous immunotherapy (MA-SCIT), along with patient satisfaction. Methods: a total of 291 patients with rhinoconjunctivitis with or without asthma with inhalant (house dust mite, grass, and pellitory) allergies were enrolled in this study. Perceived efficacy and perceived satisfaction with MA-SCIT, symptom score by VAS, ARIA classification of rhinitis, drug consumption, number of asthma worsening episodes, and asthma symptom control were evaluated by questionnaires before, after one year, at the end of treatment, and after one or two years of MA-SCIT. Results: the overall symptom score significantly decreased over the years of MA-SCIT, irrespective of specific sensitization (<i<p</i< < 0.01). There was a substantial amelioration of rhinitis severity, with a significant reduction (<i<p</i< < 0.01) in drug use. A significant reduction was observed in the asthma symptom VAS score and asthma-worsening episodes requiring systemic steroids. None of the patients reported any severe adverse reactions. Finally, 90% of the patients reported full satisfaction with the treatment. Conclusions: the study showed that AIT with carbamylated monomeric allergoids of grass, pellitory, and mites was effective and well tolerated by patients. real-life study carbamylated monomeric allergoid SCIT patient satisfaction respiratory allergy Medicine R Loredana Della Valle verfasserin aut Rocco Mangifesta verfasserin aut Arianna Lumaca verfasserin aut Francesco Cipollone verfasserin aut Franco Frati verfasserin aut Enrico Compalati verfasserin aut Eralda Lekli verfasserin aut Etleva Qirco Loloci verfasserin aut Francesca Santilli verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2022), 24, p 7384 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2022 number:24, p 7384 https://doi.org/10.3390/jcm11247384 kostenfrei https://doaj.org/article/77046e25e8094240bd11620d534939ca kostenfrei https://www.mdpi.com/2077-0383/11/24/7384 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 24, p 7384 |
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10.3390/jcm11247384 doi (DE-627)DOAJ083137319 (DE-599)DOAJ77046e25e8094240bd11620d534939ca DE-627 ger DE-627 rakwb eng Mario Di Gioacchino verfasserin aut Real-Life Effectiveness of Subcutaneous Immune Therapy with Carbamylated Monomeric Allergoids on Mite, Grass, and Pellitory Respiratory Allergy: A Retrospective Study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: real-life studies are encouraged to evaluate the effectiveness and safety of allergen immunotherapy (AIT). In this context, a retrospective cohort study was conducted to assess the effectiveness and safety of carbamylated monomeric allergoid subcutaneous immunotherapy (MA-SCIT), along with patient satisfaction. Methods: a total of 291 patients with rhinoconjunctivitis with or without asthma with inhalant (house dust mite, grass, and pellitory) allergies were enrolled in this study. Perceived efficacy and perceived satisfaction with MA-SCIT, symptom score by VAS, ARIA classification of rhinitis, drug consumption, number of asthma worsening episodes, and asthma symptom control were evaluated by questionnaires before, after one year, at the end of treatment, and after one or two years of MA-SCIT. Results: the overall symptom score significantly decreased over the years of MA-SCIT, irrespective of specific sensitization (<i<p</i< < 0.01). There was a substantial amelioration of rhinitis severity, with a significant reduction (<i<p</i< < 0.01) in drug use. A significant reduction was observed in the asthma symptom VAS score and asthma-worsening episodes requiring systemic steroids. None of the patients reported any severe adverse reactions. Finally, 90% of the patients reported full satisfaction with the treatment. Conclusions: the study showed that AIT with carbamylated monomeric allergoids of grass, pellitory, and mites was effective and well tolerated by patients. real-life study carbamylated monomeric allergoid SCIT patient satisfaction respiratory allergy Medicine R Loredana Della Valle verfasserin aut Rocco Mangifesta verfasserin aut Arianna Lumaca verfasserin aut Francesco Cipollone verfasserin aut Franco Frati verfasserin aut Enrico Compalati verfasserin aut Eralda Lekli verfasserin aut Etleva Qirco Loloci verfasserin aut Francesca Santilli verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2022), 24, p 7384 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2022 number:24, p 7384 https://doi.org/10.3390/jcm11247384 kostenfrei https://doaj.org/article/77046e25e8094240bd11620d534939ca kostenfrei https://www.mdpi.com/2077-0383/11/24/7384 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 24, p 7384 |
| allfields_unstemmed |
