TRK Protein Expression in Merkel Cell Carcinoma Is Not Caused by <i<NTRK</i< Fusions

Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous malignant tumor with neuroendocrine differentiation, with a rapidly growing incidence rate, high risk of recurrence, and aggressive behavior. The available therapeutic options for advanced disease are limited and there is a pressing need...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Rocco Cappellesso [verfasserIn] Lorenzo Nicolè [verfasserIn] Paolo Del Fiore [verfasserIn] Luisa Barzon [verfasserIn] Alessandro Sinigaglia [verfasserIn] Silvia Riccetti [verfasserIn] Renato Franco [verfasserIn] Federica Zito Marino [verfasserIn] Giada Munari [verfasserIn] Carolina Zamuner [verfasserIn] Francesco Cavallin [verfasserIn] Marta Sbaraglia [verfasserIn] Francesca Galuppini [verfasserIn] Franco Bassetto [verfasserIn] Mauro Alaibac [verfasserIn] Vanna Chiarion-Sileni [verfasserIn] Luisa Piccin [verfasserIn] Clara Benna [verfasserIn] Matteo Fassan [verfasserIn] Simone Mocellin [verfasserIn] Angelo Paolo Dei Tos [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Merkel cell carcinoma EPR17341

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 23(2022), 23, p 15366
Übergeordnetes Werk:	volume:23 ; year:2022 ; number:23, p 15366

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijms232315366

Katalog-ID:	DOAJ083422013

Internformat


LEADER	01000caa a22002652 4500
001	DOAJ083422013
003	DE-627
005	20240414155458.0
007	cr uuu---uuuuu
008	230311s2022 xx \|\|\|\|\|o 00\| \|\|eng c
024	7		\|a 10.3390/ijms232315366 \|2 doi
035			\|a (DE-627)DOAJ083422013
035			\|a (DE-599)DOAJ911338472ccb45c7ae45f338a5919c80
040			\|a DE-627 \|b ger \|c DE-627 \|e rakwb
041			\|a eng
050		0	\|a QH301-705.5
050		0	\|a QD1-999
100	0		\|a Rocco Cappellesso \|e verfasserin \|4 aut
245	1	0	\|a TRK Protein Expression in Merkel Cell Carcinoma Is Not Caused by <i<NTRK</i< Fusions
264		1	\|c 2022
336			\|a Text \|b txt \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
520			\|a Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous malignant tumor with neuroendocrine differentiation, with a rapidly growing incidence rate, high risk of recurrence, and aggressive behavior. The available therapeutic options for advanced disease are limited and there is a pressing need for new treatments. Tumors harboring fusions involving one of the neurotrophin receptor tyrosine kinase (<i<NTRK</i<) genes are now actionable with targeted inhibitors. <i<NTRK</i<-fused genes have been identified in neuroendocrine tumors of other sites; thus, a series of 76 MCCs were firstly analyzed with pan-TRK immunohistochemistry and the positive ones with real-time RT-PCR, RNA-based NGS, and FISH to detect the eventual underlying gene fusion. Despite 34 MCCs showing pan-TRK expression, <i<NTRK</i< fusions were not found in any cases. As in other tumors with neural differentiation, TRK expression seems to be physiological and not caused by gene fusions.
650		4	\|a <i<NTRK1</i<
650		4	\|a <i<NTRK2</i<
650		4	\|a <i<NTRK3</i<
650		4	\|a Merkel cell carcinoma
650		4	\|a EPR17341
653		0	\|a Biology (General)
653		0	\|a Chemistry
700	0		\|a Lorenzo Nicolè \|e verfasserin \|4 aut
700	0		\|a Paolo Del Fiore \|e verfasserin \|4 aut
700	0		\|a Luisa Barzon \|e verfasserin \|4 aut
700	0		\|a Alessandro Sinigaglia \|e verfasserin \|4 aut
700	0		\|a Silvia Riccetti \|e verfasserin \|4 aut
700	0		\|a Renato Franco \|e verfasserin \|4 aut
700	0		\|a Federica Zito Marino \|e verfasserin \|4 aut
700	0		\|a Giada Munari \|e verfasserin \|4 aut
700	0		\|a Carolina Zamuner \|e verfasserin \|4 aut
700	0		\|a Francesco Cavallin \|e verfasserin \|4 aut
700	0		\|a Marta Sbaraglia \|e verfasserin \|4 aut
700	0		\|a Francesca Galuppini \|e verfasserin \|4 aut
700	0		\|a Franco Bassetto \|e verfasserin \|4 aut
700	0		\|a Mauro Alaibac \|e verfasserin \|4 aut
700	0		\|a Vanna Chiarion-Sileni \|e verfasserin \|4 aut
700	0		\|a Luisa Piccin \|e verfasserin \|4 aut
700	0		\|a Clara Benna \|e verfasserin \|4 aut
700	0		\|a Matteo Fassan \|e verfasserin \|4 aut
700	0		\|a Simone Mocellin \|e verfasserin \|4 aut
700	0		\|a Angelo Paolo Dei Tos \|e verfasserin \|4 aut
773	0	8	\|i In \|t International Journal of Molecular Sciences \|d MDPI AG, 2003 \|g 23(2022), 23, p 15366 \|w (DE-627)316340715 \|w (DE-600)2019364-6 \|x 14220067 \|7 nnns
773	1	8	\|g volume:23 \|g year:2022 \|g number:23, p 15366
856	4	0	\|u https://doi.org/10.3390/ijms232315366 \|z kostenfrei
856	4	0	\|u https://doaj.org/article/911338472ccb45c7ae45f338a5919c80 \|z kostenfrei
856	4	0	\|u https://www.mdpi.com/1422-0067/23/23/15366 \|z kostenfrei
856	4	2	\|u https://doaj.org/toc/1661-6596 \|y Journal toc \|z kostenfrei
856	4	2	\|u https://doaj.org/toc/1422-0067 \|y Journal toc \|z kostenfrei
912			\|a GBV_USEFLAG_A
912			\|a SYSFLAG_A
912			\|a GBV_DOAJ
912			\|a GBV_ILN_20
912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_31
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_95
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_206
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_602
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4700
951			\|a AR
952			\|d 23 \|j 2022 \|e 23, p 15366

