Respiratory tract infection of fatal severe human bocavirus 1 in a 13-month-old child: A case report and literature review

Human bocavirus 1 (HBoV1) belongs to the family Parvoviridae and it is acknowledged that HBoV1 is a respiratory pathogen. We report the case of a 13-month-old boy who presented with a cough, shortness of breath, and wheezing, and who eventually died of severe pneumonia and acute respiratory distress...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Jing Liao [verfasserIn] Zhongying Yang [verfasserIn] Yu He [verfasserIn] Jianhua Wei [verfasserIn] Luo Ren [verfasserIn] Enmei Liu [verfasserIn] Na Zang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	human bocavirus 1 severe infection children respiratory STAT1 variant

Übergeordnetes Werk:	In: Frontiers in Pediatrics - Frontiers Media S.A., 2013, 10(2022)
Übergeordnetes Werk:	volume:10 ; year:2022

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fped.2022.949817

Katalog-ID:	DOAJ083299335

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allfields	10.3389/fped.2022.949817 doi (DE-627)DOAJ083299335 (DE-599)DOAJ7b9d4e3693cb47dba8d68d131137bf35 DE-627 ger DE-627 rakwb eng RJ1-570 Jing Liao verfasserin aut Respiratory tract infection of fatal severe human bocavirus 1 in a 13-month-old child: A case report and literature review 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Human bocavirus 1 (HBoV1) belongs to the family Parvoviridae and it is acknowledged that HBoV1 is a respiratory pathogen. We report the case of a 13-month-old boy who presented with a cough, shortness of breath, and wheezing, and who eventually died of severe pneumonia and acute respiratory distress syndrome (ARDS). Metagenomics next-generation sequencing (mNGS) showed that HBoV1 was the only detected pathogen. The nasopharyngeal aspirate viral load was 2.08 × 1010 copies/ml and the serum viral load was 2.37 × 105 copies/ml. The child was still oxygen deficient under mechanical ventilation. Chest imaging suggested diffuse lesions in both lungs, an injury caused by ARDS. In this case, the clinical symptoms and signs of the child, the high viral load, viremia, and the detection of mNGS in the tracheal aspirate all supported that HBoV1 could cause severe acute respiratory tract infection in children without other pathogen infections. human bocavirus 1 severe infection children respiratory STAT1 variant Pediatrics Zhongying Yang verfasserin aut Yu He verfasserin aut Jianhua Wei verfasserin aut Luo Ren verfasserin aut Enmei Liu verfasserin aut Na Zang verfasserin aut In Frontiers in Pediatrics Frontiers Media S.A., 2013 10(2022) (DE-627)742738744 (DE-600)2711999-3 22962360 nnns volume:10 year:2022 https://doi.org/10.3389/fped.2022.949817 kostenfrei https://doaj.org/article/7b9d4e3693cb47dba8d68d131137bf35 kostenfrei https://www.frontiersin.org/articles/10.3389/fped.2022.949817/full kostenfrei https://doaj.org/toc/2296-2360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2022
spelling	10.3389/fped.2022.949817 doi (DE-627)DOAJ083299335 (DE-599)DOAJ7b9d4e3693cb47dba8d68d131137bf35 DE-627 ger DE-627 rakwb eng RJ1-570 Jing Liao verfasserin aut Respiratory tract infection of fatal severe human bocavirus 1 in a 13-month-old child: A case report and literature review 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Human bocavirus 1 (HBoV1) belongs to the family Parvoviridae and it is acknowledged that HBoV1 is a respiratory pathogen. We report the case of a 13-month-old boy who presented with a cough, shortness of breath, and wheezing, and who eventually died of severe pneumonia and acute respiratory distress syndrome (ARDS). Metagenomics next-generation sequencing (mNGS) showed that HBoV1 was the only detected pathogen. The nasopharyngeal aspirate viral load was 2.08 × 1010 copies/ml and the serum viral load was 2.37 × 105 copies/ml. The child was still oxygen deficient under mechanical ventilation. Chest imaging suggested diffuse lesions in both lungs, an injury caused by ARDS. In this case, the clinical symptoms and signs of the child, the high viral load, viremia, and the detection of mNGS in the tracheal aspirate all supported that HBoV1 could cause severe acute respiratory tract infection in children without other pathogen infections. human bocavirus 1 severe infection children respiratory STAT1 variant Pediatrics Zhongying Yang verfasserin aut Yu He verfasserin aut Jianhua Wei verfasserin aut Luo Ren verfasserin aut Enmei Liu verfasserin aut Na Zang verfasserin aut In Frontiers in Pediatrics Frontiers Media S.A., 2013 10(2022) (DE-627)742738744 (DE-600)2711999-3 22962360 nnns volume:10 year:2022 https://doi.org/10.3389/fped.2022.949817 kostenfrei https://doaj.org/article/7b9d4e3693cb47dba8d68d131137bf35 kostenfrei https://www.frontiersin.org/articles/10.3389/fped.2022.949817/full kostenfrei https://doaj.org/toc/2296-2360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2022
