Leaves of <i<Cedrela sinensis</i< Attenuate Chronic Unpredictable Mild Stress-Induced Depression-like Behavior via Regulation of Hormonal and Inflammatory Imbalance
This study aimed to evaluate the protective effects of ethyl acetate fraction from <i<Cedrela sinensis</i< (EFCS) against chronic unpredictable mild stress (CUMS)-induced behavioral dysfunction and stress response in C57BL/6 mice. The physiological compounds of EFCS were identified as ru...
Ausführliche Beschreibung
Autor*in: |
Hye Rin Jeong [verfasserIn] Jong Min Kim [verfasserIn] Uk Lee [verfasserIn] Jin Yong Kang [verfasserIn] Seon Kyeong Park [verfasserIn] Hyo Lim Lee [verfasserIn] Jong Hyun Moon [verfasserIn] Min Ji Kim [verfasserIn] Min Ji Go [verfasserIn] Ho Jin Heo [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2022 |
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Schlagwörter: |
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Übergeordnetes Werk: |
In: Antioxidants - MDPI AG, 2013, 11(2022), 12, p 2448 |
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Übergeordnetes Werk: |
volume:11 ; year:2022 ; number:12, p 2448 |
Links: |
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DOI / URN: |
10.3390/antiox11122448 |
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Katalog-ID: |
DOAJ083243003 |
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10.3390/antiox11122448 doi (DE-627)DOAJ083243003 (DE-599)DOAJbb1d90a9f8754d3f85381c7448cf3b58 DE-627 ger DE-627 rakwb eng RM1-950 Hye Rin Jeong verfasserin aut Leaves of <i<Cedrela sinensis</i< Attenuate Chronic Unpredictable Mild Stress-Induced Depression-like Behavior via Regulation of Hormonal and Inflammatory Imbalance 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This study aimed to evaluate the protective effects of ethyl acetate fraction from <i<Cedrela sinensis</i< (EFCS) against chronic unpredictable mild stress (CUMS)-induced behavioral dysfunction and stress response in C57BL/6 mice. The physiological compounds of EFCS were identified as rutin, isoquercitrin, ethyl gallate, quercitrin, kaempferol-3-O-rhamnoside, and ethyl digallate, using UPLC-Q-TOF/MS<sup<E</sup<. To evaluate the neuroprotective effect of EFCS, H<sub<2</sub<O<sub<2</sub<<sup<−</sup< and corticosterone-induced neuronal cell viability was conducted in human neuroblastoma MC-IXC cells. It was found that EFCS alleviated depression-like behavior by conducting the sucrose preference test (SPT), forced swimming test (FST), open field test (OFT), and tail suspension test (TST). EFCS inhibited mitochondrial dysfunction related to neuronal energy metabolism by regulating reactive oxygen species (ROS) levels, mitochondrial membrane potential (MMP), and ATP contents in brain tissue. In addition, the administration of EFCS regulated the stress hormones in serum. EFCS regulated stress-related indicators such as CRF, ACTH, CYP11B1, and BDNF. Moreover, EFCS downregulated the inflammatory responses and apoptosis proteins such as caspase-1, TNF-α, IL-1β, p-JNK, BAX, and p-tau in brain tissues. These results suggest that EFCS might be a potential natural plant material that alleviates CUMS-induced behavior disorder by regulating inflammation in brain tissue against CUMS-induced depression. <i<Cedrela sinensis</i< chronic unpredictable mild stress depression mitochondrial function inflammation hormone changes Therapeutics. Pharmacology Jong Min Kim verfasserin aut Uk Lee verfasserin aut Jin Yong Kang verfasserin aut Seon Kyeong Park verfasserin aut Hyo Lim Lee verfasserin aut Jong Hyun Moon verfasserin aut Min Ji Kim verfasserin aut Min Ji Go verfasserin aut Ho Jin Heo verfasserin aut In Antioxidants MDPI AG, 2013 11(2022), 12, p 2448 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:11 year:2022 number:12, p 2448 https://doi.org/10.3390/antiox11122448 kostenfrei https://doaj.org/article/bb1d90a9f8754d3f85381c7448cf3b58 kostenfrei https://www.mdpi.com/2076-3921/11/12/2448 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 12, p 2448 |