Indexfelder

author_variant	r c rc l n ln p d f pdf l b lb a s as s r sr r f rf f z m fzm g m gm c z cz f c fc m s ms f g fg f b fb m a ma v c s vcs l p lp c b cb m f mf s m sm a p d t apdt
matchkey_str	article:14220067:2022----::rpoenxrsinneklelacnminta
hierarchy_sort_str	2022
callnumber-subject-code	QH
publishDate	2022
allfields	10.3390/ijms232315366 doi (DE-627)DOAJ083422013 (DE-599)DOAJ911338472ccb45c7ae45f338a5919c80 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Rocco Cappellesso verfasserin aut TRK Protein Expression in Merkel Cell Carcinoma Is Not Caused by <i<NTRK</i< Fusions 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous malignant tumor with neuroendocrine differentiation, with a rapidly growing incidence rate, high risk of recurrence, and aggressive behavior. The available therapeutic options for advanced disease are limited and there is a pressing need for new treatments. Tumors harboring fusions involving one of the neurotrophin receptor tyrosine kinase (<i<NTRK</i<) genes are now actionable with targeted inhibitors. <i<NTRK</i<-fused genes have been identified in neuroendocrine tumors of other sites; thus, a series of 76 MCCs were firstly analyzed with pan-TRK immunohistochemistry and the positive ones with real-time RT-PCR, RNA-based NGS, and FISH to detect the eventual underlying gene fusion. Despite 34 MCCs showing pan-TRK expression, <i<NTRK</i< fusions were not found in any cases. As in other tumors with neural differentiation, TRK expression seems to be physiological and not caused by gene fusions. <i<NTRK1</i< <i<NTRK2</i< <i<NTRK3</i< Merkel cell carcinoma EPR17341 Biology (General) Chemistry Lorenzo Nicolè verfasserin aut Paolo Del Fiore verfasserin aut Luisa Barzon verfasserin aut Alessandro Sinigaglia verfasserin aut Silvia Riccetti verfasserin aut Renato Franco verfasserin aut Federica Zito Marino verfasserin aut Giada Munari verfasserin aut Carolina Zamuner verfasserin aut Francesco Cavallin verfasserin aut Marta Sbaraglia verfasserin aut Francesca Galuppini verfasserin aut Franco Bassetto verfasserin aut Mauro Alaibac verfasserin aut Vanna Chiarion-Sileni verfasserin aut Luisa Piccin verfasserin aut Clara Benna verfasserin aut Matteo Fassan verfasserin aut Simone Mocellin verfasserin aut Angelo Paolo Dei Tos verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 23, p 15366 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:23, p 15366 https://doi.org/10.3390/ijms232315366 kostenfrei https://doaj.org/article/911338472ccb45c7ae45f338a5919c80 kostenfrei https://www.mdpi.com/1422-0067/23/23/15366 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 23, p 15366
spelling	10.3390/ijms232315366 doi (DE-627)DOAJ083422013 (DE-599)DOAJ911338472ccb45c7ae45f338a5919c80 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Rocco Cappellesso verfasserin aut TRK Protein Expression in Merkel Cell Carcinoma Is Not Caused by <i<NTRK</i< Fusions 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous malignant tumor with neuroendocrine differentiation, with a rapidly growing incidence rate, high risk of recurrence, and aggressive behavior. The available therapeutic options for advanced disease are limited and there is a pressing need for new treatments. Tumors harboring fusions involving one of the neurotrophin receptor tyrosine kinase (<i<NTRK</i<) genes are now actionable with targeted inhibitors. <i<NTRK</i<-fused genes have been identified in neuroendocrine tumors of other sites; thus, a series of 76 MCCs were firstly analyzed with pan-TRK immunohistochemistry and the positive ones with real-time RT-PCR, RNA-based NGS, and FISH to detect the eventual underlying gene fusion. Despite 34 MCCs showing pan-TRK expression, <i<NTRK</i< fusions were not found in any cases. As in other tumors with neural differentiation, TRK expression seems to be physiological and not caused by gene fusions. <i<NTRK1</i< <i<NTRK2</i< <i<NTRK3</i< Merkel cell carcinoma EPR17341 Biology (General) Chemistry Lorenzo Nicolè verfasserin aut Paolo Del Fiore verfasserin aut Luisa Barzon verfasserin aut Alessandro Sinigaglia verfasserin aut Silvia Riccetti verfasserin aut Renato Franco verfasserin aut Federica Zito Marino verfasserin aut Giada Munari verfasserin aut Carolina Zamuner verfasserin aut Francesco Cavallin verfasserin aut Marta Sbaraglia verfasserin aut Francesca Galuppini verfasserin aut Franco Bassetto verfasserin aut Mauro Alaibac verfasserin aut Vanna Chiarion-Sileni verfasserin aut Luisa Piccin verfasserin aut Clara Benna verfasserin aut Matteo Fassan verfasserin aut Simone Mocellin verfasserin aut Angelo Paolo Dei Tos verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 23, p 15366 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:23, p 15366 https://doi.org/10.3390/ijms232315366 kostenfrei https://doaj.org/article/911338472ccb45c7ae45f338a5919c80 kostenfrei https://www.mdpi.com/1422-0067/23/23/15366 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 23, p 15366
