TRK Protein Expression in Merkel Cell Carcinoma Is Not Caused by <i<NTRK</i< Fusions
Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous malignant tumor with neuroendocrine differentiation, with a rapidly growing incidence rate, high risk of recurrence, and aggressive behavior. The available therapeutic options for advanced disease are limited and there is a pressing need...
Ausführliche Beschreibung
Autor*in: |
Rocco Cappellesso [verfasserIn] Lorenzo Nicolè [verfasserIn] Paolo Del Fiore [verfasserIn] Luisa Barzon [verfasserIn] Alessandro Sinigaglia [verfasserIn] Silvia Riccetti [verfasserIn] Renato Franco [verfasserIn] Federica Zito Marino [verfasserIn] Giada Munari [verfasserIn] Carolina Zamuner [verfasserIn] Francesco Cavallin [verfasserIn] Marta Sbaraglia [verfasserIn] Francesca Galuppini [verfasserIn] Franco Bassetto [verfasserIn] Mauro Alaibac [verfasserIn] Vanna Chiarion-Sileni [verfasserIn] Luisa Piccin [verfasserIn] Clara Benna [verfasserIn] Matteo Fassan [verfasserIn] Simone Mocellin [verfasserIn] Angelo Paolo Dei Tos [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2022 |
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In: International Journal of Molecular Sciences - MDPI AG, 2003, 23(2022), 23, p 15366 |
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Übergeordnetes Werk: |
volume:23 ; year:2022 ; number:23, p 15366 |
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DOI / URN: |
10.3390/ijms232315366 |
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Katalog-ID: |
DOAJ083422013 |
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520 | |a Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous malignant tumor with neuroendocrine differentiation, with a rapidly growing incidence rate, high risk of recurrence, and aggressive behavior. The available therapeutic options for advanced disease are limited and there is a pressing need for new treatments. Tumors harboring fusions involving one of the neurotrophin receptor tyrosine kinase (<i<NTRK</i<) genes are now actionable with targeted inhibitors. <i<NTRK</i<-fused genes have been identified in neuroendocrine tumors of other sites; thus, a series of 76 MCCs were firstly analyzed with pan-TRK immunohistochemistry and the positive ones with real-time RT-PCR, RNA-based NGS, and FISH to detect the eventual underlying gene fusion. Despite 34 MCCs showing pan-TRK expression, <i<NTRK</i< fusions were not found in any cases. As in other tumors with neural differentiation, TRK expression seems to be physiological and not caused by gene fusions. | ||
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10.3390/ijms232315366 doi (DE-627)DOAJ083422013 (DE-599)DOAJ911338472ccb45c7ae45f338a5919c80 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Rocco Cappellesso verfasserin aut TRK Protein Expression in Merkel Cell Carcinoma Is Not Caused by <i<NTRK</i< Fusions 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous malignant tumor with neuroendocrine differentiation, with a rapidly growing incidence rate, high risk of recurrence, and aggressive behavior. The available therapeutic options for advanced disease are limited and there is a pressing need for new treatments. Tumors harboring fusions involving one of the neurotrophin receptor tyrosine kinase (<i<NTRK</i<) genes are now actionable with targeted inhibitors. <i<NTRK</i<-fused genes have been identified in neuroendocrine tumors of other sites; thus, a series of 76 MCCs were firstly analyzed with pan-TRK immunohistochemistry and the positive ones with real-time RT-PCR, RNA-based NGS, and FISH to detect the eventual underlying gene fusion. Despite 34 MCCs showing pan-TRK expression, <i<NTRK</i< fusions were not found in any cases. As in other tumors with neural differentiation, TRK expression seems to be physiological and not caused by gene fusions. <i<NTRK1</i< <i<NTRK2</i< <i<NTRK3</i< Merkel cell carcinoma EPR17341 Biology (General) Chemistry Lorenzo Nicolè verfasserin aut Paolo Del Fiore verfasserin aut Luisa Barzon verfasserin aut Alessandro Sinigaglia verfasserin aut Silvia Riccetti verfasserin aut Renato Franco verfasserin aut Federica Zito Marino verfasserin aut Giada Munari verfasserin aut Carolina Zamuner verfasserin aut Francesco Cavallin verfasserin aut Marta Sbaraglia verfasserin aut Francesca Galuppini verfasserin aut Franco Bassetto verfasserin aut Mauro Alaibac verfasserin aut Vanna Chiarion-Sileni verfasserin aut Luisa Piccin verfasserin aut Clara Benna verfasserin aut Matteo Fassan verfasserin aut Simone Mocellin verfasserin aut Angelo Paolo Dei Tos verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 23, p 15366 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:23, p 15366 https://doi.org/10.3390/ijms232315366 kostenfrei https://doaj.org/article/911338472ccb45c7ae45f338a5919c80 kostenfrei https://www.mdpi.com/1422-0067/23/23/15366 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 23, p 15366 |
