Monitoring of time-resolved singlet oxygen luminescence at 1270nm by an optical fiber detection system

Singlet oxygen (1O2) is the main cytotoxic substance in Type II photodynamic therapy (PDT). The luminescence of 1O2 at 1270[Formula: see text]nm is extremely weak with a low quantum yield, making the direct detection of 1O2 at 1270[Formula: see text]nm very challenging. In this study, a set of highl...
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Autor*in:	Cheng Zhang [verfasserIn] Hongxin Lin [verfasserIn] Ying Hu [verfasserIn] Jian Sui [verfasserIn] Lisheng Lin [verfasserIn] Buhong Li [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Singlet oxygen photodynamic therapy optical fiber detection system vasoconstriction

Übergeordnetes Werk:	In: Journal of Innovative Optical Health Sciences - World Scientific Publishing, 2017, 15(2022), 06
Übergeordnetes Werk:	volume:15 ; year:2022 ; number:06

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1142/S1793545822400119

Katalog-ID:	DOAJ083633448

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520			\|a Singlet oxygen (1O2) is the main cytotoxic substance in Type II photodynamic therapy (PDT). The luminescence of 1O2 at 1270[Formula: see text]nm is extremely weak with a low quantum yield, making the direct detection of 1O2 at 1270[Formula: see text]nm very challenging. In this study, a set of highly sensitive optical fiber detection system is built up to detect the luminescence of photosensitized 1O2. We use this system to test the luminescence characteristics of 1O2 in pig skin tissue ex vivo and mouse auricle skin in vivo. The experimental results show that the designed system can quantitatively detect photosensitized 1O2 luminescence. The 1O2 luminescence signal at 1270[Formula: see text]nm is successfully detected in pig skin ex vivo. Compared with RB in an aqueous solution, the lifetime of 1O2 increases to [Formula: see text]s in pig skin tissue ex vivo. Experiments on living mice suggest that an enhancement of 1O2 intensity with the increase of the TMPyP concentration. When the dose is 25[Formula: see text]mg/kg, the vasoconstriction can reach more than 80%. The results of this study hold the potential application for clinical PDT dose monitoring using an optical fiber detection system.
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allfields	10.1142/S1793545822400119 doi (DE-627)DOAJ083633448 (DE-599)DOAJbeff923e443746888e81d37de3b07e1f DE-627 ger DE-627 rakwb eng QC350-467 Cheng Zhang verfasserin aut Monitoring of time-resolved singlet oxygen luminescence at 1270nm by an optical fiber detection system 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Singlet oxygen (1O2) is the main cytotoxic substance in Type II photodynamic therapy (PDT). The luminescence of 1O2 at 1270[Formula: see text]nm is extremely weak with a low quantum yield, making the direct detection of 1O2 at 1270[Formula: see text]nm very challenging. In this study, a set of highly sensitive optical fiber detection system is built up to detect the luminescence of photosensitized 1O2. We use this system to test the luminescence characteristics of 1O2 in pig skin tissue ex vivo and mouse auricle skin in vivo. The experimental results show that the designed system can quantitatively detect photosensitized 1O2 luminescence. The 1O2 luminescence signal at 1270[Formula: see text]nm is successfully detected in pig skin ex vivo. Compared with RB in an aqueous solution, the lifetime of 1O2 increases to [Formula: see text]s in pig skin tissue ex vivo. Experiments on living mice suggest that an enhancement of 1O2 intensity with the increase of the TMPyP concentration. When the dose is 25[Formula: see text]mg/kg, the vasoconstriction can reach more than 80%. The results of this study hold the potential application for clinical PDT dose monitoring using an optical fiber detection system. Singlet oxygen photodynamic therapy optical fiber detection system vasoconstriction Technology T Optics. Light Hongxin Lin verfasserin aut Ying Hu verfasserin aut Jian Sui verfasserin aut Lisheng Lin verfasserin aut Buhong Li verfasserin aut In Journal of Innovative Optical Health Sciences World Scientific Publishing, 2017 15(2022), 06 (DE-627)60940315X (DE-600)2515441-2 17937205 nnns volume:15 year:2022 number:06 https://doi.org/10.1142/S1793545822400119 kostenfrei https://doaj.org/article/beff923e443746888e81d37de3b07e1f kostenfrei https://www.worldscientific.com/doi/10.1142/S1793545822400119 kostenfrei https://doaj.org/toc/1793-5458 Journal toc kostenfrei https://doaj.org/toc/1793-7205 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2022 06