allfields_unstemmed	10.3390/ijms232315366 doi (DE-627)DOAJ083422013 (DE-599)DOAJ911338472ccb45c7ae45f338a5919c80 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Rocco Cappellesso verfasserin aut TRK Protein Expression in Merkel Cell Carcinoma Is Not Caused by <i<NTRK</i< Fusions 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous malignant tumor with neuroendocrine differentiation, with a rapidly growing incidence rate, high risk of recurrence, and aggressive behavior. The available therapeutic options for advanced disease are limited and there is a pressing need for new treatments. Tumors harboring fusions involving one of the neurotrophin receptor tyrosine kinase (<i<NTRK</i<) genes are now actionable with targeted inhibitors. <i<NTRK</i<-fused genes have been identified in neuroendocrine tumors of other sites; thus, a series of 76 MCCs were firstly analyzed with pan-TRK immunohistochemistry and the positive ones with real-time RT-PCR, RNA-based NGS, and FISH to detect the eventual underlying gene fusion. Despite 34 MCCs showing pan-TRK expression, <i<NTRK</i< fusions were not found in any cases. As in other tumors with neural differentiation, TRK expression seems to be physiological and not caused by gene fusions. <i<NTRK1</i< <i<NTRK2</i< <i<NTRK3</i< Merkel cell carcinoma EPR17341 Biology (General) Chemistry Lorenzo Nicolè verfasserin aut Paolo Del Fiore verfasserin aut Luisa Barzon verfasserin aut Alessandro Sinigaglia verfasserin aut Silvia Riccetti verfasserin aut Renato Franco verfasserin aut Federica Zito Marino verfasserin aut Giada Munari verfasserin aut Carolina Zamuner verfasserin aut Francesco Cavallin verfasserin aut Marta Sbaraglia verfasserin aut Francesca Galuppini verfasserin aut Franco Bassetto verfasserin aut Mauro Alaibac verfasserin aut Vanna Chiarion-Sileni verfasserin aut Luisa Piccin verfasserin aut Clara Benna verfasserin aut Matteo Fassan verfasserin aut Simone Mocellin verfasserin aut Angelo Paolo Dei Tos verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 23, p 15366 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:23, p 15366 https://doi.org/10.3390/ijms232315366 kostenfrei https://doaj.org/article/911338472ccb45c7ae45f338a5919c80 kostenfrei https://www.mdpi.com/1422-0067/23/23/15366 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 23, p 15366
allfieldsGer	10.3390/ijms232315366 doi (DE-627)DOAJ083422013 (DE-599)DOAJ911338472ccb45c7ae45f338a5919c80 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Rocco Cappellesso verfasserin aut TRK Protein Expression in Merkel Cell Carcinoma Is Not Caused by <i<NTRK</i< Fusions 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous malignant tumor with neuroendocrine differentiation, with a rapidly growing incidence rate, high risk of recurrence, and aggressive behavior. The available therapeutic options for advanced disease are limited and there is a pressing need for new treatments. Tumors harboring fusions involving one of the neurotrophin receptor tyrosine kinase (<i<NTRK</i<) genes are now actionable with targeted inhibitors. <i<NTRK</i<-fused genes have been identified in neuroendocrine tumors of other sites; thus, a series of 76 MCCs were firstly analyzed with pan-TRK immunohistochemistry and the positive ones with real-time RT-PCR, RNA-based NGS, and FISH to detect the eventual underlying gene fusion. Despite 34 MCCs showing pan-TRK expression, <i<NTRK</i< fusions were not found in any cases. As in other tumors with neural differentiation, TRK expression seems to be physiological and not caused by gene fusions. <i<NTRK1</i< <i<NTRK2</i< <i<NTRK3</i< Merkel cell carcinoma EPR17341 Biology (General) Chemistry Lorenzo Nicolè verfasserin aut Paolo