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10.3390/antiox11122448 doi (DE-627)DOAJ083243003 (DE-599)DOAJbb1d90a9f8754d3f85381c7448cf3b58 DE-627 ger DE-627 rakwb eng RM1-950 Hye Rin Jeong verfasserin aut Leaves of <i<Cedrela sinensis</i< Attenuate Chronic Unpredictable Mild Stress-Induced Depression-like Behavior via Regulation of Hormonal and Inflammatory Imbalance 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This study aimed to evaluate the protective effects of ethyl acetate fraction from <i<Cedrela sinensis</i< (EFCS) against chronic unpredictable mild stress (CUMS)-induced behavioral dysfunction and stress response in C57BL/6 mice. The physiological compounds of EFCS were identified as rutin, isoquercitrin, ethyl gallate, quercitrin, kaempferol-3-O-rhamnoside, and ethyl digallate, using UPLC-Q-TOF/MS<sup<E</sup<. To evaluate the neuroprotective effect of EFCS, H<sub<2</sub<O<sub<2</sub<<sup<−</sup< and corticosterone-induced neuronal cell viability was conducted in human neuroblastoma MC-IXC cells. It was found that EFCS alleviated depression-like behavior by conducting the sucrose preference test (SPT), forced swimming test (FST), open field test (OFT), and tail suspension test (TST). EFCS inhibited mitochondrial dysfunction related to neuronal energy metabolism by regulating reactive oxygen species (ROS) levels, mitochondrial membrane potential (MMP), and ATP contents in brain tissue. In addition, the administration of EFCS regulated the stress hormones in serum. EFCS regulated stress-related indicators such as CRF, ACTH, CYP11B1, and BDNF. Moreover, EFCS downregulated the inflammatory responses and apoptosis proteins such as caspase-1, TNF-α, IL-1β, p-JNK, BAX, and p-tau in brain tissues. These results suggest that EFCS might be a potential natural plant material that alleviates CUMS-induced behavior disorder by regulating inflammation in brain tissue against CUMS-induced depression. <i<Cedrela sinensis</i< chronic unpredictable mild stress depression mitochondrial function inflammation hormone changes Therapeutics. Pharmacology Jong Min Kim verfasserin aut Uk Lee verfasserin aut Jin Yong Kang verfasserin aut Seon Kyeong Park verfasserin aut Hyo Lim Lee verfasserin aut Jong Hyun Moon verfasserin aut Min Ji Kim verfasserin aut Min Ji Go verfasserin aut Ho Jin Heo verfasserin aut In Antioxidants MDPI AG, 2013 11(2022), 12, p 2448 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:11 year:2022 number:12, p 2448 https://doi.org/10.3390/antiox11122448 kostenfrei https://doaj.org/article/bb1d90a9f8754d3f85381c7448cf3b58 kostenfrei https://www.mdpi.com/2076-3921/11/12/2448 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 12, p 2448 |
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10.3390/antiox11122448 doi (DE-627)DOAJ083243003 (DE-599)DOAJbb1d90a9f8754d3f85381c7448cf3b58 DE-627 ger DE-627 rakwb eng RM1-950 Hye Rin Jeong verfasserin aut Leaves of <i<Cedrela sinensis</i< Attenuate Chronic Unpredictable Mild Stress-Induced Depression-like Behavior via Regulation of Hormonal and Inflammatory Imbalance 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This study aimed to evaluate the protective effects of ethyl acetate fraction from <i<Cedrela sinensis</i< (EFCS) against chronic unpredictable mild stress (CUMS)-induced behavioral dysfunction and stress response in C57BL/6 mice. The physiological compounds of EFCS were identified as rutin, isoquercitrin, ethyl gallate, quercitrin, kaempferol-3-O-rhamnoside, and ethyl digallate, using UPLC-Q-TOF/MS<sup<E</sup<. To evaluate the neuroprotective effect of EFCS, H<sub<2</sub<O<sub<2</sub<<sup<−</sup< and corticosterone-induced neuronal cell viability was conducted in human neuroblastoma MC-IXC cells. It was found that EFCS alleviated depression-like behavior by conducting the sucrose preference test (SPT), forced swimming test (FST), open field test (OFT), and tail suspension test (TST). EFCS inhibited mitochondrial dysfunction related to neuronal energy metabolism by regulating reactive oxygen species (ROS) levels, mitochondrial membrane potential (MMP), and ATP contents in brain tissue. In addition, the administration of EFCS regulated the stress hormones in serum. EFCS regulated stress-related indicators such as CRF, ACTH, CYP11B1, and BDNF. Moreover, EFCS downregulated the inflammatory responses and apoptosis proteins such as caspase-1, TNF-α, IL-1β, p-JNK, BAX, and p-tau in brain tissues. These results suggest that EFCS might be a potential natural plant material that alleviates CUMS-induced behavior disorder by regulating inflammation in brain tissue against CUMS-induced depression. <i<Cedrela sinensis</i< chronic unpredictable mild stress depression mitochondrial function inflammation hormone changes Therapeutics. Pharmacology Jong Min Kim verfasserin aut Uk Lee verfasserin aut Jin Yong Kang verfasserin aut Seon Kyeong Park verfasserin aut Hyo Lim Lee verfasserin aut Jong Hyun Moon verfasserin aut Min Ji Kim verfasserin aut Min Ji Go verfasserin aut Ho Jin Heo verfasserin aut In Antioxidants MDPI AG, 2013 11(2022), 12, p 2448 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:11 year:2022 number:12, p 2448 https://doi.org/10.3390/antiox11122448 kostenfrei https://doaj.org/article/bb1d90a9f8754d3f85381c7448cf3b58 kostenfrei https://www.mdpi.com/2076-3921/11/12/2448 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 12, p 2448 |
