Identification of <i<JPX-RABEP1</i< Pair as an Immune-Related Biomarker and Therapeutic Target in Pulmonary Arterial Hypertension by Bioinformatics and Experimental Analyses

Pulmonary arterial hypertension (PAH) is a pulmonary vascular disease characterized by pulmonary vascular remodeling and right heart enlargement the pathogenesis of PAH is complicated; no biologic-based therapy is available for the treatment of PAH, but recent studies suggest that inflammatory respo...
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Autor*in:	Qian Gong [verfasserIn] Zhewei Hu [verfasserIn] Qiao Jin [verfasserIn] Yan Yan [verfasserIn] Yan Liu [verfasserIn] Jin He [verfasserIn] Lenan Zhuang [verfasserIn] Huanan Wang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	bioinformatics analysis pulmonary arterial hypertension non-coding RNAs immune cell infiltration

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 23(2022), 24, p 15559
Übergeordnetes Werk:	volume:23 ; year:2022 ; number:24, p 15559

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijms232415559

Katalog-ID:	DOAJ083150390

Internformat


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520			\|a Pulmonary arterial hypertension (PAH) is a pulmonary vascular disease characterized by pulmonary vascular remodeling and right heart enlargement the pathogenesis of PAH is complicated; no biologic-based therapy is available for the treatment of PAH, but recent studies suggest that inflammatory response and abnormal proliferation of pulmonary artery smooth muscle cells are the main pathogenic mechanism, while the role of immune-related long non-coding RNAs (lncRNAs) remains unclear. The aim of this study was to systematically analyze immune-related lncRNAs in PAH. Here, we downloaded a publicly available microarray data from PAH and control patients (GSE113439). A total of 243 up-regulated and 203 down-regulated differentially expressed genes (DEGs) were screened, and immune-related DEGs were further obtained from ImmPort. The immune-related lncRNAs were obtained by co-expression analysis of immune-related mRNAs. Then, immune-related lncRNAs-mRNAs network including 2 lncRNAs and 6 mRNAs was constructed which share regulatory miRNAs and have significant correlation. Among the lncRNA-mRNA pairs, one pair (<i<JPX-RABEP1</i<) was verified in the validating dataset GSE53408 and PAH mouse model. Furthermore, the immune cell infiltration analysis of the GSE113439 dataset revealed that the <i<JPX-RABEP1</i< pair may participate in the occurrence and development of PAH through immune cell infiltration. Together, our findings reveal that the lncRNA-mRNA pair <i<JPX-RABEP1</i< may be a novel biomarker and therapeutic target for PAH.
650		4	\|a bioinformatics analysis
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650		4	\|a non-coding RNAs
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allfields	10.3390/ijms232415559 doi (DE-627)DOAJ083150390 (DE-599)DOAJ0d2747347bce4e08b250c72acb1274ac DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Qian Gong verfasserin aut Identification of <i<JPX-RABEP1</i< Pair as an Immune-Related Biomarker and Therapeutic Target in Pulmonary Arterial Hypertension by Bioinformatics and Experimental Analyses 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Pulmonary arterial hypertension (PAH) is a pulmonary vascular disease characterized by pulmonary vascular remodeling and right heart enlargement the pathogenesis of PAH is complicated; no biologic-based therapy is available for the treatment of PAH, but recent studies suggest that inflammatory response and abnormal proliferation of pulmonary artery smooth muscle cells are the main pathogenic mechanism, while the role of immune-related long non-coding RNAs (lncRNAs) remains unclear. The aim of this study was to systematically analyze immune-related lncRNAs in PAH. Here, we downloaded a publicly available microarray data from PAH and control patients (GSE113439). A total of 243 up-regulated and 203 down-regulated differentially expressed genes (DEGs) were screened, and immune-related DEGs were further obtained from ImmPort. The immune-related lncRNAs were obtained by co-expression analysis of immune-related mRNAs. Then, immune-related lncRNAs-mRNAs network including 2 lncRNAs and 6 mRNAs was constructed which share regulatory miRNAs and have significant correlation. Among the lncRNA-mRNA pairs, one pair (<i<JPX-RABEP1</i<) was verified in the validating dataset GSE53408 and PAH mouse model. Furthermore, the immune cell infiltration analysis of the GSE113439 dataset revealed that the <i<JPX-RABEP1</i< pair may participate in the occurrence and development of PAH through immune cell infiltration. Together, our findings reveal that the lncRNA-mRNA pair <i<JPX-RABEP1</i< may be a novel biomarker and therapeutic target for PAH. bioinformatics analysis pulmonary arterial hypertension non-coding RNAs immune cell infiltration Biology (General) Chemistry Zhewei Hu verfasserin aut Qiao Jin verfasserin aut Yan Yan verfasserin aut Yan Liu verfasserin aut Jin He verfasserin aut Lenan Zhuang verfasserin aut Huanan Wang verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 24, p 15559 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:24, p 15559 https://doi.org/10.3390/ijms232415559 kostenfrei https://doaj.org/article/0d2747347bce4e08b250c72acb1274ac kostenfrei https://www.mdpi.com/1422-0067/23/24/15559 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 24, p 15559