Del Fiore verfasserin aut Luisa Barzon verfasserin aut Alessandro Sinigaglia verfasserin aut Silvia Riccetti verfasserin aut Renato Franco verfasserin aut Federica Zito Marino verfasserin aut Giada Munari verfasserin aut Carolina Zamuner verfasserin aut Francesco Cavallin verfasserin aut Marta Sbaraglia verfasserin aut Francesca Galuppini verfasserin aut Franco Bassetto verfasserin aut Mauro Alaibac verfasserin aut Vanna Chiarion-Sileni verfasserin aut Luisa Piccin verfasserin aut Clara Benna verfasserin aut Matteo Fassan verfasserin aut Simone Mocellin verfasserin aut Angelo Paolo Dei Tos verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 23, p 15366 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:23, p 15366 https://doi.org/10.3390/ijms232315366 kostenfrei https://doaj.org/article/911338472ccb45c7ae45f338a5919c80 kostenfrei https://www.mdpi.com/1422-0067/23/23/15366 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 23, p 15366
allfieldsSound	10.3390/ijms232315366 doi (DE-627)DOAJ083422013 (DE-599)DOAJ911338472ccb45c7ae45f338a5919c80 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Rocco Cappellesso verfasserin aut TRK Protein Expression in Merkel Cell Carcinoma Is Not Caused by <i<NTRK</i< Fusions 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous malignant tumor with neuroendocrine differentiation, with a rapidly growing incidence rate, high risk of recurrence, and aggressive behavior. The available therapeutic options for advanced disease are limited and there is a pressing need for new treatments. Tumors harboring fusions involving one of the neurotrophin receptor tyrosine kinase (<i<NTRK</i<) genes are now actionable with targeted inhibitors. <i<NTRK</i<-fused genes have been identified in neuroendocrine tumors of other sites; thus, a series of 76 MCCs were firstly analyzed with pan-TRK immunohistochemistry and the positive ones with real-time RT-PCR, RNA-based NGS, and FISH to detect the eventual underlying gene fusion. Despite 34 MCCs showing pan-TRK expression, <i<NTRK</i< fusions were not found in any cases. As in other tumors with neural differentiation, TRK expression seems to be physiological and not caused by gene fusions. <i<NTRK1</i< <i<NTRK2</i< <i<NTRK3</i< Merkel cell carcinoma EPR17341 Biology (General) Chemistry Lorenzo Nicolè verfasserin aut Paolo Del Fiore verfasserin aut Luisa Barzon verfasserin aut Alessandro Sinigaglia verfasserin aut Silvia Riccetti verfasserin aut Renato Franco verfasserin aut Federica Zito Marino verfasserin aut Giada Munari verfasserin aut Carolina Zamuner verfasserin aut Francesco Cavallin verfasserin aut Marta Sbaraglia verfasserin aut Francesca Galuppini verfasserin aut Franco Bassetto verfasserin aut Mauro Alaibac verfasserin aut Vanna Chiarion-Sileni verfasserin aut Luisa Piccin verfasserin aut Clara Benna verfasserin aut Matteo Fassan verfasserin aut Simone Mocellin verfasserin aut Angelo Paolo Dei Tos verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 23, p 15366 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:23, p 15366 https://doi.org/10.3390/ijms232315366 kostenfrei https://doaj.org/article/911338472ccb45c7ae45f338a5919c80 kostenfrei https://www.mdpi.com/1422-0067/23/23/15366 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 23, p 15366
language	English
source	In International Journal of Molecular Sciences 23(2022), 23, p 15366 volume:23 year:2022 number:23, p 15366
sourceStr	In International Journal of Molecular Sciences 23(2022), 23, p 15366 volume:23 year:2022 number:23, p 15366
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	<i<NTRK1</i< <i<NTRK2</i< <i<NTRK3</i< Merkel cell carcinoma EPR17341 Biology (General) Chemistry
isfreeaccess_bool	true
container_title	International Journal of Molecular Sciences
authorswithroles_txt_mv	Rocco Cappellesso @@aut@@ Lorenzo Nicolè @@aut@@ Paolo Del Fiore @@aut@@ Luisa Barzon @@aut@@ Alessandro Sinigaglia @@aut@@ Silvia Riccetti @@aut@@ Renato Franco @@aut@@ Federica Zito Marino @@aut@@ Giada Munari @@aut@@ Carolina Zamuner @@aut@@ Francesco Cavallin @@aut@@ Marta Sbaraglia @@aut@@ Francesca Galuppini @@aut@@ Franco Bassetto @@aut@@ Mauro Alaibac @@aut@@ Vanna Chiarion-Sileni @@aut@@ Luisa Piccin @@aut@@ Clara Benna @@aut@@ Matteo Fassan @@aut@@ Simone Mocellin @@aut@@ Angelo Paolo Dei Tos @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	316340715
