Identification of Novel Plasma Biomarkers for Abdominal Aortic Aneurysm by Protein Array Analysis

Abdominal aortic aneurysm (AAA) is a potentially life-threatening disease that is common in the aging population. Currently, there are no approved diagnostic biomarkers or therapeutic drugs for AAA. We aimed to identify novel plasma biomarkers or potential therapeutic targets for AAA using a high-th...
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Autor*in:	Jianqiang Wu [verfasserIn] Wei Wang [verfasserIn] Ting Xie [verfasserIn] Zhaoran Chen [verfasserIn] Lei Zhou [verfasserIn] Xiaohong Song [verfasserIn] Haoxuan Kan [verfasserIn] Yanze Lv [verfasserIn] Lianglin Wu [verfasserIn] Fangda Li [verfasserIn] Dan Yang [verfasserIn] Yuexin Chen [verfasserIn] Bao Liu [verfasserIn] Yuehong Zheng [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	abdominal aortic aneurysm biomarker discovery protein array analysis type 2 diabetes therapeutic targets

Übergeordnetes Werk:	In: Biomolecules - MDPI AG, 2013, 12(2022), 12, p 1853
Übergeordnetes Werk:	volume:12 ; year:2022 ; number:12, p 1853

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/biom12121853

Katalog-ID:	DOAJ08322243X

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520			\|a Abdominal aortic aneurysm (AAA) is a potentially life-threatening disease that is common in the aging population. Currently, there are no approved diagnostic biomarkers or therapeutic drugs for AAA. We aimed to identify novel plasma biomarkers or potential therapeutic targets for AAA using a high-throughput protein array-based method. Proteomics expression profiles were investigated in plasma from AAA patients and healthy controls (HC) using 440-cytokine protein array analysis. Several promising biomarkers were further validated in independent cohorts using enzyme-linked immunosorbent assay (ELISA). Thirty-nine differentially expressed plasma proteins were identified between AAA and HC. Legumain (LGMN) was significantly higher in AAA patients and was validated in another large cohort. Additionally, “AAA without diabetes” (AAN) patients and “AAA complicated with type 2 diabetes mellitus” (AAM) patients had different cytokine expression patterns in their plasma, and nine plasma proteins were differentially expressed among the AAN, AAM, and HC subjects. Delta-like protein 1 (DLL1), receptor tyrosine-protein kinase erbB-3 (ERBB3), and dipeptidyl peptidase 4 (DPPIV) were significantly higher in AAM than in AAN. This study identified several promising plasma biomarkers of AAA. Their role as therapeutic targets for AAA warrants further investigation.
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allfields	10.3390/biom12121853 doi (DE-627)DOAJ08322243X (DE-599)DOAJ8a831152321442adb220620ccbd61c11 DE-627 ger DE-627 rakwb eng QR1-502 Jianqiang Wu verfasserin aut Identification of Novel Plasma Biomarkers for Abdominal Aortic Aneurysm by Protein Array Analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abdominal aortic aneurysm (AAA) is a potentially life-threatening disease that is common in the aging population. Currently, there are no approved diagnostic biomarkers or therapeutic drugs for AAA. We aimed to identify novel plasma biomarkers or potential therapeutic targets for AAA using a high-throughput protein array-based method. Proteomics expression profiles were investigated in plasma from AAA patients and healthy controls (HC) using 440-cytokine protein array analysis. Several promising biomarkers were further validated in independent cohorts using enzyme-linked immunosorbent assay (ELISA). Thirty-nine differentially expressed plasma proteins were identified between AAA and HC. Legumain (LGMN) was significantly higher in AAA patients and was validated in another large cohort. Additionally, “AAA without diabetes” (AAN) patients and “AAA complicated with type 2 diabetes mellitus” (AAM) patients had different cytokine expression patterns in their plasma, and nine plasma proteins were differentially expressed among the AAN, AAM, and HC subjects. Delta-like protein 1 (DLL1), receptor tyrosine-protein kinase erbB-3 (ERBB3), and dipeptidyl peptidase 4 (DPPIV) were significantly higher in AAM than in AAN. This study identified several promising plasma biomarkers of AAA. Their role as therapeutic targets for AAA warrants further investigation. abdominal aortic aneurysm biomarker discovery protein array analysis type 2 diabetes therapeutic targets Microbiology Wei Wang verfasserin aut Ting Xie verfasserin aut Zhaoran Chen verfasserin aut Lei Zhou verfasserin aut Xiaohong Song verfasserin aut Haoxuan Kan verfasserin aut Yanze Lv verfasserin aut Lianglin Wu verfasserin aut Fangda Li verfasserin aut Dan Yang verfasserin aut Yuexin Chen verfasserin aut Bao Liu verfasserin aut Yuehong Zheng verfasserin aut In Biomolecules MDPI AG, 2013 12(2022), 12, p 1853 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:12 year:2022 number:12, p 1853 https://doi.org/10.3390/biom12121853 kostenfrei https://doaj.org/article/8a831152321442adb220620ccbd61c11 kostenfrei https://www.mdpi.com/2218-273X/12/12/1853 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 12, p 1853