spelling	10.3390/ijms232415559 doi (DE-627)DOAJ083150390 (DE-599)DOAJ0d2747347bce4e08b250c72acb1274ac DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Qian Gong verfasserin aut Identification of <i<JPX-RABEP1</i< Pair as an Immune-Related Biomarker and Therapeutic Target in Pulmonary Arterial Hypertension by Bioinformatics and Experimental Analyses 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Pulmonary arterial hypertension (PAH) is a pulmonary vascular disease characterized by pulmonary vascular remodeling and right heart enlargement the pathogenesis of PAH is complicated; no biologic-based therapy is available for the treatment of PAH, but recent studies suggest that inflammatory response and abnormal proliferation of pulmonary artery smooth muscle cells are the main pathogenic mechanism, while the role of immune-related long non-coding RNAs (lncRNAs) remains unclear. The aim of this study was to systematically analyze immune-related lncRNAs in PAH. Here, we downloaded a publicly available microarray data from PAH and control patients (GSE113439). A total of 243 up-regulated and 203 down-regulated differentially expressed genes (DEGs) were screened, and immune-related DEGs were further obtained from ImmPort. The immune-related lncRNAs were obtained by co-expression analysis of immune-related mRNAs. Then, immune-related lncRNAs-mRNAs network including 2 lncRNAs and 6 mRNAs was constructed which share regulatory miRNAs and have significant correlation. Among the lncRNA-mRNA pairs, one pair (<i<JPX-RABEP1</i<) was verified in the validating dataset GSE53408 and PAH mouse model. Furthermore, the immune cell infiltration analysis of the GSE113439 dataset revealed that the <i<JPX-RABEP1</i< pair may participate in the occurrence and development of PAH through immune cell infiltration. Together, our findings reveal that the lncRNA-mRNA pair <i<JPX-RABEP1</i< may be a novel biomarker and therapeutic target for PAH. bioinformatics analysis pulmonary arterial hypertension non-coding RNAs immune cell infiltration Biology (General) Chemistry Zhewei Hu verfasserin aut Qiao Jin verfasserin aut Yan Yan verfasserin aut Yan Liu verfasserin aut Jin He verfasserin aut Lenan Zhuang verfasserin aut Huanan Wang verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 24, p 15559 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:24, p 15559 https://doi.org/10.3390/ijms232415559 kostenfrei https://doaj.org/article/0d2747347bce4e08b250c72acb1274ac kostenfrei https://www.mdpi.com/1422-0067/23/24/15559 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 24, p 15559
allfields_unstemmed	10.3390/ijms232415559 doi (DE-627)DOAJ083150390 (DE-599)DOAJ0d2747347bce4e08b250c72acb1274ac DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Qian Gong verfasserin aut Identification of <i<JPX-RABEP1</i< Pair as an Immune-Related Biomarker and Therapeutic Target in Pulmonary Arterial Hypertension by Bioinformatics and Experimental Analyses 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Pulmonary arterial hypertension (PAH) is a pulmonary vascular disease characterized by pulmonary vascular remodeling and right heart enlargement the pathogenesis of PAH is complicated; no biologic-based therapy is available for the treatment of PAH, but recent studies suggest that inflammatory response and abnormal proliferation of pulmonary artery smooth muscle cells are the main pathogenic mechanism, while the role of immune-related long non-coding RNAs (lncRNAs) remains unclear. The aim of this study was to systematically analyze immune-related lncRNAs in PAH. Here, we downloaded a publicly available microarray data from PAH and control patients (GSE113439). A total of 243 up-regulated and 203 down-regulated differentially expressed genes (DEGs) were screened, and immune-related DEGs were further obtained from ImmPort. The immune-related lncRNAs were obtained by co-expression analysis of immune-related mRNAs. Then, immune-related lncRNAs-mRNAs network including 2 lncRNAs and 6 mRNAs was constructed which share regulatory miRNAs and have significant