id	DOAJ083422013
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ083422013</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240414155458.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230311s2022 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3390/ijms232315366</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ083422013</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ911338472ccb45c7ae45f338a5919c80</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QH301-705.5</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QD1-999</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Rocco Cappellesso</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">TRK Protein Expression in Merkel Cell Carcinoma Is Not Caused by <i<NTRK</i< Fusions</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous malignant tumor with neuroendocrine differentiation, with a rapidly growing incidence rate, high risk of recurrence, and aggressive behavior. The available therapeutic options for advanced disease are limited and there is a pressing need for new treatments. Tumors harboring fusions involving one of the neurotrophin receptor tyrosine kinase (<i<NTRK</i<) genes are now actionable with targeted inhibitors. <i<NTRK</i<-fused genes have been identified in neuroendocrine tumors of other sites; thus, a series of 76 MCCs were firstly analyzed with pan-TRK immunohistochemistry and the positive ones with real-time RT-PCR, RNA-based NGS, and FISH to detect the eventual underlying gene fusion. Despite 34 MCCs showing pan-TRK expression, <i<NTRK</i< fusions were not found in any cases. As in other tumors with neural differentiation, TRK expression seems to be physiological and not caused by gene fusions.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a"><i<NTRK1</i<</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a"><i<NTRK2</i<</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a"><i<NTRK3</i<</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Merkel cell carcinoma</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">EPR17341</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Biology (General)</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Chemistry</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lorenzo Nicolè</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Paolo Del Fiore</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Luisa Barzon</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alessandro Sinigaglia</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Silvia Riccetti</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Renato Franco</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Federica Zito Marino</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Giada Munari</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Carolina Zamuner</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Francesco Cavallin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Marta Sbaraglia</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Francesca Galuppini</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Franco Bassetto</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mauro Alaibac</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Vanna Chiarion-Sileni</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Luisa Piccin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Clara Benna</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Matteo Fassan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Simone Mocellin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Angelo Paolo Dei Tos</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">International Journal of Molecular Sciences</subfield><subfield code="d">MDPI AG, 2003</subfield><subfield code="g">23(2022), 23, p 15366</subfield><subfield code="w">(DE-627)316340715</subfield><subfield code="w">(DE-600)2019364-6</subfield><subfield code="x">14220067</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:23</subfield><subfield code="g">year:2022</subfield><subfield code="g">number:23, p 15366</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.3390/ijms232315366</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/911338472ccb45c7ae45f338a5919c80</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://www.mdpi.com/1422-0067/23/23/15366</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/1661-6596</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/1422-0067</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_224</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2009</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2011</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2055</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2111</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">23</subfield><subfield code="j">2022</subfield><subfield code="e">23, p 15366</subfield></datafield></record></collection>
