A Rare Case of Blastic Plasmacytoid Dendritic Cell Neoplasm in a Child Mimicking Lymphoma/Leukemia Cutis

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare tumor that affects elderly individuals and presents a poor prognosis. Skin is the most common site of involvement, accounting for 89% of the cases. Extracutaneous organs, especially bone marrow, lymph nodes, and peripheral blood, can be...
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Autor*in:	Phanitchanat Phusuphitchayanan [verfasserIn] Voraphol Vejjabhinanta [verfasserIn] Chayamon Takpradit [verfasserIn] Poonnawis Sudtikoonaseth [verfasserIn] Manasmon Chairatchaneeboon [verfasserIn] Thamonpan Kiatvichukul [verfasserIn] Sanya Sukpanichnant [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	blastic plasmacytoid dendritic cell neoplasm plasmacytoid dendritic cell lymphoma cutis leukemia cutis

Übergeordnetes Werk:	In: Dermatopathology - MDPI AG, 2016, 9(2022), 4, Seite 321-326
Übergeordnetes Werk:	volume:9 ; year:2022 ; number:4 ; pages:321-326

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/dermatopathology9040038

Katalog-ID:	DOAJ083196420

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allfields	10.3390/dermatopathology9040038 doi (DE-627)DOAJ083196420 (DE-599)DOAJ74757056be59460d80730c83362e4db3 DE-627 ger DE-627 rakwb eng RL1-803 Phanitchanat Phusuphitchayanan verfasserin aut A Rare Case of Blastic Plasmacytoid Dendritic Cell Neoplasm in a Child Mimicking Lymphoma/Leukemia Cutis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare tumor that affects elderly individuals and presents a poor prognosis. Skin is the most common site of involvement, accounting for 89% of the cases. Extracutaneous organs, especially bone marrow, lymph nodes, and peripheral blood, can be involved at the time of diagnosis. We report a case of BPDCN in a child, presenting with a cutaneous lesion mimicking lymphoma or leukemia cutis. The histologic findings revealed a dense diffuse infiltration by monomorphic agranular medium-sized blast cells with sparing of the grenz zone, whose first immunophenotypic profile raised the possibility of diagnosing B lymphoblastic lymphoma or leukemia. However, the absence of CD10 expression and strongly positive expression for CD4, CD56, CD45RA, and the plasmacytoid dendritic cell-associated antigens, including CD123, supported the definite diagnosis of BPDCN. The patient responded well to a systemic combination chemotherapy regimen, modified from the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) protocol for anaplastic large cell lymphoma (ALCL), that differed from the established recommendation using ALL protocol. Owing to the patient’s excellent treatment outcome, this regimen could represent an effective alternative regimen for BPDCN in children. blastic plasmacytoid dendritic cell neoplasm plasmacytoid dendritic cell lymphoma cutis leukemia cutis Dermatology Voraphol Vejjabhinanta verfasserin aut Chayamon Takpradit verfasserin aut Poonnawis Sudtikoonaseth verfasserin aut Manasmon Chairatchaneeboon verfasserin aut Thamonpan Kiatvichukul verfasserin aut Sanya Sukpanichnant verfasserin aut In Dermatopathology MDPI AG, 2016 9(2022), 4, Seite 321-326 (DE-627)790616246 (DE-600)2777118-0 22963529 nnns volume:9 year:2022 number:4 pages:321-326 https://doi.org/10.3390/dermatopathology9040038 kostenfrei https://doaj.org/article/74757056be59460d80730c83362e4db3 kostenfrei https://www.mdpi.com/2296-3529/9/4/38 kostenfrei https://doaj.org/toc/2296-3529 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2018 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022 4 321-326