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10.3390/ijms232315366 doi (DE-627)DOAJ083422013 (DE-599)DOAJ911338472ccb45c7ae45f338a5919c80 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Rocco Cappellesso verfasserin aut TRK Protein Expression in Merkel Cell Carcinoma Is Not Caused by <i<NTRK</i< Fusions 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous malignant tumor with neuroendocrine differentiation, with a rapidly growing incidence rate, high risk of recurrence, and aggressive behavior. The available therapeutic options for advanced disease are limited and there is a pressing need for new treatments. Tumors harboring fusions involving one of the neurotrophin receptor tyrosine kinase (<i<NTRK</i<) genes are now actionable with targeted inhibitors. <i<NTRK</i<-fused genes have been identified in neuroendocrine tumors of other sites; thus, a series of 76 MCCs were firstly analyzed with pan-TRK immunohistochemistry and the positive ones with real-time RT-PCR, RNA-based NGS, and FISH to detect the eventual underlying gene fusion. Despite 34 MCCs showing pan-TRK expression, <i<NTRK</i< fusions were not found in any cases. As in other tumors with neural differentiation, TRK expression seems to be physiological and not caused by gene fusions. <i<NTRK1</i< <i<NTRK2</i< <i<NTRK3</i< Merkel cell carcinoma EPR17341 Biology (General) Chemistry Lorenzo Nicolè verfasserin aut Paolo Del Fiore verfasserin aut Luisa Barzon verfasserin aut Alessandro Sinigaglia verfasserin aut Silvia Riccetti verfasserin aut Renato Franco verfasserin aut Federica Zito Marino verfasserin aut Giada Munari verfasserin aut Carolina Zamuner verfasserin aut Francesco Cavallin verfasserin aut Marta Sbaraglia verfasserin aut Francesca Galuppini verfasserin aut Franco Bassetto verfasserin aut Mauro Alaibac verfasserin aut Vanna Chiarion-Sileni verfasserin aut Luisa Piccin verfasserin aut Clara Benna verfasserin aut Matteo Fassan verfasserin aut Simone Mocellin verfasserin aut Angelo Paolo Dei Tos verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 23, p 15366 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:23, p 15366 https://doi.org/10.3390/ijms232315366 kostenfrei https://doaj.org/article/911338472ccb45c7ae45f338a5919c80 kostenfrei https://www.mdpi.com/1422-0067/23/23/15366 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 23, p 15366 |
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10.3390/ijms232315366 doi (DE-627)DOAJ083422013 (DE-599)DOAJ911338472ccb45c7ae45f338a5919c80 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Rocco Cappellesso verfasserin aut TRK Protein Expression in Merkel Cell Carcinoma Is Not Caused by <i<NTRK</i< Fusions 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous malignant tumor with neuroendocrine differentiation, with a rapidly growing incidence rate, high risk of recurrence, and aggressive behavior. The available therapeutic options for advanced disease are limited and there is a pressing need for new treatments. Tumors harboring fusions involving one of the neurotrophin receptor tyrosine kinase (<i<NTRK</i<) genes are now actionable with targeted inhibitors. <i<NTRK</i<-fused genes have been identified in neuroendocrine tumors of other sites; thus, a series of 76 MCCs were firstly analyzed with pan-TRK immunohistochemistry and the positive ones with real-time RT-PCR, RNA-based NGS, and FISH to detect the eventual underlying gene fusion. Despite 34 MCCs showing pan-TRK expression, <i<NTRK</i< fusions were not found in any cases. As in other tumors with neural differentiation, TRK expression seems to be physiological and not caused by gene fusions. <i<NTRK1</i< <i<NTRK2</i< <i<NTRK3</i< Merkel cell carcinoma EPR17341 Biology (General) Chemistry Lorenzo Nicolè verfasserin aut Paolo Del Fiore verfasserin aut Luisa Barzon verfasserin aut Alessandro Sinigaglia verfasserin aut Silvia Riccetti verfasserin aut Renato Franco verfasserin aut Federica Zito Marino verfasserin aut Giada Munari verfasserin aut Carolina Zamuner verfasserin aut Francesco Cavallin verfasserin aut Marta Sbaraglia verfasserin aut Francesca Galuppini verfasserin aut Franco Bassetto verfasserin aut Mauro Alaibac verfasserin aut Vanna Chiarion-Sileni verfasserin aut Luisa Piccin verfasserin aut Clara Benna verfasserin aut Matteo Fassan verfasserin aut Simone Mocellin verfasserin aut Angelo Paolo Dei Tos verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 23, p 15366 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:23, p 15366 https://doi.org/10.3390/ijms232315366 kostenfrei https://doaj.org/article/911338472ccb45c7ae45f338a5919c80 kostenfrei https://www.mdpi.com/1422-0067/23/23/15366 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 23, p 15366 |
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QH301-705.5 QD1-999 TRK Protein Expression in Merkel Cell Carcinoma Is Not Caused by <i<NTRK</i< Fusions <i<NTRK1</i< <i<NTRK2</i< <i<NTRK3</i< Merkel cell carcinoma EPR17341 |
