Serum Inflammatory Markers and Their Associations with the Integrity of the Cingulum Bundle in Schizophrenia, from Prodromal Stages to Chronic Psychosis
Peripheral cytokines may affect the brain through chronic activation of microglia and, as a result, can potentially lead to decreased integrity of white matter of cingulum bundle (CB). Therefore, the aim of the study was to analyze the relationships between peripheral inflammatory markers and the in...
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| Autor*in: |
Anna Michalczyk [verfasserIn] Ernest Tyburski [verfasserIn] Piotr Podwalski [verfasserIn] Katarzyna Waszczuk [verfasserIn] Krzysztof Rudkowski [verfasserIn] Jolanta Kucharska-Mazur [verfasserIn] Monika Mak [verfasserIn] Katarzyna Rek-Owodziń [verfasserIn] Piotr Plichta [verfasserIn] Maksymilian Bielecki [verfasserIn] Wojciech Andrusewicz [verfasserIn] Elżbieta Cecerska-Heryć [verfasserIn] Agnieszka Samochowiec [verfasserIn] Błażej Misiak [verfasserIn] Leszek Sagan [verfasserIn] Jerzy Samochowiec [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Journal of Clinical Medicine - MDPI AG, 2013, 11(2022), 21, p 6352 |
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| Übergeordnetes Werk: |
volume:11 ; year:2022 ; number:21, p 6352 |
| Links: |
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| DOI / URN: |
10.3390/jcm11216352 |
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DOAJ083587411 |
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| 520 | |a Peripheral cytokines may affect the brain through chronic activation of microglia and, as a result, can potentially lead to decreased integrity of white matter of cingulum bundle (CB). Therefore, the aim of the study was to analyze the relationships between peripheral inflammatory markers and the integrity of the CB in various states: from healthy controls, through prodromal states and first-episode psychosis, to long-term schizophrenia. The integrity of the CB was measured using diffusion tensor imaging. We analyzed six parameters: CRP, IL-6, IL-8, IL-10, TNF-α, and IFN-γ. We found that levels of IL-6 and IFN-γ differed significantly between groups. Initial analysis showed some correlations between the inflammatory markers and CB integrity, in particular a correlation with IL-6 that was present in several groups. However, none of the analyzed parameters were associated with the integrity of the CB after correction for multiple comparisons. Conclusions: Our results supported our hypothesis that there are increased levels of inflammatory markers in psychotic disorders, but did not allow to confirm our hypothesis that there is a link between increased peripheral inflammatory markers and decreased integrity of the CB. However, we found some interesting trend levels that need to be verified in larger studies. | ||
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10.3390/jcm11216352 doi (DE-627)DOAJ083587411 (DE-599)DOAJ52dbf64f5da44f788259c5c720330d4a DE-627 ger DE-627 rakwb eng Anna Michalczyk verfasserin aut Serum Inflammatory Markers and Their Associations with the Integrity of the Cingulum Bundle in Schizophrenia, from Prodromal Stages to Chronic Psychosis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Peripheral cytokines may affect the brain through chronic activation of microglia and, as a result, can potentially lead to decreased integrity of white matter of cingulum bundle (CB). Therefore, the aim of the study was to analyze the relationships between peripheral inflammatory markers and the integrity of the CB in various states: from healthy controls, through prodromal states and first-episode psychosis, to long-term schizophrenia. The integrity of the CB was measured using diffusion tensor imaging. We analyzed six parameters: CRP, IL-6, IL-8, IL-10, TNF-α, and IFN-γ. We found that levels of IL-6 and IFN-γ differed significantly between groups. Initial analysis showed some correlations between the inflammatory markers and CB integrity, in particular a correlation with IL-6 that was present in several groups. However, none of the analyzed parameters were associated with the integrity of the CB after correction for multiple comparisons. Conclusions: Our results supported our hypothesis that there are increased levels of inflammatory markers in psychotic disorders, but did not allow to confirm our hypothesis that there is a link between