spelling	10.1142/S1793545822400119 doi (DE-627)DOAJ083633448 (DE-599)DOAJbeff923e443746888e81d37de3b07e1f DE-627 ger DE-627 rakwb eng QC350-467 Cheng Zhang verfasserin aut Monitoring of time-resolved singlet oxygen luminescence at 1270nm by an optical fiber detection system 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Singlet oxygen (1O2) is the main cytotoxic substance in Type II photodynamic therapy (PDT). The luminescence of 1O2 at 1270[Formula: see text]nm is extremely weak with a low quantum yield, making the direct detection of 1O2 at 1270[Formula: see text]nm very challenging. In this study, a set of highly sensitive optical fiber detection system is built up to detect the luminescence of photosensitized 1O2. We use this system to test the luminescence characteristics of 1O2 in pig skin tissue ex vivo and mouse auricle skin in vivo. The experimental results show that the designed system can quantitatively detect photosensitized 1O2 luminescence. The 1O2 luminescence signal at 1270[Formula: see text]nm is successfully detected in pig skin ex vivo. Compared with RB in an aqueous solution, the lifetime of 1O2 increases to [Formula: see text]s in pig skin tissue ex vivo. Experiments on living mice suggest that an enhancement of 1O2 intensity with the increase of the TMPyP concentration. When the dose is 25[Formula: see text]mg/kg, the vasoconstriction can reach more than 80%. The results of this study hold the potential application for clinical PDT dose monitoring using an optical fiber detection system. Singlet oxygen photodynamic therapy optical fiber detection system vasoconstriction Technology T Optics. Light Hongxin Lin verfasserin aut Ying Hu verfasserin aut Jian Sui verfasserin aut Lisheng Lin verfasserin aut Buhong Li verfasserin aut In Journal of Innovative Optical Health Sciences World Scientific Publishing, 2017 15(2022), 06 (DE-627)60940315X (DE-600)2515441-2 17937205 nnns volume:15 year:2022 number:06 https://doi.org/10.1142/S1793545822400119 kostenfrei https://doaj.org/article/beff923e443746888e81d37de3b07e1f kostenfrei https://www.worldscientific.com/doi/10.1142/S1793545822400119 kostenfrei https://doaj.org/toc/1793-5458 Journal toc kostenfrei https://doaj.org/toc/1793-7205 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2022 06
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allfieldsGer	10.1142/S1793545822400119 doi (DE-627)DOAJ083633448 (DE-599)DOAJbeff923e443746888e81d37de3b07e1f DE-627 ger DE-627 rakwb eng QC350-467 Cheng Zhang verfasserin aut Monitoring of time-resolved singlet oxygen luminescence at 1270nm by an optical fiber detection system 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Singlet oxygen (1O2) is the main cytotoxic substance in Type II photodynamic therapy (PDT). The luminescence of 1O2 at 1270[Formula: see text]nm is extremely weak with a low quantum yield, making the direct detection of 1O2 at 1270[Formula: see text]nm very challenging. In this study, a set of highly sensitive optical fiber detection system is built up to detect the luminescence of photosensitized 1O2. We use this system to test the luminescence characteristics of 1O2 in pig skin tissue ex vivo and mouse auricle skin in vivo. The experimental results show that the designed system can quantitatively detect photosensitized 1O2 luminescence. The 1O2 luminescence signal at 1270[Formula: see text]nm is successfully detected in pig skin ex vivo. Compared with RB in an aqueous solution, the lifetime of 1O2 increases to [Formula: see text]s in pig skin tissue ex vivo. Experiments on living mice suggest that an enhancement of 1O2 intensity with the increase of the TMPyP concentration. When the dose is 25[Formula: see text]mg/kg, the vasoconstriction can reach more than 80%. The results of this study hold the potential application for clinical PDT dose monitoring using an optical fiber detection system. Singlet oxygen photodynamic therapy optical fiber detection system vasoconstriction Technology T Optics. Light Hongxin Lin verfasserin aut Ying Hu verfasserin aut Jian Sui verfasserin aut Lisheng Lin verfasserin aut Buhong Li verfasserin aut In Journal of Innovative Optical Health Sciences World Scientific Publishing, 2017 15(2022), 06 (DE-627)60940315X (DE-600)2515441-2 17937205 nnns volume:15 year:2022 number:06 https://doi.org/10.1142/S1793545822400119 kostenfrei https://doaj.org/article/beff923e443746888e81d37de3b07e1f kostenfrei https://www.worldscientific.com/doi/10.1142/S1793545822400119 kostenfrei https://doaj.org/toc/1793-5458 Journal toc kostenfrei https://doaj.org/toc/1793-7205 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2022 06