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10.3390/antiox11122448 doi (DE-627)DOAJ083243003 (DE-599)DOAJbb1d90a9f8754d3f85381c7448cf3b58 DE-627 ger DE-627 rakwb eng RM1-950 Hye Rin Jeong verfasserin aut Leaves of <i<Cedrela sinensis</i< Attenuate Chronic Unpredictable Mild Stress-Induced Depression-like Behavior via Regulation of Hormonal and Inflammatory Imbalance 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This study aimed to evaluate the protective effects of ethyl acetate fraction from <i<Cedrela sinensis</i< (EFCS) against chronic unpredictable mild stress (CUMS)-induced behavioral dysfunction and stress response in C57BL/6 mice. The physiological compounds of EFCS were identified as rutin, isoquercitrin, ethyl gallate, quercitrin, kaempferol-3-O-rhamnoside, and ethyl digallate, using UPLC-Q-TOF/MS<sup<E</sup<. To evaluate the neuroprotective effect of EFCS, H<sub<2</sub<O<sub<2</sub<<sup<−</sup< and corticosterone-induced neuronal cell viability was conducted in human neuroblastoma MC-IXC cells. It was found that EFCS alleviated depression-like behavior by conducting the sucrose preference test (SPT), forced swimming test (FST), open field test (OFT), and tail suspension test (TST). EFCS inhibited mitochondrial dysfunction related to neuronal energy metabolism by regulating reactive oxygen species (ROS) levels, mitochondrial membrane potential (MMP), and ATP contents in brain tissue. In addition, the administration of EFCS regulated the stress hormones in serum. EFCS regulated stress-related indicators such as CRF, ACTH, CYP11B1, and BDNF. Moreover, EFCS downregulated the inflammatory responses and apoptosis proteins such as caspase-1, TNF-α, IL-1β, p-JNK, BAX, and p-tau in brain tissues. These results suggest that EFCS might be a potential natural plant material that alleviates CUMS-induced behavior disorder by regulating inflammation in brain tissue against CUMS-induced depression. <i<Cedrela sinensis</i< chronic unpredictable mild stress depression mitochondrial function inflammation hormone changes Therapeutics. Pharmacology Jong Min Kim verfasserin aut Uk Lee verfasserin aut Jin Yong Kang verfasserin aut Seon Kyeong Park verfasserin aut Hyo Lim Lee verfasserin aut Jong Hyun Moon verfasserin aut Min Ji Kim verfasserin aut Min Ji Go verfasserin aut Ho Jin Heo verfasserin aut In Antioxidants MDPI AG, 2013 11(2022), 12, p 2448 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:11 year:2022 number:12, p 2448 https://doi.org/10.3390/antiox11122448 kostenfrei https://doaj.org/article/bb1d90a9f8754d3f85381c7448cf3b58 kostenfrei https://www.mdpi.com/2076-3921/11/12/2448 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 12, p 2448 |
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Leaves of <i<Cedrela sinensis</i< Attenuate Chronic Unpredictable Mild Stress-Induced Depression-like Behavior via Regulation of Hormonal and Inflammatory Imbalance |
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This study aimed to evaluate the protective effects of ethyl acetate fraction from <i<Cedrela sinensis</i< (EFCS) against chronic unpredictable mild stress (CUMS)-induced behavioral dysfunction and stress response in C57BL/6 mice. The physiological compounds of EFCS were identified as rutin, isoquercitrin, ethyl gallate, quercitrin, kaempferol-3-O-rhamnoside, and ethyl digallate, using UPLC-Q-TOF/MS<sup<E</sup<. To evaluate the neuroprotective effect of EFCS, H<sub<2</sub<O<sub<2</sub<<sup<−</sup< and corticosterone-induced neuronal cell viability was conducted in human neuroblastoma MC-IXC cells. It was found that EFCS alleviated depression-like behavior by conducting the sucrose preference test (SPT), forced swimming test (FST), open field test (OFT), and tail suspension test (TST). EFCS inhibited mitochondrial dysfunction related to neuronal energy metabolism by regulating reactive oxygen species (ROS) levels, mitochondrial membrane potential (MMP), and ATP contents in brain tissue. In addition, the administration of EFCS regulated the stress hormones in serum. EFCS regulated stress-related indicators such as CRF, ACTH, CYP11B1, and BDNF. Moreover, EFCS downregulated the inflammatory responses and apoptosis proteins such as caspase-1, TNF-α, IL-1β, p-JNK, BAX, and p-tau in brain tissues. These results suggest that EFCS might be a potential natural plant material that alleviates CUMS-induced behavior disorder by regulating inflammation in brain tissue against CUMS-induced depression. |