callnumber-first	Q - Science
author	Rocco Cappellesso
spellingShingle	Rocco Cappellesso misc QH301-705.5 misc QD1-999 misc <i<NTRK1</i< misc <i<NTRK2</i< misc <i<NTRK3</i< misc Merkel cell carcinoma misc EPR17341 misc Biology (General) misc Chemistry TRK Protein Expression in Merkel Cell Carcinoma Is Not Caused by <i<NTRK</i< Fusions
authorStr	Rocco Cappellesso
ppnlink_with_tag_str_mv	@@773@@(DE-627)316340715
format	electronic Article
delete_txt_mv	keep
author_role	aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut
collection	DOAJ
remote_str	true
callnumber-label	QH301-705
illustrated	Not Illustrated
issn	14220067
topic_title	QH301-705.5 QD1-999 TRK Protein Expression in Merkel Cell Carcinoma Is Not Caused by <i<NTRK</i< Fusions <i<NTRK1</i< <i<NTRK2</i< <i<NTRK3</i< Merkel cell carcinoma EPR17341
topic	misc QH301-705.5 misc QD1-999 misc <i<NTRK1</i< misc <i<NTRK2</i< misc <i<NTRK3</i< misc Merkel cell carcinoma misc EPR17341 misc Biology (General) misc Chemistry
topic_unstemmed	misc QH301-705.5 misc QD1-999 misc <i<NTRK1</i< misc <i<NTRK2</i< misc <i<NTRK3</i< misc Merkel cell carcinoma misc EPR17341 misc Biology (General) misc Chemistry
topic_browse	misc QH301-705.5 misc QD1-999 misc <i<NTRK1</i< misc <i<NTRK2</i< misc <i<NTRK3</i< misc Merkel cell carcinoma misc EPR17341 misc Biology (General) misc Chemistry
format_facet	Elektronische Aufsätze Aufsätze Elektronische Ressource
format_main_str_mv	Text Zeitschrift/Artikel
carriertype_str_mv	cr
hierarchy_parent_title	International Journal of Molecular Sciences
hierarchy_parent_id	316340715
hierarchy_top_title	International Journal of Molecular Sciences
isfreeaccess_txt	true
familylinks_str_mv	(DE-627)316340715 (DE-600)2019364-6
title	TRK Protein Expression in Merkel Cell Carcinoma Is Not Caused by <i<NTRK</i< Fusions
ctrlnum	(DE-627)DOAJ083422013 (DE-599)DOAJ911338472ccb45c7ae45f338a5919c80
title_full	TRK Protein Expression in Merkel Cell Carcinoma Is Not Caused by <i<NTRK</i< Fusions
author_sort	Rocco Cappellesso
journal	International Journal of Molecular Sciences
journalStr	International Journal of Molecular Sciences
callnumber-first-code	Q
lang_code	eng
isOA_bool	true
recordtype	marc
publishDateSort	2022
contenttype_str_mv	txt
author_browse	Rocco Cappellesso Lorenzo Nicolè Paolo Del Fiore Luisa Barzon Alessandro Sinigaglia Silvia Riccetti Renato Franco Federica Zito Marino Giada Munari Carolina Zamuner Francesco Cavallin Marta Sbaraglia Francesca Galuppini Franco Bassetto Mauro Alaibac Vanna Chiarion-Sileni Luisa Piccin Clara Benna Matteo Fassan Simone Mocellin Angelo Paolo Dei Tos
container_volume	23
class	QH301-705.5 QD1-999
format_se	Elektronische Aufsätze
author-letter	Rocco Cappellesso
doi_str_mv	10.3390/ijms232315366
author2-role	verfasserin
title_sort	trk protein expression in merkel cell carcinoma is not caused by <i<ntrk</i< fusions
callnumber	QH301-705.5
title_auth	TRK Protein Expression in Merkel Cell Carcinoma Is Not Caused by <i<NTRK</i< Fusions
abstract	Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous malignant tumor with neuroendocrine differentiation, with a rapidly growing incidence rate, high risk of recurrence, and aggressive behavior. The available therapeutic options for advanced disease are limited and there is a pressing need for new treatments. Tumors harboring fusions involving one of the neurotrophin receptor tyrosine kinase (<i<NTRK</i<) genes are now actionable with targeted inhibitors. <i<NTRK</i<-fused genes have been identified in neuroendocrine tumors of other sites; thus, a series of 76 MCCs were firstly analyzed with pan-TRK immunohistochemistry and the positive ones with real-time RT-PCR, RNA-based NGS, and FISH to detect the eventual underlying gene fusion. Despite 34 MCCs showing pan-TRK expression, <i<NTRK</i< fusions were not found in any cases. As in other tumors with neural differentiation, TRK expression seems to be physiological and not caused by gene fusions.