10.3390/jcm11247384 doi (DE-627)DOAJ083137319 (DE-599)DOAJ77046e25e8094240bd11620d534939ca DE-627 ger DE-627 rakwb eng Mario Di Gioacchino verfasserin aut Real-Life Effectiveness of Subcutaneous Immune Therapy with Carbamylated Monomeric Allergoids on Mite, Grass, and Pellitory Respiratory Allergy: A Retrospective Study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: real-life studies are encouraged to evaluate the effectiveness and safety of allergen immunotherapy (AIT). In this context, a retrospective cohort study was conducted to assess the effectiveness and safety of carbamylated monomeric allergoid subcutaneous immunotherapy (MA-SCIT), along with patient satisfaction. Methods: a total of 291 patients with rhinoconjunctivitis with or without asthma with inhalant (house dust mite, grass, and pellitory) allergies were enrolled in this study. Perceived efficacy and perceived satisfaction with MA-SCIT, symptom score by VAS, ARIA classification of rhinitis, drug consumption, number of asthma worsening episodes, and asthma symptom control were evaluated by questionnaires before, after one year, at the end of treatment, and after one or two years of MA-SCIT. Results: the overall symptom score significantly decreased over the years of MA-SCIT, irrespective of specific sensitization (<i<p</i< < 0.01). There was a substantial amelioration of rhinitis severity, with a significant reduction (<i<p</i< < 0.01) in drug use. A significant reduction was observed in the asthma symptom VAS score and asthma-worsening episodes requiring systemic steroids. None of the patients reported any severe adverse reactions. Finally, 90% of the patients reported full satisfaction with the treatment. Conclusions: the study showed that AIT with carbamylated monomeric allergoids of grass, pellitory, and mites was effective and well tolerated by patients. real-life study carbamylated monomeric allergoid SCIT patient satisfaction respiratory allergy Medicine R Loredana Della Valle verfasserin aut Rocco Mangifesta verfasserin aut Arianna Lumaca verfasserin aut Francesco Cipollone verfasserin aut Franco Frati verfasserin aut Enrico Compalati verfasserin aut Eralda Lekli verfasserin aut Etleva Qirco Loloci verfasserin aut Francesca Santilli verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2022), 24, p 7384 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2022 number:24, p 7384 https://doi.org/10.3390/jcm11247384 kostenfrei https://doaj.org/article/77046e25e8094240bd11620d534939ca kostenfrei https://www.mdpi.com/2077-0383/11/24/7384 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 24, p 7384 |
| allfieldsGer |
10.3390/jcm11247384 doi (DE-627)DOAJ083137319 (DE-599)DOAJ77046e25e8094240bd11620d534939ca DE-627 ger DE-627 rakwb eng Mario Di Gioacchino verfasserin aut Real-Life Effectiveness of Subcutaneous Immune Therapy with Carbamylated Monomeric Allergoids on Mite, Grass, and Pellitory Respiratory Allergy: A Retrospective Study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: real-life studies are encouraged to evaluate the effectiveness and safety of allergen immunotherapy (AIT). In this context, a retrospective cohort study was conducted to assess the effectiveness and safety of carbamylated monomeric allergoid subcutaneous immunotherapy (MA-SCIT), along with patient satisfaction. Methods: a total of 291 patients with rhinoconjunctivitis with or without asthma with inhalant (house dust mite, grass, and pellitory) allergies were enrolled in this study. Perceived efficacy and perceived satisfaction with MA-SCIT, symptom score by VAS, ARIA classification of rhinitis, drug consumption, number of asthma worsening episodes, and asthma symptom control were evaluated by questionnaires before, after one year, at the end of treatment, and after one or two years of MA-SCIT. Results: the overall symptom score significantly decreased over the years of MA-SCIT, irrespective of specific sensitization (<i<p</i< < 0.01). There was a substantial amelioration of rhinitis severity, with a significant reduction (<i<p</i< < 0.01) in drug use. A significant reduction was observed in the asthma symptom VAS score and asthma-worsening episodes requiring systemic steroids. None of the patients reported any severe adverse reactions. Finally, 90% of the patients reported full satisfaction with the treatment. Conclusions: the study showed that AIT with carbamylated monomeric allergoids of grass, pellitory, and mites was effective and well tolerated by patients. real-life study carbamylated monomeric allergoid SCIT patient satisfaction respiratory allergy Medicine R Loredana Della Valle verfasserin aut Rocco Mangifesta verfasserin aut Arianna Lumaca verfasserin aut Francesco Cipollone verfasserin aut Franco Frati verfasserin aut Enrico Compalati verfasserin aut Eralda Lekli verfasserin aut Etleva Qirco Loloci verfasserin aut Francesca Santilli verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2022), 24, p 7384 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2022 number:24, p 7384 https://doi.org/10.3390/jcm11247384 kostenfrei https://doaj.org/article/77046e25e8094240bd11620d534939ca kostenfrei https://www.mdpi.com/2077-0383/11/24/7384 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 24, p 7384 |
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Real-Life Effectiveness of Subcutaneous Immune Therapy with Carbamylated Monomeric Allergoids on Mite, Grass, and Pellitory Respiratory Allergy: A Retrospective Study |