allfieldsSound	10.1142/S1793545822400119 doi (DE-627)DOAJ083633448 (DE-599)DOAJbeff923e443746888e81d37de3b07e1f DE-627 ger DE-627 rakwb eng QC350-467 Cheng Zhang verfasserin aut Monitoring of time-resolved singlet oxygen luminescence at 1270nm by an optical fiber detection system 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Singlet oxygen (1O2) is the main cytotoxic substance in Type II photodynamic therapy (PDT). The luminescence of 1O2 at 1270[Formula: see text]nm is extremely weak with a low quantum yield, making the direct detection of 1O2 at 1270[Formula: see text]nm very challenging. In this study, a set of highly sensitive optical fiber detection system is built up to detect the luminescence of photosensitized 1O2. We use this system to test the luminescence characteristics of 1O2 in pig skin tissue ex vivo and mouse auricle skin in vivo. The experimental results show that the designed system can quantitatively detect photosensitized 1O2 luminescence. The 1O2 luminescence signal at 1270[Formula: see text]nm is successfully detected in pig skin ex vivo. Compared with RB in an aqueous solution, the lifetime of 1O2 increases to [Formula: see text]s in pig skin tissue ex vivo. Experiments on living mice suggest that an enhancement of 1O2 intensity with the increase of the TMPyP concentration. When the dose is 25[Formula: see text]mg/kg, the vasoconstriction can reach more than 80%. The results of this study hold the potential application for clinical PDT dose monitoring using an optical fiber detection system. Singlet oxygen photodynamic therapy optical fiber detection system vasoconstriction Technology T Optics. Light Hongxin Lin verfasserin aut Ying Hu verfasserin aut Jian Sui verfasserin aut Lisheng Lin verfasserin aut Buhong Li verfasserin aut In Journal of Innovative Optical Health Sciences World Scientific Publishing, 2017 15(2022), 06 (DE-627)60940315X (DE-600)2515441-2 17937205 nnns volume:15 year:2022 number:06 https://doi.org/10.1142/S1793545822400119 kostenfrei https://doaj.org/article/beff923e443746888e81d37de3b07e1f kostenfrei https://www.worldscientific.com/doi/10.1142/S1793545822400119 kostenfrei https://doaj.org/toc/1793-5458 Journal toc kostenfrei https://doaj.org/toc/1793-7205 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2022 06
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The luminescence of 1O2 at 1270[Formula: see text]nm is extremely weak with a low quantum yield, making the direct detection of 1O2 at 1270[Formula: see text]nm very challenging. In this study, a set of highly sensitive optical fiber detection system is built up to detect the luminescence of photosensitized 1O2. We use this system to test the luminescence characteristics of 1O2 in pig skin tissue ex vivo and mouse auricle skin in vivo. The experimental results show that the designed system can quantitatively detect photosensitized 1O2 luminescence. The 1O2 luminescence signal at 1270[Formula: see text]nm is successfully detected in pig skin ex vivo. Compared with RB in an aqueous solution, the lifetime of 1O2 increases to [Formula: see text]s in pig skin tissue ex vivo. Experiments on living mice suggest that an enhancement of 1O2 intensity with the increase of the TMPyP concentration. When the dose is 25[Formula: see text]mg/kg, the vasoconstriction can reach more than 80%. 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callnumber-first	Q - Science
author	Cheng Zhang
spellingShingle	Cheng Zhang misc QC350-467 misc Singlet oxygen misc photodynamic therapy misc optical fiber detection system misc vasoconstriction misc Technology misc T misc Optics. Light Monitoring of time-resolved singlet oxygen luminescence at 1270nm by an optical fiber detection system
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topic_title	QC350-467 Monitoring of time-resolved singlet oxygen luminescence at 1270nm by an optical fiber detection system Singlet oxygen photodynamic therapy optical fiber detection system vasoconstriction
topic	misc QC350-467 misc Singlet oxygen misc photodynamic therapy misc optical fiber detection system misc vasoconstriction misc Technology misc T misc Optics. Light
topic_unstemmed	misc QC350-467 misc Singlet oxygen misc photodynamic therapy misc optical fiber detection system misc vasoconstriction misc Technology misc T misc Optics. Light
topic_browse	misc QC350-467 misc Singlet oxygen misc photodynamic therapy misc optical fiber detection system misc vasoconstriction misc Technology misc T misc Optics. Light
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title	Monitoring of time-resolved singlet oxygen luminescence at 1270nm by an optical fiber detection system
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title_full	Monitoring of time-resolved singlet oxygen luminescence at 1270nm by an optical fiber detection system
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author_browse	Cheng Zhang Hongxin Lin Ying Hu Jian Sui Lisheng Lin Buhong Li