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misc QH301-705.5 misc QD1-999 misc <i<NTRK1</i< misc <i<NTRK2</i< misc <i<NTRK3</i< misc Merkel cell carcinoma misc EPR17341 misc Biology (General) misc Chemistry |
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misc QH301-705.5 misc QD1-999 misc <i<NTRK1</i< misc <i<NTRK2</i< misc <i<NTRK3</i< misc Merkel cell carcinoma misc EPR17341 misc Biology (General) misc Chemistry |
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misc QH301-705.5 misc QD1-999 misc <i<NTRK1</i< misc <i<NTRK2</i< misc <i<NTRK3</i< misc Merkel cell carcinoma misc EPR17341 misc Biology (General) misc Chemistry |
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TRK Protein Expression in Merkel Cell Carcinoma Is Not Caused by <i<NTRK</i< Fusions |
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TRK Protein Expression in Merkel Cell Carcinoma Is Not Caused by <i<NTRK</i< Fusions |
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Rocco Cappellesso |
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Rocco Cappellesso Lorenzo Nicolè Paolo Del Fiore Luisa Barzon Alessandro Sinigaglia Silvia Riccetti Renato Franco Federica Zito Marino Giada Munari Carolina Zamuner Francesco Cavallin Marta Sbaraglia Francesca Galuppini Franco Bassetto Mauro Alaibac Vanna Chiarion-Sileni Luisa Piccin Clara Benna Matteo Fassan Simone Mocellin Angelo Paolo Dei Tos |
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trk protein expression in merkel cell carcinoma is not caused by <i<ntrk</i< fusions |
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TRK Protein Expression in Merkel Cell Carcinoma Is Not Caused by <i<NTRK</i< Fusions |
abstract |
Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous malignant tumor with neuroendocrine differentiation, with a rapidly growing incidence rate, high risk of recurrence, and aggressive behavior. The available therapeutic options for advanced disease are limited and there is a pressing need for new treatments. Tumors harboring fusions involving one of the neurotrophin receptor tyrosine kinase (<i<NTRK</i<) genes are now actionable with targeted inhibitors. <i<NTRK</i<-fused genes have been identified in neuroendocrine tumors of other sites; thus, a series of 76 MCCs were firstly analyzed with pan-TRK immunohistochemistry and the positive ones with real-time RT-PCR, RNA-based NGS, and FISH to detect the eventual underlying gene fusion. Despite 34 MCCs showing pan-TRK expression, <i<NTRK</i< fusions were not found in any cases. As in other tumors with neural differentiation, TRK expression seems to be physiological and not caused by gene fusions. |
abstractGer |
Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous malignant tumor with neuroendocrine differentiation, with a rapidly growing incidence rate, high risk of recurrence, and aggressive behavior. The available therapeutic options for advanced disease are limited and there is a pressing need for new treatments. Tumors harboring fusions involving one of the neurotrophin receptor tyrosine kinase (<i<NTRK</i<) genes are now actionable with targeted inhibitors. <i<NTRK</i<-fused genes have been identified in neuroendocrine tumors of other sites; thus, a series of 76 MCCs were firstly analyzed with pan-TRK immunohistochemistry and the positive ones with real-time RT-PCR, RNA-based NGS, and FISH to detect the eventual underlying gene fusion. Despite 34 MCCs showing pan-TRK expression, <i<NTRK</i< fusions were not found in any cases. As in other tumors with neural differentiation, TRK expression seems to be physiological and not caused by gene fusions. |
abstract_unstemmed |
Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous malignant tumor with neuroendocrine differentiation, with a rapidly growing incidence rate, high risk of recurrence, and aggressive behavior. The available therapeutic options for advanced disease are limited and there is a pressing need for new treatments. Tumors harboring fusions involving one of the neurotrophin receptor tyrosine kinase (<i<NTRK</i<) genes are now actionable with targeted inhibitors. <i<NTRK</i<-fused genes have been identified in neuroendocrine tumors of other sites; thus, a series of 76 MCCs were firstly analyzed with pan-TRK immunohistochemistry and the positive ones with real-time RT-PCR, RNA-based NGS, and FISH to detect the eventual underlying gene fusion. Despite 34 MCCs showing pan-TRK expression, <i<NTRK</i< fusions were not found in any cases. As in other tumors with neural differentiation, TRK expression seems to be physiological and not caused by gene fusions. |
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TRK Protein Expression in Merkel Cell Carcinoma Is Not Caused by <i<NTRK</i< Fusions |
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