Colon-Targeted eNAMPT-Specific Peptide Systems for Treatment of DSS-Induced Acute and Chronic Colitis in Mouse

Nicotinamide phosphoribosyl transferase (NAMPT) is required to maintain the NAD<sup<+</sup< pool, among which extracellular (e) NAMPT is associated with inflammation, mainly mediated by macrophages. However, the role of (e) NAMPT in inflammatory macrophages in ulcerative colitis is insuf...
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Autor*in:	Jae-Sung Kim [verfasserIn] Hyo Keun Kim [verfasserIn] Minsoo Kim [verfasserIn] Sein Jang [verfasserIn] Euni Cho [verfasserIn] Seok-Jun Mun [verfasserIn] Joongho Lee [verfasserIn] Dawon Hong [verfasserIn] Seokhyun Yoon [verfasserIn] Chul-Su Yang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	NAMPT TLR4 CYBB NLRP3 inflammasome colitis

Übergeordnetes Werk:	In: Antioxidants - MDPI AG, 2013, 11(2022), 12, p 2376
Übergeordnetes Werk:	volume:11 ; year:2022 ; number:12, p 2376

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/antiox11122376

Katalog-ID:	DOAJ083243771

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520			\|a Nicotinamide phosphoribosyl transferase (NAMPT) is required to maintain the NAD<sup<+</sup< pool, among which extracellular (e) NAMPT is associated with inflammation, mainly mediated by macrophages. However, the role of (e) NAMPT in inflammatory macrophages in ulcerative colitis is insufficiently understood. Here our analyses of single-cell RNA-seq data revealed that the levels of NAMPT and CYBB/NOX2 in macrophages were elevated in patients with colitis and in mouse models of acute and chronic colitis. These findings indicate the clinical significance of NAMPT and CYBB in colitis. Further, we found that eNAMPT directly binds the extracellular domains of CYBB and TLR4 in activated NLRP3 inflammasomes. Moreover, we developed a recombinant 12-residue TK peptide designated colon-targeted (CT)-conjugated multifunctional NAMPT (rCT-NAMPT), comprising CT as the colon-targeting moiety, which harbors the minimal essential residues required for CYBB/TLR4 binding. rCT-NAMPT effectively suppressed the severity of disease in DSS-induced acute and chronic colitis models through targeting the colon and inhibiting the interaction of NAMPT with CYBB or TLR4. Together, our data show that rCT-NAMPT may serve as an effective novel candidate therapeutic for colitis by modulating the NLRP3 inflammasome-mediated immune signaling system.
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allfields	10.3390/antiox11122376 doi (DE-627)DOAJ083243771 (DE-599)DOAJ91b1d680f4d74c0c934b8260b80a797b DE-627 ger DE-627 rakwb eng RM1-950 Jae-Sung Kim verfasserin aut Colon-Targeted eNAMPT-Specific Peptide Systems for Treatment of DSS-Induced Acute and Chronic Colitis in Mouse 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nicotinamide phosphoribosyl transferase (NAMPT) is required to maintain the NAD<sup<+</sup< pool, among which extracellular (e) NAMPT is associated with inflammation, mainly mediated by macrophages. However, the role of (e) NAMPT in inflammatory macrophages in ulcerative colitis is insufficiently understood. Here our analyses of single-cell RNA-seq data revealed that the levels of NAMPT and CYBB/NOX2 in macrophages were elevated in patients with colitis and in mouse models of acute and chronic colitis. These findings indicate the clinical significance of NAMPT and CYBB in colitis. Further, we found that eNAMPT directly binds the extracellular domains of CYBB and TLR4 in activated NLRP3 inflammasomes. Moreover, we developed a recombinant 12-residue TK peptide designated colon-targeted (CT)-conjugated multifunctional NAMPT (rCT-NAMPT), comprising CT as the colon-targeting moiety, which harbors the minimal essential residues required for CYBB/TLR4 binding. rCT-NAMPT effectively suppressed the severity of disease in DSS-induced acute and chronic colitis models through targeting the colon and