increased peripheral inflammatory markers and decreased integrity of the CB. However, we found some interesting trend levels that need to be verified in larger studies. schizophrenia first episode psychosis UHR diffusion tensor imaging cingulum bundle inflammatory markers Medicine R Ernest Tyburski verfasserin aut Piotr Podwalski verfasserin aut Katarzyna Waszczuk verfasserin aut Krzysztof Rudkowski verfasserin aut Jolanta Kucharska-Mazur verfasserin aut Monika Mak verfasserin aut Katarzyna Rek-Owodziń verfasserin aut Piotr Plichta verfasserin aut Maksymilian Bielecki verfasserin aut Wojciech Andrusewicz verfasserin aut Elżbieta Cecerska-Heryć verfasserin aut Agnieszka Samochowiec verfasserin aut Błażej Misiak verfasserin aut Leszek Sagan verfasserin aut Jerzy Samochowiec verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2022), 21, p 6352 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2022 number:21, p 6352 https://doi.org/10.3390/jcm11216352 kostenfrei https://doaj.org/article/52dbf64f5da44f788259c5c720330d4a kostenfrei https://www.mdpi.com/2077-0383/11/21/6352 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 21, p 6352 |
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10.3390/jcm11216352 doi (DE-627)DOAJ083587411 (DE-599)DOAJ52dbf64f5da44f788259c5c720330d4a DE-627 ger DE-627 rakwb eng Anna Michalczyk verfasserin aut Serum Inflammatory Markers and Their Associations with the Integrity of the Cingulum Bundle in Schizophrenia, from Prodromal Stages to Chronic Psychosis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Peripheral cytokines may affect the brain through chronic activation of microglia and, as a result, can potentially lead to decreased integrity of white matter of cingulum bundle (CB). Therefore, the aim of the study was to analyze the relationships between peripheral inflammatory markers and the integrity of the CB in various states: from healthy controls, through prodromal states and first-episode psychosis, to long-term schizophrenia. The integrity of the CB was measured using diffusion tensor imaging. We analyzed six parameters: CRP, IL-6, IL-8, IL-10, TNF-α, and IFN-γ. We found that levels of IL-6 and IFN-γ differed significantly between groups. Initial analysis showed some correlations between the inflammatory markers and CB integrity, in particular a correlation with IL-6 that was present in several groups. However, none of the analyzed parameters were associated with the integrity of the CB after correction for multiple comparisons. Conclusions: Our results supported our hypothesis that there are increased levels of inflammatory markers in psychotic disorders, but did not allow to confirm our hypothesis that there is a link between increased peripheral inflammatory markers and decreased integrity of the CB. However, we found some interesting trend levels that need to be verified in larger studies. schizophrenia first episode psychosis UHR diffusion tensor imaging cingulum bundle inflammatory markers Medicine R Ernest Tyburski verfasserin aut Piotr Podwalski verfasserin aut Katarzyna Waszczuk verfasserin aut Krzysztof Rudkowski verfasserin aut Jolanta Kucharska-Mazur verfasserin aut Monika Mak verfasserin aut Katarzyna Rek-Owodziń verfasserin aut Piotr Plichta verfasserin aut Maksymilian Bielecki verfasserin aut Wojciech Andrusewicz verfasserin aut Elżbieta Cecerska-Heryć verfasserin aut Agnieszka Samochowiec verfasserin aut Błażej Misiak verfasserin aut Leszek Sagan verfasserin aut Jerzy Samochowiec verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2022), 21, p 6352 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2022 number:21, p 6352 https://doi.org/10.3390/jcm11216352 kostenfrei https://doaj.org/article/52dbf64f5da44f788259c5c720330d4a kostenfrei https://www.mdpi.com/2077-0383/11/21/6352 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 21, p 6352 |
| allfields_unstemmed |