spelling	10.3390/biom12121853 doi (DE-627)DOAJ08322243X (DE-599)DOAJ8a831152321442adb220620ccbd61c11 DE-627 ger DE-627 rakwb eng QR1-502 Jianqiang Wu verfasserin aut Identification of Novel Plasma Biomarkers for Abdominal Aortic Aneurysm by Protein Array Analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abdominal aortic aneurysm (AAA) is a potentially life-threatening disease that is common in the aging population. Currently, there are no approved diagnostic biomarkers or therapeutic drugs for AAA. We aimed to identify novel plasma biomarkers or potential therapeutic targets for AAA using a high-throughput protein array-based method. Proteomics expression profiles were investigated in plasma from AAA patients and healthy controls (HC) using 440-cytokine protein array analysis. Several promising biomarkers were further validated in independent cohorts using enzyme-linked immunosorbent assay (ELISA). Thirty-nine differentially expressed plasma proteins were identified between AAA and HC. Legumain (LGMN) was significantly higher in AAA patients and was validated in another large cohort. Additionally, “AAA without diabetes” (AAN) patients and “AAA complicated with type 2 diabetes mellitus” (AAM) patients had different cytokine expression patterns in their plasma, and nine plasma proteins were differentially expressed among the AAN, AAM, and HC subjects. Delta-like protein 1 (DLL1), receptor tyrosine-protein kinase erbB-3 (ERBB3), and dipeptidyl peptidase 4 (DPPIV) were significantly higher in AAM than in AAN. This study identified several promising plasma biomarkers of AAA. Their role as therapeutic targets for AAA warrants further investigation. abdominal aortic aneurysm biomarker discovery protein array analysis type 2 diabetes therapeutic targets Microbiology Wei Wang verfasserin aut Ting Xie verfasserin aut Zhaoran Chen verfasserin aut Lei Zhou verfasserin aut Xiaohong Song verfasserin aut Haoxuan Kan verfasserin aut Yanze Lv verfasserin aut Lianglin Wu verfasserin aut Fangda Li verfasserin aut Dan Yang verfasserin aut Yuexin Chen verfasserin aut Bao Liu verfasserin aut Yuehong Zheng verfasserin aut In Biomolecules MDPI AG, 2013 12(2022), 12, p 1853 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:12 year:2022 number:12, p 1853 https://doi.org/10.3390/biom12121853 kostenfrei https://doaj.org/article/8a831152321442adb220620ccbd61c11 kostenfrei https://www.mdpi.com/2218-273X/12/12/1853 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 12, p 1853
allfields_unstemmed	10.3390/biom12121853 doi (DE-627)DOAJ08322243X (DE-599)DOAJ8a831152321442adb220620ccbd61c11 DE-627 ger DE-627 rakwb eng QR1-502 Jianqiang Wu verfasserin aut Identification of Novel Plasma Biomarkers for Abdominal Aortic Aneurysm by Protein Array Analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abdominal aortic aneurysm (AAA) is a potentially life-threatening disease that is common in the aging population. Currently, there are no approved diagnostic biomarkers or therapeutic drugs for AAA. We aimed to identify novel plasma biomarkers or potential therapeutic targets for AAA using a high-throughput protein array-based method. Proteomics expression profiles were investigated in plasma from AAA patients and healthy controls (HC) using 440-cytokine protein array analysis. Several promising biomarkers were further validated in independent cohorts using enzyme-linked immunosorbent assay (ELISA). Thirty-nine differentially expressed plasma proteins were identified between AAA and HC. Legumain (LGMN) was significantly higher in AAA patients and was validated in another large cohort. Additionally, “AAA without diabetes” (AAN) patients and “AAA complicated with type 2 diabetes mellitus” (AAM) patients had different cytokine expression patterns in their plasma, and nine plasma proteins were differentially expressed among the AAN, AAM, and HC subjects. Delta-like protein 1 (DLL1), receptor tyrosine-protein kinase erbB-3 (ERBB3), and dipeptidyl peptidase 4 (DPPIV) were significantly higher in AAM than in AAN. This study identified several promising plasma biomarkers of AAA. Their role as therapeutic targets for AAA warrants further investigation. abdominal aortic aneurysm biomarker discovery protein array analysis type 2 diabetes therapeutic targets Microbiology Wei Wang verfasserin aut Ting Xie verfasserin aut Zhaoran Chen verfasserin aut Lei Zhou verfasserin aut Xiaohong Song verfasserin aut Haoxuan Kan verfasserin aut Yanze Lv verfasserin aut Lianglin Wu verfasserin aut Fangda Li verfasserin aut Dan Yang verfasserin aut Yuexin Chen verfasserin aut Bao Liu verfasserin aut Yuehong Zheng verfasserin aut In Biomolecules MDPI AG, 2013 12(2022), 12, p 1853 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:12 year:2022 number:12, p 1853 https://doi.org/10.3390/biom12121853 kostenfrei https://doaj.org/article/8a831152321442adb220620ccbd61c11 kostenfrei https://www.mdpi.com/2218-273X/12/12/1853 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 12, p 1853
