Clinical Value of Ultrasonography and Serum Markers in Preoperative N Staging of Thyroid Cancer

We aimed to determine factors influencing lymph node metastasis (LNM) and develop a more effective method to assess preoperative N staging. Overall, data of 2130 patients who underwent thyroidectomy for thyroid cancer between 2018 and 2021 were retrospectively analysed. Patients were divided into gr...
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Autor*in:	Hui Wang [verfasserIn] Shanshan Zhao [verfasserIn] Chunyang Xu [verfasserIn] Jincao Yao [verfasserIn] Xiuhua Yu [verfasserIn] Dong Xu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	lymph node metastasis neoplasm staging thyroglobulin thyroid cancer ultrasonography

Übergeordnetes Werk:	In: Cells - MDPI AG, 2012, 11(2022), 22, p 3621
Übergeordnetes Werk:	volume:11 ; year:2022 ; number:22, p 3621

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cells11223621

Katalog-ID:	DOAJ083494006

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topic_facet	lymph node metastasis neoplasm staging thyroglobulin thyroid cancer ultrasonography Cytology
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authorswithroles_txt_mv	Hui Wang @@aut@@ Shanshan Zhao @@aut@@ Chunyang Xu @@aut@@ Jincao Yao @@aut@@ Xiuhua Yu @@aut@@ Dong Xu @@aut@@
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callnumber-first	Q - Science
author	Hui Wang
spellingShingle	Hui Wang misc QH573-671 misc lymph node metastasis misc neoplasm staging misc thyroglobulin misc thyroid cancer misc ultrasonography misc Cytology Clinical Value of Ultrasonography and Serum Markers in Preoperative N Staging of Thyroid Cancer
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topic_title	QH573-671 Clinical Value of Ultrasonography and Serum Markers in Preoperative N Staging of Thyroid Cancer lymph node metastasis neoplasm staging thyroglobulin thyroid cancer ultrasonography
topic	misc QH573-671 misc lymph node metastasis misc neoplasm staging misc thyroglobulin misc thyroid cancer misc ultrasonography misc Cytology
topic_unstemmed	misc QH573-671 misc lymph node metastasis misc neoplasm staging misc thyroglobulin misc thyroid cancer misc ultrasonography misc Cytology
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title	Clinical Value of Ultrasonography and Serum Markers in Preoperative N Staging of Thyroid Cancer
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title_full	Clinical Value of Ultrasonography and Serum Markers in Preoperative N Staging of Thyroid Cancer
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author_browse	Hui Wang Shanshan Zhao Chunyang Xu Jincao Yao Xiuhua Yu Dong Xu
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title_sort	clinical value of ultrasonography and serum markers in preoperative n staging of thyroid cancer
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title_auth	Clinical Value of Ultrasonography and Serum Markers in Preoperative N Staging of Thyroid Cancer
abstract	We aimed to determine factors influencing lymph node metastasis (LNM) and develop a more effective method to assess preoperative N staging. Overall, data of 2130 patients who underwent thyroidectomy for thyroid cancer between 2018 and 2021 were retrospectively analysed. Patients were divided into groups according to pN0, pN1a, and pN1b stages. Pathology was used to analyse the correlation between preoperative serum marker indicators and LNM. Receiver operating characteristic curves were used to compare the diagnostic value of ultrasound (US) examination alone, serum thyroglobulin, age, and combined method for LNM. A significant moderate agreement was observed between preoperative US and postoperative pathology for N staging. Between the pN0 and pN1 (pN1a + pN1b) groups, the differences in free triiodothyronine, anti-thyroid peroxidase antibody, and serum thyroglobulin levels were statistically significant. Among the indicators, serum thyroglobulin was an independent predictor of LNM. The area under the receiver operating characteristic curve was 0.610 for serum thyroglobulin level for predicting LNM, 0.689 for US alone, and 0.742 for the combined method. Both preoperative US and serum thyroglobulin level provide a specific value when evaluating the N staging of thyroid cancer, and the combined method is more valuable in the diagnosis of LNM than US alone.
abstractGer	We aimed to determine factors influencing lymph node metastasis (LNM) and develop a more effective method to assess preoperative N staging. Overall, data of 2130 patients who underwent thyroidectomy for thyroid cancer between 2018 and 2021 were retrospectively analysed. Patients were divided into groups according to pN0, pN1a, and pN1b stages. Pathology was used to analyse the correlation between preoperative serum marker indicators and LNM. Receiver operating characteristic curves were used to compare the diagnostic value of ultrasound (US) examination alone, serum thyroglobulin, age, and combined method for LNM. A significant moderate agreement was observed between preoperative US and postoperative pathology for N staging. Between the pN0 and pN1 (pN1a + pN1b) groups, the differences in free triiodothyronine, anti-thyroid peroxidase antibody, and serum thyroglobulin levels were statistically significant. Among the indicators, serum thyroglobulin was an independent predictor of LNM. The area under the receiver operating characteristic curve was 0.610 for serum thyroglobulin level for predicting LNM, 0.689 for US alone, and 0.742 for the combined method. Both preoperative US and serum thyroglobulin level provide a specific value when evaluating the N staging of thyroid cancer, and the combined method is more valuable in the diagnosis of LNM than US alone.
abstract_unstemmed	We aimed to determine factors influencing lymph node metastasis (LNM) and develop a more effective method to assess preoperative N staging. Overall, data of 2130 patients who underwent thyroidectomy for thyroid cancer between 2018 and 2021 were retrospectively analysed. Patients were divided into groups according to pN0, pN1a, and pN1b stages. Pathology was used to analyse the correlation between preoperative serum marker indicators and LNM. Receiver operating characteristic curves were used to compare the diagnostic value of ultrasound (US) examination alone, serum thyroglobulin, age, and combined method for LNM. A significant moderate agreement was observed between preoperative US and postoperative pathology for N staging. Between the pN0 and pN1 (pN1a + pN1b) groups, the differences in free triiodothyronine, anti-thyroid peroxidase antibody, and serum thyroglobulin levels were statistically significant. Among the indicators, serum thyroglobulin was an independent predictor of LNM. The area under the receiver operating characteristic curve was 0.610 for serum thyroglobulin level for predicting LNM, 0.689 for US alone, and 0.742 for the combined method. Both preoperative US and serum thyroglobulin level provide a specific value when evaluating the N staging of thyroid cancer, and the combined method is more valuable in the diagnosis of LNM than US alone.
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title_short	Clinical Value of Ultrasonography and Serum Markers in Preoperative N Staging of Thyroid Cancer
url	https://doi.org/10.3390/cells11223621 https://doaj.org/article/8aa44c75d9f04cb1b3ad6a5fb676dae3 https://www.mdpi.com/2073-4409/11/22/3621 https://doaj.org/toc/2073-4409
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author2	Shanshan Zhao Chunyang Xu Jincao Yao Xiuhua Yu Dong Xu
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up_date	2024-07-03T17:47:01.170Z
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Clinical Value of Ultrasonography and Serum Markers in Preoperative N Staging of Thyroid Cancer

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