Butenolide derivatives from Aspergillus terreus selectively inhibit butyrylcholinesterase

Two undescribed butenolide derivatives, asperteretal J (1) and K (2), together with 13 known ones (3–15) were isolated from an endophytic fungus Aspergillus terreus SGP-1, the fermentation product of which exhibited selective inhibitory activity toward butyrylcholinesterase. The structures of the ne...
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Autor*in:	Xiang Cui [verfasserIn] Shanshan Deng [verfasserIn] Guoyin Li [verfasserIn] Yunxia Zhang [verfasserIn] Lining Wang [verfasserIn] Changjing Wu [verfasserIn] Yanru Deng [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Aspergillus terreus secondary metabolites butenolide derivatives structure elucidation butyrylcholinesterase inhibitor

Übergeordnetes Werk:	In: Frontiers in Chemistry - Frontiers Media S.A., 2014, 10(2022)
Übergeordnetes Werk:	volume:10 ; year:2022

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fchem.2022.1063284

Katalog-ID:	DOAJ083287094

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container_title	Frontiers in Chemistry
authorswithroles_txt_mv	Xiang Cui @@aut@@ Shanshan Deng @@aut@@ Guoyin Li @@aut@@ Yunxia Zhang @@aut@@ Lining Wang @@aut@@ Changjing Wu @@aut@@ Yanru Deng @@aut@@
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callnumber-first	Q - Science
author	Xiang Cui
spellingShingle	Xiang Cui misc QD1-999 misc Aspergillus terreus misc secondary metabolites misc butenolide derivatives misc structure elucidation misc butyrylcholinesterase inhibitor misc Chemistry Butenolide derivatives from Aspergillus terreus selectively inhibit butyrylcholinesterase
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topic_title	QD1-999 Butenolide derivatives from Aspergillus terreus selectively inhibit butyrylcholinesterase Aspergillus terreus secondary metabolites butenolide derivatives structure elucidation butyrylcholinesterase inhibitor
topic	misc QD1-999 misc Aspergillus terreus misc secondary metabolites misc butenolide derivatives misc structure elucidation misc butyrylcholinesterase inhibitor misc Chemistry
topic_unstemmed	misc QD1-999 misc Aspergillus terreus misc secondary metabolites misc butenolide derivatives misc structure elucidation misc butyrylcholinesterase inhibitor misc Chemistry
topic_browse	misc QD1-999 misc Aspergillus terreus misc secondary metabolites misc butenolide derivatives misc structure elucidation misc butyrylcholinesterase inhibitor misc Chemistry
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title	Butenolide derivatives from Aspergillus terreus selectively inhibit butyrylcholinesterase
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title_full	Butenolide derivatives from Aspergillus terreus selectively inhibit butyrylcholinesterase
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title_sort	butenolide derivatives from aspergillus terreus selectively inhibit butyrylcholinesterase
callnumber	QD1-999
title_auth	Butenolide derivatives from Aspergillus terreus selectively inhibit butyrylcholinesterase
abstract	Two undescribed butenolide derivatives, asperteretal J (1) and K (2), together with 13 known ones (3–15) were isolated from an endophytic fungus Aspergillus terreus SGP-1, the fermentation product of which exhibited selective inhibitory activity toward butyrylcholinesterase. The structures of the new compounds were elucidated based on HRMS and NMR data, and the absolute configurations were determined by specific optical rotation comparison. All compounds were evaluated for cholinesterase inhibitory effects with galantamine as a positive control. Compounds 4–8 selectively inhibited butyrylcholinesterase with IC50 values of 18.4–45.8 µM in a competitive manner, with Ki values of 12.3–38.2 µM. The structure-activity relationship was discussed. Molecular docking and dynamic simulation of the inhibitor-enzyme complex were performed to better understand the interactions.
abstractGer	Two undescribed butenolide derivatives, asperteretal J (1) and K (2), together with 13 known ones (3–15) were isolated from an endophytic fungus Aspergillus terreus SGP-1, the fermentation product of which exhibited selective inhibitory activity toward butyrylcholinesterase. The structures of the new compounds were elucidated based on HRMS and NMR data, and the absolute configurations were determined by specific optical rotation comparison. All compounds were evaluated for cholinesterase inhibitory effects with galantamine as a positive control. Compounds 4–8 selectively inhibited butyrylcholinesterase with IC50 values of 18.4–45.8 µM in a competitive manner, with Ki values of 12.3–38.2 µM. The structure-activity relationship was discussed. Molecular docking and dynamic simulation of the inhibitor-enzyme complex were performed to better understand the interactions.
abstract_unstemmed	Two undescribed butenolide derivatives, asperteretal J (1) and K (2), together with 13 known ones (3–15) were isolated from an endophytic fungus Aspergillus terreus SGP-1, the fermentation product of which exhibited selective inhibitory activity toward butyrylcholinesterase. The structures of the new compounds were elucidated based on HRMS and NMR data, and the absolute configurations were determined by specific optical rotation comparison. All compounds were evaluated for cholinesterase inhibitory effects with galantamine as a positive control. Compounds 4–8 selectively inhibited butyrylcholinesterase with IC50 values of 18.4–45.8 µM in a competitive manner, with Ki values of 12.3–38.2 µM. The structure-activity relationship was discussed. Molecular docking and dynamic simulation of the inhibitor-enzyme complex were performed to better understand the interactions.
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title_short	Butenolide derivatives from Aspergillus terreus selectively inhibit butyrylcholinesterase
url	https://doi.org/10.3389/fchem.2022.1063284 https://doaj.org/article/2146690aba5e480a8c5f58d66df66d16 https://www.frontiersin.org/articles/10.3389/fchem.2022.1063284/full https://doaj.org/toc/2296-2646
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Butenolide derivatives from Aspergillus terreus selectively inhibit butyrylcholinesterase

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