10.3390/jcm11216352 doi (DE-627)DOAJ083587411 (DE-599)DOAJ52dbf64f5da44f788259c5c720330d4a DE-627 ger DE-627 rakwb eng Anna Michalczyk verfasserin aut Serum Inflammatory Markers and Their Associations with the Integrity of the Cingulum Bundle in Schizophrenia, from Prodromal Stages to Chronic Psychosis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Peripheral cytokines may affect the brain through chronic activation of microglia and, as a result, can potentially lead to decreased integrity of white matter of cingulum bundle (CB). Therefore, the aim of the study was to analyze the relationships between peripheral inflammatory markers and the integrity of the CB in various states: from healthy controls, through prodromal states and first-episode psychosis, to long-term schizophrenia. The integrity of the CB was measured using diffusion tensor imaging. We analyzed six parameters: CRP, IL-6, IL-8, IL-10, TNF-α, and IFN-γ. We found that levels of IL-6 and IFN-γ differed significantly between groups. Initial analysis showed some correlations between the inflammatory markers and CB integrity, in particular a correlation with IL-6 that was present in several groups. However, none of the analyzed parameters were associated with the integrity of the CB after correction for multiple comparisons. Conclusions: Our results supported our hypothesis that there are increased levels of inflammatory markers in psychotic disorders, but did not allow to confirm our hypothesis that there is a link between increased peripheral inflammatory markers and decreased integrity of the CB. However, we found some interesting trend levels that need to be verified in larger studies. schizophrenia first episode psychosis UHR diffusion tensor imaging cingulum bundle inflammatory markers Medicine R Ernest Tyburski verfasserin aut Piotr Podwalski verfasserin aut Katarzyna Waszczuk verfasserin aut Krzysztof Rudkowski verfasserin aut Jolanta Kucharska-Mazur verfasserin aut Monika Mak verfasserin aut Katarzyna Rek-Owodziń verfasserin aut Piotr Plichta verfasserin aut Maksymilian Bielecki verfasserin aut Wojciech Andrusewicz verfasserin aut Elżbieta Cecerska-Heryć verfasserin aut Agnieszka Samochowiec verfasserin aut Błażej Misiak verfasserin aut Leszek Sagan verfasserin aut Jerzy Samochowiec verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2022), 21, p 6352 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2022 number:21, p 6352 https://doi.org/10.3390/jcm11216352 kostenfrei https://doaj.org/article/52dbf64f5da44f788259c5c720330d4a kostenfrei https://www.mdpi.com/2077-0383/11/21/6352 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 21, p 6352 |
| allfieldsGer |
10.3390/jcm11216352 doi (DE-627)DOAJ083587411 (DE-599)DOAJ52dbf64f5da44f788259c5c720330d4a DE-627 ger DE-627 rakwb eng Anna Michalczyk verfasserin aut Serum Inflammatory Markers and Their Associations with the Integrity of the Cingulum Bundle in Schizophrenia, from Prodromal Stages to Chronic Psychosis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Peripheral cytokines may affect the brain through chronic activation of microglia and, as a result, can potentially lead to decreased integrity of white matter of cingulum bundle (CB). Therefore, the aim of the study was to analyze the relationships between peripheral inflammatory markers and the integrity of the CB in various states: from healthy controls, through prodromal states and first-episode psychosis, to long-term schizophrenia. The integrity of the CB was measured using diffusion tensor imaging. We analyzed six parameters: CRP, IL-6, IL-8, IL-10, TNF-α, and IFN-γ. We found that levels of IL-6 and IFN-γ differed significantly between groups. Initial analysis showed some correlations between the inflammatory markers and CB integrity, in particular a correlation with IL-6 that was present in several groups. However, none of the analyzed parameters were associated with the integrity of the CB after correction for multiple comparisons. Conclusions: Our results supported our hypothesis that there are increased levels of inflammatory markers in psychotic disorders, but did not allow to confirm our hypothesis that there is a link between increased peripheral inflammatory markers and decreased integrity of the CB. However, we found some interesting trend levels that need to be verified in larger studies. schizophrenia first episode psychosis UHR diffusion tensor imaging cingulum bundle inflammatory markers Medicine R Ernest Tyburski verfasserin aut Piotr Podwalski verfasserin aut Katarzyna Waszczuk verfasserin aut Krzysztof Rudkowski verfasserin aut Jolanta Kucharska-Mazur verfasserin aut Monika Mak verfasserin aut Katarzyna Rek-Owodziń verfasserin aut Piotr Plichta verfasserin aut Maksymilian Bielecki verfasserin aut Wojciech Andrusewicz verfasserin aut Elżbieta Cecerska-Heryć verfasserin aut Agnieszka Samochowiec verfasserin aut Błażej Misiak verfasserin aut Leszek Sagan verfasserin aut Jerzy Samochowiec verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2022), 21, p 6352 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2022 number:21, p 6352 https://doi.org/10.3390/jcm11216352 kostenfrei https://doaj.org/article/52dbf64f5da44f788259c5c720330d4a kostenfrei https://www.mdpi.com/2077-0383/11/21/6352 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 21, p 6352 |