inhibiting the interaction of NAMPT with CYBB or TLR4. Together, our data show that rCT-NAMPT may serve as an effective novel candidate therapeutic for colitis by modulating the NLRP3 inflammasome-mediated immune signaling system. NAMPT TLR4 CYBB NLRP3 inflammasome colitis Therapeutics. Pharmacology Hyo Keun Kim verfasserin aut Minsoo Kim verfasserin aut Sein Jang verfasserin aut Euni Cho verfasserin aut Seok-Jun Mun verfasserin aut Joongho Lee verfasserin aut Dawon Hong verfasserin aut Seokhyun Yoon verfasserin aut Chul-Su Yang verfasserin aut In Antioxidants MDPI AG, 2013 11(2022), 12, p 2376 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:11 year:2022 number:12, p 2376 https://doi.org/10.3390/antiox11122376 kostenfrei https://doaj.org/article/91b1d680f4d74c0c934b8260b80a797b kostenfrei https://www.mdpi.com/2076-3921/11/12/2376 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 12, p 2376
spelling	10.3390/antiox11122376 doi (DE-627)DOAJ083243771 (DE-599)DOAJ91b1d680f4d74c0c934b8260b80a797b DE-627 ger DE-627 rakwb eng RM1-950 Jae-Sung Kim verfasserin aut Colon-Targeted eNAMPT-Specific Peptide Systems for Treatment of DSS-Induced Acute and Chronic Colitis in Mouse 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nicotinamide phosphoribosyl transferase (NAMPT) is required to maintain the NAD<sup<+</sup< pool, among which extracellular (e) NAMPT is associated with inflammation, mainly mediated by macrophages. However, the role of (e) NAMPT in inflammatory macrophages in ulcerative colitis is insufficiently understood. Here our analyses of single-cell RNA-seq data revealed that the levels of NAMPT and CYBB/NOX2 in macrophages were elevated in patients with colitis and in mouse models of acute and chronic colitis. These findings indicate the clinical significance of NAMPT and CYBB in colitis. Further, we found that eNAMPT directly binds the extracellular domains of CYBB and TLR4 in activated NLRP3 inflammasomes. Moreover, we developed a recombinant 12-residue TK peptide designated colon-targeted (CT)-conjugated multifunctional NAMPT (rCT-NAMPT), comprising CT as the colon-targeting moiety, which harbors the minimal essential residues required for CYBB/TLR4 binding. rCT-NAMPT effectively suppressed the severity of disease in DSS-induced acute and chronic colitis models through targeting the colon and inhibiting the interaction of NAMPT with CYBB or TLR4. Together, our data show that rCT-NAMPT may serve as an effective novel candidate therapeutic for colitis by modulating the NLRP3 inflammasome-mediated immune signaling system. NAMPT TLR4 CYBB NLRP3 inflammasome colitis Therapeutics. Pharmacology Hyo Keun Kim verfasserin aut Minsoo Kim verfasserin aut Sein Jang verfasserin aut Euni Cho verfasserin aut Seok-Jun Mun verfasserin aut Joongho Lee verfasserin aut Dawon Hong verfasserin aut Seokhyun Yoon verfasserin aut Chul-Su Yang verfasserin aut In Antioxidants MDPI AG, 2013 11(2022), 12, p 2376 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:11 year:2022 number:12, p 2376 https://doi.org/10.3390/antiox11122376 kostenfrei https://doaj.org/article/91b1d680f4d74c0c934b8260b80a797b kostenfrei https://www.mdpi.com/2076-3921/11/12/2376 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 12, p 2376
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allfieldsGer	10.3390/antiox11122376 doi (DE-627)DOAJ083243771 (DE-599)DOAJ91b1d680f4d74c0c934b8260b80a797b DE-627 ger DE-627 rakwb eng RM1-950 Jae-Sung Kim verfasserin aut Colon-Targeted eNAMPT-Specific Peptide Systems for Treatment of DSS-Induced Acute and Chronic Colitis in Mouse 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nicotinamide phosphoribosyl transferase (NAMPT) is required to maintain the NAD<sup<+</sup< pool, among which extracellular (e) NAMPT is associated with inflammation, mainly mediated by macrophages. However, the role of (e) NAMPT in inflammatory macrophages in ulcerative colitis is insufficiently