spelling	10.3390/dermatopathology9040038 doi (DE-627)DOAJ083196420 (DE-599)DOAJ74757056be59460d80730c83362e4db3 DE-627 ger DE-627 rakwb eng RL1-803 Phanitchanat Phusuphitchayanan verfasserin aut A Rare Case of Blastic Plasmacytoid Dendritic Cell Neoplasm in a Child Mimicking Lymphoma/Leukemia Cutis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare tumor that affects elderly individuals and presents a poor prognosis. Skin is the most common site of involvement, accounting for 89% of the cases. Extracutaneous organs, especially bone marrow, lymph nodes, and peripheral blood, can be involved at the time of diagnosis. We report a case of BPDCN in a child, presenting with a cutaneous lesion mimicking lymphoma or leukemia cutis. The histologic findings revealed a dense diffuse infiltration by monomorphic agranular medium-sized blast cells with sparing of the grenz zone, whose first immunophenotypic profile raised the possibility of diagnosing B lymphoblastic lymphoma or leukemia. However, the absence of CD10 expression and strongly positive expression for CD4, CD56, CD45RA, and the plasmacytoid dendritic cell-associated antigens, including CD123, supported the definite diagnosis of BPDCN. The patient responded well to a systemic combination chemotherapy regimen, modified from the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) protocol for anaplastic large cell lymphoma (ALCL), that differed from the established recommendation using ALL protocol. Owing to the patient’s excellent treatment outcome, this regimen could represent an effective alternative regimen for BPDCN in children. blastic plasmacytoid dendritic cell neoplasm plasmacytoid dendritic cell lymphoma cutis leukemia cutis Dermatology Voraphol Vejjabhinanta verfasserin aut Chayamon Takpradit verfasserin aut Poonnawis Sudtikoonaseth verfasserin aut Manasmon Chairatchaneeboon verfasserin aut Thamonpan Kiatvichukul verfasserin aut Sanya Sukpanichnant verfasserin aut In Dermatopathology MDPI AG, 2016 9(2022), 4, Seite 321-326 (DE-627)790616246 (DE-600)2777118-0 22963529 nnns volume:9 year:2022 number:4 pages:321-326 https://doi.org/10.3390/dermatopathology9040038 kostenfrei https://doaj.org/article/74757056be59460d80730c83362e4db3 kostenfrei https://www.mdpi.com/2296-3529/9/4/38 kostenfrei https://doaj.org/toc/2296-3529 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2018 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022 4 321-326
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author	Phanitchanat Phusuphitchayanan
spellingShingle	Phanitchanat Phusuphitchayanan misc RL1-803 misc blastic plasmacytoid dendritic cell neoplasm misc plasmacytoid dendritic cell misc lymphoma cutis misc leukemia cutis misc Dermatology A Rare Case of Blastic Plasmacytoid Dendritic Cell Neoplasm in a Child Mimicking Lymphoma/Leukemia Cutis
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topic_title	RL1-803 A Rare Case of Blastic Plasmacytoid Dendritic Cell Neoplasm in a Child Mimicking Lymphoma/Leukemia Cutis blastic plasmacytoid dendritic cell neoplasm plasmacytoid dendritic cell lymphoma cutis leukemia cutis
topic	misc RL1-803 misc blastic plasmacytoid dendritic cell neoplasm misc plasmacytoid dendritic cell misc lymphoma cutis misc leukemia cutis misc Dermatology
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title	A Rare Case of Blastic Plasmacytoid Dendritic Cell Neoplasm in a Child Mimicking Lymphoma/Leukemia Cutis
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title_full	A Rare Case of Blastic Plasmacytoid Dendritic Cell Neoplasm in a Child Mimicking Lymphoma/Leukemia Cutis
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author_browse	Phanitchanat Phusuphitchayanan Voraphol Vejjabhinanta Chayamon Takpradit Poonnawis Sudtikoonaseth Manasmon Chairatchaneeboon Thamonpan Kiatvichukul Sanya Sukpanichnant
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title_sort	rare case of blastic plasmacytoid dendritic cell neoplasm in a child mimicking lymphoma/leukemia cutis
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title_auth	A Rare Case of Blastic Plasmacytoid Dendritic Cell Neoplasm in a Child Mimicking Lymphoma/Leukemia Cutis
abstract	Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare tumor that affects elderly individuals and presents a poor prognosis. Skin is the most common site of involvement, accounting for 89% of the cases. Extracutaneous organs, especially bone marrow, lymph nodes, and peripheral blood, can be involved at the time of diagnosis. We report a case of BPDCN in a child, presenting with a cutaneous lesion mimicking lymphoma or leukemia cutis. The histologic findings revealed a dense diffuse infiltration by monomorphic agranular medium-sized blast cells with sparing of the grenz zone, whose first immunophenotypic profile raised the possibility of diagnosing B lymphoblastic lymphoma or leukemia. However, the absence of CD10 expression and strongly positive expression for CD4, CD56, CD45RA, and the plasmacytoid dendritic cell-associated antigens, including CD123, supported the definite diagnosis of BPDCN. The patient responded well to a systemic combination chemotherapy regimen, modified from the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) protocol for anaplastic large cell lymphoma (ALCL), that differed from the established recommendation using ALL protocol. Owing to the patient’s excellent treatment outcome, this regimen could represent an effective alternative regimen for BPDCN in children.