correlation. Among the lncRNA-mRNA pairs, one pair (<i<JPX-RABEP1</i<) was verified in the validating dataset GSE53408 and PAH mouse model. Furthermore, the immune cell infiltration analysis of the GSE113439 dataset revealed that the <i<JPX-RABEP1</i< pair may participate in the occurrence and development of PAH through immune cell infiltration. Together, our findings reveal that the lncRNA-mRNA pair <i<JPX-RABEP1</i< may be a novel biomarker and therapeutic target for PAH. bioinformatics analysis pulmonary arterial hypertension non-coding RNAs immune cell infiltration Biology (General) Chemistry Zhewei Hu verfasserin aut Qiao Jin verfasserin aut Yan Yan verfasserin aut Yan Liu verfasserin aut Jin He verfasserin aut Lenan Zhuang verfasserin aut Huanan Wang verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 24, p 15559 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:24, p 15559 https://doi.org/10.3390/ijms232415559 kostenfrei https://doaj.org/article/0d2747347bce4e08b250c72acb1274ac kostenfrei https://www.mdpi.com/1422-0067/23/24/15559 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 24, p 15559
allfieldsGer	10.3390/ijms232415559 doi (DE-627)DOAJ083150390 (DE-599)DOAJ0d2747347bce4e08b250c72acb1274ac DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Qian Gong verfasserin aut Identification of <i<JPX-RABEP1</i< Pair as an Immune-Related Biomarker and Therapeutic Target in Pulmonary Arterial Hypertension by Bioinformatics and Experimental Analyses 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Pulmonary arterial hypertension (PAH) is a pulmonary vascular disease characterized by pulmonary vascular remodeling and right heart enlargement the pathogenesis of PAH is complicated; no biologic-based therapy is available for the treatment of PAH, but recent studies suggest that inflammatory response and abnormal proliferation of pulmonary artery smooth muscle cells are the main pathogenic mechanism, while the role of immune-related long non-coding RNAs (lncRNAs) remains unclear. The aim of this study was to systematically analyze immune-related lncRNAs in PAH. Here, we downloaded a publicly available microarray data from PAH and control patients (GSE113439). A total of 243 up-regulated and 203 down-regulated differentially expressed genes (DEGs) were screened, and immune-related DEGs were further obtained from ImmPort. The immune-related lncRNAs were obtained by co-expression analysis of immune-related mRNAs. Then, immune-related lncRNAs-mRNAs network including 2 lncRNAs and 6 mRNAs was constructed which share regulatory miRNAs and have significant correlation. Among the lncRNA-mRNA pairs, one pair (<i<JPX-RABEP1</i<) was verified in the validating dataset GSE53408 and PAH mouse model. Furthermore, the immune cell infiltration analysis of the GSE113439 dataset revealed that the <i<JPX-RABEP1</i< pair may participate in the occurrence and development of PAH through immune cell infiltration. Together, our findings reveal that the lncRNA-mRNA pair <i<JPX-RABEP1</i< may be a novel biomarker and therapeutic target for PAH. bioinformatics analysis pulmonary arterial hypertension non-coding RNAs immune cell infiltration Biology (General) Chemistry Zhewei Hu verfasserin aut Qiao Jin verfasserin aut Yan Yan verfasserin aut Yan Liu verfasserin aut Jin He verfasserin aut Lenan Zhuang verfasserin aut Huanan Wang verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 24, p 15559 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:24, p 15559 https://doi.org/10.3390/ijms232415559 kostenfrei https://doaj.org/article/0d2747347bce4e08b250c72acb1274ac kostenfrei https://www.mdpi.com/1422-0067/23/24/15559 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 24, p 15559
allfieldsSound	10.3390/ijms232415559 doi (DE-627)DOAJ083150390 (DE-599)DOAJ0d2747347bce4e08b250c72acb1274ac DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Qian Gong verfasserin aut Identification of <i<JPX-RABEP1</i< Pair as an Immune-Related Biomarker and Therapeutic Target in Pulmonary Arterial Hypertension by Bioinformatics and Experimental Analyses 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Pulmonary arterial hypertension (PAH) is a pulmonary vascular disease characterized by pulmonary vascular remodeling and right heart enlargement the pathogenesis of PAH is complicated; no biologic-based therapy is available for the treatment of PAH, but recent studies suggest that inflammatory response and abnormal proliferation of pulmonary artery smooth muscle cells are the main pathogenic mechanism, while the role of immune-related long non-coding RNAs (lncRNAs) remains unclear. The aim of this study was to systematically analyze immune-related lncRNAs in PAH. Here, we downloaded a publicly available microarray data from PAH and