understood. Here our analyses of single-cell RNA-seq data revealed that the levels of NAMPT and CYBB/NOX2 in macrophages were elevated in patients with colitis and in mouse models of acute and chronic colitis. These findings indicate the clinical significance of NAMPT and CYBB in colitis. Further, we found that eNAMPT directly binds the extracellular domains of CYBB and TLR4 in activated NLRP3 inflammasomes. Moreover, we developed a recombinant 12-residue TK peptide designated colon-targeted (CT)-conjugated multifunctional NAMPT (rCT-NAMPT), comprising CT as the colon-targeting moiety, which harbors the minimal essential residues required for CYBB/TLR4 binding. rCT-NAMPT effectively suppressed the severity of disease in DSS-induced acute and chronic colitis models through targeting the colon and inhibiting the interaction of NAMPT with CYBB or TLR4. Together, our data show that rCT-NAMPT may serve as an effective novel candidate therapeutic for colitis by modulating the NLRP3 inflammasome-mediated immune signaling system. NAMPT TLR4 CYBB NLRP3 inflammasome colitis Therapeutics. Pharmacology Hyo Keun Kim verfasserin aut Minsoo Kim verfasserin aut Sein Jang verfasserin aut Euni Cho verfasserin aut Seok-Jun Mun verfasserin aut Joongho Lee verfasserin aut Dawon Hong verfasserin aut Seokhyun Yoon verfasserin aut Chul-Su Yang verfasserin aut In Antioxidants MDPI AG, 2013 11(2022), 12, p 2376 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:11 year:2022 number:12, p 2376 https://doi.org/10.3390/antiox11122376 kostenfrei https://doaj.org/article/91b1d680f4d74c0c934b8260b80a797b kostenfrei https://www.mdpi.com/2076-3921/11/12/2376 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 12, p 2376
allfieldsSound	10.3390/antiox11122376 doi (DE-627)DOAJ083243771 (DE-599)DOAJ91b1d680f4d74c0c934b8260b80a797b DE-627 ger DE-627 rakwb eng RM1-950 Jae-Sung Kim verfasserin aut Colon-Targeted eNAMPT-Specific Peptide Systems for Treatment of DSS-Induced Acute and Chronic Colitis in Mouse 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nicotinamide phosphoribosyl transferase (NAMPT) is required to maintain the NAD<sup<+</sup< pool, among which extracellular (e) NAMPT is associated with inflammation, mainly mediated by macrophages. However, the role of (e) NAMPT in inflammatory macrophages in ulcerative colitis is insufficiently understood. Here our analyses of single-cell RNA-seq data revealed that the levels of NAMPT and CYBB/NOX2 in macrophages were elevated in patients with colitis and in mouse models of acute and chronic colitis. These findings indicate the clinical significance of NAMPT and CYBB in colitis. Further, we found that eNAMPT directly binds the extracellular domains of CYBB and TLR4 in activated NLRP3 inflammasomes. Moreover, we developed a recombinant 12-residue TK peptide designated colon-targeted (CT)-conjugated multifunctional NAMPT (rCT-NAMPT), comprising CT as the colon-targeting moiety, which harbors the minimal essential residues required for CYBB/TLR4 binding. rCT-NAMPT effectively suppressed the severity of disease in DSS-induced acute and chronic colitis models through targeting the colon and inhibiting the interaction of NAMPT with CYBB or TLR4. Together, our data show that rCT-NAMPT may serve as an effective novel candidate therapeutic for colitis by modulating the NLRP3 inflammasome-mediated immune signaling system. NAMPT TLR4 CYBB NLRP3 inflammasome colitis Therapeutics. Pharmacology Hyo Keun Kim verfasserin aut Minsoo Kim verfasserin aut Sein Jang verfasserin aut Euni Cho verfasserin aut Seok-Jun Mun verfasserin aut Joongho Lee verfasserin aut Dawon Hong verfasserin aut Seokhyun Yoon verfasserin aut Chul-Su Yang verfasserin aut In Antioxidants MDPI AG, 2013 11(2022), 12, p 2376 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:11 year:2022 number:12, p 2376 https://doi.org/10.3390/antiox11122376 kostenfrei https://doaj.org/article/91b1d680f4d74c0c934b8260b80a797b kostenfrei https://www.mdpi.com/2076-3921/11/12/2376 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 12, p 2376