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allfieldsSound	10.3389/fped.2022.949817 doi (DE-627)DOAJ083299335 (DE-599)DOAJ7b9d4e3693cb47dba8d68d131137bf35 DE-627 ger DE-627 rakwb eng RJ1-570 Jing Liao verfasserin aut Respiratory tract infection of fatal severe human bocavirus 1 in a 13-month-old child: A case report and literature review 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Human bocavirus 1 (HBoV1) belongs to the family Parvoviridae and it is acknowledged that HBoV1 is a respiratory pathogen. We report the case of a 13-month-old boy who presented with a cough, shortness of breath, and wheezing, and who eventually died of severe pneumonia and acute respiratory distress syndrome (ARDS). Metagenomics next-generation sequencing (mNGS) showed that HBoV1 was the only detected pathogen. The nasopharyngeal aspirate viral load was 2.08 × 1010 copies/ml and the serum viral load was 2.37 × 105 copies/ml. The child was still oxygen deficient under mechanical ventilation. Chest imaging suggested diffuse lesions in both lungs, an injury caused by ARDS. In this case, the clinical symptoms and signs of the child, the high viral load, viremia, and the detection of mNGS in the tracheal aspirate all supported that HBoV1 could cause severe acute respiratory tract infection in children without other pathogen infections. human bocavirus 1 severe infection children respiratory STAT1 variant Pediatrics Zhongying Yang verfasserin aut Yu He verfasserin aut Jianhua Wei verfasserin aut Luo Ren verfasserin aut Enmei Liu verfasserin aut Na Zang verfasserin aut In Frontiers in Pediatrics Frontiers Media S.A., 2013 10(2022) (DE-627)742738744 (DE-600)2711999-3 22962360 nnns volume:10 year:2022 https://doi.org/10.3389/fped.2022.949817 kostenfrei https://doaj.org/article/7b9d4e3693cb47dba8d68d131137bf35 kostenfrei https://www.frontiersin.org/articles/10.3389/fped.2022.949817/full kostenfrei https://doaj.org/toc/2296-2360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2022
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callnumber-first	R - Medicine
author	Jing Liao
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title	Respiratory tract infection of fatal severe human bocavirus 1 in a 13-month-old child: A case report and literature review
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title_full	Respiratory tract infection of fatal severe human bocavirus 1 in a 13-month-old child: A case report and literature review
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title_sort	respiratory tract infection of fatal severe human bocavirus 1 in a 13-month-old child: a case report and literature review
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title_auth	Respiratory tract infection of fatal severe human bocavirus 1 in a 13-month-old child: A case report and literature review
abstract	Human bocavirus 1 (HBoV1) belongs to the family Parvoviridae and it is acknowledged that HBoV1 is a respiratory pathogen. We report the case of a 13-month-old boy who presented with a cough, shortness of breath, and wheezing, and who eventually died of severe pneumonia and acute respiratory distress syndrome (ARDS). Metagenomics next-generation sequencing (mNGS) showed that HBoV1 was the only detected pathogen. The nasopharyngeal aspirate viral load was 2.08 × 1010 copies/ml and the serum viral load was 2.37 × 105 copies/ml. The child was still oxygen deficient under mechanical ventilation. Chest imaging suggested diffuse lesions in both lungs, an injury caused by ARDS. In this case, the clinical symptoms and signs of the child, the high viral load, viremia, and the detection of mNGS in the tracheal aspirate all supported that HBoV1 could cause severe acute respiratory tract infection in children without other pathogen infections.
abstractGer	Human bocavirus 1 (HBoV1) belongs to the family Parvoviridae and it is acknowledged that HBoV1 is a respiratory pathogen. We report the case of a 13-month-old boy who presented with a cough, shortness of breath, and wheezing, and who eventually died of severe pneumonia and acute respiratory distress syndrome (ARDS). Metagenomics next-generation sequencing (mNGS) showed that HBoV1 was the only detected pathogen. The nasopharyngeal aspirate viral load was 2.08 × 1010 copies/ml and the serum viral load was 2.37 × 105 copies/ml. The child was still oxygen deficient under mechanical ventilation. Chest imaging suggested diffuse lesions in both lungs, an injury caused by ARDS. In this case, the clinical symptoms and signs of the child, the high viral load, viremia, and the detection of mNGS in the tracheal aspirate all supported that HBoV1 could cause severe acute respiratory tract infection in children without other pathogen infections.
abstract_unstemmed	Human bocavirus 1 (HBoV1) belongs to the family Parvoviridae and it is acknowledged that HBoV1 is a respiratory pathogen. We report the case of a 13-month-old boy who presented with a cough, shortness of breath, and wheezing, and who eventually died of severe pneumonia and acute respiratory distress syndrome (ARDS). Metagenomics next-generation sequencing (mNGS) showed that HBoV1 was the only detected pathogen. The nasopharyngeal aspirate viral load was 2.08 × 1010 copies/ml and the serum viral load was 2.37 × 105 copies/ml. The child was still oxygen deficient under mechanical ventilation. Chest imaging suggested diffuse lesions in both lungs, an injury caused by ARDS. In this case, the clinical symptoms and signs of the child, the high viral load, viremia, and the detection of mNGS in the tracheal aspirate all supported that HBoV1 could cause severe acute respiratory tract infection in children without other pathogen infections.
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title_short	Respiratory tract infection of fatal severe human bocavirus 1 in a 13-month-old child: A case report and literature review
url	https://doi.org/10.3389/fped.2022.949817 https://doaj.org/article/7b9d4e3693cb47dba8d68d131137bf35 https://www.frontiersin.org/articles/10.3389/fped.2022.949817/full https://doaj.org/toc/2296-2360
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