control patients (GSE113439). A total of 243 up-regulated and 203 down-regulated differentially expressed genes (DEGs) were screened, and immune-related DEGs were further obtained from ImmPort. The immune-related lncRNAs were obtained by co-expression analysis of immune-related mRNAs. Then, immune-related lncRNAs-mRNAs network including 2 lncRNAs and 6 mRNAs was constructed which share regulatory miRNAs and have significant correlation. Among the lncRNA-mRNA pairs, one pair (<i<JPX-RABEP1</i<) was verified in the validating dataset GSE53408 and PAH mouse model. Furthermore, the immune cell infiltration analysis of the GSE113439 dataset revealed that the <i<JPX-RABEP1</i< pair may participate in the occurrence and development of PAH through immune cell infiltration. Together, our findings reveal that the lncRNA-mRNA pair <i<JPX-RABEP1</i< may be a novel biomarker and therapeutic target for PAH. bioinformatics analysis pulmonary arterial hypertension non-coding RNAs immune cell infiltration Biology (General) Chemistry Zhewei Hu verfasserin aut Qiao Jin verfasserin aut Yan Yan verfasserin aut Yan Liu verfasserin aut Jin He verfasserin aut Lenan Zhuang verfasserin aut Huanan Wang verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 24, p 15559 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:24, p 15559 https://doi.org/10.3390/ijms232415559 kostenfrei https://doaj.org/article/0d2747347bce4e08b250c72acb1274ac kostenfrei https://www.mdpi.com/1422-0067/23/24/15559 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 24, p 15559
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source	In International Journal of Molecular Sciences 23(2022), 24, p 15559 volume:23 year:2022 number:24, p 15559
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author	Qian Gong
spellingShingle	Qian Gong misc QH301-705.5 misc QD1-999 misc bioinformatics analysis misc pulmonary arterial hypertension misc non-coding RNAs misc immune cell infiltration misc Biology (General) misc Chemistry Identification of <i<JPX-RABEP1</i< Pair as an Immune-Related Biomarker and Therapeutic Target in Pulmonary Arterial Hypertension by Bioinformatics and Experimental Analyses
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topic_title	QH301-705.5 QD1-999 Identification of <i<JPX-RABEP1</i< Pair as an Immune-Related Biomarker and Therapeutic Target in Pulmonary Arterial Hypertension by Bioinformatics and Experimental Analyses bioinformatics analysis pulmonary arterial hypertension non-coding RNAs immune cell infiltration
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title	Identification of <i<JPX-RABEP1</i< Pair as an Immune-Related Biomarker and Therapeutic Target in Pulmonary Arterial Hypertension by Bioinformatics and Experimental Analyses
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title_sort	identification of <i<jpx-rabep1</i< pair as an immune-related biomarker and therapeutic target in pulmonary arterial hypertension by bioinformatics and experimental analyses
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title_auth	Identification of <i<JPX-RABEP1</i< Pair as an Immune-Related Biomarker and Therapeutic Target in Pulmonary Arterial Hypertension by Bioinformatics and Experimental Analyses
abstract	Pulmonary arterial hypertension (PAH) is a pulmonary vascular disease characterized by pulmonary vascular remodeling and right heart enlargement the pathogenesis of PAH is complicated; no biologic-based therapy is available for the treatment of PAH, but recent studies suggest that inflammatory response and abnormal proliferation of pulmonary artery smooth muscle cells are the main pathogenic mechanism, while the role of immune-related long non-coding RNAs (lncRNAs) remains unclear. The aim of this study was to systematically analyze immune-related lncRNAs in PAH. Here, we downloaded a publicly available microarray data from PAH and control patients (GSE113439). A total of 243 up-regulated and 203 down-regulated differentially expressed genes (DEGs) were screened, and immune-related DEGs were further obtained from ImmPort. The immune-related lncRNAs were obtained by co-expression analysis of immune-related mRNAs. Then, immune-related lncRNAs-mRNAs network including 2 lncRNAs and 6 mRNAs was constructed which share regulatory miRNAs and have significant correlation. Among the lncRNA-mRNA pairs, one pair (<i<JPX-RABEP1</i<) was verified in the validating dataset GSE53408 and PAH mouse model. Furthermore, the immune cell infiltration analysis of the GSE113439 dataset revealed that the <i<JPX-RABEP1</i< pair may participate in the occurrence and development of PAH through immune cell infiltration. Together, our findings reveal that the lncRNA-mRNA pair <i<JPX-RABEP1</i< may be a novel biomarker and therapeutic target for PAH.