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title_sort	monitoring of time-resolved singlet oxygen luminescence at 1270nm by an optical fiber detection system
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title_auth	Monitoring of time-resolved singlet oxygen luminescence at 1270nm by an optical fiber detection system
abstract	Singlet oxygen (1O2) is the main cytotoxic substance in Type II photodynamic therapy (PDT). The luminescence of 1O2 at 1270[Formula: see text]nm is extremely weak with a low quantum yield, making the direct detection of 1O2 at 1270[Formula: see text]nm very challenging. In this study, a set of highly sensitive optical fiber detection system is built up to detect the luminescence of photosensitized 1O2. We use this system to test the luminescence characteristics of 1O2 in pig skin tissue ex vivo and mouse auricle skin in vivo. The experimental results show that the designed system can quantitatively detect photosensitized 1O2 luminescence. The 1O2 luminescence signal at 1270[Formula: see text]nm is successfully detected in pig skin ex vivo. Compared with RB in an aqueous solution, the lifetime of 1O2 increases to [Formula: see text]s in pig skin tissue ex vivo. Experiments on living mice suggest that an enhancement of 1O2 intensity with the increase of the TMPyP concentration. When the dose is 25[Formula: see text]mg/kg, the vasoconstriction can reach more than 80%. The results of this study hold the potential application for clinical PDT dose monitoring using an optical fiber detection system.
abstractGer	Singlet oxygen (1O2) is the main cytotoxic substance in Type II photodynamic therapy (PDT). The luminescence of 1O2 at 1270[Formula: see text]nm is extremely weak with a low quantum yield, making the direct detection of 1O2 at 1270[Formula: see text]nm very challenging. In this study, a set of highly sensitive optical fiber detection system is built up to detect the luminescence of photosensitized 1O2. We use this system to test the luminescence characteristics of 1O2 in pig skin tissue ex vivo and mouse auricle skin in vivo. The experimental results show that the designed system can quantitatively detect photosensitized 1O2 luminescence. The 1O2 luminescence signal at 1270[Formula: see text]nm is successfully detected in pig skin ex vivo. Compared with RB in an aqueous solution, the lifetime of 1O2 increases to [Formula: see text]s in pig skin tissue ex vivo. Experiments on living mice suggest that an enhancement of 1O2 intensity with the increase of the TMPyP concentration. When the dose is 25[Formula: see text]mg/kg, the vasoconstriction can reach more than 80%. The results of this study hold the potential application for clinical PDT dose monitoring using an optical fiber detection system.
abstract_unstemmed	Singlet oxygen (1O2) is the main cytotoxic substance in Type II photodynamic therapy (PDT). The luminescence of 1O2 at 1270[Formula: see text]nm is extremely weak with a low quantum yield, making the direct detection of 1O2 at 1270[Formula: see text]nm very challenging. In this study, a set of highly sensitive optical fiber detection system is built up to detect the luminescence of photosensitized 1O2. We use this system to test the luminescence characteristics of 1O2 in pig skin tissue ex vivo and mouse auricle skin in vivo. The experimental results show that the designed system can quantitatively detect photosensitized 1O2 luminescence. The 1O2 luminescence signal at 1270[Formula: see text]nm is successfully detected in pig skin ex vivo. Compared with RB in an aqueous solution, the lifetime of 1O2 increases to [Formula: see text]s in pig skin tissue ex vivo. Experiments on living mice suggest that an enhancement of 1O2 intensity with the increase of the TMPyP concentration. When the dose is 25[Formula: see text]mg/kg, the vasoconstriction can reach more than 80%. The results of this study hold the potential application for clinical PDT dose monitoring using an optical fiber detection system.
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title_short	Monitoring of time-resolved singlet oxygen luminescence at 1270nm by an optical fiber detection system
url	https://doi.org/10.1142/S1793545822400119 https://doaj.org/article/beff923e443746888e81d37de3b07e1f https://www.worldscientific.com/doi/10.1142/S1793545822400119 https://doaj.org/toc/1793-5458 https://doaj.org/toc/1793-7205
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up_date	2024-07-03T18:33:16.679Z
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Monitoring of time-resolved singlet oxygen luminescence at 1270nm by an optical fiber detection system

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