allfieldsGer	10.3390/biom12121853 doi (DE-627)DOAJ08322243X (DE-599)DOAJ8a831152321442adb220620ccbd61c11 DE-627 ger DE-627 rakwb eng QR1-502 Jianqiang Wu verfasserin aut Identification of Novel Plasma Biomarkers for Abdominal Aortic Aneurysm by Protein Array Analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abdominal aortic aneurysm (AAA) is a potentially life-threatening disease that is common in the aging population. Currently, there are no approved diagnostic biomarkers or therapeutic drugs for AAA. We aimed to identify novel plasma biomarkers or potential therapeutic targets for AAA using a high-throughput protein array-based method. Proteomics expression profiles were investigated in plasma from AAA patients and healthy controls (HC) using 440-cytokine protein array analysis. Several promising biomarkers were further validated in independent cohorts using enzyme-linked immunosorbent assay (ELISA). Thirty-nine differentially expressed plasma proteins were identified between AAA and HC. Legumain (LGMN) was significantly higher in AAA patients and was validated in another large cohort. Additionally, “AAA without diabetes” (AAN) patients and “AAA complicated with type 2 diabetes mellitus” (AAM) patients had different cytokine expression patterns in their plasma, and nine plasma proteins were differentially expressed among the AAN, AAM, and HC subjects. Delta-like protein 1 (DLL1), receptor tyrosine-protein kinase erbB-3 (ERBB3), and dipeptidyl peptidase 4 (DPPIV) were significantly higher in AAM than in AAN. This study identified several promising plasma biomarkers of AAA. Their role as therapeutic targets for AAA warrants further investigation. abdominal aortic aneurysm biomarker discovery protein array analysis type 2 diabetes therapeutic targets Microbiology Wei Wang verfasserin aut Ting Xie verfasserin aut Zhaoran Chen verfasserin aut Lei Zhou verfasserin aut Xiaohong Song verfasserin aut Haoxuan Kan verfasserin aut Yanze Lv verfasserin aut Lianglin Wu verfasserin aut Fangda Li verfasserin aut Dan Yang verfasserin aut Yuexin Chen verfasserin aut Bao Liu verfasserin aut Yuehong Zheng verfasserin aut In Biomolecules MDPI AG, 2013 12(2022), 12, p 1853 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:12 year:2022 number:12, p 1853 https://doi.org/10.3390/biom12121853 kostenfrei https://doaj.org/article/8a831152321442adb220620ccbd61c11 kostenfrei https://www.mdpi.com/2218-273X/12/12/1853 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 12, p 1853
allfieldsSound	10.3390/biom12121853 doi (DE-627)DOAJ08322243X (DE-599)DOAJ8a831152321442adb220620ccbd61c11 DE-627 ger DE-627 rakwb eng QR1-502 Jianqiang Wu verfasserin aut Identification of Novel Plasma Biomarkers for Abdominal Aortic Aneurysm by Protein Array Analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abdominal aortic aneurysm (AAA) is a potentially life-threatening disease that is common in the aging population. Currently, there are no approved diagnostic biomarkers or therapeutic drugs for AAA. We aimed to identify novel plasma biomarkers or potential therapeutic targets for AAA using a high-throughput protein array-based method. Proteomics expression profiles were investigated in plasma from AAA patients and healthy controls (HC) using 440-cytokine protein array analysis. Several promising biomarkers were further validated in independent cohorts using enzyme-linked immunosorbent assay (ELISA). Thirty-nine differentially expressed plasma proteins were identified between AAA and HC. Legumain (LGMN) was significantly higher in AAA patients and was validated in another large cohort. Additionally, “AAA without diabetes” (AAN) patients and “AAA complicated with type 2 diabetes mellitus” (AAM) patients had different cytokine expression patterns in their plasma, and nine plasma proteins were differentially expressed among the AAN, AAM, and HC subjects. Delta-like protein 1 (DLL1), receptor tyrosine-protein kinase erbB-3 (ERBB3), and dipeptidyl peptidase 4 (DPPIV) were significantly higher in