abstractGer	Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous malignant tumor with neuroendocrine differentiation, with a rapidly growing incidence rate, high risk of recurrence, and aggressive behavior. The available therapeutic options for advanced disease are limited and there is a pressing need for new treatments. Tumors harboring fusions involving one of the neurotrophin receptor tyrosine kinase (<i<NTRK</i<) genes are now actionable with targeted inhibitors. <i<NTRK</i<-fused genes have been identified in neuroendocrine tumors of other sites; thus, a series of 76 MCCs were firstly analyzed with pan-TRK immunohistochemistry and the positive ones with real-time RT-PCR, RNA-based NGS, and FISH to detect the eventual underlying gene fusion. Despite 34 MCCs showing pan-TRK expression, <i<NTRK</i< fusions were not found in any cases. As in other tumors with neural differentiation, TRK expression seems to be physiological and not caused by gene fusions.
abstract_unstemmed	Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous malignant tumor with neuroendocrine differentiation, with a rapidly growing incidence rate, high risk of recurrence, and aggressive behavior. The available therapeutic options for advanced disease are limited and there is a pressing need for new treatments. Tumors harboring fusions involving one of the neurotrophin receptor tyrosine kinase (<i<NTRK</i<) genes are now actionable with targeted inhibitors. <i<NTRK</i<-fused genes have been identified in neuroendocrine tumors of other sites; thus, a series of 76 MCCs were firstly analyzed with pan-TRK immunohistochemistry and the positive ones with real-time RT-PCR, RNA-based NGS, and FISH to detect the eventual underlying gene fusion. Despite 34 MCCs showing pan-TRK expression, <i<NTRK</i< fusions were not found in any cases. As in other tumors with neural differentiation, TRK expression seems to be physiological and not caused by gene fusions.
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
container_issue	23, p 15366
title_short	TRK Protein Expression in Merkel Cell Carcinoma Is Not Caused by <i<NTRK</i< Fusions
url	https://doi.org/10.3390/ijms232315366 https://doaj.org/article/911338472ccb45c7ae45f338a5919c80 https://www.mdpi.com/1422-0067/23/23/15366 https://doaj.org/toc/1661-6596 https://doaj.org/toc/1422-0067
remote_bool	true
author2	Lorenzo Nicolè Paolo Del Fiore Luisa Barzon Alessandro Sinigaglia Silvia Riccetti Renato Franco Federica Zito Marino Giada Munari Carolina Zamuner Francesco Cavallin Marta Sbaraglia Francesca Galuppini Franco Bassetto Mauro Alaibac Vanna Chiarion-Sileni Luisa Piccin Clara Benna Matteo Fassan Simone Mocellin Angelo Paolo Dei Tos
author2Str	Lorenzo Nicolè Paolo Del Fiore Luisa Barzon Alessandro Sinigaglia Silvia Riccetti Renato Franco Federica Zito Marino Giada Munari Carolina Zamuner Francesco Cavallin Marta Sbaraglia Francesca Galuppini Franco Bassetto Mauro Alaibac Vanna Chiarion-Sileni Luisa Piccin Clara Benna Matteo Fassan Simone Mocellin Angelo Paolo Dei Tos
ppnlink	316340715
callnumber-subject	QH - Natural History and Biology
mediatype_str_mv	c
isOA_txt	true
hochschulschrift_bool	false
doi_str	10.3390/ijms232315366
callnumber-a	QH301-705.5
up_date	2024-07-03T17:23:02.238Z
_version_	1803579432359690240
fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ083422013</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240414155458.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230311s2022 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3390/ijms232315366</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ083422013</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ911338472ccb45c7ae45f338a5919c80</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QH301-705.5</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QD1-999</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Rocco Cappellesso</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">TRK Protein Expression in Merkel Cell Carcinoma Is Not Caused by <i<NTRK</i< Fusions</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous malignant tumor