language	English
source	In Antioxidants 11(2022), 12, p 2376 volume:11 year:2022 number:12, p 2376
sourceStr	In Antioxidants 11(2022), 12, p 2376 volume:11 year:2022 number:12, p 2376
format_phy_str_mv	Article
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topic_facet	NAMPT TLR4 CYBB NLRP3 inflammasome colitis Therapeutics. Pharmacology
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container_title	Antioxidants
authorswithroles_txt_mv	Jae-Sung Kim @@aut@@ Hyo Keun Kim @@aut@@ Minsoo Kim @@aut@@ Sein Jang @@aut@@ Euni Cho @@aut@@ Seok-Jun Mun @@aut@@ Joongho Lee @@aut@@ Dawon Hong @@aut@@ Seokhyun Yoon @@aut@@ Chul-Su Yang @@aut@@
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callnumber-first	R - Medicine
author	Jae-Sung Kim
spellingShingle	Jae-Sung Kim misc RM1-950 misc NAMPT misc TLR4 misc CYBB misc NLRP3 inflammasome misc colitis misc Therapeutics. Pharmacology Colon-Targeted eNAMPT-Specific Peptide Systems for Treatment of DSS-Induced Acute and Chronic Colitis in Mouse
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topic_title	RM1-950 Colon-Targeted eNAMPT-Specific Peptide Systems for Treatment of DSS-Induced Acute and Chronic Colitis in Mouse NAMPT TLR4 CYBB NLRP3 inflammasome colitis
topic	misc RM1-950 misc NAMPT misc TLR4 misc CYBB misc NLRP3 inflammasome misc colitis misc Therapeutics. Pharmacology
topic_unstemmed	misc RM1-950 misc NAMPT misc TLR4 misc CYBB misc NLRP3 inflammasome misc colitis misc Therapeutics. Pharmacology
topic_browse	misc RM1-950 misc NAMPT misc TLR4 misc CYBB misc NLRP3 inflammasome misc colitis misc Therapeutics. Pharmacology
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title	Colon-Targeted eNAMPT-Specific Peptide Systems for Treatment of DSS-Induced Acute and Chronic Colitis in Mouse
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title_full	Colon-Targeted eNAMPT-Specific Peptide Systems for Treatment of DSS-Induced Acute and Chronic Colitis in Mouse
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author_browse	Jae-Sung Kim Hyo Keun Kim Minsoo Kim Sein Jang Euni Cho Seok-Jun Mun Joongho Lee Dawon Hong Seokhyun Yoon Chul-Su Yang
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title_sort	colon-targeted enampt-specific peptide systems for treatment of dss-induced acute and chronic colitis in mouse
callnumber	RM1-950
title_auth	Colon-Targeted eNAMPT-Specific Peptide Systems for Treatment of DSS-Induced Acute and Chronic Colitis in Mouse
abstract	Nicotinamide phosphoribosyl transferase (NAMPT) is required to maintain the NAD<sup<+</sup< pool, among which extracellular (e) NAMPT is associated with inflammation, mainly mediated by macrophages. However, the role of (e) NAMPT in inflammatory macrophages in ulcerative colitis is insufficiently understood. Here our analyses of single-cell RNA-seq data revealed that the levels of NAMPT and CYBB/NOX2 in macrophages were elevated in patients with colitis and in mouse models of acute and chronic colitis. These findings indicate the clinical significance of NAMPT and CYBB in colitis. Further, we found that eNAMPT directly binds the extracellular domains of CYBB and TLR4 in activated NLRP3 inflammasomes. Moreover, we developed a recombinant 12-residue TK peptide designated colon-targeted (CT)-conjugated multifunctional NAMPT (rCT-NAMPT), comprising CT as the colon-targeting moiety, which harbors the minimal essential residues required for CYBB/TLR4 binding. rCT-NAMPT effectively suppressed the severity of disease in DSS-induced acute and chronic colitis models through targeting the colon and inhibiting the interaction of NAMPT with CYBB or TLR4. Together, our data show that rCT-NAMPT may serve as an effective novel candidate therapeutic for colitis by modulating the NLRP3 inflammasome-mediated immune signaling system.