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Background: real-life studies are encouraged to evaluate the effectiveness and safety of allergen immunotherapy (AIT). In this context, a retrospective cohort study was conducted to assess the effectiveness and safety of carbamylated monomeric allergoid subcutaneous immunotherapy (MA-SCIT), along with patient satisfaction. Methods: a total of 291 patients with rhinoconjunctivitis with or without asthma with inhalant (house dust mite, grass, and pellitory) allergies were enrolled in this study. Perceived efficacy and perceived satisfaction with MA-SCIT, symptom score by VAS, ARIA classification of rhinitis, drug consumption, number of asthma worsening episodes, and asthma symptom control were evaluated by questionnaires before, after one year, at the end of treatment, and after one or two years of MA-SCIT. Results: the overall symptom score significantly decreased over the years of MA-SCIT, irrespective of specific sensitization (<i<p</i< < 0.01). There was a substantial amelioration of rhinitis severity, with a significant reduction (<i<p</i< < 0.01) in drug use. A significant reduction was observed in the asthma symptom VAS score and asthma-worsening episodes requiring systemic steroids. None of the patients reported any severe adverse reactions. Finally, 90% of the patients reported full satisfaction with the treatment. Conclusions: the study showed that AIT with carbamylated monomeric allergoids of grass, pellitory, and mites was effective and well tolerated by patients. |
| abstractGer |
Background: real-life studies are encouraged to evaluate the effectiveness and safety of allergen immunotherapy (AIT). In this context, a retrospective cohort study was conducted to assess the effectiveness and safety of carbamylated monomeric allergoid subcutaneous immunotherapy (MA-SCIT), along with patient satisfaction. Methods: a total of 291 patients with rhinoconjunctivitis with or without asthma with inhalant (house dust mite, grass, and pellitory) allergies were enrolled in this study. Perceived efficacy and perceived satisfaction with MA-SCIT, symptom score by VAS, ARIA classification of rhinitis, drug consumption, number of asthma worsening episodes, and asthma symptom control were evaluated by questionnaires before, after one year, at the end of treatment, and after one or two years of MA-SCIT. Results: the overall symptom score significantly decreased over the years of MA-SCIT, irrespective of specific sensitization (<i<p</i< < 0.01). There was a substantial amelioration of rhinitis severity, with a significant reduction (<i<p</i< < 0.01) in drug use. A significant reduction was observed in the asthma symptom VAS score and asthma-worsening episodes requiring systemic steroids. None of the patients reported any severe adverse reactions. Finally, 90% of the patients reported full satisfaction with the treatment. Conclusions: the study showed that AIT with carbamylated monomeric allergoids of grass, pellitory, and mites was effective and well tolerated by patients. |
| abstract_unstemmed |
Background: real-life studies are encouraged to evaluate the effectiveness and safety of allergen immunotherapy (AIT). In this context, a retrospective cohort study was conducted to assess the effectiveness and safety of carbamylated monomeric allergoid subcutaneous immunotherapy (MA-SCIT), along with patient satisfaction. Methods: a total of 291 patients with rhinoconjunctivitis with or without asthma with inhalant (house dust mite, grass, and pellitory) allergies were enrolled in this study. Perceived efficacy and perceived satisfaction with MA-SCIT, symptom score by VAS, ARIA classification of rhinitis, drug consumption, number of asthma worsening episodes, and asthma symptom control were evaluated by questionnaires before, after one year, at the end of treatment, and after one or two years of MA-SCIT. Results: the overall symptom score significantly decreased over the years of MA-SCIT, irrespective of specific sensitization (<i<p</i< < 0.01). There was a substantial amelioration of rhinitis severity, with a significant reduction (<i<p</i< < 0.01) in drug use. A significant reduction was observed in the asthma symptom VAS score and asthma-worsening episodes requiring systemic steroids. None of the patients reported any severe adverse reactions. Finally, 90% of the patients reported full satisfaction with the treatment. Conclusions: the study showed that AIT with carbamylated monomeric allergoids of grass, pellitory, and mites was effective and well tolerated by patients. |
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Real-Life Effectiveness of Subcutaneous Immune Therapy with Carbamylated Monomeric Allergoids on Mite, Grass, and Pellitory Respiratory Allergy: A Retrospective Study |
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https://doi.org/10.3390/jcm11247384 https://doaj.org/article/77046e25e8094240bd11620d534939ca https://www.mdpi.com/2077-0383/11/24/7384 https://doaj.org/toc/2077-0383 |
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Loredana Della Valle Rocco Mangifesta Arianna Lumaca Francesco Cipollone Franco Frati Enrico Compalati Eralda Lekli Etleva Qirco Loloci Francesca Santilli |
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Loredana Della Valle Rocco Mangifesta Arianna Lumaca Francesco Cipollone Franco Frati Enrico Compalati Eralda Lekli Etleva Qirco Loloci Francesca Santilli |
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