abstractGer	Pulmonary arterial hypertension (PAH) is a pulmonary vascular disease characterized by pulmonary vascular remodeling and right heart enlargement the pathogenesis of PAH is complicated; no biologic-based therapy is available for the treatment of PAH, but recent studies suggest that inflammatory response and abnormal proliferation of pulmonary artery smooth muscle cells are the main pathogenic mechanism, while the role of immune-related long non-coding RNAs (lncRNAs) remains unclear. The aim of this study was to systematically analyze immune-related lncRNAs in PAH. Here, we downloaded a publicly available microarray data from PAH and control patients (GSE113439). A total of 243 up-regulated and 203 down-regulated differentially expressed genes (DEGs) were screened, and immune-related DEGs were further obtained from ImmPort. The immune-related lncRNAs were obtained by co-expression analysis of immune-related mRNAs. Then, immune-related lncRNAs-mRNAs network including 2 lncRNAs and 6 mRNAs was constructed which share regulatory miRNAs and have significant correlation. Among the lncRNA-mRNA pairs, one pair (<i<JPX-RABEP1</i<) was verified in the validating dataset GSE53408 and PAH mouse model. Furthermore, the immune cell infiltration analysis of the GSE113439 dataset revealed that the <i<JPX-RABEP1</i< pair may participate in the occurrence and development of PAH through immune cell infiltration. Together, our findings reveal that the lncRNA-mRNA pair <i<JPX-RABEP1</i< may be a novel biomarker and therapeutic target for PAH.
abstract_unstemmed	Pulmonary arterial hypertension (PAH) is a pulmonary vascular disease characterized by pulmonary vascular remodeling and right heart enlargement the pathogenesis of PAH is complicated; no biologic-based therapy is available for the treatment of PAH, but recent studies suggest that inflammatory response and abnormal proliferation of pulmonary artery smooth muscle cells are the main pathogenic mechanism, while the role of immune-related long non-coding RNAs (lncRNAs) remains unclear. The aim of this study was to systematically analyze immune-related lncRNAs in PAH. Here, we downloaded a publicly available microarray data from PAH and control patients (GSE113439). A total of 243 up-regulated and 203 down-regulated differentially expressed genes (DEGs) were screened, and immune-related DEGs were further obtained from ImmPort. The immune-related lncRNAs were obtained by co-expression analysis of immune-related mRNAs. Then, immune-related lncRNAs-mRNAs network including 2 lncRNAs and 6 mRNAs was constructed which share regulatory miRNAs and have significant correlation. Among the lncRNA-mRNA pairs, one pair (<i<JPX-RABEP1</i<) was verified in the validating dataset GSE53408 and PAH mouse model. Furthermore, the immune cell infiltration analysis of the GSE113439 dataset revealed that the <i<JPX-RABEP1</i< pair may participate in the occurrence and development of PAH through immune cell infiltration. Together, our findings reveal that the lncRNA-mRNA pair <i<JPX-RABEP1</i< may be a novel biomarker and therapeutic target for PAH.
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container_issue	24, p 15559
title_short	Identification of <i<JPX-RABEP1</i< Pair as an Immune-Related Biomarker and Therapeutic Target in Pulmonary Arterial Hypertension by Bioinformatics and Experimental Analyses
url	https://doi.org/10.3390/ijms232415559 https://doaj.org/article/0d2747347bce4e08b250c72acb1274ac https://www.mdpi.com/1422-0067/23/24/15559 https://doaj.org/toc/1661-6596 https://doaj.org/toc/1422-0067
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author2	Zhewei Hu Qiao Jin Yan Yan Yan Liu Jin He Lenan Zhuang Huanan Wang
author2Str	Zhewei Hu Qiao Jin Yan Yan Yan Liu Jin He Lenan Zhuang Huanan Wang
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doi_str	10.3390/ijms232415559
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up_date	2024-07-03T15:49:38.678Z
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