abstractGer	Nicotinamide phosphoribosyl transferase (NAMPT) is required to maintain the NAD<sup<+</sup< pool, among which extracellular (e) NAMPT is associated with inflammation, mainly mediated by macrophages. However, the role of (e) NAMPT in inflammatory macrophages in ulcerative colitis is insufficiently understood. Here our analyses of single-cell RNA-seq data revealed that the levels of NAMPT and CYBB/NOX2 in macrophages were elevated in patients with colitis and in mouse models of acute and chronic colitis. These findings indicate the clinical significance of NAMPT and CYBB in colitis. Further, we found that eNAMPT directly binds the extracellular domains of CYBB and TLR4 in activated NLRP3 inflammasomes. Moreover, we developed a recombinant 12-residue TK peptide designated colon-targeted (CT)-conjugated multifunctional NAMPT (rCT-NAMPT), comprising CT as the colon-targeting moiety, which harbors the minimal essential residues required for CYBB/TLR4 binding. rCT-NAMPT effectively suppressed the severity of disease in DSS-induced acute and chronic colitis models through targeting the colon and inhibiting the interaction of NAMPT with CYBB or TLR4. Together, our data show that rCT-NAMPT may serve as an effective novel candidate therapeutic for colitis by modulating the NLRP3 inflammasome-mediated immune signaling system.
abstract_unstemmed	Nicotinamide phosphoribosyl transferase (NAMPT) is required to maintain the NAD<sup<+</sup< pool, among which extracellular (e) NAMPT is associated with inflammation, mainly mediated by macrophages. However, the role of (e) NAMPT in inflammatory macrophages in ulcerative colitis is insufficiently understood. Here our analyses of single-cell RNA-seq data revealed that the levels of NAMPT and CYBB/NOX2 in macrophages were elevated in patients with colitis and in mouse models of acute and chronic colitis. These findings indicate the clinical significance of NAMPT and CYBB in colitis. Further, we found that eNAMPT directly binds the extracellular domains of CYBB and TLR4 in activated NLRP3 inflammasomes. Moreover, we developed a recombinant 12-residue TK peptide designated colon-targeted (CT)-conjugated multifunctional NAMPT (rCT-NAMPT), comprising CT as the colon-targeting moiety, which harbors the minimal essential residues required for CYBB/TLR4 binding. rCT-NAMPT effectively suppressed the severity of disease in DSS-induced acute and chronic colitis models through targeting the colon and inhibiting the interaction of NAMPT with CYBB or TLR4. Together, our data show that rCT-NAMPT may serve as an effective novel candidate therapeutic for colitis by modulating the NLRP3 inflammasome-mediated immune signaling system.
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title_short	Colon-Targeted eNAMPT-Specific Peptide Systems for Treatment of DSS-Induced Acute and Chronic Colitis in Mouse
url	https://doi.org/10.3390/antiox11122376 https://doaj.org/article/91b1d680f4d74c0c934b8260b80a797b https://www.mdpi.com/2076-3921/11/12/2376 https://doaj.org/toc/2076-3921
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author2	Hyo Keun Kim Minsoo Kim Sein Jang Euni Cho Seok-Jun Mun Joongho Lee Dawon Hong Seokhyun Yoon Chul-Su Yang
author2Str	Hyo Keun Kim Minsoo Kim Sein Jang Euni Cho Seok-Jun Mun Joongho Lee Dawon Hong Seokhyun Yoon Chul-Su Yang
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up_date	2024-07-03T16:22:46.486Z
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Colon-Targeted eNAMPT-Specific Peptide Systems for Treatment of DSS-Induced Acute and Chronic Colitis in Mouse

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