abstractGer	Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare tumor that affects elderly individuals and presents a poor prognosis. Skin is the most common site of involvement, accounting for 89% of the cases. Extracutaneous organs, especially bone marrow, lymph nodes, and peripheral blood, can be involved at the time of diagnosis. We report a case of BPDCN in a child, presenting with a cutaneous lesion mimicking lymphoma or leukemia cutis. The histologic findings revealed a dense diffuse infiltration by monomorphic agranular medium-sized blast cells with sparing of the grenz zone, whose first immunophenotypic profile raised the possibility of diagnosing B lymphoblastic lymphoma or leukemia. However, the absence of CD10 expression and strongly positive expression for CD4, CD56, CD45RA, and the plasmacytoid dendritic cell-associated antigens, including CD123, supported the definite diagnosis of BPDCN. The patient responded well to a systemic combination chemotherapy regimen, modified from the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) protocol for anaplastic large cell lymphoma (ALCL), that differed from the established recommendation using ALL protocol. Owing to the patient’s excellent treatment outcome, this regimen could represent an effective alternative regimen for BPDCN in children.
abstract_unstemmed	Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare tumor that affects elderly individuals and presents a poor prognosis. Skin is the most common site of involvement, accounting for 89% of the cases. Extracutaneous organs, especially bone marrow, lymph nodes, and peripheral blood, can be involved at the time of diagnosis. We report a case of BPDCN in a child, presenting with a cutaneous lesion mimicking lymphoma or leukemia cutis. The histologic findings revealed a dense diffuse infiltration by monomorphic agranular medium-sized blast cells with sparing of the grenz zone, whose first immunophenotypic profile raised the possibility of diagnosing B lymphoblastic lymphoma or leukemia. However, the absence of CD10 expression and strongly positive expression for CD4, CD56, CD45RA, and the plasmacytoid dendritic cell-associated antigens, including CD123, supported the definite diagnosis of BPDCN. The patient responded well to a systemic combination chemotherapy regimen, modified from the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) protocol for anaplastic large cell lymphoma (ALCL), that differed from the established recommendation using ALL protocol. Owing to the patient’s excellent treatment outcome, this regimen could represent an effective alternative regimen for BPDCN in children.
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title_short	A Rare Case of Blastic Plasmacytoid Dendritic Cell Neoplasm in a Child Mimicking Lymphoma/Leukemia Cutis
url	https://doi.org/10.3390/dermatopathology9040038 https://doaj.org/article/74757056be59460d80730c83362e4db3 https://www.mdpi.com/2296-3529/9/4/38 https://doaj.org/toc/2296-3529
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up_date	2024-07-03T16:05:49.651Z
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The patient responded well to a systemic combination chemotherapy regimen, modified from the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) protocol for anaplastic large cell lymphoma (ALCL), that differed from the established recommendation using ALL protocol. 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A Rare Case of Blastic Plasmacytoid Dendritic Cell Neoplasm in a Child Mimicking Lymphoma/Leukemia Cutis

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