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10.3390/jcm11216352 doi (DE-627)DOAJ083587411 (DE-599)DOAJ52dbf64f5da44f788259c5c720330d4a DE-627 ger DE-627 rakwb eng Anna Michalczyk verfasserin aut Serum Inflammatory Markers and Their Associations with the Integrity of the Cingulum Bundle in Schizophrenia, from Prodromal Stages to Chronic Psychosis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Peripheral cytokines may affect the brain through chronic activation of microglia and, as a result, can potentially lead to decreased integrity of white matter of cingulum bundle (CB). Therefore, the aim of the study was to analyze the relationships between peripheral inflammatory markers and the integrity of the CB in various states: from healthy controls, through prodromal states and first-episode psychosis, to long-term schizophrenia. The integrity of the CB was measured using diffusion tensor imaging. We analyzed six parameters: CRP, IL-6, IL-8, IL-10, TNF-α, and IFN-γ. We found that levels of IL-6 and IFN-γ differed significantly between groups. Initial analysis showed some correlations between the inflammatory markers and CB integrity, in particular a correlation with IL-6 that was present in several groups. However, none of the analyzed parameters were associated with the integrity of the CB after correction for multiple comparisons. Conclusions: Our results supported our hypothesis that there are increased levels of inflammatory markers in psychotic disorders, but did not allow to confirm our hypothesis that there is a link between increased peripheral inflammatory markers and decreased integrity of the CB. However, we found some interesting trend levels that need to be verified in larger studies. schizophrenia first episode psychosis UHR diffusion tensor imaging cingulum bundle inflammatory markers Medicine R Ernest Tyburski verfasserin aut Piotr Podwalski verfasserin aut Katarzyna Waszczuk verfasserin aut Krzysztof Rudkowski verfasserin aut Jolanta Kucharska-Mazur verfasserin aut Monika Mak verfasserin aut Katarzyna Rek-Owodziń verfasserin aut Piotr Plichta verfasserin aut Maksymilian Bielecki verfasserin aut Wojciech Andrusewicz verfasserin aut Elżbieta Cecerska-Heryć verfasserin aut Agnieszka Samochowiec verfasserin aut Błażej Misiak verfasserin aut Leszek Sagan verfasserin aut Jerzy Samochowiec verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2022), 21, p 6352 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2022 number:21, p 6352 https://doi.org/10.3390/jcm11216352 kostenfrei https://doaj.org/article/52dbf64f5da44f788259c5c720330d4a kostenfrei https://www.mdpi.com/2077-0383/11/21/6352 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 21, p 6352 |
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serum inflammatory markers and their associations with the integrity of the cingulum bundle in schizophrenia, from prodromal stages to chronic psychosis |
| title_auth |
Serum Inflammatory Markers and Their Associations with the Integrity of the Cingulum Bundle in Schizophrenia, from Prodromal Stages to Chronic Psychosis |
| abstract |
Peripheral cytokines may affect the brain through chronic activation of microglia and, as a result, can potentially lead to decreased integrity of white matter of cingulum bundle (CB). Therefore, the aim of the study was to analyze the relationships between peripheral inflammatory markers and the integrity of the CB in various states: from healthy controls, through prodromal states and first-episode psychosis, to long-term schizophrenia. The integrity of the CB was measured using diffusion tensor imaging. We analyzed six parameters: CRP, IL-6, IL-8, IL-10, TNF-α, and IFN-γ. We found that levels of IL-6 and IFN-γ differed significantly between groups. Initial analysis showed some correlations between the inflammatory markers and CB integrity, in particular a correlation with IL-6 that was present in several groups. However, none of the analyzed parameters were associated with the integrity of the CB after correction for multiple comparisons. Conclusions: Our results supported our hypothesis that there are increased levels of inflammatory markers in psychotic disorders, but did not allow to confirm our hypothesis that there is a link between increased peripheral inflammatory markers and decreased integrity of the CB. However, we found some interesting trend levels that need to be verified in larger studies. |