AAM than in AAN. This study identified several promising plasma biomarkers of AAA. Their role as therapeutic targets for AAA warrants further investigation. abdominal aortic aneurysm biomarker discovery protein array analysis type 2 diabetes therapeutic targets Microbiology Wei Wang verfasserin aut Ting Xie verfasserin aut Zhaoran Chen verfasserin aut Lei Zhou verfasserin aut Xiaohong Song verfasserin aut Haoxuan Kan verfasserin aut Yanze Lv verfasserin aut Lianglin Wu verfasserin aut Fangda Li verfasserin aut Dan Yang verfasserin aut Yuexin Chen verfasserin aut Bao Liu verfasserin aut Yuehong Zheng verfasserin aut In Biomolecules MDPI AG, 2013 12(2022), 12, p 1853 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:12 year:2022 number:12, p 1853 https://doi.org/10.3390/biom12121853 kostenfrei https://doaj.org/article/8a831152321442adb220620ccbd61c11 kostenfrei https://www.mdpi.com/2218-273X/12/12/1853 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 12, p 1853
language	English
source	In Biomolecules 12(2022), 12, p 1853 volume:12 year:2022 number:12, p 1853
sourceStr	In Biomolecules 12(2022), 12, p 1853 volume:12 year:2022 number:12, p 1853
format_phy_str_mv	Article
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topic_facet	abdominal aortic aneurysm biomarker discovery protein array analysis type 2 diabetes therapeutic targets Microbiology
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authorswithroles_txt_mv	Jianqiang Wu @@aut@@ Wei Wang @@aut@@ Ting Xie @@aut@@ Zhaoran Chen @@aut@@ Lei Zhou @@aut@@ Xiaohong Song @@aut@@ Haoxuan Kan @@aut@@ Yanze Lv @@aut@@ Lianglin Wu @@aut@@ Fangda Li @@aut@@ Dan Yang @@aut@@ Yuexin Chen @@aut@@ Bao Liu @@aut@@ Yuehong Zheng @@aut@@
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callnumber-first	Q - Science
author	Jianqiang Wu
spellingShingle	Jianqiang Wu misc QR1-502 misc abdominal aortic aneurysm misc biomarker discovery misc protein array analysis misc type 2 diabetes misc therapeutic targets misc Microbiology Identification of Novel Plasma Biomarkers for Abdominal Aortic Aneurysm by Protein Array Analysis
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topic_title	QR1-502 Identification of Novel Plasma Biomarkers for Abdominal Aortic Aneurysm by Protein Array Analysis abdominal aortic aneurysm biomarker discovery protein array analysis type 2 diabetes therapeutic targets
topic	misc QR1-502 misc abdominal aortic aneurysm misc biomarker discovery misc protein array analysis misc type 2 diabetes misc therapeutic targets misc Microbiology
topic_unstemmed	misc QR1-502 misc abdominal aortic aneurysm misc biomarker discovery misc protein array analysis misc type 2 diabetes misc therapeutic targets misc Microbiology
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title	Identification of Novel Plasma Biomarkers for Abdominal Aortic Aneurysm by Protein Array Analysis
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title_full	Identification of Novel Plasma Biomarkers for Abdominal Aortic Aneurysm by Protein Array Analysis
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title_sort	identification of novel plasma biomarkers for abdominal aortic aneurysm by protein array analysis
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title_auth	Identification of Novel Plasma Biomarkers for Abdominal Aortic Aneurysm by Protein Array Analysis
abstract	Abdominal aortic aneurysm (AAA) is a potentially life-threatening disease that is common in the aging population. Currently, there are no approved diagnostic biomarkers or therapeutic drugs for AAA. We aimed to identify novel plasma biomarkers or potential therapeutic targets for AAA using a high-throughput protein array-based method. Proteomics expression profiles were investigated in plasma from AAA patients and healthy controls (HC) using 440-cytokine protein array analysis. Several promising biomarkers were further validated in independent cohorts using enzyme-linked immunosorbent assay (ELISA). Thirty-nine differentially expressed plasma proteins were identified between AAA and HC. Legumain (LGMN) was significantly higher in AAA patients and was validated in another large cohort. Additionally, “AAA without diabetes” (AAN) patients and “AAA complicated with type 2 diabetes mellitus” (AAM) patients had different cytokine expression patterns in their plasma, and nine plasma proteins were differentially expressed among the AAN, AAM, and HC subjects. Delta-like protein 1 (DLL1), receptor tyrosine-protein kinase erbB-3 (ERBB3), and dipeptidyl peptidase 4 (DPPIV) were significantly higher in AAM than in AAN. This study identified several promising plasma biomarkers of AAA. Their role as therapeutic targets for AAA warrants further investigation.