abstractGer |
This study aimed to evaluate the protective effects of ethyl acetate fraction from <i<Cedrela sinensis</i< (EFCS) against chronic unpredictable mild stress (CUMS)-induced behavioral dysfunction and stress response in C57BL/6 mice. The physiological compounds of EFCS were identified as rutin, isoquercitrin, ethyl gallate, quercitrin, kaempferol-3-O-rhamnoside, and ethyl digallate, using UPLC-Q-TOF/MS<sup<E</sup<. To evaluate the neuroprotective effect of EFCS, H<sub<2</sub<O<sub<2</sub<<sup<−</sup< and corticosterone-induced neuronal cell viability was conducted in human neuroblastoma MC-IXC cells. It was found that EFCS alleviated depression-like behavior by conducting the sucrose preference test (SPT), forced swimming test (FST), open field test (OFT), and tail suspension test (TST). EFCS inhibited mitochondrial dysfunction related to neuronal energy metabolism by regulating reactive oxygen species (ROS) levels, mitochondrial membrane potential (MMP), and ATP contents in brain tissue. In addition, the administration of EFCS regulated the stress hormones in serum. EFCS regulated stress-related indicators such as CRF, ACTH, CYP11B1, and BDNF. Moreover, EFCS downregulated the inflammatory responses and apoptosis proteins such as caspase-1, TNF-α, IL-1β, p-JNK, BAX, and p-tau in brain tissues. These results suggest that EFCS might be a potential natural plant material that alleviates CUMS-induced behavior disorder by regulating inflammation in brain tissue against CUMS-induced depression. |
abstract_unstemmed |
This study aimed to evaluate the protective effects of ethyl acetate fraction from <i<Cedrela sinensis</i< (EFCS) against chronic unpredictable mild stress (CUMS)-induced behavioral dysfunction and stress response in C57BL/6 mice. The physiological compounds of EFCS were identified as rutin, isoquercitrin, ethyl gallate, quercitrin, kaempferol-3-O-rhamnoside, and ethyl digallate, using UPLC-Q-TOF/MS<sup<E</sup<. To evaluate the neuroprotective effect of EFCS, H<sub<2</sub<O<sub<2</sub<<sup<−</sup< and corticosterone-induced neuronal cell viability was conducted in human neuroblastoma MC-IXC cells. It was found that EFCS alleviated depression-like behavior by conducting the sucrose preference test (SPT), forced swimming test (FST), open field test (OFT), and tail suspension test (TST). EFCS inhibited mitochondrial dysfunction related to neuronal energy metabolism by regulating reactive oxygen species (ROS) levels, mitochondrial membrane potential (MMP), and ATP contents in brain tissue. In addition, the administration of EFCS regulated the stress hormones in serum. EFCS regulated stress-related indicators such as CRF, ACTH, CYP11B1, and BDNF. Moreover, EFCS downregulated the inflammatory responses and apoptosis proteins such as caspase-1, TNF-α, IL-1β, p-JNK, BAX, and p-tau in brain tissues. These results suggest that EFCS might be a potential natural plant material that alleviates CUMS-induced behavior disorder by regulating inflammation in brain tissue against CUMS-induced depression. |
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container_issue |
12, p 2448 |
title_short |
Leaves of <i<Cedrela sinensis</i< Attenuate Chronic Unpredictable Mild Stress-Induced Depression-like Behavior via Regulation of Hormonal and Inflammatory Imbalance |
url |
https://doi.org/10.3390/antiox11122448 https://doaj.org/article/bb1d90a9f8754d3f85381c7448cf3b58 https://www.mdpi.com/2076-3921/11/12/2448 https://doaj.org/toc/2076-3921 |
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Jong Min Kim Uk Lee Jin Yong Kang Seon Kyeong Park Hyo Lim Lee Jong Hyun Moon Min Ji Kim Min Ji Go Ho Jin Heo |
author2Str |
Jong Min Kim Uk Lee Jin Yong Kang Seon Kyeong Park Hyo Lim Lee Jong Hyun Moon Min Ji Kim Min Ji Go Ho Jin Heo |
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up_date |
2024-07-03T16:22:27.837Z |
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