| abstractGer |
Peripheral cytokines may affect the brain through chronic activation of microglia and, as a result, can potentially lead to decreased integrity of white matter of cingulum bundle (CB). Therefore, the aim of the study was to analyze the relationships between peripheral inflammatory markers and the integrity of the CB in various states: from healthy controls, through prodromal states and first-episode psychosis, to long-term schizophrenia. The integrity of the CB was measured using diffusion tensor imaging. We analyzed six parameters: CRP, IL-6, IL-8, IL-10, TNF-α, and IFN-γ. We found that levels of IL-6 and IFN-γ differed significantly between groups. Initial analysis showed some correlations between the inflammatory markers and CB integrity, in particular a correlation with IL-6 that was present in several groups. However, none of the analyzed parameters were associated with the integrity of the CB after correction for multiple comparisons. Conclusions: Our results supported our hypothesis that there are increased levels of inflammatory markers in psychotic disorders, but did not allow to confirm our hypothesis that there is a link between increased peripheral inflammatory markers and decreased integrity of the CB. However, we found some interesting trend levels that need to be verified in larger studies. |
| abstract_unstemmed |
Peripheral cytokines may affect the brain through chronic activation of microglia and, as a result, can potentially lead to decreased integrity of white matter of cingulum bundle (CB). Therefore, the aim of the study was to analyze the relationships between peripheral inflammatory markers and the integrity of the CB in various states: from healthy controls, through prodromal states and first-episode psychosis, to long-term schizophrenia. The integrity of the CB was measured using diffusion tensor imaging. We analyzed six parameters: CRP, IL-6, IL-8, IL-10, TNF-α, and IFN-γ. We found that levels of IL-6 and IFN-γ differed significantly between groups. Initial analysis showed some correlations between the inflammatory markers and CB integrity, in particular a correlation with IL-6 that was present in several groups. However, none of the analyzed parameters were associated with the integrity of the CB after correction for multiple comparisons. Conclusions: Our results supported our hypothesis that there are increased levels of inflammatory markers in psychotic disorders, but did not allow to confirm our hypothesis that there is a link between increased peripheral inflammatory markers and decreased integrity of the CB. However, we found some interesting trend levels that need to be verified in larger studies. |
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21, p 6352 |
| title_short |
Serum Inflammatory Markers and Their Associations with the Integrity of the Cingulum Bundle in Schizophrenia, from Prodromal Stages to Chronic Psychosis |
| url |
https://doi.org/10.3390/jcm11216352 https://doaj.org/article/52dbf64f5da44f788259c5c720330d4a https://www.mdpi.com/2077-0383/11/21/6352 https://doaj.org/toc/2077-0383 |
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Ernest Tyburski Piotr Podwalski Katarzyna Waszczuk Krzysztof Rudkowski Jolanta Kucharska-Mazur Monika Mak Katarzyna Rek-Owodziń Piotr Plichta Maksymilian Bielecki Wojciech Andrusewicz Elżbieta Cecerska-Heryć Agnieszka Samochowiec Błażej Misiak Leszek Sagan Jerzy Samochowiec |
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Ernest Tyburski Piotr Podwalski Katarzyna Waszczuk Krzysztof Rudkowski Jolanta Kucharska-Mazur Monika Mak Katarzyna Rek-Owodziń Piotr Plichta Maksymilian Bielecki Wojciech Andrusewicz Elżbieta Cecerska-Heryć Agnieszka Samochowiec Błażej Misiak Leszek Sagan Jerzy Samochowiec |
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2024-07-03T18:18:26.372Z |
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