abstractGer	Abdominal aortic aneurysm (AAA) is a potentially life-threatening disease that is common in the aging population. Currently, there are no approved diagnostic biomarkers or therapeutic drugs for AAA. We aimed to identify novel plasma biomarkers or potential therapeutic targets for AAA using a high-throughput protein array-based method. Proteomics expression profiles were investigated in plasma from AAA patients and healthy controls (HC) using 440-cytokine protein array analysis. Several promising biomarkers were further validated in independent cohorts using enzyme-linked immunosorbent assay (ELISA). Thirty-nine differentially expressed plasma proteins were identified between AAA and HC. Legumain (LGMN) was significantly higher in AAA patients and was validated in another large cohort. Additionally, “AAA without diabetes” (AAN) patients and “AAA complicated with type 2 diabetes mellitus” (AAM) patients had different cytokine expression patterns in their plasma, and nine plasma proteins were differentially expressed among the AAN, AAM, and HC subjects. Delta-like protein 1 (DLL1), receptor tyrosine-protein kinase erbB-3 (ERBB3), and dipeptidyl peptidase 4 (DPPIV) were significantly higher in AAM than in AAN. This study identified several promising plasma biomarkers of AAA. Their role as therapeutic targets for AAA warrants further investigation.
abstract_unstemmed	Abdominal aortic aneurysm (AAA) is a potentially life-threatening disease that is common in the aging population. Currently, there are no approved diagnostic biomarkers or therapeutic drugs for AAA. We aimed to identify novel plasma biomarkers or potential therapeutic targets for AAA using a high-throughput protein array-based method. Proteomics expression profiles were investigated in plasma from AAA patients and healthy controls (HC) using 440-cytokine protein array analysis. Several promising biomarkers were further validated in independent cohorts using enzyme-linked immunosorbent assay (ELISA). Thirty-nine differentially expressed plasma proteins were identified between AAA and HC. Legumain (LGMN) was significantly higher in AAA patients and was validated in another large cohort. Additionally, “AAA without diabetes” (AAN) patients and “AAA complicated with type 2 diabetes mellitus” (AAM) patients had different cytokine expression patterns in their plasma, and nine plasma proteins were differentially expressed among the AAN, AAM, and HC subjects. Delta-like protein 1 (DLL1), receptor tyrosine-protein kinase erbB-3 (ERBB3), and dipeptidyl peptidase 4 (DPPIV) were significantly higher in AAM than in AAN. This study identified several promising plasma biomarkers of AAA. Their role as therapeutic targets for AAA warrants further investigation.
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title_short	Identification of Novel Plasma Biomarkers for Abdominal Aortic Aneurysm by Protein Array Analysis
url	https://doi.org/10.3390/biom12121853 https://doaj.org/article/8a831152321442adb220620ccbd61c11 https://www.mdpi.com/2218-273X/12/12/1853 https://doaj.org/toc/2218-273X
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up_date	2024-07-03T16:15:00.599Z
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Delta-like protein 1 (DLL1), receptor tyrosine-protein kinase erbB-3 (ERBB3), and dipeptidyl peptidase 4 (DPPIV) were significantly higher in AAM than in AAN. This study identified several promising plasma biomarkers of AAA. 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Identification of Novel Plasma Biomarkers for Abdominal Aortic Aneurysm by Protein Array Analysis

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