with neuroendocrine differentiation, with a rapidly growing incidence rate, high risk of recurrence, and aggressive behavior. The available therapeutic options for advanced disease are limited and there is a pressing need for new treatments. Tumors harboring fusions involving one of the neurotrophin receptor tyrosine kinase (<i<NTRK</i<) genes are now actionable with targeted inhibitors. <i<NTRK</i<-fused genes have been identified in neuroendocrine tumors of other sites; thus, a series of 76 MCCs were firstly analyzed with pan-TRK immunohistochemistry and the positive ones with real-time RT-PCR, RNA-based NGS, and FISH to detect the eventual underlying gene fusion. Despite 34 MCCs showing pan-TRK expression, <i<NTRK</i< fusions were not found in any cases. As in other tumors with neural differentiation, TRK expression seems to be physiological and not caused by gene fusions.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a"><i<NTRK1</i<</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a"><i<NTRK2</i<</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a"><i<NTRK3</i<</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Merkel cell carcinoma</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">EPR17341</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Biology (General)</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Chemistry</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lorenzo Nicolè</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Paolo Del Fiore</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Luisa Barzon</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alessandro Sinigaglia</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Silvia Riccetti</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Renato Franco</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Federica Zito Marino</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Giada Munari</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Carolina Zamuner</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Francesco Cavallin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Marta Sbaraglia</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Francesca Galuppini</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Franco Bassetto</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mauro Alaibac</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Vanna Chiarion-Sileni</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Luisa Piccin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Clara Benna</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Matteo Fassan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Simone Mocellin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Angelo Paolo Dei Tos</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">International Journal of Molecular Sciences</subfield><subfield code="d">MDPI AG, 2003</subfield><subfield code="g">23(2022), 23, p 15366</subfield><subfield code="w">(DE-627)316340715</subfield><subfield code="w">(DE-600)2019364-6</subfield><subfield code="x">14220067</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:23</subfield><subfield code="g">year:2022</subfield><subfield code="g">number:23, p 15366</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.3390/ijms232315366</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/911338472ccb45c7ae45f338a5919c80</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://www.mdpi.com/1422-0067/23/23/15366</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/1661-6596</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/1422-0067</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_224</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2009</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2011</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2055</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2111</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">23</subfield><subfield code="j">2022</subfield><subfield code="e">23, p 15366</subfield></datafield></record></collection>
score	7.3998413

Nicht das Richtige dabei?

Schreiben Sie uns!

TRK Protein Expression in Merkel Cell Carcinoma Is Not Caused by <i<NTRK</i< Fusions

Nicht das Richtige dabei?

Zugang & Verfügbarkeit

Vorhandene Bände

Nicht das Richtige dabei?